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Weight loss therapy consisting of 20 to 30 lifestyle-modification group visits is associated with modest (4–8 kg) weight loss. (SOR A, based on homogeneous randomized controlled trials [RCTs].) For patients who participate in group visits, use of sibutramine (15 mg p.o. daily) and compliance with food journaling are both associated with greater weight loss. (SOR B, based on an RCT and an outcomes study.)