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(1 - 17 of 17)
- Title
- Variants of the Serotonin Transporter Gene and NEO-PI-R Neuroticism: No Association in the BLSA and SardiNIA Samples.
- Creator
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Terracciano, Antonio, Balaci, Lenuta, Thayer, Jason, Scally, Matthew, Kokinos, Sarah, Ferrucci, Luigi, Tanaka, Toshiko, Zonderman, Alan, Sanna, Serena, Olla, Nazario, Zuncheddu,...
Show moreTerracciano, Antonio, Balaci, Lenuta, Thayer, Jason, Scally, Matthew, Kokinos, Sarah, Ferrucci, Luigi, Tanaka, Toshiko, Zonderman, Alan, Sanna, Serena, Olla, Nazario, Zuncheddu, Maria, Naitza, Silvia, Busonero, Fabio, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Costa, Paul
Show less - Abstract/Description
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The polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism-related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5-HTTLPR. However, studies that used the NEO-PI-R or related instruments (NEO-PI, NEO-FFI)...
Show moreThe polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism-related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5-HTTLPR. However, studies that used the NEO-PI-R or related instruments (NEO-PI, NEO-FFI) to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia (Italy) that is several times larger than previous samples that used the NEO-PI-R (N = 3,913). The association was also tested in a sample (N = 548) from the Baltimore Longitudinal Study of Aging (BLSA), in which repeated NEO-PI-R assessments were obtained. In the SardiNIA sample, we found no significant association of the 5-HTTLPR genotypes with Neuroticism or its facets (Anxiety, Angry-Hostility, Depression, Self-Consciousness, Impulsiveness, and Vulnerability). In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA (N = 3,972) and nine SNPs in the BLSA (N = 1,182) that map within or near the serotonin transporter gene (SLC6A4), and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits.
Show less - Date Issued
- 2009
- Identifier
- FSU_migr_geriatrics_faculty_publications-0022, 10.1002/ajmg.b.30932
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- Citation
- Title
- Sex-Specific Correlates of Walking Speed in a Wide Age-Ranged Population.
- Creator
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Tolea, Magdalena, Costa, Paul, Terracciano, Antonio, Griswold, Michael, Simonsick, Eleanor M., Najjar, Samer, Scuteri, Angelo, Deiana, Barbara, Orrù, Marco, Masala, Marco, Uda,...
Show moreTolea, Magdalena, Costa, Paul, Terracciano, Antonio, Griswold, Michael, Simonsick, Eleanor M., Najjar, Samer, Scuteri, Angelo, Deiana, Barbara, Orrù, Marco, Masala, Marco, Uda, Manuela, Schlessinger, David, Ferrucci, Luigi
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The goals of this cross-sectional study were to explore correlates of walking speed in a large wide age-ranged population and to identify factors affecting lower walking speed at older ages. Participants were 3,872 community-dwelling adults in the first follow-up of the SardiNIA study who completed a 4-m walking test. Sex-specific correlates of walking speed included marital status, height, waist circumference, pulse wave velocity, comorbidity, subjective health, strength, and personality....
Show moreThe goals of this cross-sectional study were to explore correlates of walking speed in a large wide age-ranged population and to identify factors affecting lower walking speed at older ages. Participants were 3,872 community-dwelling adults in the first follow-up of the SardiNIA study who completed a 4-m walking test. Sex-specific correlates of walking speed included marital status, height, waist circumference, pulse wave velocity, comorbidity, subjective health, strength, and personality. Effect modifiers of the age-walking speed association included extraversion (<55 >years, p = .019) and education (<55 >years, p = .021; > or =55 years, p = .012) in women, and openness (<55 >years, p = .005), waist circumference (<55 >years, p = .010), and subjective health (<55 >years, p = .014) in men. The strong impact of personality suggests that certain personality traits may be associated with behaviors that affect physical performance and condition the reduced mobility mostly at younger ages. If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_geriatrics_faculty_publications-0020, 10.1093/geronb/gbp130
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- Citation
- Title
- Trait Antagonism and the Progression of Arterial Thickening: Women with Antagonistic Traits Have Similar Carotid Arterial Thickness as Men.
