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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Small helical membrane proteins are functionally very important. They are involved in many cellular transport and signal transduction pathways maintaining the chemical, mechanical and electrical potentials of cells. They constitute...
Structural biology has been successful in the characterization of soluble protein, which has given insight in the inner working of several thousands of proteins. However, structural characterization of proteins has been limited in two...
Solid-state NMR takes advantage of studying membrane proteins in a native membrane-like lipid bilayer and has been used for generating exciting results. The magic angle spinning ssNMR of randomly oriented liposomes provides complementary...
Membrane proteins account for 1/3 of the proteins encoded within known genomes and at least 60% of current drug targets. While the field of structural biology has achieved remarkable success in determining the three dimensional...
Structural biology of membrane proteins and ion channels are of great interest because of their important roles in many cellular and physiological processes including ion/molecular transport, communication and energy transduction....
Despite the importance of membrane proteins for cellular functions, membrane proteins remain one of the most challenging arena of structural biology. A significant progress has been made in the recent years to overcome challenges...
Membrane proteins contribute about 30% of the proteome and about 60% of the drugs in the market target membrane proteins. But only about 1.5% of structures in Protein Data Bank are membrane proteins which reflect the challenges in...
The M2 proton channel from Influenza A is an established drug target, with multiple functions during the viral lifecycle. Amino acid mutations, in the residues lining the channel pore, have rendered M2 resistant to previously licensed...
Solid-state nuclear magnetic resonance (NMR) provides a unique approach for structure determination and functional studies of membrane proteins in a native lipid bilayer environment. Here, polarization inversion spin exchange at magic...
CrgA is a small helical membrane protein from Mycobacterium tuberculosis (Mtb) and known to recruit other cell division proteins to the divisome, a substantial protein complex for Mtb cell division. There is a lack of information about...
Orientational restraints resulting from a wide range of anisotropic nuclear spin interactions such as chemical shifts, heteronuclear dipolar interactions, and quadrupolar interactions, have been widely used for determining the structures...
M2 is an important drug target, this transmembrane protein forms a tetrameric proton channel essential for the life cycle of the Influenza A virus. The recent S31N mutation rendered this protein resistant to the used antiviral drugs, ...
Structural Characterizaton of Rv0008C: An Integral Membrane Protein from Mycobacterium Tuberculosis by Solution Nuclear Magnetic Resonance Spectroscopy
Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, has been a leading cause of death in the world infecting over one third of the world population (WHO 1999). A detailed structural understanding of the membrane...
Although still in a developing age, solid-state nuclear magnetic resonance (NMR) spectroscopy has been proved to be a powerful tool to study the structure and dynamics of membrane proteins. Here this technique is applied to investigate...
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