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Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.

Full Title:

Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.

Creator:

Description:

Replicative polymerase stalling is coordinated with replicative helicase stalling in eukaryotes, but the mechanism underlying this coordination is not known. Cdc45 activates the Mcm2-7 helicase. We report here that Cdc45 from budding...

Date:

2013-03-15

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_23382391, 10.1074/jbc.M112.440941, PMC3597796, 23382391, M112.440941

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_23382391

Repository ID:

fsu:523864

Mcm10 coordinates the timely assembly and activation of the replication fork helicase

Full Title:

Mcm10 coordinates the timely assembly and activation of the replication fork helicase

Creator:

Perez-Arnaiz, Patricia, Bruck, Irina, Kaplan, Daniel L.

Description:

Mcm10 is an essential replication factor that is required for DNA replication in eukaryotes. Two key steps in the initiation of DNA replication are the assembly and activation of Cdc45-Mcm2-7-GINS (CMG) replicative helicase. However, it...

Date:

2016-01-08

Format:

text

Collection:

Department of Physics

Identifiers:

FSU_libsubv1_wos_000371264000034, 10.1093/nar/gkv1260

URLs:

http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000371264000034

Repository ID:

fsu:402940

replication initiation protein Sld2 regulates helicase assembly.

Full Title:

The replication initiation protein Sld2 regulates helicase assembly.

Creator:

Bruck, Irina, Kaplan, Daniel L

Description:

Assembly of the Cdc45-Mcm2-7-GINS (CMG) replicative helicase complex must be regulated to ensure that DNA unwinding is coupled with DNA synthesis. Sld2 is required for the initiation of DNA replication in budding yeast. We identified a...

Date:

2014-01-24

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_24307213, 10.1074/jbc.M113.532085, PMC3900945, 24307213, M113.532085

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_24307213

Repository ID:

fsu:523882

Eukaryotic Replicative Helicase Subunit Interaction With Dna And Its Role In Dna Replication

Full Title:

Eukaryotic Replicative Helicase Subunit Interaction With Dna And Its Role In Dna Replication

Creator:

Martinez, Matthew P., Wacker, Amanda L., Bruck, Irina, Kaplan, Daniel L.

Description:

The replicative helicase unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. In eukaryotes, the replicative helicase is composed of the Cdc45 protein, the...

Date:

2017-04

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_libsubv1_wos_000404391700012, 10.3390/genes8040117

URLs:

http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000404391700012

Repository ID:

fsu:503629

Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication.

Full Title:

Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication.

Creator:

Martinez, Matthew P, Wacker, Amanda L, Bruck, Irina, Kaplan, Daniel L

Description:

Date:

2017-04-06

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_28383499, 10.3390/genes8040117, PMC5406864, 28383499, genes8040117

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_28383499

Repository ID:

fsu:524017

Mcm10 coordinates the timely assembly and activation of the replication fork helicase.

Full Title:

Mcm10 coordinates the timely assembly and activation of the replication fork helicase.

Creator:

Perez-Arnaiz, Patricia, Bruck, Irina, Kaplan, Daniel L

Description:

Date:

2016-01-08

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_26582917, 10.1093/nar/gkv1260, PMC4705653, 26582917, gkv1260

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_26582917

Repository ID:

fsu:523954

Dpb11 May Function With Rpa And Dna To Initiate Dna Replication

Full Title:

Dpb11 May Function With Rpa And Dna To Initiate Dna Replication

Creator:

Bruck, Irina, Dhingra, Nalini, Martinez, Matthew P., Kaplan, Daniel L.

Description:

Dpb11 is required for the initiation of DNA replication in budding yeast. We found that Dpb11 binds tightly to single-stranded DNA (ssDNA) or branched DNA structures, while its human homolog, TopBP1, binds tightly to branched-DNA...

