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Genetics of Serum BDNF
Title
Genetics of Serum BDNF: Meta-analysis of the Val66Met and Genome-wide Association Study.
Creator
Terracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger,...
Show moreTerracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger, David
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Abstract/Description
Abstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of...
Show moreAbstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of serum BDNF to be 0.48 from sib-pairs. There was no association between serum BDNF and Val66Met in the SardiNIA sample and in a meta-analysis of published studies (k = 13 studies, total n = 4727, P = 0.92). Although no genome-wide significant associations were identified, some evidence of association was found in the BDNF gene (rs11030102, P = 0.001) and at two loci (rs7170215, P = 4.8 × 10(-5) and rs11073742 P = 1.2 × 10(-5)) near and within NTRK3 gene, a neurotrophic tyrosine kinase receptor. Conclusions. Our study and meta-analysis of the literature indicate that the BDNF Val66Met variant is not associated with serum BDNF, but other variants in the BDNF and NTRK3 genes might regulate the level of serum BDNF.
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Date Issued
2011
Identifier
FSU_migr_mhs-0014, 10.3109/15622975.2011.616533
Format
Citation
Genome-Wide Association Scan of Trait Depression
Title
Genome-Wide Association Scan of Trait Depression.
Creator
Terracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa...
Show moreTerracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa, Paul
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Abstract/Description
BACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a...
Show moreBACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a genetically homogeneous area of Sardinia, Italy (n = 3972) and from the Baltimore Longitudinal Study of Aging in the United States (n = 839). RESULTS: Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷·), a gene involved in circadian rhythm. A plausible biological association was also found with single nucleotide polymorphisms within GRM8 (rs17864092; p = 5 × 10⁻⁶), a metabotropic receptor for glutamate, a major excitatory neurotransmitter in the central nervous system. CONCLUSIONS: These findings suggest shared genetic basis underlying the continuum from personality traits to psychopathology.
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Date Issued
2010
Identifier
FSU_migr_mhs-0023, 10.1016/j.biopsych.2010.06.030
Format
Citation
Limits of Evidence Based Medicine and Its Application to Mental Health Evidence-Based Practice. (Part One)
Title
The Limits of Evidence Based Medicine and Its Application to Mental Health Evidence-Based Practice. (Part One).
Creator
Gomory, Tomi
Abstract/Description
The present article outlines the major limitations of Evidence Based Medicine (EBM) and through a close review demonstrates that the three component EBM process model is a pseudo-scientific tool. Its "objective" component is the collection, systematic analysis, and listing of "effective" treatments applying a research hierarchy from most rigorous (systematic reviews of randomized control trials) to least rigorous (expert opinion). Its two subjective components are the clinical judgment of...
Show moreThe present article outlines the major limitations of Evidence Based Medicine (EBM) and through a close review demonstrates that the three component EBM process model is a pseudo-scientific tool. Its "objective" component is the collection, systematic analysis, and listing of "effective" treatments applying a research hierarchy from most rigorous (systematic reviews of randomized control trials) to least rigorous (expert opinion). Its two subjective components are the clinical judgment of helping professionals about which "evidence-based" treatment to select and the specific and unique relevant personal preferences of the potential recipients regarding treatment. This procedural mishmash provides no more rigor in choosing "best practice" than has been provided by good clinical practitioners in the past since both turn out to be subjective and authority based. The article also discusses EBM's further methodological dilution in the National Institute of Mental Health (NIMH) endorsed Evidence Based Mental Health Practice (EBP) movement. In EBP the allegedly rigorous EBM protocol is altered. Instead of systematic expert protocol driven EBM reviews of randomized controlled trials, NIMH sanctioned expert consensus panels decide "evidence-based practices." This further problematizes the development of best practices in mental health by converting it to a political process. The article concludes with some observations on these issues. In a second article (part two) forthcoming, Assertive Community Treatment (ACT) is examined as an example of an EBP that fails as a scientifically effective treatment despite its EBP certification and general popularity among practitioners.
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Date Issued
2013
Identifier
FSU_migr_csw_faculty_publications-0031
Format
Citation
Limits of Evidence Based Medicine and Its Application to Mental Health Evidence-Based Practice. (Part Two)
Title
The Limits of Evidence Based Medicine and Its Application to Mental Health Evidence-Based Practice. (Part Two): Assertive Community Treatment assertively reviewed.
Creator
Gomory, Tomi
Abstract/Description
This article is the second of two published in EHPP, the first appeared in the current spring 2013 volume. The first article argued the very serious limitations of Evidence-Based Medicine (EBM) and its very popular mental health offshoot Evidence-Based Practice (EBP)(Gomory, in press). The present article is meant to be a consolidation and update of a 1999 analysis of Assertive Community Treatment (ACT), the best "validated" mental health EBP according the National Institute of Mental Health ...
