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Increasing medication adherence in patients with epilepsy is important because, if taken properly, antiepileptic medication can reduce seizure frequency, and thus, improve quality of life and reduce hospital and emergency room visits. The goal of this study was to examine if non-professionals (undergraduates) can improve medication adherence among persons with epilepsy by implementing simple, but time-intensive interventions. Participants were eleven patients with epilepsy at a neurological clinic in Tallahassee that were referred by their neurologist based on his perception that their adherence was low and that they were favorable toward research. Study design was quasi-experimental in which each participant served as his or her own control. The first phase used a self-report diary in which baseline data was collected for at least one month to establish initial levels of adherence. Interventions included customized picture reminders, Didits (inexpensive device attached to side of medication container for keeping track of medication taking), and weekly phone calls that provided support and encouragement for taking one's medication. This study demonstrated that time-intensive interventions can be implemented by non-professionals, which can make interventions more widely available. Structured interviews suggested that the interventions were generally viewed positively by participants. However, due to difficulties with the self-report diary as the primary measure of adherence, we were not able to determine if the interventions actually improved participants' adherence. Future research should employ more objective measures of adherence, such as the Medication Event Monitoring System (MEMS) (See Paschal, Hawley, St. Romain, & Ablah, 2008 for review of measures).