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Brown, J. (2013). The Effects of Sodium Selenate, a PP2A Activator, on Conditioned Taste Aversion Learning. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-8533
A proper balance between the phosphorylation and dephosphorylation of intracellular substrates in several brain regions is necessary for learning. conditioned taste aversion (CTA) has several properties that make it an advantageous model for studying learning. Oberbeck et al. (2010) found that okadaic acid, a protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor, enhanced CTA learning when administered to the amygdala. Endogenous modulators of protein phosphatases are not practical tools for studying phosphatase dependent processes of learning and memory in vivo, so it is important to find new chemicals with increased specificity for phosphatases to better define their activity (Mansuy & Shenolikar, 2006). Corcoran et al (2010) found that sodium selenate (Na2SeO4) is a specific and potent activator of the PP2A heterotrimer. However, sodium selenate has not been utilized in CTA experiments, nor has a dose-response curve been characterized for its toxicity.! The following experiments elucidated the dose-response relationship between systemic injections of sodium selenate and its toxicity, the dose-response relationship between systemic injections of sodium selenate and activation in the neurovisceral axis, and the role of PP2A in the learning and memory processes involved in CTA.
A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of Master of Science.
Bibliography Note
Includes bibliographical references.
Advisory Committee
Thomas A. Houpt, Professor Directing Thesis; Debra A. Fadool, Committee Member; Michael Meredith, Committee Member.
Publisher
Florida State University
Identifier
FSU_migr_etd-8533
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Brown, J. (2013). The Effects of Sodium Selenate, a PP2A Activator, on Conditioned Taste Aversion Learning. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-8533