Show moreThis article is the second of two published in EHPP, the first appeared in the current spring 2013 volume. The first article argued the very serious limitations of Evidence-Based Medicine (EBM) and its very popular mental health offshoot Evidence-Based Practice (EBP)(Gomory, in press). The present article is meant to be a consolidation and update of a 1999 analysis of Assertive Community Treatment (ACT), the best "validated" mental health EBP according the National Institute of Mental Health (NIMH) and academic researchers. The present analysis reconfirms the failure of ACT as a treatment modality and a platform for successfully reducing hospitalization its touted consistent effect accept when ACT can apply administrative coercion to keep its clients out of the hospital or quickly discharge them. When ACT fails to have such administrative coercive control it does no better than other community mental health delivery systems. The use of ACT coercion begun over forty-years ago, the article further argues, set the table for conventionalizing psychiatric coercion as evidence-based best practice.
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Date Issued
2013
Identifier
FSU_migr_csw_faculty_publications-0033
Format
Citation
Madness or Mental Illness?
Title
Madness or Mental Illness?: Revisiting Historians of Psychiatry.
Creator
Gomory, Tomi, Cohen, David, Kirk, Stuart A.
Abstract/Description
Is madness medical disease, problems in living, or social labeling of deviance? Does the word merely refer to behavior peculiar enough to be disturbing? Are the mad mad because of mental, physical, or environmental vulnerabilities? No one knows the answers to these questions because there is no scientific validation for any theory or specific causes of madness. Nonetheless, a view of madness as medical/bodily disease has been receiving concrete and rhetorical support from the government...
Show moreIs madness medical disease, problems in living, or social labeling of deviance? Does the word merely refer to behavior peculiar enough to be disturbing? Are the mad mad because of mental, physical, or environmental vulnerabilities? No one knows the answers to these questions because there is no scientific validation for any theory or specific causes of madness. Nonetheless, a view of madness as medical/bodily disease has been receiving concrete and rhetorical support from the government mental health bureaucracy, Big Pharma, mental health lobby groups, the organized profession of psychiatry, hundreds of thousands of providers of mental health services and countless books and articles. This article explores the role that medicalized language and its use by seven noted historians of psychiatry (Norman Dain, Albert Deutsch, Gerald Grob, Roy Porter, Charles Rosenberg, Andrew Scull, and Edward Shorter) might have played in shaping the contemporary view of madness as mental illness. The evidence we uncover suggests that historical "facts" about madness, much as psychiatric "facts" supporting the disease model, are shaped by belief, bias, error or ambiguous rhetoric rather than the facts of the matter.
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Date Issued
2013
Identifier
FSU_migr_csw_faculty_publications-0041, 10.1007/s12144-013-9168-3
Format
Citation
Meta-Analysis and Imputation Refines the Association of 15q25 with Smoking Quantity
Title
Meta-Analysis and Imputation Refines the Association of 15q25 with Smoking Quantity.
Creator
Liu, Jason, Tozzi, Federica, Waterworth, Dawn, Pillai, Sreekumar, Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher, Yuan, Xin, Waeber, Gérard,...
Show moreLiu, Jason, Tozzi, Federica, Waterworth, Dawn, Pillai, Sreekumar, Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher, Yuan, Xin, Waeber, Gérard, Vollenweider, Peter, Preisig, Martin, Wareham, Nicholas, Zhao, Jing, Loos, Ruth, Barroso, Inês, Khaw, Kay-Tee, Grundy, Scott M., Barter, Philip, Mahley, Robert, Kesaniemi, Antero, McPherson, Ruth, Vincent, John, Strauss, John, Kennedy, James, Farmer, Anne, McGuffin, Peter, Day, Richard, Matthews, Keith, Bakke, Per, Gulsvik, A. (Amund), Lucae, Susanne, Ising, Marcus, Brueckl, Tanja, Horstmann, Sonja, Wichmann, H.-Erich (Heinz-Erich), Rawal, Rajesh, Dahmen, Norbert, Lamina, Claudia, Polasek, Ozren, Zgaga, Lina, Huffman, Jennifer, Campbell, Susan, Kooner, Jaspal, Chambers, John, Burnett, Mary, Devaney, Joseph, Pichard, Augusto, Kent, Kenneth, Satler, Lowell, Lindsay, Joseph, Waksman, Ron, Epstein, Stephen, Wilson, James F. (James Flett), Wild, Sarah, Campbell, Harry, Vitart, Veronique, Reilly, Muredach, Li, Mingyao, Qu, Liming, Wilensky, Robert, Matthai, William, Hakonarson, Hakon, Rader, Daniel, Franke, Andre, Wittig, Michael, Schäfer, Arne, Uda, Manuela, Terracciano, Antonio, Xiao, Xiangjun, Busonero, Fabio, Scheet, Paul A. (Paul Anthony), Schlessinger, David, St Clair, David, Rujescu, Dan, Abecasis, Gonçalo, Grabe, Hans, Teumer, Alexander, Völzke, Henry, Petersmann, Astrid, John, Ulrich, Rudan, Igor, Hayward, Caroline, Wright, Alan, Kolcic, Ivana, Wright, Benjamin, Thompson, John, Balmforth, Anthony, Hall, A. S. (Alistair Scott), Samani, Nilesh J., Anderson, Carl, Ahmad, Tariq, Mathew, Christopher, Parkes, Miles, Satsangi, Jack, Caulfield, Mark, Munroe, Patricia, Farrall, Martin, Dominiczak, A. F., Worthington, Jane, Thomson, Wendy, Eyre, Steve, Barton, Anne, Mooser, Vincent, Francks, Clyde, Marchini, Jonathan
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Abstract/Description
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic...
