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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
In eukaryotes, damaged or unneeded proteins are typically degraded by the ubiquitin-proteasome system. In this system, the protein substrate is often first covalently modified with a chain of ubiquitin polypeptides. This chain serves as...
Oxytocin (OXT) is a pleiotropic regulator of physiology and behavior. An emerging body of evidence demonstrates a role for OXT in the transition to postnatal life of the infant. To identify potential sites of OXT action via the OXT...
An exact semi-analytical method of calculating the scattered fields from a chiral-coated conducting object under arbitrary shaped beam illumination is developed. The scattered fields and the fields within the chiral coating are expanded...
Results are presented from a search for the electroweak production of supersymmetric particles in pp collisions in final states with two T leptons. The data sample corresponds to an integrated luminosity between 18.1 fb(-1) and 19.6 fb(...
Smoking-specific experiential avoidance is related to the maintenance of cigarette smoking. However, it is unclear whether sustained smoking abstinence is associated with subsequent reductions in smoking-specific experiential avoidance....
Filter or screening methods are often used as a preprocessing step for reducing the number of variables used by a learning algorithm in obtaining a classification or regression model. While there are many such filter methods, there is a...
The Mississippi River (MR) serves as the primary source of freshwater and nutrients to the northern Gulf of Mexico (nGOM). Whether this input of freshwater also enriches microbial diversity as the MR plume migrates and mixes with the...
Pancreatic islets manage elevations in blood glucose level by secreting insulin into the bloodstream in a pulsatile manner. Pulsatile insulin secretion is governed by islet oscillations such as bursting electrical activity and periodic...
Substance use disorders (SUDs) and Cluster B personality disorders (PDs) may have shared risk through profiles of personality and motivational traits. The present study sought to replicate in a national sample of adults past research...
Many studies have reported on the trends of precipitation in Mid-Eastern China (EC). However, the trends of convective and stratiform precipitation are still unknown. Here, we examine the trends of summer convective and stratiform...
An ultimate goal in carbon nanoscience is to decipher formation mechanisms of highly ordered systems. Here, we disclose chemical processes that result in formation of high-symmetry clusterfullerenes, which attract interest for use in...
We use techniques from convex projective geometry to produce many new examples of thin subgroups of lattices in special linear groups that are isomorphic to the fundamental groups of finite-volume hyperbolic manifolds. More specifically, ...
Characteristics of tropical cyclones (TCs) in global climate models (GCMs) are known to be influenced by details of the model configurations, including horizontal resolution and parameterization schemes. Understanding model-to-model...
Hyperactivity, or excess gross motor activity, is considered a core and ubiquitous characteristic of ADHD. Alternate models question this premise, and propose that hyperactive behavior reflects, to a large extent, purposeful behavior to...
Sex differences in gene expression have been widely studied in Drosophila melanogaster Sex differences vary across strains, but many molecular studies focus on only a single strain, or on genes that show sexually dimorphic expression in...
Exercise-induced muscle damage (EIMD) caused by unaccustomed or strenuous exercise can result in reduced muscle force, increased muscle soreness, increased intramuscular proteins in the blood, and reduced performance. Pre- and post...
Developmental, Component-Based Model of Reading Fluency: An Investigation of Predictors of Word-Reading Fluency, Text-Reading Fluency, and Reading Comprehension.
The primary goal was to expand our understanding of text reading fluency (efficiency or automaticity)-how its relation to other constructs (e.g., word reading fluency and reading comprehension) changes over time and how it is different...
Chemical weathering consumes atmospheric carbon dioxide through the breakdown of silicate minerals and is thought to stabilize Earth's long-term climate. However, the potential influence of silicate weathering on atmospheric pCO(2)...
Inhibition of striated muscle contraction at resting Ca(2+) depends on the C-terminal half of troponin I (TnI) in thin filaments. Much focus has been on a short inhibitory peptide (Ip) sequence within TnI, but structural studies and...
Permafrost is an extreme habitat yet it hosts microbial populations that remain active over millennia. Using permafrost collected from a Pleistocene chronosequence (19 to 33 ka), we hypothesized that the functional genetic potential of...
The accumulation of misfolded proteins is associated with multiple neurodegenerative disorders, but it remains poorly defined how this accumulation causes cytotoxicity. Here, we demonstrate that the Cdc48/p97 segregase machinery drives...
In “‘Ma voix se dégagea’: Music, Risk, and the Heroine’s Voice in George Sand’s Malgrétout, ” I argue that Sand’s 1870 novel Malgrétout offers a view of the complexity of Sand’s thinking about sound, whether in a child’s holistic and...
Plasma insulin oscillations are known to have physiological importance in the regulation of blood glucose. In insulin-secreting beta-cells of pancreatic islets, K(ATP) channels play a key role in regulating glucose-dependent insulin...
Researchers have identified sources of individual differences in writing across beginning and developing writers. The aim of the present study was to further clarify the sources of this variability by investigating the extent to which...
Replicative polymerase stalling is coordinated with replicative helicase stalling in eukaryotes, but the mechanism underlying this coordination is not known. Cdc45 activates the Mcm2-7 helicase. We report here that Cdc45 from budding...