- Creator
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Sutin, Angelina, Scuteri, Angelo, Lakatta, Edward, Tarasov, Kirill, Ferrucci, Luigi, Costa, Paul, Schlessinger, David, Uda, Manuela, Terracciano, Antonio
- Abstract/Description
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A large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based sample from Sardinia, Italy (n=5614), this study examined how trait antagonism (low agreeableness) and its facets are associated with carotid artery intima-media thickness, a measure of arterial thickening. Controlling for demographic and cardiovascular risk...
Show moreA large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based sample from Sardinia, Italy (n=5614), this study examined how trait antagonism (low agreeableness) and its facets are associated with carotid artery intima-media thickness, a measure of arterial thickening. Controlling for demographic and cardiovascular risk factors, low agreeableness and, in particular, low straightforwardness and low compliance, were associated with greater carotid thickening, measured concurrently and prospectively, and with increases in intima-media thickness over 3 years. Indeed, those in the bottom 10% of agreeableness had a 40% increase in risk for elevated intima-media thickness. Although men have thicker arterial walls, women with antagonistic traits had similar carotid thickening as antagonistic men. Antagonistic individuals, especially those who are manipulative and aggressive, have greater increases in arterial thickening, independent of traditional cardiovascular risk factors.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_mhs-0022, 10.1161/HYPERTENSIONAHA.110.155317
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- Citation
- Title
- BDNF Val66Met is Associated with Introversion and Interacts with 5-HTTLPR to Influence Neuroticism.
- Creator
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Terracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Deiana, Barbara, Balaci, Lenuta, Sanna, Serena, Olla, Nazario, Maschio, Andrea, Uda, Manuela, Ferrucci, Luigi,...
Show moreTerracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Deiana, Barbara, Balaci, Lenuta, Sanna, Serena, Olla, Nazario, Maschio, Andrea, Uda, Manuela, Ferrucci, Luigi, Schlessinger, David, Costa, Paul
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Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurotransmission, and has been linked to neuroticism, a major risk factor for psychiatric disorders. A recent genome-wide association (GWA) scan, however, found the BDNF Val66Met polymorphism (rs6265) associated with extraversion but not with neuroticism. In this study, we examine the links between BDNF and personality traits, assessed using the Revised NEO Personality Inventory (NEO-PI-R), in a sample from SardiNIA ...
Show moreBrain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurotransmission, and has been linked to neuroticism, a major risk factor for psychiatric disorders. A recent genome-wide association (GWA) scan, however, found the BDNF Val66Met polymorphism (rs6265) associated with extraversion but not with neuroticism. In this study, we examine the links between BDNF and personality traits, assessed using the Revised NEO Personality Inventory (NEO-PI-R), in a sample from SardiNIA (n=1560) and the Baltimore Longitudinal Study of Aging (BLSA; n=1131). Consistent with GWA results, we found that BDNF Met carriers were more introverted. By contrast, in both samples and in a meta-analysis inclusive of published data (n=15251), we found no evidence for a main effect of BDNF Val66Met on neuroticism. Finally, on the basis of recent reports of an epistatic effect between BDNF and the serotonin transporter, we explored a Val66Met x 5-HTTLPR interaction in a larger SardiNIA sample (n=2333). We found that 5-HTTLPR LL carriers scored lower on neuroticism in the presence of the BDNF Val variant, but scored higher on neuroticism in the presence of the BDNF Met variant. Our findings support the association between the BDNF Met variant and introversion and suggest that BDNF interacts with the serotonin transporter gene to influence neuroticism.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_mhs-0029, 10.1038/npp.2009.213
- Format
- Citation
- Title
- Facets of Personality Linked to Underweight and Overweight.