Show moreSmoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
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Date Issued
2010
Identifier
FSU_migr_geriatrics_faculty_publications-0018, 10.1038/ng.572
Format
Citation
Neural Correlates of Neuroticism Differ by Sex Prospectively Mediate Depressive Symptoms Among Older Women
Title
The Neural Correlates of Neuroticism Differ by Sex Prospectively Mediate Depressive Symptoms Among Older Women.
Creator
Sutin, Angelina, Beason-Held, Lori, Dotson, Vonetta, Resnick, Susan M., Costa, Paul
Abstract/Description
BACKGROUND: Mood disorders in old age increase the risk of morbidity and mortality for individuals and healthcare costs for society. Trait Neuroticism, a strong risk factor for such disorders into old age, shares common genetic variance with depression, but the more proximal biological mechanisms that mediate this connection are not well understood. Further, whether sex differences in the neural correlates of Neuroticism mirror sex differences in behavioral measures is unknown. The present...
Show moreBACKGROUND: Mood disorders in old age increase the risk of morbidity and mortality for individuals and healthcare costs for society. Trait Neuroticism, a strong risk factor for such disorders into old age, shares common genetic variance with depression, but the more proximal biological mechanisms that mediate this connection are not well understood. Further, whether sex differences in the neural correlates of Neuroticism mirror sex differences in behavioral measures is unknown. The present research identifies sex differences in the stable neural activity associated with Neuroticism and tests whether this activity prospectively mediates Neuroticism and subsequent depressive symptoms. METHODS: A total of 100 (46 female) older participants (>55years) underwent a resting-state PET scan twice, approximately two years apart, and completed measures of Neuroticism and depressive symptoms twice. RESULTS: Replicating at both time points, Neuroticism correlated positively with resting-state regional cerebral blood-flow activity in the hippocampus and midbrain in women and the middle temporal gyrus in men. For women, hippocampal activity mediated the association between Neuroticism at baseline and depressive symptoms at follow-up. The reverse mediational model was not significant. CONCLUSIONS: Neuroticism was associated with stable neural activity in regions implicated in emotional processing and regulation for women but not men. Among women, Neuroticism prospectively predicted depressive symptoms through greater activity in the right hippocampus, suggesting one neural mechanism between Neuroticism and depression for women. Identifying responsible mechanisms for the association between Neuroticism and psychiatric disorders may help guide research on pharmacological interventions for such disorders across the lifespan.
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Date Issued
2010
Identifier
FSU_migr_mhs-0021, 10.1016/j.jad.2010.06.004
Format
Citation
Neuroticism, Depressive Symptoms, and Serum BDNF
Title
Neuroticism, Depressive Symptoms, and Serum BDNF.
Creator
Terracciano, Antonio, Lobina, Monia, Piras, Maria, Mulas, Antonella, Cannas, Alessandra, Meirelles, Osorio, Sutin, Angelina, Zonderman, Alan, Uda, Manuela, Crisponi, Laura,...
Show moreTerracciano, Antonio, Lobina, Monia, Piras, Maria, Mulas, Antonella, Cannas, Alessandra, Meirelles, Osorio, Sutin, Angelina, Zonderman, Alan, Uda, Manuela, Crisponi, Laura, Schlessinger, David
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Abstract/Description
OBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. We test whether serum and plasma levels of BDNF are associated with trait neuroticism and its facets and with state measures of depressive symptoms. METHODS: In a community-based cohort (N = 2099), we measured serum and plasma BDNF concentrations and administered the Revised NEO Personality Inventory and the Center for Epidemiological Studies...
