unspeakable visions of the individual: the beat generation and the affirmative apocalypse
Abstract: Traditional histories have credited the Beat Generation writers with helping to bring about the counterculture of the 1960s by challenging the mainstream cultural mores of the 1950s. In this oft-cited and tired interpretation, the Beats are retroactively painted over with James Dean-esque gloss: they become "writers without a cause," normalized in the same cultural universe as Marilyn Monroe and Elvis Presley. In this paper, I will propose that this traditional interpretation of the Beats omits the looming specter of the apocalypse in the writers' lives and work, as well as in larger American culture as a whole. I suggest that the notion of the 1960s as shaped by the 1950s is incomplete without an appreciation for the role of the apocalyptic within 1950s American culture. The burgeoning Cold War, Soviet communism, and the development and use of the atomic bomb all combined to present a forceful argument that these writers were indeed witnessing the end of days. Rather than a group drawn together in opposition to "the man" as countercultural histories would argue, the Beats articulated a shared belief in the imminent end of the world. The apocalypse represented a crucially important creative connection between the writers: theirs was a disagreement over what America should be, framed by an apocalypse understood to be spiritually cleansing. As such, the Beats eagerly anticipated the end of the world, a sentiment which I have termed the "affirmative apocalypse" and which I believe sheds new light on a formative period in modern American history., Advisor: Dr. Neil Jumonville, Florida State University, College of Arts and Sciences, Dept. of History., Thesis (Honors paper)--Florida State University, 2010.
Écriture d’invention en français et le genre de l’Autofiction
The goal of this project is to create a short composition in French that reflects the themes of and that utilizes the literary elements found in the genre of “Autofiction”. Autofiction is to literature what multimedia and collage are the visual arts: a shifting mix of genres and intentions that draws content from unexpected and novel sources. I intend to tell the story of a singular event from the life of my great aunt on my mother’s side. Acting as both a historically minded narrator and someone implicitly entailed by these events, my thesis will have a skeleton of truth encased by fiction; and, like most works of Autofiction, in some parts it is the thin fiction of my conjecture and in others it is the fleshy kind of fiction that can only develop over decades of familial mythos. The story integrates multimedia elements to further add historical legitimacy to the story., Keywords: Français, Autofiction
Φ-Value Analysis of Symfoil-4T
A critical consideration in the process of de novo protein architecture design and protein evolution is the folding pathway and
behavior a protein undertakes in transitioning to its functional tertiary structure. Of particular interest is a cryptic element within
protein primary structure that enables an efficient folding pathway, and is postulated to be a heritable element in the evolution of protein
architecture, the "folding nucleus" (FN). However, almost nothing is known regarding how the FN changes as simpler peptide motifs join to
form more complex polypeptides. To this effect, the structure and folding properties of foldable intermediates along the evolutionary
trajectory of the β-trefoil protein type were tested. This study specifically used and compared data from Symfoil-4T (an engineered β-trefoil
protein) to several mutants to show that the FN is acquired during gene fusion events, incorporating novel turn structure generated by gene
fusion. Furthermore, the FN of β-trefoils are adjusted by circular permutation in response to destabilizing functional mutations to allow the
survival of FN (which is made possible by the intrinsic C3 cyclic symmetry of β-trefoil architecture) identifying a selective advantage that
helps explain extant cyclic structural symmetry in the proteome., Keywords: protein, folding, FGF-1, Symfoil-4T, Submitted Note: A Thesis submitted to the Department of Biological Sciences in partial fulfillment of the requirements for
graduation with Honors in the Major., Degree Awarded: Spring Semester, 2017., Date of Defense: December 1, 2015.
Shifts in circadian rhythms, like in shift work or jet lag, have been shown to increase the risk of many metabolic disorders.
Therefore, it is not surprising that many genes involved in the circadian clock mechanism have demonstrated a regulatory role in metabolism.
It has been shown that E3 ubiquitin ligases can influence metabolism as well. In initial studies, my lab created a knockout of two E3
ubiquitin ligases thought to be essential to the clock, βTRCP1/2, in a mouse model in order to study the proteasomal degradation machinery in
mammals. Upon characterizing the circadian phenotype of this mouse, we noticed an unprecedented, metabolic phenotype after deletion of these
vital ligases. These novel mutant mice lose over 30% of their body weight within 5 days while still maintaining an eating and drinking regime
similar to wild-type mice. In this project, in vivo and sequence analysis studies aimed to look further into the causes of this phenomenon
and the molecular mechanisms underlying them., Keywords: Circadian, Metabolism, Period, Submitted Note: A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for
graduation with Honors in the Major., Degree Awarded: Spring Semester, 2015., Date of Defense: April 6, 2015.