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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Extracellular vesicles (EVs) or exosomes are responsible for a variety of signaling processes and overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique...
Small intestinal submucosa (SIS) is an extracellular matrix (ECM) harvested from pig. It contains primarily collagen with multiple proteins and growth factors. It is a biocompatible scaffold that supports cell growth in vitro and can be...
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders and causes cognitive impairment and memory deficits of the patients. The mechanism of AD is not well known, due to the lack of study materials, e.g., human...
Heart related diseases have been the leading cause of death in the United States. Approximately 29% of patients die within 1 year after an initial stroke. Anticoagulants have been prescribed to prevent many thrombotic disorders to occur....
The aim of this work is to develop a deeper understanding of the nuances involved in designing and optimizing the performance of gas/liquid plasma reactors for chemical synthesis. The design of such reactors requires integrating...
Pulsed gas phase corona discharge was studied as a possible new technology for the removal of nitrogen oxides and volatile organic compounds from contaminated gases. The combination of pulsed positive streamer corona discharge with a...
Vitrimers are a new category of polymer that incorporates an associative bond exchange molecular network rearrangement mechanism (MNR), which happens in a single step rather than in discrete dissociation and association steps. Based on a...
A new future in automotive transportation is approaching where vehicles are powered by new, clean and efficient energy sources. While different technologies will contribute to this future, many see fuel cells as the leading long term...
Designer self-assembling peptides (small proteins) such as RADA16-I (1, 2, 7) and MAX8 (2) are being used as nanofiber scaffolds for supporting tissue regeneration. Specific applications of these materials in regenerative medicine...
Colloidal suspensions transform between fluid and disordered solid states when parameters such as the colloid volume fraction and the strength and nature of the colloidal interactions are varied. Seemingly subtle changes in the...
Over the last decade advanced oxidation reduction processes (AORP) have acquired significant importance in degrading minute concentrations (ppb to ppm levels) of recalcitrant contaminants that are difficult to degrade using conventional...
Copolymerization of propylene with 1, 9 decadiene using an isospecific metallocene catalyst leads to isotacic poly(propylenes) with H-type intermolecular linkages, resembling chemical crosslinks and leading to enhanced melt strength. In...
MRI magnets are constantly evolving with technologies for higher fields, improving sensitivity and increasing resolution. Major achievements in MRI magnet technology in recent years include the successful construction of a 21.1-T, 900...
Scientists have used computers to model a plethora of systems since the rise of the computer age. The most common use of modeling is to analyze an existing system. With a complete model of an existing system the parameters can be changed...
Polyethylenes with halogen substitution at a precise distance along the methylene backbone are unique models to study the effect of nano-structured chain-defects on folding and crystallization of polymers. Prior work has shown that the...
Polymers are essential to modern life. Yet there still remains a wealth of knowledge to discover regarding novel polymeric materials, processing techniques, and applications. The synthesis and application of nanostructured amphiphilic...
The study of melt miscibility and structure-property relations of different types of polyolefins provide an important pathway to material design for different applications. In this work we study melt and crystalline properties of blends...
High field 1H and 23Na MRI provide sensitive metrics of quantifying ischemic stroke over time. In this work, the efficacy of human mesenchymal stem cells (hMSC) aggregated into 3D spheroids (a-hMSC) as a treatment method for ischemic...
In this work, we study the dynamics of polyelectrolytes in microchannel and nanochannel flows under externally applied pressure and electric fields using both theoretical and computational approaches. Hydrodynamic interactions, acting...
Human mesenchymal stem cells (hMSCs) isolated from bone marrow have multi-lineage differentiation potential and have attracted considerable attention in bone tissue regeneration. However, previous studies have shown that 2D-expanded...
Diffusion Tensor Imaging (DTI) provides a unique contrast based on the restricted directionality of water movement in an anisotropic environment. As such, DTI-based tractography can be used to characterize and quantify the structural...
Ethylene 1-alkene copolymers with the same molar mass, same molar mass distribution and very similar average comonomer content of 3.8 +/- 0.4 mol% but different broad interchain comonomer content distribution (CCD), are found to display...
Microparticles are widely used and studied for biomedical applications and can be fabricated by bottom-up and top-down techniques. While the top-down techniques are superior to the bottom-up techniques in controlling particle geometry, ...
Diffusion tensor imaging (DTI) provides a map of diffusional anisotropy based on the Brownian motion of water within the restricted boundaries of tissues. In this work, a high angular resolution DTI acquired with 18 diffusion directions...
In the first part of this thesis, the bivariate or cross branching distribution of a film-grade ethylene 1-hexene copolymer with enhanced MD and TD Elmendorf tear (> 400 g/mil) and high dart impact, synthesized ExxonMobil Chemical...