Show moreOBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. We test whether serum and plasma levels of BDNF are associated with trait neuroticism and its facets and with state measures of depressive symptoms. METHODS: In a community-based cohort (N = 2099), we measured serum and plasma BDNF concentrations and administered the Revised NEO Personality Inventory and the Center for Epidemiological Studies Depression Scale. Covariates included age, sex, cigarette smoking, obesity, and antidepressant use. RESULTS: Serum BDNF concentrations were inversely related to neuroticism (r = -0.074, p < .001), in particular the depression facet (r = -0.08, p < .001). Lower BDNF concentrations were also associated with severe depressive symptoms (Center for Epidemiological Studies Depression Scale ≥ 28; odds ratio = 0.906; 95% confidence interval = 0.851-0.965). The association of serum BDNF with neuroticism was independent of depressive symptoms, indicating that serum BDNF might represent a biological correlate of neuroticism and not just of transient depressive states. Plasma BDNF was not associated with measures of depression. CONCLUSIONS: Our study suggests that lower serum BDNF is associated with both a dispositional vulnerability to depression and acute depressive states in the general population.
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Date Issued
2011
Identifier
FSU_migr_mhs-0019, 10.1097/PSY.0b013e3182306a4f
Format
Citation
Antidepressants and the Chemical Imbalance Theory of Depression
Title
Antidepressants and the Chemical Imbalance Theory of Depression: A Reflection and Update on the Discourse.
Creator
Lacasse, Jeffrey R., Leo, Jonathan
Date Issued
2015
Identifier
FSU_migr_csw_faculty_publications-0084
Format
Citation
Coercion
Title
Coercion: The Only Constant In Psychiatric Practice?.
Creator
Gomory, Tomi, Cohen, David, Kirk, Stuart A.
Abstract/Description
In the Western world, since at least the 15th century, state-sanctioned force has been employed to control those who disturb others by their violent or existentially destabilizing behaviors such as threatening or inflicting self-harm. Coercing the mad into madhouses, separating and detaining them from the rest of society, and forcing them to comply with their keepers' wishes, occurred before physicians became involved in theorizing about the meaning or origins of madness, and it continues to...
Show moreIn the Western world, since at least the 15th century, state-sanctioned force has been employed to control those who disturb others by their violent or existentially destabilizing behaviors such as threatening or inflicting self-harm. Coercing the mad into madhouses, separating and detaining them from the rest of society, and forcing them to comply with their keepers' wishes, occurred before physicians became involved in theorizing about the meaning or origins of madness, and it continues to distinguish psychiatric practice to this day. It is widely recognized that the mad used to be confined, beaten, tied, shocked or whirled into submission, but it seems less appreciated today by scholars, practitioners, and the general public that the physical control of "dangerous" mental patients remains a central function, and perhaps the only constant function, of public mental health systems.
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Date Issued
2013
Identifier
FSU_migr_csw_faculty_publications-0042
Format
Citation
Chronic Inflammation and Quality of Life in Older Adults
Title
Chronic Inflammation and Quality of Life in Older Adults: A Cross-Sectional Study Using Biomarkers to Predict Emotional and Relational Outcomes.
Creator
Nowakowski, Alexandra
Abstract/Description
BACKGROUND: This study explores relationships between chronic inflammation and quality of life, making a case for biopsychosocial modeling of these associations. It builds on research from social and clinical disciplines connecting chronic conditions, and inflammatory conditions specifically, to reduced quality of life. METHODS: Data from Wave I of the National Social Life, Health, and Aging Project are modeled using ordinal logistic and ordinary least-squares regression techniques....
Show moreBACKGROUND: This study explores relationships between chronic inflammation and quality of life, making a case for biopsychosocial modeling of these associations. It builds on research from social and clinical disciplines connecting chronic conditions, and inflammatory conditions specifically, to reduced quality of life. METHODS: Data from Wave I of the National Social Life, Health, and Aging Project are modeled using ordinal logistic and ordinary least-squares regression techniques. Inflammation is measured using C-reactive protein; quality of life is conceptualized as happiness with life overall as well as intimate relationships specifically. RESULTS: For most NSHAP participants, chronic inflammation significantly predicts lower odds of reporting high QoL on both emotional and relational measures. Social structural factors do not confound these associations. Inconsistent results for participants with very high (over 6 mg/L) CRP measurements suggest additional social influences. CONCLUSIONS: Findings echo strong theoretical justification for investigating relationships between CRP and QoL in greater detail. Further research should explore possible mediation of these associations by sociomedical sequelae of chronic disease as well as social relationship dynamics. Elaboration is also needed on the mechanisms by which social disadvantage may cause chronic inflammation.
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Date Issued
2014
Identifier
FSU_migr_mhs-0043, 10.1186/s12955-014-0141-0
Format
Citation
Personality Traits Prospectively Predict Verbal Fluency in a Lifespan Sample
Title
Personality Traits Prospectively Predict Verbal Fluency in a Lifespan Sample.
