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Challenges in structural approaches to cell modeling.
Experimental support for the foldability-function tradeoff hypothesis
Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism.
Changes in single-molecule integrin dynamics linked to local cellular behavior.
Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.
Structural modeling for the open state of an NMDA receptor.
Structure of myosin filaments from relaxed  flight muscle by cryo-EM at 6 Å resolution.
Semiclosed Conformations of the Ligand-Binding Domains of NMDA Receptors during Stationary Gating.
Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
Transmembrane Domain Mediates Tetramerization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.
Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains.
structure of the actin-smooth muscle myosin motor domain complex in the rigor state.
Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.
Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface.
Structure of an E. coli integral membrane sulfurtransferase and its structural transition upon SCN(-) binding defined by EPR-based hybrid method.
Prediction of homoprotein and heteroprotein complexes by protein docking and template-based modeling
Structure of Simian Immunodeficiency Virus Envelope Spikes Bound with CD4 and Monoclonal Antibody 36D5.
Interfacing Microfluidics with Negative Stain Transmission Electron Microscopy.
Non-Stem-Loop CRISPR RNA Is Processed by Dual Binding Cas6.
Mechanism and rate constants of the Cdc42 GTPase binding with intrinsically disordered effectors.
Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Phylogenomics uncovers early hybridization and adaptive loci shaping the radiation of Lake Tanganyika cichlid fishes.
Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.
DEAD-box Protein Rok1 Orchestrates 40S and 60S Ribosome Assembly by Promoting the Release of Rrp5 from Pre-40S Ribosomes to Allow for 60S Maturation.
Structural Heterogeneity in Pre-40S Ribosomes.
DNA Interactions Probed by Hydrogen-Deuterium Exchange (HDX) Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Confirm External Binding Sites on the Minichromosomal Maintenance (MCM) Helicase.
BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning.
Identification of a common Ara h 3 epitope recognized by both the capture and the detection monoclonal antibodies in an ELISA detection kit.