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Taxane derivatives of the formula ##STR1## wherein R.sub.1 is butenyl, PA0 R.sub.3 is phenyl, PA0 T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or monocylic aryl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
