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Title
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Replication timing and transcriptional control: beyond cause and effect-part III..
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Creator
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Rivera-Mulia, Juan Carlos, Gilbert, David M
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Abstract/Description
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DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in...
Show moreDNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.
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Date Issued
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2016-06-01
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Identifier
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FSU_pmch_27115331, 10.1016/j.ceb.2016.03.022, PMC4887323, 27115331, 27115331, S0955-0674(16)30072-2
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Format
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Citation
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Title
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Replicating Large Genomes: Divide and Conquer..
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Creator
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Rivera-Mulia, Juan Carlos, Gilbert, David M
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Abstract/Description
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Complete duplication of large metazoan chromosomes requires thousands of potential initiation sites, only a small fraction of which are selected in each cell cycle. Assembly of the replication machinery is highly conserved and tightly regulated during the cell cycle, but the sites of initiation are highly flexible, and their temporal order of firing is regulated at the level of large-scale multi-replicon domains. Importantly, the number of replication forks must be quickly adjusted in...
Show moreComplete duplication of large metazoan chromosomes requires thousands of potential initiation sites, only a small fraction of which are selected in each cell cycle. Assembly of the replication machinery is highly conserved and tightly regulated during the cell cycle, but the sites of initiation are highly flexible, and their temporal order of firing is regulated at the level of large-scale multi-replicon domains. Importantly, the number of replication forks must be quickly adjusted in response to replication stress to prevent genome instability. Here we argue that large genomes are divided into domains for exactly this reason. Once established, domain structure abrogates the need for precise initiation sites and creates a scaffold for the evolution of other chromosome functions.
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Date Issued
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2016-06-02
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Identifier
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FSU_pmch_27259206, 10.1016/j.molcel.2016.05.007, PMC4893193, 27259206, 27259206, S1097-2765(16)30144-7
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Format
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Citation