Date:

2017-05-03

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_libsubv1_wos_000400647000095, 10.1371/journal.pone.0177147

URLs:

http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000400647000095

Repository ID:

fsu:503572

Intact Mcm10 Coiled-coil Interaction Surface Is Important For Origin Melting, Helicase Assembly And The Recruitment Of Pol-alpha To Mcm2-7

Full Title:

An Intact Mcm10 Coiled-coil Interaction Surface Is Important For Origin Melting, Helicase Assembly And The Recruitment Of Pol-alpha To Mcm2-7

Creator:

Perez-Arnaiz, Patricia, Bruck, Irina, Colbert, Max K., Kaplan, Daniel L.

Description:

Mcm10 is an essential eukaryotic factor required for DNA replication. The replication fork helicase is composed of Cdc45, Mcm2-7 and GINS (CMG). DDK is an S-phase-specific kinase required for replication initiation, and the DNA primase...

Date:

2017-07-07

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_libsubv1_wos_000404879000030, 10.1093/nar/gkx438

URLs:

http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000404879000030

Repository ID:

fsu:506591

Origin DNA Melting-An Essential Process with Divergent Mechanisms.

Full Title:

Origin DNA Melting-An Essential Process with Divergent Mechanisms.

Creator:

Martinez, Matthew P, Jones, John M, Bruck, Irina, Kaplan, Daniel L

Description:

Origin DNA melting is an essential process in the various domains of life. The replication fork helicase unwinds DNA ahead of the replication fork, providing single-stranded DNA templates for the replicative polymerases. The replication...

Date:

2017-01-11

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_28085061, 10.3390/genes8010026, PMC5295021, 28085061, genes8010026

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_28085061

Repository ID:

fsu:524012

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.

Full Title:

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.

Creator:

Bruck, Irina, Kaplan, Daniel L

Description:

Dbf4-dependent kinase (DDK) phosphorylates minichromosome maintenance 2 (Mcm2) during S phase in yeast, and Sld3 recruits cell division cycle 45 (Cdc45) to minichromosome maintenance 2-7 (Mcm2-7). We show here DDK-phosphoryled Mcm2...

Date:

2015-09-08

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_26305950, 10.1073/pnas.1509608112, PMC4568703, 26305950, 1509608112

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_26305950

Repository ID:

fsu:523943

Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase.

Full Title:

A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase.

Creator:

Bruck, Irina, Dhingra, Nalini, Kaplan, Daniel L

Description:

The assembly of the replication fork helicase during S phase is key to the initiation of DNA replication in eukaryotic cells. One step in this assembly in budding yeast is the association of Cdc45 with the Mcm2-7 heterohexameric ATPase, ...

Date:

2017-02-24

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_28082681, 10.1074/jbc.M116.772368, PMC5336144, 28082681, M116.772368

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_28082681

Repository ID:

fsu:639743

intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7.

Full Title:

An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7.

Creator:

Perez-Arnaiz, Patricia, Bruck, Irina, Colbert, Max K, Kaplan, Daniel L

Description:

Date:

2017-05-16

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_28510759, 10.1093/nar/gkx438, PMC5499591, 28510759, 3828234

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_28510759

Repository ID:

fsu:524023

Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase.

Full Title:

Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase.

Creator:

Dhingra, Nalini, Bruck, Irina, Smith, Skye, Ning, Boting, Kaplan, Daniel L

Description:

Dpb11 is required for the initiation of DNA replication in budding yeast. Dpb11 binds to S-phase cyclin-dependent kinase-phosphorylated Sld2 and Sld3 to form a ternary complex during S phase. The replication fork helicase in eukaryotes...

Date:

2015-03-20

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_25659432, 10.1074/jbc.M115.640383, PMC4367264, 25659432, M115.640383

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_25659432

Repository ID:

fsu:523921

Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase.

Full Title:

The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase.

Creator:

Bruck, Irina, Kaplan, Daniel L

Description:

The initiation of DNA replication is a highly regulated process in eukaryotic cells, and central to the process of initiation is the assembly and activation of the replication fork helicase. The replication fork helicase is comprised of...

Date:

2015-11-06

Format:

journal article, text

Collection:

Department of Biomedical Sciences

Identifiers:

FSU_pmch_26405041, 10.1074/jbc.M115.688424, PMC4646389, 26405041, M115.688424

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_26405041

Repository ID:

fsu:523945