Creator
Sutin, Angelina, Terracciano, Antonio, Kitner-Triolo, Melissa, Uda, Manuela, Schlessinger, David, Zonderman, Alan
Abstract/Description
In a community-dwelling sample (N = 4,790; age range 14-94), we examined whether personality traits prospectively predicted performance on a verbal fluency task. Open, extraverted, and emotionally stable participants had better verbal fluency. At the facet level, dispositionally happy and self-disciplined participants retrieved more words; those prone to anxiety and depression and those who were deliberative retrieved fewer words. Education moderated the association between conscientiousness...
Show moreIn a community-dwelling sample (N = 4,790; age range 14-94), we examined whether personality traits prospectively predicted performance on a verbal fluency task. Open, extraverted, and emotionally stable participants had better verbal fluency. At the facet level, dispositionally happy and self-disciplined participants retrieved more words; those prone to anxiety and depression and those who were deliberative retrieved fewer words. Education moderated the association between conscientiousness and fluency such that participants with lower education performed better on the fluency task if they were also conscientious. Age was not a moderator at the domain level, indicating that the personality-fluency associations were consistent across the life span. A disposition toward emotional vulnerability and being less open, less happy, and undisciplined may be detrimental to cognitive performance.
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Date Issued
2011
Identifier
FSU_migr_mhs-0015, 10.1037/a0024276
Format
Citation
Perceptions of Aging Across 26 Cultures and Their Culture-Level Associates
Title
Perceptions of Aging Across 26 Cultures and Their Culture-Level Associates.
Creator
Löckenhoff, Corinna, De Fruyt, Filip, Terracciano, Antonio, McCrae, Robert R., De Bolle, Marleen, Costa, Paul, Aguilar-Vafaie, Maria, Ahn, Chang-kyu, Ahn, Hyun-nie, Alcalay,...
Show moreLöckenhoff, Corinna, De Fruyt, Filip, Terracciano, Antonio, McCrae, Robert R., De Bolle, Marleen, Costa, Paul, Aguilar-Vafaie, Maria, Ahn, Chang-kyu, Ahn, Hyun-nie, Alcalay, Lidia, Allik, Jüri, Avdeyeva, Tatyana, Barbaranelli, Claudio, Benet-Martínez, Verónica, Blatný, Marek, Bratko, Denis, Cain, Thomas, Crawford, Jarret, Lima, Margarida, Ficková, Emília, Gheorghiu, Mirona, Halberstadt, Jamin, Hrebícková, Martina, Jussim, Lee J., Klinkosz, Waldemar, Knezević, Goran, de Figueroa, Nora, Martin, Thomas, Marusić, Iris, Mastor, Khairul, Miramontez, Daniel, Nakazato, Katsuharu, Nansubuga, Florence, Pramila, V., Realo, Anu, Rolland, Jean-Pierre, Rossier, Jerome, Schmidt, Vanina, Sekowski, Andrzej, Shakespeare-Finch, Jane, Shimonaka, Yoshiko, Simonetti, Franco, Siuta, Jerzy, Smith, Peter Bevington, Szmigielska, Barbara, Wang, Lei, Yamaguchi, Mami, Yik, Michelle
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Abstract/Description
College students (N=3,435) in 26 cultures reported their perceptions of age-related changes in physical, cognitive, and socioemotional areas of functioning and rated societal views of aging within their culture. There was widespread cross-cultural consensus regarding the expected direction of aging trajectories with (a) perceived declines in societal views of aging, physical attractiveness, the ability to perform everyday tasks, and new learning; (b) perceived increases in wisdom, knowledge,...
Show moreCollege students (N=3,435) in 26 cultures reported their perceptions of age-related changes in physical, cognitive, and socioemotional areas of functioning and rated societal views of aging within their culture. There was widespread cross-cultural consensus regarding the expected direction of aging trajectories with (a) perceived declines in societal views of aging, physical attractiveness, the ability to perform everyday tasks, and new learning; (b) perceived increases in wisdom, knowledge, and received respect; and (c) perceived stability in family authority and life satisfaction. Cross-cultural variations in aging perceptions were associated with culture-level indicators of population aging, education levels, values, and national character stereotypes. These associations were stronger for societal views on aging and perceptions of socioemotional changes than for perceptions of physical and cognitive changes. A consideration of culture-level variables also suggested that previously reported differences in aging perceptions between Asian and Western countries may be related to differences in population structure.
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Date Issued
2009
Identifier
FSU_migr_geriatrics_faculty_publications-0021, 10.1037/a0016901
Format
Citation
Depressive Symptoms Are Associated with Weight Gain Among Women
Title
Depressive Symptoms Are Associated with Weight Gain Among Women.
