Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Catecholaminergic polymorphic ventricular tachycardia (CPVT), also called exercise-induced ventricular tachycardia is a hereditary disease that can cause sudden cardiac death in human patients. Interestingly, while patients with CPVT have normal function of the heart at rest, they show life-threatening arrhythmias during physical activity or acute emotional stress. Autonomic nervous system is known to have a role in arrhythmia pathogenesis, and its response changes with aging. However, little is known that how autonomic regulation with aging contributes to arrhythmia burdens in CPVT. Methods: To test our hypothesis, we examined ECG recording with a catecholaminergic challenge (isoproterenol, 3mg/kg + caffeine, 120mg/kg) in anesthetized CPVT mice at different age groups (6 weeks old, 12 weeks old, and 48 weeks old). Results: In CPVT mice, the frequency of arrhythmias were increased with aging. The resting heart rate (HR) decreased with aging, whereas the HR response after adrenergic stress was significantly increased. The average RR interval also increased in advanced age, suggesting a possibility of an increased autonomic regulation. Conclusion: We found that arrhythmia incidence worsens by lowering intrinsic HR, and possibly by a modulation of parasympathetic nerve activity in CPVT mice with advanced age.