Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Background: Body composition abnormalities are independent predictors of health outcomes in a variety of disease states. The simultaneous condition of low muscle mass and high fat mass, termed sarcopenic obesity, is an abnormal body composition phenotype associated with metabolic abnormalities and co-morbidities. Objectives: The purpose of this study was to investigate the overall body composition variability among obese patients, and to compare health characteristics between sarcopenic obese and non-sarcopenic obese patients. Methods: In this retrospective, chart review study, patients ( ≥18 years old) seeking weight loss treatment at a local center in Tallahassee, FL and with available baseline bio-electrical impedance analysis (BIA) data on file were included in this study. The ratio between fat mass index [FMI, defined as fat mass (kg) / height (m2)] and fat free mass index [FFMI, defined as fat free mass (kg)/height (m2)] were used to define sarcopenic obesity. Medical records were further reviewed for information on metabolic profile and health status. Results: Ninety-one obese patients with a mean age of 57 ± 11 years were included in this study. Body mass index (BMI) ranged from 31.6 to 68.7 kg/m2. Eighty-one percent were morbidly obese. The FMI/FFMI ratio was variable ranging from 0.35 to 2.46 kg/m2, independent of body weight. A gender-specific FMI/FFMI ratio above the median was used to depict the sarcopenic obesity phenotype. This corresponded to: FMI/FFMI ≥ 1.05 kg/m2 in women and FMI/FFMI ≥ 0.78 kg/m2 in men. As expected, men presented with higher body weight, height, waist circumference and FFMI, compared to women. On the contrary, women presented with higher percent body fat and FMI/FFMI ratio. No gender differences were observed for body mass index (BMI), fat mass and FMI. Plasma albumin concentration was lower in sarcopenic obese patients compared to non-sarcopenic obese patients (p=0.032). Sarcopenic obese patients reported a higher prevalence of low back pain compared to their counterparts. In fact, sarcopenic obesity was the strongest predictor of low back pain, with an odds ratio of 2.3 (95% CI=1.01-5.41, P=0.048). Similarly, the prevalence of alcoholism and sexual dysfunction were significantly greater among sarcopenic obese patients compared to non-sarcopenic obese patients (P=0.026 and P=0.030, respectively). Conclusion: A wide variability in body composition was observed in this cohort of patients, illustrating how the proportions of fat to fat-free tissues may differ among patients with similar BMI. We suggest the use of the FMI/FFMI ratio as a potential approach for the assessment of sarcopenic obesity in patients with severe obesity. Using this approach, patients with a sarcopenic obesity phenotype presented with higher risk of certain metabolic abnormalities and comorbidities.
A Thesis submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements for the degree of Master of Science.
Includes bibliographical references.
Carla Prado, Professor Directing Thesis; Michael Ormsbee, Committee Member; Robert J. Contreras, Committee Member.
Florida State University
Use and Reproduction
This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). The copyright in theses and dissertations completed at Florida State University is held by the students who author them.