Creator
Sutin, Angelina, Zonderman, Alan
Abstract/Description
BACKGROUND: Many studies have linked depression and obesity; few have more than two assessments of depressive symptoms and adiposity to address the potential bidirectional relationship between adiposity and depressive symptoms from young adulthood through old age. We tested whether baseline depressive symptoms are associated with changes in weight, whether baseline adiposity is associated with changes in depressive symptoms, and whether these associations vary by sex.MethodParticipants (n...
Show moreBACKGROUND: Many studies have linked depression and obesity; few have more than two assessments of depressive symptoms and adiposity to address the potential bidirectional relationship between adiposity and depressive symptoms from young adulthood through old age. We tested whether baseline depressive symptoms are associated with changes in weight, whether baseline adiposity is associated with changes in depressive symptoms, and whether these associations vary by sex.MethodParticipants (n=2251; 47% female) were from the Baltimore Longitudinal Study of Aging (BLSA). Using hierarchical linear modeling (HLM) on 30 years of data, the trajectory of adiposity and depressive symptoms over adulthood was estimated from >10 000 observations (mean=4.5 assessments per participant) of body mass index (BMI; kg/m2), waist circumference and hip circumference and >10 000 observations (mean=4.5 assessments per participant) of the Center for Epidemiological Studies Depression Scale (CES-D). Baseline depressive symptoms and adiposity were then tested as predictors of the trajectory of adiposity and depressive symptoms respectively. Additional analyses tested for sex-specific associations. RESULTS: Sex moderated the association between depressive symptoms and weight gain such that women who experienced depressed affect had greater increases in BMI (binteraction=0.12, s.e.=0.04), waist (binteraction=0.22, s.e.=0.10) and hip circumference (binteraction=0.20, s.e.=0.07) across the adult lifespan, controlling for relevant demographic and behavioral covariates. Baseline adiposity was unrelated to the trajectory of depressive symptoms (median b=0.00) for both sexes. CONCLUSIONS: Women who experience symptoms of depression tend to gain more weight across adulthood than men who experience such symptoms. Whether an individual was normal weight or overweight was unrelated to changes in depressive symptoms across adulthood.
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Date Issued
2012
Identifier
FSU_migr_mhs-0012, 10.1017/S0033291712000566
Format
Citation
Correlates of HPV Knowledge in the Era of HPV Vaccination
Title
Correlates of HPV Knowledge in the Era of HPV Vaccination: A Study of Unvaccinated Young Adult Women.
Creator
Gerend, Mary, Shepherd, Janet
Abstract/Description
Until recently, awareness of the sexually transmitted infection human papillomavirus (HPV)—the virus that causes cervical cancer—was relatively low. The purpose of this study was to identify factors associated with HPV knowledge now that HPV vaccines have become widely available. Young adult women (n = 739; aged 18-26 years) attending Florida State University who had not yet initiated HPV vaccination completed a survey between March-August 2009. The survey assessed HPV awareness, HPV...
Show moreUntil recently, awareness of the sexually transmitted infection human papillomavirus (HPV)—the virus that causes cervical cancer—was relatively low. The purpose of this study was to identify factors associated with HPV knowledge now that HPV vaccines have become widely available. Young adult women (n = 739; aged 18-26 years) attending Florida State University who had not yet initiated HPV vaccination completed a survey between March-August 2009. The survey assessed HPV awareness, HPV knowledge, demographics, socio-political variables, sexual history, and health history variables. Over 97% of participants were aware of HPV prior to study enrollment; however, knowledge of HPV was only moderate. A multivariate regression analysis examining factors related to HPV knowledge revealed five independent correlates: Latina ethnicity, premarital sex values, number of lifetime sexual partners, history of cervical dysplasia, and HIV testing. These variables accounted for 14% of the variance in HPV knowledge. Less knowledge was observed for Latinas and women opposed to premarital sex. Greater knowledge was observed for women who had been tested for HIV and women with more sexual partners or a history of cervical dysplasia. These findings can inform future HPV vaccination campaigns and may be particularly useful in developing interventions for individuals with the largest deficits in HPV knowledge.
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Date Issued
2011
Identifier
FSU_migr_mhs-0008, 10.1080/03630242.2011.540744
Format
Citation
Cross-Cultural Studies of Personality Traits and Their Relevance to Psychiatry
Title
Cross-Cultural Studies of Personality Traits and Their Relevance to Psychiatry.
Creator
Terracciano, Antonio, McCrae, Robert R.
Abstract/Description
AIMS: This article provides a brief review of recent cross-cultural research on personality traits at both individual and culture levels, highlighting the relevance of recent findings for psychiatry. METHOD: In most cultures around the world, personality traits can be clearly summarized by the five broad dimensions of the Five-Factor Model (FFM), which makes it feasible to compare cultures on personality and psychopathology. RESULTS: Maturational patterns and sex differences in personality...
