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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Eukaryotic genomes replicate via the synchronous firing of clusters of origins that together produce multi-replicon domains, each of which replicates at a defined time during S-phase. This temporal program is termed the DNA replication...
Plants are often subjected to extreme environmental conditions and must adapt rapidly. The phytohormone abscisic acid (ABA) accumulates under abiotic stress conditions, signaling transcriptional changes that trigger physiological...
DNA replication in all Eukaryotes follows a defined temporal order termed replication-timing program (RT), which is coupled with the spatial separation of chromatin distribution inside the nucleus. Early or late replicating chromatin...
Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is an oncogenic virus that has adapted unique mechanisms to modulate the cellular microenvironment of its human host. The pathogenesis of KSHV is intimately linked to its manipulation of...
Controlling spatial-temporal gene expression patterns is a fundamental task for maize growth and development. With the emergence of massively parallel sequencing, genome-wide expression data production has reached an unprecedented level....
D4Z4 is a subtelomeric macrosatellite repeat on chromosome 4q that codes for DUX4, a gene that is causal to the muscle wasting disease Facioscapulohumeral muscular dystrophy (FSHD). DUX4 expression is influenced by a number of genetic...
Assimilatory NADPH-dependent sulfite reductase (SiR) is the enzyme responsible for the six-electron reduction of sulfite to sulfide. In Enterobacteria, SiR is a dodecameric complex with two subunits: an octameric flavin-containing SiRFP, ...
The cis-regulatory elements encoded by the genome and the epigenetic regulation that influences their function are necessary for defining organismal phenotype. However, a gap exists in our understanding of the role that epigenetic...
Cells sense and respond to topographical cues in their microenvironment that influence growth, development, and migration. Cell migration and outgrowth assays have been used to study cellular movement or changes in cellular morphology...
Specific mutations in the replacement histone variant H3.3 are known to drive cancers such as glioblastomas, chondroblastomas and large cell tumors of the bone primarily in children and young adults. Several recent studies have suggested...
Zika virus is an arbovirus that has reemerged in recent years as a global health concern. A member of the Flavivirus genus, Zika virus is closely related to other major human pathogens such as dengue virus and West Nile virus, but each...
The temporal order in which segments of the genome are duplicated is referred to as the replication timing (RT) program. RT is established in each cell cycle coincident with the repositioning and anchorage of chromosomes in early G1. In...
The follicular epithelium (FE) of the Drosophila egg chamber is an excellent model system to study cell-cycle regulation, cell differentiation and cell migration in development. During oogenesis, follicle cells sequentially undergo three...
Chromatin remodelers alter DNA-histone interactions in eukaryotic organisms, and have been well characterized in yeast and Arabidopsis. While there are maize proteins with similar domains as known remodelers, the ability of the maize...
Regular emergence and re-emergence of viral pathogens emphasizes the importance of understanding viral biogeography and migration. Single-stranded DNA (ssDNA) viruses are among the least understood groups of microbial pathogens, yet the...
Select silencing of gene expression in one X chromosome in female mammals provides a means to overcome X-linked gene expression imbalances with males. Central to establishing gene silencing on the inactivated X chromosome are the actions...
Characterization of the Subcellular Localization of ORF52/KicGAS and Functional Roles during the Life Cycles of Kaposi's Sarcoma-Associated Herpesvirus
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that causes Kaposi's sarcoma (KS) and two lymphoproliferative diseases. We previously reported KSHV ORF52/KicGAS (KSHV inhibitor of cGAS) to inhibit cGAS (cyclic GMP...
Flaviviruses are positive sense single-stranded enveloped RNA viruses, most are mosquito-transmitted viruses that cause systemic infection as they disseminate through the bloodstream in vertebrate hosts. The members of the flavivirus...
Plants regulate gene expression at the transcriptional and post-transcriptional levels to produce a variety of functionally diverse cells and tissues that ensure normal growth, development, and environmental response. Although distinct...
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has been linked to severe neurological disorders such as microcephaly in newborns as well as Guillain-Barré syndrome in adults. It is closely related to other flaviviruses...
DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local...
XCI is a form of dosage compensation that is established in early development of female mammals where one X chromosome is randomly silenced, thus balancing expression of X-linked genes. XCI is achieved by many cis- and trans- elements...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
