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Meta-Analysis of Genome-Wide Association Studies for Personality
Title
Meta-Analysis of Genome-Wide Association Studies for Personality.
Creator
de Moor, Marleen, Costa, Paul, Terracciano, Antonio, Krueger, Robert F., de Geus, Eco, Toshiko, Tanaka, Penninx, Brenda, Esko, Tönu, Madden, P., Derringer, Jaime, Amin, Najaf,...
Show morede Moor, Marleen, Costa, Paul, Terracciano, Antonio, Krueger, Robert F., de Geus, Eco, Toshiko, Tanaka, Penninx, Brenda, Esko, Tönu, Madden, P., Derringer, Jaime, Amin, Najaf, Willemsen, Gonneke, Hottenga, Jouke-Jan, Distel, M., Uda, Manuela, Sanna, Serena, Spinhoven, Philip, Hartman, Catherina, Sullivan, P., Realo, Anu, Allik, Jüri, Heath, Andrew, Pergadia, M., Agrawal, Arpana, Lin, P., Grucza, Richard, Nutile, Teresa, Ciullo, Marina, Rujescu, Dan, Giegling, Ina, Konte, Bettina, Widen, Elisabeth, Cousminer, D., Eriksson, Johan, Palotie, Aarno, Peltonen, L., Luciano, Michelle, Tenesa, A., Davies, Gail, Lopez, Lorna, Hansell, Narelle, Medland, Sarah, Ferrucci, Luigi, Schlessinger, David, Montgomery, G., Wright, Margeret, Aulchenko, Y., Janssens, A., Oostra, Ben A., Metspalu, Andres, Abecasis, Gonçalo, Deary, Ian J., Räikkönen, K., Bierut, Laura, Martin, Nicholas G., van Duijn, Cornelia, Boomsma, Dorret
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Abstract/Description
Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17,375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism,...
Show morePersonality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17,375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ≈ 2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P=2.8 × 10(-8) and 3.1 × 10(-8)) and for Conscientiousness in the brain-expressed KATNAL2 gene on 18q21.1 (rs2576037, P=4.9 × 10(-8)). We further conducted a gene-based test that confirmed the association of KATNAL2 to Conscientiousness. In silico replication did not, however, show significant associations of the top SNPs with Openness and Conscientiousness, although the direction of effect of the KATNAL2 SNP on Conscientiousness was consistent in all replication samples. Larger scale GWA studies and alternative approaches are required for confirmation of KATNAL2 as a novel gene affecting Conscientiousness.
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Date Issued
2012
Identifier
FSU_migr_geriatrics_faculty_publications-0010, 10.1038/mp.2010.128
Format
Citation
Climatic Warmth and National Wealth
Title
Climatic Warmth and National Wealth: Some Culture-Level Determinants of National Character Stereotypes.
Creator
McCrae, Robert R., Terracciano, Antonio, Realo, Anu, Allik, Jüri
Abstract/Description
National character stereotypes are widely shared, but do not reflect assessed levels of personality traits. In this article we present data illustrating the divergence of stereotypes and assessed personality traits in north and south Italy, test hypotheses about the associations of temperature and national wealth with national character stereotypes in 49 cultures, and explore possible links to national values and beliefs. Results suggest that warmth and wealth are common determinants of...
Show moreNational character stereotypes are widely shared, but do not reflect assessed levels of personality traits. In this article we present data illustrating the divergence of stereotypes and assessed personality traits in north and south Italy, test hypotheses about the associations of temperature and national wealth with national character stereotypes in 49 cultures, and explore possible links to national values and beliefs. Results suggest that warmth and wealth are common determinants of national stereotypes, but that there are also idiosyncratic influences on the perceptions of individual nations.
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Date Issued
2007
Identifier
FSU_migr_geriatrics_faculty_publications-0026, 10.1002/per.647
Format
Citation