Electro-oxidation of alcohols is a very important pathway towards the production of high value chemicals and renewable energy applications. Polyhydric alcohols such as glycerol, are also interesting candidates for direct energy...
Gels are a very unique state of matter and play very important roles in nature. As a special intermediate state between solid and liquid, gels have some peculiar characteristics, such as phase transition and ion-exchange. These unique...
Model random ethylene copolymers with ethyl branches are known to exhibit strong melt memory of crystallization even above their equilibrium melting temperatures. Seeds remain in the melt at high temperatures lowering the change in free...
Poly-ϵ-caprolactone (PCL) based copolymers have received much attention as drug or growth factor delivery carriers and tissue engineering scaffolds due to their biocompatibility, biodegradability, and tunable biophysical properties....
Human mesenchymal stem cells (hMSCs) are colony-forming unit fibroblasts (CFU-F) derived from adult bone marrow and have significant potential for many cell-based tissue-engineering applications. Their therapeutic potential, however, is...
Microparticles are widely used for biomedical applications. Top-down techniques are able to generate particles with non-spherical shapes, precisely defined geometries, and complex structures and compositions. These properties allow well...
Acute pancreatitis is a sudden, severe inflammation of the pancreas which may eventually lead to life-threatening complications associated with digestive necrosis of the gland. Premature, intracellular activation of zymogens is believed...
Human mesenchymal stem cells (hMSCs) are considered as a novel candidate for cell therapy due to the differentiation potential, migration ability, and secretion function. Late stage clinical trials require a large amount of cells that...
Computational material simulation is becoming more and more important as a branch of material science. Depending on the scale of the systems, there are many simulation methods, i.e. first-principles calculation (or ab-initio), molecular...
As fuel costs continue to increase, novel methods to produce energy are becoming very important. Methods to generate hydrogen from organic material for utilization in fuel cells have been the source of much research over recent decades....
Human mesenchymal stem cells (hMSCs) isolated from various adult tissues are primary candidates in cell therapy for tissue regeneration. The pro-regenerative properties of hMSCs are largely attributed to their trophic effects by the...
The design of novel proteins with unique functions has immense application for the development of novel drugs, catalytic enzymes, vaccines, and the creation of innovative biotechnological devices. Hindering the design of novel proteins...
Viscoelastic wormlike micelles are widely used in variety of industrial processes, and daily life applications such as food, paint, pharmacy, oil-field operations and others. Wormlike micelles usually contain surfactant and salts that...
During the last decade considerable effort has focused on understanding the mechanism of action of the cellulase enzymes, optimization of the enzyme mixture to result in maximum sugar yield and development of a comprehensive kinetics...
Tissue engineering is a rapidly developing field seeking to solve biomedical problems with wide-range of clinical applications. Major obstacles to the generation of functional tissue constructs in bioreactor culture devices for these...
In-situ hydrolysis of de-lignified cellulose pulp dissolved in N-methyl morpholine oxide (NMMO) by commercially available AccelleraseTM1000 was studied under various reaction conditions and reaction schemes. The yield of reducing sugars...
Airway inflammation and remodeling are two key processes in chronic airway disease such as asthma. Inflammation in the airways is the major effect leading to narrowing of small airways and alveolar wall destruction in chronic obstructive...
A pulsed electrical discharge in water produces conductive channels called streamers or "streamer-like plasma channels" and high energy electrons which are capable of dissociating and/or ionizing water molecules. The primary species...
Although diffusion is an important phenomenon for intra-cellular metabolite transfer, it is seldom considered while modeling cellular energetics. Weisz (1973) hypothesized that most biological and biochemical systems would most...
Electrical discharge is a commonly used method to produce ions and radicals that can be used for degrading compounds as well as for chemical synthesis. Previously, the application of electrical discharges has been studied in liquids such...
Electrical discharge induced non-thermal plasma is considered a "green" treatment method for gas or water pollution control because of its capability to generate reactive radical and reactive molecular species, high efficiency, low cost, ...
Magnetic resonance imaging (MRI) relaxation and diffusion properties are sensitive to the physiological state of cells and tissues. In particular, cerebral ischemia and stroke is associated with a reduced apparent diffusion coefficient ...
Microcontact printing (μCP) is a soft lithographic technique based on transferring an ink material from a stamp on to a substrate through physical contact to produce features at the micrometer scale. Compared to other surface-patterning...
Graphite has good lifetime and rate capability in liquid electrolyte-based batteries and supercapacitors. Meanwhile, the polymer electrolyte have been considered as a promising technology for battery applications for its safety and...
The development of new storage materials will facilitate the use of hydrogen as a major energy vector in the near future. Chemical hydrides like NaBH4 have been tested as a possible precursor material for supplying hydrogen. In this...
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