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Previous biochemical findings from our lab revealed that PERIOD (PER) proteins globally regulate the molecular oscillator through both transcriptional and posttranslational mechanisms. Furthermore, our lab demonstrated that PER rhythms define a critical rhythmic nodal point in the generation of circadian rhythms. Deciphering the phase shifting mechanism is important for developing effective pharmacological or environmental (e.g., phototherapy) interventions to treat many circadian diseases, including sleep disorders in shift workers. Our novel inducible Per2 transgenic mouse in Per1/2-null background provides a unique opportunity to address how perturbations in Per expression can cause phase shifts and the opportunity to delve into whether the clock can be reset to a desirable phase by manipulating PER rhythms in a calculated manner. Although photic stimuli acutely induces both Per1 and Per2, manipulation of Per2 alone should be enough to mimic light-induced phase shifts, because Per-deficient mice are similar to wild type mice in their phase delays and advances in response to light pulses. This experiment aimed to demonstrate how we could use this novel genetic construct to gain an in-depth understanding of how we can artificially regulate rhythms in humans.