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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Eukaryotic genomes replicate via the synchronous firing of clusters of origins that together produce multi-replicon domains, each of which replicates at a defined time during S-phase. This temporal program is termed the DNA replication...
DNA replication in all Eukaryotes follows a defined temporal order termed replication-timing program (RT), which is coupled with the spatial separation of chromatin distribution inside the nucleus. Early or late replicating chromatin...
DNA replication, the duplication of genetic and epigenetic information, is the basis of biological inheritance. In all eukaryotes, DNA replication follows a tightly regulated replication-timing program, which dynamically changes during...
The time at which DNA replicates during S-phase (replication timing; RT) is a precisely orchestrated, yet large-scale epigenetic property that offers an unparalleled window into the structure and regulation of the genome. While the...
DNA replication in eukaryotic cells follows a temporal order that is consistent from cell cycle to cell cycle and is correlated with the spatial organization of DNA in the nucleus. This "replication-timing program" is conserved in...
DNA is replicated in a defined temporal order termed the RT program. Ordered DNA replication is conserved in eukaryotes, yet its biological significance remains enigmatic. 3D genome organization as assayed by Hi-C has revealed that RT is...
The temporal order in which segments of the genome are duplicated is referred to as the replication timing (RT) program. RT is established in each cell cycle coincident with the repositioning and anchorage of chromosomes in early G1. In...
Replicative DNA polymerases require a ssDNA template, yet polymerases themselves lack dsDNA unwinding activity (Kawasaki and Sugino, 2001). Enter the helicase, a motor protein that uses NTP-dependent conformational changes to unwind...
DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