- Creator
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Terracciano, Antonio, Sutin, Angelina, McCrae, Robert R., Deiana, Barbara, Ferrucci, Luigi, Schlessinger, David, Uda, Manuela, Costa, Paul
- Abstract/Description
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OBJECTIVE: Personality traits underlie maladaptive behaviors, and cognitive and emotional disturbances that contribute to major preventable causes of global disease burden. This study examines detailed personality profiles of underweight, normal, and overweight individuals to provide insights into the causes and treatments of abnormal weight. METHODS: More than half of the population from four towns in Sardinia, Italy (n = 5693; age = 14-94 years; mean +/- standard deviation = 43 +/- 17 years...
Show moreOBJECTIVE: Personality traits underlie maladaptive behaviors, and cognitive and emotional disturbances that contribute to major preventable causes of global disease burden. This study examines detailed personality profiles of underweight, normal, and overweight individuals to provide insights into the causes and treatments of abnormal weight. METHODS: More than half of the population from four towns in Sardinia, Italy (n = 5693; age = 14-94 years; mean +/- standard deviation = 43 +/- 17 years) were assessed on multiple anthropometric measures and 30 facets that comprehensively cover the five major dimensions of personality, using the Revised NEO Personality Inventory. RESULTS: High Neuroticism and low Conscientiousness were associated with being underweight and obese, respectively. High Impulsiveness (specifically eating-behavior items) and low Order were associated with body mass index categories of overweight and obese, and with measures of abdominal adiposity (waist and hip circumference). Those scoring in the top 10% of Impulsiveness were about 4 kg heavier than those in the bottom 10%, an effect independent and larger than the FTO genetic variant. Prospective analyses confirmed that Impulsiveness and Order were significant predictors of general and central measures of adiposity assessed 3 years later. CONCLUSIONS: Overweight and obese individuals have difficulty resisting cravings and lack methodical and organized behaviors that might influence diet and weight control. Although individuals' traits have limited impact on the current obesogenic epidemic, personality traits can improve clinical assessment, suggest points of intervention, and help tailor prevention and treatment approaches.
Show less - Date Issued
- 2009
- Identifier
- FSU_migr_mhs-0033, 10.1097/PSY.0b013e3181a2925b
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- Citation
- Title
- Genetics of Serum BDNF: Meta-analysis of the Val66Met and Genome-wide Association Study.
- Creator
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Terracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger,...
Show moreTerracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger, David
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Abstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of...
Show moreAbstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of serum BDNF to be 0.48 from sib-pairs. There was no association between serum BDNF and Val66Met in the SardiNIA sample and in a meta-analysis of published studies (k = 13 studies, total n = 4727, P = 0.92). Although no genome-wide significant associations were identified, some evidence of association was found in the BDNF gene (rs11030102, P = 0.001) and at two loci (rs7170215, P = 4.8 × 10(-5) and rs11073742 P = 1.2 × 10(-5)) near and within NTRK3 gene, a neurotrophic tyrosine kinase receptor. Conclusions. Our study and meta-analysis of the literature indicate that the BDNF Val66Met variant is not associated with serum BDNF, but other variants in the BDNF and NTRK3 genes might regulate the level of serum BDNF.
Show less - Date Issued
- 2011
- Identifier
- FSU_migr_mhs-0014, 10.3109/15622975.2011.616533
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- Citation
- Title
- Genome-Wide Association Scan of Trait Depression.
- Creator
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Terracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa...
Show moreTerracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa, Paul
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BACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a...
Show moreBACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a genetically homogeneous area of Sardinia, Italy (n = 3972) and from the Baltimore Longitudinal Study of Aging in the United States (n = 839). RESULTS: Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷·), a gene involved in circadian rhythm. A plausible biological association was also found with single nucleotide polymorphisms within GRM8 (rs17864092; p = 5 × 10⁻⁶), a metabotropic receptor for glutamate, a major excitatory neurotransmitter in the central nervous system. CONCLUSIONS: These findings suggest shared genetic basis underlying the continuum from personality traits to psychopathology.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_mhs-0023, 10.1016/j.biopsych.2010.06.030
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- Citation
- Title
- Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers.
