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BDNF Val66Met and cognition

Title: BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association.
Name(s): Mandelman, S D, author
Grigorenko, E L, author
Type of Resource: text
Genre: Text
Date Issued: 2012-03-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The Val66Met, G196A (rs6265) polymorphism in the brain-derived neurotrophic factor gene, BDNF, located at 11p13, has been associated with a wide range of cognitive functions. Yet, the pattern of results is complex and conflicting. In this study, we conducted a meta-analysis that included 23 publications containing 31 independent samples comprised of 7095 individuals. The phenotypes that were examined in this analysis covered a wide variety of cognitive functions and included indicators of general cognitive ability, memory, executive function, visual processing skills and cognitive fluency. The meta-analysis did not establish significant genetic associations between the Val66Met polymorphism and any of the phenotypes that were included.
Identifier: FSU_pmch_21980924 (IID), 10.1111/j.1601-183X.2011.00738.x (DOI), PMC3268899 (PMCID), 21980924 (RID), 21980924 (EID)
Grant Number: DC007665, HD052120, R01 DC007665, R01 DC007665-05, R21 TW006764, R21 TW006764-02
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Alleles
Brain-Derived Neurotrophic Factor/genetics
Genetic Association Studies
Neuropsychological Tests
Polymorphism, Single Nucleotide
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: Genes, brain, and behavior.
Issue: iss. 2, vol. 11

Choose the citation style.
Mandelman, S. D., & Grigorenko, E. L. (2012). BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association. Genes, Brain, And Behavior. Retrieved from