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Michel Foucault's structures of knowledge define meaning in history. In the museum, meaning is made through the material evidence of people and their environment. This study examines how Foucault's classification paradigm established in The Order of Things: An Archaelogy of Knowledge assigns meaning and order in two historical and one contemporary museum. Foucault's Renaissance episteme is analyzed in the Palazzo Medici, his Classical episteme is examined through the Studio Aldrovandi, and Foucault's Modern episteme is analyzed in the Walker Art Center. Specific attention is given to the gardens attached to each museum. This study will help individuals interested in museums to more fully realize the shifts and ruptures in the construction of knowledge in the museum from the fifteenth to the modern era.