Purpose There are multiple perspectives of divestiture and its performance that require reconciliation. While research finds a positive market response to divestment announcement, divestiture of prior acquisitions are generally viewed...
Statistical relationships between higher-order moments of probability density functions (PDFs) are used to analyze top-of-atmosphere radiance measurements made by the Atmospheric Infrared Sounder (AIRS) and radiance calculations from the...
Measurement Of The Cross Section For Electroweak Production Of Z Gamma In Association With Two Jets And Constraints On Anomalous Quartic Gauge Couplings In Proton-proton Collisions At Root S=8 Tev
A measurement is presented of the cross section for the electroweak production of a Z boson and a photon in association with two jets in proton-proton collisions at root s = 8 TeV. The Z bosons are identified through their decays to...
Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca(2+) ...
The National Cancer Institute Thesaurus (NCIt), developed and maintained by the National Cancer Institute, is an important reference terminology in the cancer domain. As a controlled terminology needs to continuously incorporate new...
The cartilage endplate (CEP) is implicated as the main pathway of nutrient supply to the healthy human intervertebral disc (IVD). In this study, the diffusivities of nutrient/metabolite solutes in healthy CEP were assessed, and further...
Quantum anomalous Hall effect has been observed in magnetically doped topological insulators. However, full quantization, up until now, is limited within the sub-1 K temperature regime, although the material's magnetic ordering...
Modern microbial and ecosystem sciences require diverse interdisciplinary teams that are often challenged in "speaking" to one another due to different languages and data product types. Here we introduce the IsoGenie Database (IsoGenieDB...
Response management and damage assessment during and after environmental disasters such as the Deepwater Horizon (DWH) oil spill require an ecological baseline and a solid understanding of the main drivers of the ecosystem. During the...
Major depressive symptoms represent a significant risk for suicidal ideation and behavior. Given that suicide is fearsome, the interpersonal theory of suicide proposes that individuals who engage in suicidal behavior possess not only the...
Exposure to inorganic arsenic, a ubiquitous environmental toxic metalloid, leads to carcinogenesis. However, the mechanism is unknown. Several studies have shown that inorganic arsenic exposure alters specific gene expression patterns, ...
This paper describes high-resolution in situ observations of temperature and, for the first time, of salinity in the uppermost skin layer of the ocean, including the influence of large surface blooms of cyanobacteria on those skin...
The Z-disk is a complex structure comprising some 40 proteins that are involved in the transmission of force developed during muscle contraction and in important signalling pathways that govern muscle homeostasis. In the Z-disk the ends...
Persistent-current switch for pancake coils of rare earth-barium-copper-oxide high-temperature superconductor: Design and test results of a double-pancake coil operated in liquid nitrogen (77-65 K) and in solid nitrogen (60-57 K).
We present design and test results of a superconducting persistent current switch (PCS) for pancake coils of rare-earth-barium-copper-oxide, REBCO, high-temperature superconductor (HTS). Here, a REBCO double-pancake (DP) coil, 152-mm ID, ...
Strong quasar-galaxy lensing provides a powerful tool to probe the interstellar medium (ISM) of the lens galaxy using radiation from the background quasar. Using the Cosmic Origins Spectrograph (COS) on board the Hubble Space Telescope, ...
Normalized differential cross sections for top quark pair production are measured in the dilepton (e(+)e(-), mu(+)mu(-), and mu(-/+), e(+/-)) decay channels in proton-proton collisions at a center-of-mass energy of 13 TeV. The...
The same selective forces that give rise to rapid inter- and intraspecific divergence in snake venoms can also favor differences in venoms across life-history stages. Ontogenetic changes in venom composition are well known and widespread...
La voix est indéniablement pour nos sensibilités modernes à la fois une expression intime de l’individu et une arme de séduction à la frontière du dedans et du dehors, de l’âme et du corps, de la parole et de la musique. Mais le Moyen...
Children and adolescents with bipolar disorder are at increased risk for suicide. Sleep disturbances are common among youth with bipolar disorder and are also independently implicated in suicide risk; thus, comorbid sleep disorders may...
We present time-integrated four-wave mixing measurements on monolayer MoSe2 in magnetic fields up to 25 T. The experimental data together with time-dependent density function theory calculations provide interesting insights into the...
Animal behavioural traits often covary with gene expression, pointing towards a genomic constraint on organismal responses to environmental cues. This pattern highlights a gap in our understanding of the time course of environmentally...
Animal models capable of differentiating the neurobiological intricacies between physical and emotional stress are scarce. Current models rely primarily on physical stressors (e.g., chronic unpredictable or mild stress, social defeat, ...
Fluorescent protein (FP) biosensors based on Förster resonance energy transfer (FRET) are commonly used to study molecular processes in living cells. There are FP-FRET biosensors for many cellular molecules, but it remains difficult to...
This study focused on the academic performance and use of disability support services of students with different types of disabilities who attend a post-secondary education institution. Findings show different patterns of academic...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
