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Nanotechnology is an interdisciplinary field which focuses on taking advantage of the unique properties of materials on the nanoscale. Nanotechnology holds promise to develop many fields of research, such as materials science, medicine, molecular biology, microfabrication, and even art. Personal past work in nanotechnology has involved developing biosensors patterned with lipid multilayer diffraction gratings to detect analytes, organic vapors, and pH. Lipids serve as a model for cell binding with compounds, since they make up the membranes that monitor the cell’s interaction with an environment. The lipid diffraction gratings are constructed using a process termed nanointaglio to deposit the ink (lipid) onto a substrate. This thesis focuses on improving the optical properties of the lipid gratings constructed in order to lower the limit of detection, enhancing the sensor’s sensitivity. For this purpose, gold nanoparticles are being proposed as a possible means to amplify the diffraction intensity signal. Gold is recommended for this purpose due to its unique and well defined optical properties at the nanoscale, namely light scattering. Particles ranging from 20 to 80 nm were tested, each facing difficulties in incorporation. The results here show that producing lipid multilayer gratings from liposome encapsulation of hydrophilic gold nanoparticles provides the most reliable method of producing uniform gratings. 60 nm gold nanoparticles produced the strongest diffraction intensity relative to the other sized nanoparticles tested. These results require additional characterization in order to assure gold nanoparticle incorporation into the gratings and the replication of the intensities should be tested further.