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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The hydraulic analogy for electrical circuits is a well-known, if limited, model for understanding potential and current. The work described in this thesis extends this analogy to chemical reactions by constructing apparatuses that model...
Solid-state carbon-13 nuclear magnetic resonance (NMR) spectroscopy has come to be considered the pre-eminent analytical technique for the study of soil organic matter in its entirety. Despite its widespread use, carbon-13 CP-MAS NMR of...
Solid films of C60 and C70 fullerenes are evaluated in propylene carbonate/lithium perchlorate, an electrolyte commonly used in lithium batteries. Cyclic voltammetry, chronopotentiometry, and an effusion test, show that reduced C60 and...
The photophysical characteristics of 5-arylvinyl-5Oe-methyl-2, 2Oe-bipyridyls (AVMB) and their zinc complexes were investigated in order to recognize the factors that influence the emission band shift and fluorescence quantum yield change...
This dissertation studies the size- and site-dependent optical and magnetic properties of II-VI quantum dots (QDs). The first chapter provides a theoretical background used to analyze the data and the properties expected for diluted...
Box C/D snoRNPs catylze the specific 2'O-methylation of rRNA in important regions the ribosome, although the role of the modifications is unclear. Eukaryotic box C/D snoRNPs consists of a box C/D RNA and four proteins, Fibrillarin, Nop56...
Microwaves have been for their ability to heat water and food rapidly. And thanks to scientific technology and global marketing, the microwave oven was invented and got widely used in 1970's and 1980's. . Microwave radiation has specific...
Small nucleolar RNAs (snoRNAs) are localized in the nucleolus as small ribonucleoprotein particle (snoRNP) that are RNA-protein complexes and catalyze site specific modifications on the ribosomal RNA. When compared to many protein...
Oxide ceramics are materials with a wide range of properties. Insulators are most common, however semiconductors, strongly correlated electron materials, and even superconductors are all relevant oxide materials. Here we seek to...
This dissertation presents the first single crystal 55Mn NMR characterization of three compounds related to Mn12-acetate [Mn12O12(O2CCH3)16(H2O)4]× 2CH3COOH-4H2O (henceforth Mn12-Ac) that have come to be known as Single-Molecule Magnets ...
Electron transfer dynamics at the nanocrystalline semiconducting metal oxide interface plays a pivotal role in diverse applications such as dye-sensitized solar cells (DSSCs), dye-sensitized photoelectric solar cells (DSPECs), sensors...
Solution-Phase Hydrogen/Deuterium Exchnage Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Technique Development and Application to Muscle Biochemistry
Proteins are vital macromolecules of every living cell. They undertake a variety of tasks that are essential for life. Most proteins function in assemblies rather than individually. Protein function is strongly correlated to structure...
Materials synthesis far from thermodynamic equilibrium can yield hierarchical order that spans from molecular to macroscopic length scales. Here we study the formation of microscopic and macroscopic inorganic tubes during spatially...
Our lab was faced with a synthetic challenge during studies towards the total synthesis of the anti-malaria drug, artemisinin. Known methods such as the Aldol condensation, the Horner-Wadsworth-Emmons and the Wittig reactions were...
Human glucokinase is a 52 kDa single polypeptide chain containing 465 amino acids and a single binding site. It catalyzes the ATP dependent phosphorylation of glucose in the beta pancreatic cells, which ultimately serves as the glucose...
One of the mechanisms of cardiac arrhythmias is the self-organization of electrical waves in the heart. These waves can anchor to scar tissue, collagen fibers, and coronary vessels. The anchoring generates stationary electrical signals...
CRISPR-cas systems have been found to confer RNA guided immunity in prokaryotes comparable to the eukaryotic RNA interference. These Clustered Regularly Interspaced Short Palindromic Repeats, as their name entails, are repeated sequences...
This work describes the activation profiles and regulatory cascades of the human kallikrein-related peptidases. The human kallikrein (KLK)-related peptidases are the largest family of serine peptidases, comprising 15 members (KLK1–15)...
Extended Metal Atom Chains (EMACs) are compounds that consist of three or more metal atoms that are directly bonded with the support of equatorial organic ligands. This dissertation is focused on the high frequency electron magnetic...
All functional RNAs contain post-transcriptionally modified nucleotides. 2'-O-ribose methylation and pseudouridylation are the two major types of modifications, which occur by box C/D and box H/ACA ribonucleoprotein (RNP) complexes, ...
Nanoparticles have been extensively studied in the past few decades due to the possibilities they offer in applications ranging from medicine to energy generation. A new class of ultra-small noble metal nanoparticles consisting of tens...
Vitrimers are a new category of polymer that incorporates an associative bond exchange molecular network rearrangement mechanism (MNR), which happens in a single step rather than in discrete dissociation and association steps. Based on a...
The search for alternative nuclear fuels, materials suitable for nuclear waste repositories, and new superconducting materials has been underway for decades. We have explored metal flux and mixed-metal flux synthesis and supercritical...
