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Cresswell-Clay, E. C. (2019). Compartmental Modeling of Calcium Dynamics in Astrocytes. Retrieved from http://purl.flvc.org/fsu/fd/2019_Fall_CresswellClay_fsu_0071E_15551
We create a novel framework to enable the exploration of spatial calcium dynamics in astrocytes via compartmentalization of the cell domain. The cell is split up into spatially partitioned compartments representing sub-cellular domains with varied physiology. These compartments are modeled with systems of ordinary differential equations with diffusive transfer between compartments as in previous work. Stochasticity is leveraged to investigate the effect of mGluR-mediated inositol-triphosphate production which models the main form input due to neuronal activity. The compartmentalized astrocyte is able to represent several hierarchies of calcium dynamics across the cell in both spatial and temporal scales.
A Dissertation submitted to the Department of Scientific Computing in partial fulfillment of the requirements for the degree of Doctor of Philosophy.
Bibliography Note
Includes bibliographical references.
Advisory Committee
Gordon Erlebacher, Professor Directing Dissertation; Richard Bertram, University Representative; Anke Meyer-Baese, Committee Member; Michael Mascagni, Committee Member; Brian Quaife, Committee Member.
Publisher
Florida State University
Identifier
2019_Fall_CresswellClay_fsu_0071E_15551
Cresswell-Clay, E. C. (2019). Compartmental Modeling of Calcium Dynamics in Astrocytes. Retrieved from http://purl.flvc.org/fsu/fd/2019_Fall_CresswellClay_fsu_0071E_15551
