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intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7.
Dpb11 may function with RPA and DNA to initiate DNA replication.
Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication.
Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase.
Origin DNA Melting-An Essential Process with Divergent Mechanisms.
Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation.
Mcm10 coordinates the timely assembly and activation of the replication fork helicase.
Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase.
Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.
Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase.
Impact of age-associated cyclopurine lesions on DNA repair helicases.
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
replication initiation protein Sld2 regulates helicase assembly.
Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.