Petroleum, one of the most complex mixtures on Earth, has been extensively studied for decades. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and the ultrahigh resolution it provides, however, has dramatically...
Block copolymer ionomers are a class of polymers that contain a hydrophobic block and a block containing charged repeat units. In the first set of experiments, micelles were created from such a polymer. A set of fluorescence probe...
Nanotechnology is a new frontier for the advancement of science and technology. Nanomaterials are playing a crucial role and that they will continue to do so is beyond doubt. They are being used in electronic, magnetic, optical and...
Polyelectrolytes can be used in a variety of forms from Layer-by-Layer assembled thin films to spun polyelectrolyte complex as free-standing membranes. The Layer-by-Layer methodology is used to adsorb oppositely charged polyelectrolytes...
This dissertation presents studies by magnetization, dc magnetic susceptibility and EPR spectroscopy on several new spin-frustrated polyoxometalate (POM) lattices of increasing spin sizes and complexities. Measurements have been made...
The stationary phase used in a chromatography column and the way it is packed inside the column greatly influences the separation in a chromatographic system. In capillary electrochromatography, the column plays an even more vital role...
This dissertation aims to advance the understanding and applicability of nanotechnology through the use of nanoparticles as conjugated delivery agents. By providing multi-functionality of a nanoparticle and a nucleic acid therapeutic, ...
The work described in this thesis includes research done on two major projects, chemical heterogeneity and sequence length heterogeneities in copolymers. In the chemical heterogeneity project, we present a method by which to obtain the...
The focus of this dissertation is the study of the magnetic properties of several novel lanthanide and actinide metal complexes, of particular concentration is the use of SQUID magnetochemistry coupled with electron paramagnetic...
Metal nanoparticles are an important tool in energy transfer assays. The aim of this dissertation is to look deeply into the properties of small gold nanoparticles (Au NP) and how they can affect the experimental observables in energy...
Changes in environmental conditions cause alterations in the metabolism of cells. The field of metabolomics seeks to assay for and understand on a whole-cell level how metabolism responds to these changes. In this dissertation, a method...
Nanoparticles are at the forefront of science and technology today. This dissertation will expand the basic fundamental understanding of the phenomenon known as resonant energy transfer. A number of analytical techniques were utilized to...
With the advent of two "soft" ionization techniques in the late 1980s—electrospray ionization (ESI) and matrix assisted laser desorption/ionization (MALDI) for the routine and general formation of intact molecular ions—and continuing...
Removal of introns from pre-mRNA in eukaryotes is mediated by the spliceosome, a dynamic supramolecular complex comprising five small nuclear (sn)RNAs and numerous proteins, organized into small ribonucleoprotein (snRNP) particles. At...
During the last decade, homogeneous gold catalysis emerged as one of the most efficient tools for C-C and C-X (O, N, S ') formations in the organic chemist's tool box. Gold catalysis enriched the world of synthetic organic chemistry with...
Carbon is an extraordinary element due its facile bonding properties. Nowhere is this uniqueness more evident than in the variety of structures that spontaneously form in carbon vapor. Structural transitions as a function of increasing...
The scope of this dissertation is two-fold: assembly of histidine-tagged peptides and proteins directly to the surface of a 1.5 nm AuNP and the assembly and delivery of nano-medical materials for MR imaging and gene therapy. Chapter 1 is...
Nature presents active components in the form of proteins and molecular motors that are involved in locomotion and inter compartmental transport. Inspired by nature, this dissertation focuses on presenting experimental means to...
Matrix metalloproteinases (MMPs), a family of enzymes known for their proteolytic activities on processing extracellular matrix substrates, may play an integral role in blood-brain barrier opening following an ischemic stroke. Several...
Living organisms engineer complex architectures that address many of their survival needs such as strength, flexibility, self-healing properties, and the fast transport of resources. The typical starting materials are abundant and...
Photographer David Douglas Duncan captured several images of the Middle East and South Asia throughout the 1940s and 1950s. His photographs were published in several photo essays in Life magazine. This study will focus on a portion of...
This doctoral thesis encompasses wide expanses of studies, which aim to advance the understanding of structure-property relationships in fast ion conductors (FICs) with a variety of characterization tools. In particular, powder X-ray...
This dissertation describes the methodology for using microwave chemistry to control the reaction kinetics and/or thermodynamics of semiconductor nanocrystalline materials. The introduction provides a background of synthetic methods for...
The cyclic voltammetry of ultrathin fihns of polyacetylene comprised of 2-3 nm micro fibrils and their aggregate 20 nm fibrils in methylene chloride, acetonitrile, propylene carbonate, and sulfo]ane shows many similarities, including a...
The work described in this thesis details the development of a quintuple-detector SEC separation to measure chemical heterogeneity and determine the solution conformation for copolymers and polymer blends. Chemical heterogeneity affects...
Structural foams reinforced with carbon nanotubes could prove to be beneficial in numerous industrial applications. High internal phase emulsion foams are emerging as new and important forms of microcellular foams. Microcellular foams, ...
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