Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
In the olfactory bulb (OB), vasoactive intestinal polypeptide (VIP) neurons have a role in modulation of the interneuronal network. It has been known to be expressed in the granule cell layer (GCL), external plexiform layer (EPL), and...
This thesis directly deals with the developmental path and business aspects behind bringing a drug to market. The drug and science that is focused on pertains to concussion and treatment of this condition. If you are a scientist...
The Uniform Determination of Death Act (UDDA) states that an individual is dead when "all functions of the entire brain" have ceased irreversibly. However, it has been questioned whether some functions of the hypothalamus, particularly...
In male hamsters mating behavior is dependent on sufficient androgens and chemosensory input from the main olfactory and vomeronasal systems, whose central pathways contain cell bodies and fibers of gonadotropin-releasing hormone (GnRH)...
The aggresome is a key cytoplasmic organelle for sequestration and clearance of toxic protein aggregates. When proteasome-dependent degradation fails, misfolded proteins can be sequestered into aggresomes, which facilitate their...
Variation in bitter taste perception plays a crucial role in dietary choice and much research has been done to better understand the factors that cause variation in bitter taste perception. One factor that may cause variation in bitter...
I defend a theory of mental representation that satisfies naturalistic constraints. Briefly, we begin by distinguishing (i) what makes something a representation from (ii) given that a thing is a representation, what determines what it...
Paternal behavior is an interesting and important research topic due to its integral contribution to the fitness and well-being of multiple species, including humans. Although paternal behavior is well described in literature, attempts...
Social and physical aspects of sexual intercourse provide protective benefits on mental and physical health in humans. Similarly, in rodents, mating promotes resistance to anxiety- and- depressive-like behaviors. Furthermore, our lab has...
Major depressive disorder is a serious public mental health concern with prevalent sex differences, affecting twice as many women as men. The non-competitive NMDA receptor antagonist ketamine is being used clinically at low doses as an...
Attention deficit/hyperactivity disorder (ADHD) is a condition characterized by excessive levels of impulsivity, inattention, and hyperactivity. Mice subjected to deletion of the Kv1.3 potassium ion channel (knockout, KO) were observed...
Diet-induced obesity (DIO) is a growing health concern in the United States, with more than a third of the population suffering from this disease. Deficits in many sensory processes such as olfaction, audition and vision have been linked...
Epigenetic regulation of gene expression involves a steady-state balance of acetylation carried about by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HATs act as transcriptional co-activators and HDACs interact...
The venom of spider Plectreurys tristis contains a variety of peptide toxins that selectively target neuronal ion channels. O-palmitoylation of a threonine or serine residue, along with a characteristic and highly constrained disulfide...
Previous studies suggest that the PER protein and its rhythmicity is the most critical component for clock functioning. This project expands on this premise to look at degradation methods used by mammals to degrade PER in the clock...
We investigated sex differences in the resting-state neural correlates of Openness to Experience, a universal personality trait defined by cognitive flexibility, attention to feelings, creativity, and preference for novelty. Using...
Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders....
This experiment was designed to examine the impact of chronic stress exposure on nicotine consumption. Adolescent (postnatal days, PD 38-75) male mice underwent 10 days of social defeat, were treated with one month (long-term) of forced...
BACKGROUND: Mood disorders in old age increase the risk of morbidity and mortality for individuals and healthcare costs for society. Trait Neuroticism, a strong risk factor for such disorders into old age, shares common genetic variance...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
