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Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
Description:
This invention relates to a method for making radiosensitizing diamines. This method comprises converting a compound having formula (5): ##STR1## to a compound having formula (6): ##STR2## using dimethyl sulfoxide activated by oxalyl...
Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
Description:
A compound or a salt thereof comprising a polyamine containing at least 2 electron-affinic groups is provided. In a preferred embodiment, the polyamine compound has the structure: wherein: PA1 A is a spacer; R.sup.1, R.sup.2, R.sub.3, ...
Radiosensitizing taxanes and their pharmaceutical preparations
Description:
Taxanes containing electron-affinic radiosensitizing functional groups, their pharmaceutical preparations, and methods of making and using this new class of highly potent radiosensitizers of tumor cells.
Radiosensitizing diamines and their pharmaceutical preparations
Description:
A compound comprising a diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula ##STR1## wherein A comprises a carbon chain...
Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups and method of application thereof
Description:
A compound comprising and diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula ##STR1## wherein A comprises a carbon carbon...
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