Show moreAIMS: This article provides a brief review of recent cross-cultural research on personality traits at both individual and culture levels, highlighting the relevance of recent findings for psychiatry. METHOD: In most cultures around the world, personality traits can be clearly summarized by the five broad dimensions of the Five-Factor Model (FFM), which makes it feasible to compare cultures on personality and psychopathology. RESULTS: Maturational patterns and sex differences in personality traits generally show cultural invariance, which generates the hypothesis that age of onset, clinical evolution, and sex differences in the prevalence of psychiatric disorders might follow similar universal patterns. The average personality profiles from 51 cultures show meaningful geographical distributions and associations with culture-level variables, but are clearly unrelated to national character stereotypes. CONCLUSIONS: Aggregate personality scores can potentially be related to epidemiological data on psychiatric disorders, and dimensional personality models have implications for psychiatric diagnosis and treatment around the world.
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Date Issued
2006
Identifier
FSU_migr_geriatrics_faculty_publications-0034
Format
Citation
Effect of Birth Cohort on Well-Being
Title
The Effect of Birth Cohort on Well-Being: The Legacy of Economic Hard Times.
Creator
Sutin, Angelina, Terracciano, Antonio, Milaneschi, Yuri, An, Yang, Ferrucci, Luigi, Zonderman, Alan
Abstract/Description
In the present research, we examined the effects of age, cohort, and time of measurement on well-being across adulthood. Cross-sectional and longitudinal analyses of two independent samples-one with more than 10,000 repeated assessments across 30 years (mean assessments per participant = 4.44, SD = 3.47) and one with nationally representative data-suggested that well-being declines with age. This decline, however, reversed when we controlled for birth cohort. That is, once we accounted for...
Show moreIn the present research, we examined the effects of age, cohort, and time of measurement on well-being across adulthood. Cross-sectional and longitudinal analyses of two independent samples-one with more than 10,000 repeated assessments across 30 years (mean assessments per participant = 4.44, SD = 3.47) and one with nationally representative data-suggested that well-being declines with age. This decline, however, reversed when we controlled for birth cohort. That is, once we accounted for the fact that older cohorts had lower levels of well-being, all cohorts increased in well-being with age relative to their own baseline. Participants tested more recently had higher well-being, but time of measurement, unlike cohort, did not change the shape of the trajectory. Although well-being increased with age for everyone, cohorts that lived through the economic challenges of the early 20th century had lower well-being than those born during more prosperous times.
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Date Issued
2013
Identifier
FSU_migr_mhs-0010, 10.1177/0956797612459658
Format
Citation
What Are the Most Effective Methods for Managing General Psychosocial Stress?
Title
What Are the Most Effective Methods for Managing General Psychosocial Stress?.
Creator
Rodby, Katherine, Rodríguez, Jose
Abstract/Description
Mindfulness-based stress reduction (MBSR), cognitive-behavioral stress reduction (CBSR), and somatic relaxation are all effective therapies for psychosocial stress. Exercise also reduces stress and improves mental health (SOR B, based on small randomized controlled trials [RCTs]). Anxiolytic agents and antidepressants may be used in refractory cases. (SOR C, expert opinion.)
Date Issued
2009
Identifier
FSU_migr_fmr-0011
Format
Citation
Self-Directed Care
Title
Self-Directed Care: Participants' Service Utilization and Outcomes.
Creator
Spaulding-Givens, Jennifer, Lacasse, Jeffrey R.
Abstract/Description
Objective: Self-directed care (SDC) is a mental health service delivery model in which participants budget the state dollars allotted for their care to purchase the goods and services they deem most appropriate for achieving their recovery goals. This study examines the demographic characteristics, service utilization patterns, and outcomes of individuals enrolled in the Florida Self-Directed Care (FloridaSDC) program, which is the oldest and most established SDC program in the United States...
Show moreObjective: Self-directed care (SDC) is a mental health service delivery model in which participants budget the state dollars allotted for their care to purchase the goods and services they deem most appropriate for achieving their recovery goals. This study examines the demographic characteristics, service utilization patterns, and outcomes of individuals enrolled in the Florida Self-Directed Care (FloridaSDC) program, which is the oldest and most established SDC program in the United States for individuals diagnosed with a severe and persistent mental illness. Methods: This is a naturalistic descriptive study in which demographic, service utilization, and outcome data (i.e., Functional Assessment Rating Scores (FARS), days in the community, days worked, monthly income, discharge status) were collected from the clinical and fiscal records of 136 FloridaSDC participants. Results: Key findings suggest that FloridaSDC participants had very little income and largely utilized their budgets to subsidize their living expenses. Though most participants did not work or earn income and very few left the program due to employment, participants' FARs scores improved modestly and nearly all participants remained in the community throughout the study period. Conclusions and Implications for Practice: Participants' service purchases were rational given the poverty in which they live, and their outcomes did not suffer when they controlled decisions regarding their service needs. These findings highlight the utility and value of the personalized budgeting and individualized planning components of self-directed care. Findings also point to the need for practitioners to implement innovative strategies to enhance participants' employment readiness and supported employment opportunities.