- Creator
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Hartz, Sarah, Short, Susan, Saccone, Nancy, Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah, Sun, Juzhong, Chen,...
Show moreHartz, Sarah, Short, Susan, Saccone, Nancy, Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah, Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Gubjartsson, Daniel, Hansel, Nadia, Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikäinen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Rosenberger, Albert, Scheet, Paul A. (Paul Anthony), Shaffer, John, Teumer, Alexander, Thompson, John, Vink, Jacqueline, Vogelzangs, Nicole, Wenzlaff, Angela, Wheeler, William, Xiao, Xiangjun, Yang, Bao-Zhu, Aggen, Steven, Balmforth, Anthony, Baumeister, Sebastian, Beaty, Terri H., Bennett, Siiri, Bergen, Andrew, Boyd, Heather, Broms, Ulla, Campbell, Harry, Chatterjee, Nilanjan, Chen, Jingchun, Cheng, Yu-Ching, Cichon, Sven, Couper, David, Cucca, Francesco, Dick, Danielle M. (Danielle Marie), Foroud, Tatiana, Furberg, Helena, Giegling, Ina, Gu, Fangyi, Hall, A. S. (Alistair Scott), Hällfors, Jenni, Han, Shizhong, Hartmann, Annette, Hayward, Caroline, Heikkilä, Kauko, Hewitt, John K., Hottenga, Jouke-Jan, Jensen, Majken, Jousilahti, Pekka, Kaakinen, Marika, Kittner, Steven, Konte, Bettina, Korhonen, Tellervo, Landi, Maria-Teresa, Laatikainen, Tiina, Leppert, Mark, Levy, Steven, Mathias, Rasika, McNeil, Daniel, Medland, Sarah, Montgomery, Grant, Muley, Thomas, Murray, Tanda, Nauck, Matthias, North, Kari, Pergadia, Michele, Polasek, Ozren, Ramos, Erin Michele, Ripatti, Samuli, Risch, Angela, Ruczinski, Ingo, Rudan, Igor, Salomaa, Veikko, Schlessinger, David, Styrkársdóttir, Unnur, Terracciano, Antonio, Uda, Manuela, Willemsen, Gonneke, Wu, Xifeng, Abecasis, Gonçalo, Barnes, Kathleen, Bickeböller, Heike, Boerwinkle, Eric, Boomsma, Dorret, Caporaso, Neil, Duan, Jubao, Edenberg, Howard, Francks, Clyde, Gejman, Pablo, Gelernter, Joel, Grabe, Hans, Hops, Hyman, Jarvelin, Marjo-Riitta, Viikari, Jorma, Kähönen, Mika, Kendler, Kenneth S., Lehtimäki, Terho, Levinson, Douglas, Marazita, Mary, Marchini, Jonathan, Melbye, Mads, Mitchell, Braxton, Murray, Jeffrey, Nöthen, Markus, Penninx, Brenda, Raitakari, Olli, Rietschel, Marcella, Rujescu, Dan, Samani, Nilesh J., Sanders, Alan, Schwartz, Ann, Shete, Sanjay, Shi, Jianxin, Spitz, Margaret R., Stefansson, Kari, Swan, Gary, Thorgeirsson, Thorgeir, Völzke, Henry, Wei, Qingyi, Wichmann, H.-Erich (Heinz-Erich), Amos, Christopher I., Breslau, Naomi, Cannon, Dale S., Ehringer, Marissa, Grucza, Richard, Hatsukami, Dorothy, Heath, Andrew, Johnson, Eric, Kaprio, Jaakko, Madden, Pamela, Martin, Nicholas G., Stevens, Victoria, Stitzel, Jerry, Weiss, Robert, Kraft, Peter, Bierut, Laura
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CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally...
Show moreCONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13,843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19,505) (P = .01). CONCLUSION: These results highlight an increased genetic vulnerability to smoking in early-onset smokers.
