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The present invention enables a safe and noninvasive assessment of tumor resistance using one diffusion or sodium MRI scan over the entire tumor. The evaluation can be done before therapy and can help select a strategy of treatment. The invention can be used in different types of tumors in most parts of the human body. The level of tumor resistance can be determined reproducibly and quickly. The results can be used immediately to create individualized therapy. The invention allows clinicians to avoid ineffective therapies, which may be more harmful than useful, or come up with the other more appropriate alternatives.