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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Our lab was faced with a synthetic challenge during studies towards the total synthesis of the anti-malaria drug, artemisinin. Known methods such as the Aldol condensation, the Horner-Wadsworth-Emmons and the Wittig reactions were...
One of the mechanisms of cardiac arrhythmias is the self-organization of electrical waves in the heart. These waves can anchor to scar tissue, collagen fibers, and coronary vessels. The anchoring generates stationary electrical signals...
Global demand for clean sustainable energy is growing with the planet's population. While fossil fuels are the current standard, many are looking to the nearly endless energy supplied by the Sun. Because of the potential cost benefit...
This work presents a full experimental and theoretical study of the first radical enyne cascade in which chemo- and regioselective interaction of the triple bond with Bu3Sn radicals originates from a conceptually novel source and...
Non-covalent molecular interactions are a ubiquitous part of molecular interaction and the driving force behind macromolecules and host-guest binding. However, a more recent non-covalent molecular interaction, the cation-π interaction, ...
Modern protein catalysts are often viewed as possessing exquisite specificities for their cognate physiological substrates. In contrast, primordial catalysts are thought to have possessed much broader substrate specificities, a...
Malaria is a global epidemic, resulting in the deaths of nearly one million people every year. Part 1 of this dissertation will focus on the history of Malaria and ways to combat this devastating disease. Artemisinin has emerged as the...
This dissertation is divided into two parts, both of which describe the synthesis of various organic molecules. Much of the work is already published, as noted where appropriate in the chapter headings. The first part of this work covers...
The Iron-dependent Regulator (IdeR) is a 230-amino acid transcriptional repressor that regulates iron homeostasis, oxidative stress response and virulence in Mycobacterium tuberculosis. IdeR binds to DNA as a dimer of dimers to repress...
Damage continues to plague the structural integrity of polymer composites. Continued stress leads to cracking and weakening of a composite system. Engineering polymer composites with carbon nanotube reinforcements and self-healing...
BAD is a pro-apoptotic member of the Bcl-2 family of cell death regulators. The Bcl-2 family controls the permeability of the outer mitochondrial membrane via interactions between pro- and anti-apoptotic members of the family. Once the...
This thesis presents the synthesis of a chiral 6-membered NHC catalyst copper catalyst and its use in the β-borylation and allylic substitution reactions. The application of the catalyst in the known β-borylation reaction demonstrates...
In this dissertation is described the formal synthesis of the natural product palmerolide A, using an addition/ fragmentation reaction of vinylogous acyl triflates developed in the Dudley Lab. In the first chapter, the isolation and...
This dissertation is organized in two parts. The first part summarizes work in a newly developed synthetic route to perovskite-like MOFs, offering control over particle size and morphology. The second part of the dissertation cover...
A generalized ensemble based enhanced sampling scheme, the Orthogonal Space Sampling (OSS) approach, is introduced in this thesis. Due to the fact that the OSS scheme simultaneously accelerates the motions of a target event and its...
Microfluidics is the field of study involving the manipulation of fluid in devices with micron scale length dimensions and, typically, nano- to picoliter fluid volumes. Miniaturization gives rise to specific advantages in the field of...
Sugar kinases are enzymes known to catalyze the phosphorylation of different sugar substrates. The sugar kinases encompassed by the ROK (repressor, open reading frame, kinase) superfamily offer a unique opportunity to explore the...
Water soluble polyelectrolytes have gained great interest for their low toxicity and wide applications. Oppositely charged polyelectrolytes (polycations and polyanions) can produce thin multilayers through a layer-by-layer technique and...
Multiferroic materials are rare compounds featuring at least two ferroic properties with a majority of them displaying (anti)ferro – electricity or magnetism. Currently, the most famous compounds displaying such be-havior are oxide...
[1, 2]-Anionic rearrangements are important tools for altering the complexity of molecules at hand. In Part I of this dissertation, an anionic rearrangement of 2-benzyloxypyridine is described. Pyridine-directed metallation of the...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