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Date Issued
2015
Identifier
FSU_migr_csw_faculty_publications-0029, 10.1037/prj0000103
Format
Citation
Serotonina y Depresión
Title
Serotonina y Depresión: Una Desconexión Entre la Publicidad y Literature Cíentifica.
Creator
Lacasse, Jeffrey R., Leo, Jonathan
Date Issued
2006
Identifier
FSU_migr_csw_faculty_publications-0043
Format
Citation
Serotonin and Depression
Title
Serotonin and Depression: A Disconnect Between the Advertisements and the Scientific Literature.
Creator
Lacasse, Jeffrey R., Leo, Jonathan
Date Issued
2005
Identifier
FSU_migr_csw_faculty_publications-0032
Format
Citation
Trait Antagonism and the Progression of Arterial Thickening
Title
Trait Antagonism and the Progression of Arterial Thickening: Women with Antagonistic Traits Have Similar Carotid Arterial Thickness as Men.
Creator
Sutin, Angelina, Scuteri, Angelo, Lakatta, Edward, Tarasov, Kirill, Ferrucci, Luigi, Costa, Paul, Schlessinger, David, Uda, Manuela, Terracciano, Antonio
Abstract/Description
A large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based sample from Sardinia, Italy (n=5614), this study examined how trait antagonism (low agreeableness) and its facets are associated with carotid artery intima-media thickness, a measure of arterial thickening. Controlling for demographic and cardiovascular risk...
Show moreA large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based sample from Sardinia, Italy (n=5614), this study examined how trait antagonism (low agreeableness) and its facets are associated with carotid artery intima-media thickness, a measure of arterial thickening. Controlling for demographic and cardiovascular risk factors, low agreeableness and, in particular, low straightforwardness and low compliance, were associated with greater carotid thickening, measured concurrently and prospectively, and with increases in intima-media thickness over 3 years. Indeed, those in the bottom 10% of agreeableness had a 40% increase in risk for elevated intima-media thickness. Although men have thicker arterial walls, women with antagonistic traits had similar carotid thickening as antagonistic men. Antagonistic individuals, especially those who are manipulative and aggressive, have greater increases in arterial thickening, independent of traditional cardiovascular risk factors.
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Date Issued
2010
Identifier
FSU_migr_mhs-0022, 10.1161/HYPERTENSIONAHA.110.155317
Format
Citation
Trait Dissociation and the Subjective Affective, Motivational, and Phenomenological Experience of Self-Defining Memories
Title
Trait Dissociation and the Subjective Affective, Motivational, and Phenomenological Experience of Self-Defining Memories.
Creator
Sutin, Angelina, Stockdale, Gary
Abstract/Description
The present research reports 2 studies that examine the relation between nonpathological trait dissociation and the subjective affect, motivation, and phenomenology of self-defining memories. In Study 1 (N=293), participants retrieved and rated the emotional and motivational experience of a general and a positive and negative achievement-related memory. Study 2 (N=449) extended these ratings to relationship-related memories and the phenomenological experience of the memory. Dissociation was...
Show moreThe present research reports 2 studies that examine the relation between nonpathological trait dissociation and the subjective affect, motivation, and phenomenology of self-defining memories. In Study 1 (N=293), participants retrieved and rated the emotional and motivational experience of a general and a positive and negative achievement-related memory. Study 2 (N=449) extended these ratings to relationship-related memories and the phenomenological experience of the memory. Dissociation was associated with incongruent affect in valenced memories (e.g., positive affect in a negative memory) and memories that were visually incoherent and saturated with power motivation, hubristic pride, and shame, regardless of valence or domain. The present findings demonstrate that autobiographical memories, which integrate emotional, motivational, and phenomenological components, reflect the emotional and motivational processes inherent to dissociation.
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Date Issued
2011
Identifier
FSU_migr_mhs-0017, 10.1111/j.1467-6494.2010.00708.x
Format
Citation
Questionable Advertising of Psychotropic Medications and Disease Mongering
Title
Questionable Advertising of Psychotropic Medications and Disease Mongering.
Creator
Lacasse, Jeffrey R., Leo, Jonathan
Date Issued
2006
Identifier
FSU_migr_csw_faculty_publications-0035, 10.1371/journal.pmed.0030321
Format
Citation