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Engineered human acidic fibroblast growth factors and associated methods. (2010). Engineered human acidic fibroblast growth factors and associated methods. Retrieved from http://purl.flvc.org/fsu/fd/FSU_uspto_7790682
An engineered, purified polypeptide of acidic fibroblast growth factor (FGF-1) is described, the amino acid sequence of which consists essentially of SEQ ID NO: 1. The engineered polypeptide provides 70 times the mitogenic activity of wild type acidic fibroblast growth factor. Other engineered FGFs are also described, having altered properties, including reduced heparin binding affinity and increased mitogenicity as demonstrated with a model mammalian cell line derived from mice, NIH 3T3 fibroblasts.
Engineered human acidic fibroblast growth factors and associated methods. (2010). Engineered human acidic fibroblast growth factors and associated methods. Retrieved from http://purl.flvc.org/fsu/fd/FSU_uspto_7790682
