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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The linker of the nucleoskeleton and cytoskeleton (LINC) protein complex bridges the inner and outer nuclear membranes and regulates a range of nuclear activities that include telomere tethering and chromosome movement. The canonical...
Eukaryotic genomes replicate via the synchronous firing of clusters of origins that together produce multi-replicon domains, each of which replicates at a defined time during S-phase. This temporal program is termed the DNA replication...
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus of significant public health concern closely related to other highly pathogenic flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV). With the rise of ZIKV in...
Plants are often subjected to extreme environmental conditions and must adapt rapidly. The phytohormone abscisic acid (ABA) accumulates under abiotic stress conditions, signaling transcriptional changes that trigger physiological...
A hallmark of cancerous transformation is altered chromosome structure. Inappropriate regulation of chromatin structure inhibits normal cell function, and may represent the origin of transformation. A handful of important studies have...
Controlling spatial-temporal gene expression patterns is a fundamental task for maize growth and development. With the emergence of massively parallel sequencing, genome-wide expression data production has reached an unprecedented level....
The DNA in the eukaryotic genome is wrapped in 147--bp segments around an octamer of histone proteins to form the fundamental subunit of chromatin, the nucleosome. Nucleosomes regulate the access of proteins to DNA, thus regulating...
DNA replication in eukaryotic cells follows a temporal order that is consistent from cell cycle to cell cycle and is correlated with the spatial organization of DNA in the nucleus. This "replication-timing program" is conserved in...
DNA is replicated in a defined temporal order termed the RT program. Ordered DNA replication is conserved in eukaryotes, yet its biological significance remains enigmatic. 3D genome organization as assayed by Hi-C has revealed that RT is...
During the age of non-avian dinosaurs, ancestors of present-day mammals were likely small insectivores, relegated to nocturnal and subterranean niches. This nocturnal "bottle-neck" is postulated as a driving force of numerous...
The temporal order in which segments of the genome are duplicated is referred to as the replication timing (RT) program. RT is established in each cell cycle coincident with the repositioning and anchorage of chromosomes in early G1. In...
Chromatin remodelers alter DNA-histone interactions in eukaryotic organisms, and have been well characterized in yeast and Arabidopsis. While there are maize proteins with similar domains as known remodelers, the ability of the maize...
DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local...
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