Show less - Date Issued
- 2012
- Identifier
- FSU_migr_geriatrics_faculty_publications-0040, 10.1001/archgenpsychiatry.2012.124
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- Citation
- Title
- High Neuroticism and Low Conscientiousness Are Associated with Interleukin-6.
- Creator
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Sutin, Angelina, Terracciano, Antonio, Deiana, Barbara, Naitza, Silvia, Ferrucci, Luigi, Uda, Manuela, Schlessinger, David, Costa, Paul
- Abstract/Description
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BACKGROUND: High Neuroticism and low Conscientiousness are frequently implicated in health-risk behaviors, such as smoking and overeating, as well as health outcomes, including mortality. Their associations with physiological markers of morbidity and mortality, such as inflammation, are less well documented. The present research examines the association between the five major dimensions of personality and interleukin-6 (IL-6), a pro-inflammatory cytokine often elevated in patients with...
Show moreBACKGROUND: High Neuroticism and low Conscientiousness are frequently implicated in health-risk behaviors, such as smoking and overeating, as well as health outcomes, including mortality. Their associations with physiological markers of morbidity and mortality, such as inflammation, are less well documented. The present research examines the association between the five major dimensions of personality and interleukin-6 (IL-6), a pro-inflammatory cytokine often elevated in patients with chronic morbidity and frailty. METHOD: A population-based sample (n=4923) from four towns in Sardinia, Italy, had their levels of IL-6 measured and completed a comprehensive personality questionnaire, the NEO-PI-R. Analyses controlled for factors known to have an effect on IL-6: age; sex; smoking; weight; aspirin use; disease burden. RESULTS: High Neuroticism and low Conscientiousness were both associated with higher levels of IL-6. The findings remained significant after controlling for the relevant covariates. Similar results were found for C-reactive protein, a related marker of chronic inflammation. Further, smoking and weight partially mediated the association between impulsivity-related traits and higher IL-6 levels. Finally, logistic regressions revealed that participants either in the top 10% of the distribution of Neuroticism or the bottom 10% of conscientiousness had an approximately 40% greater risk of exceeding clinically relevant thresholds of IL-6. CONCLUSIONS: Consistent with the literature on personality and self-reported health, individuals high on Neuroticism or low on Conscientiousness show elevated levels of this inflammatory cytokine. Identifying critical medical biomarkers associated with personality may help to elucidate the physiological mechanisms responsible for the observed connections between personality traits and physical health.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_mhs-0026, 10.1017/S0033291709992029
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- Citation
- Title
- Impulsivity-Related Traits Are Associated with Higher White Blood Cell Counts.
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Sutin, Angelina, Milaneschi, Yuri, Cannas, Alessandra, Ferrucci, Luigi, Uda, Manuela, Schlessinger, David, Zonderman, Alan, Terracciano, Antonio
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A chronically elevated white blood cell (WBC) count is a risk factor for morbidity and mortality. The present research tests whether facets of impulsivity-impulsiveness, excitement-seeking, self-discipline, and deliberation-are associated with chronically elevated WBC counts. Community-dwelling participants (N = 5,652) from Sardinia, Italy, completed a standard personality questionnaire and provided blood samples concurrently and again 3 years later. Higher scores on impulsivity, in...
Show moreA chronically elevated white blood cell (WBC) count is a risk factor for morbidity and mortality. The present research tests whether facets of impulsivity-impulsiveness, excitement-seeking, self-discipline, and deliberation-are associated with chronically elevated WBC counts. Community-dwelling participants (N = 5,652) from Sardinia, Italy, completed a standard personality questionnaire and provided blood samples concurrently and again 3 years later. Higher scores on impulsivity, in particular impulsiveness and excitement-seeking, were related to higher total WBC counts and higher lymphocyte counts at both time points. Impulsiveness was a predictor of chronic inflammation: for every standard deviation difference in this trait, there was an almost 25% higher risk of elevated WBC counts at both time points (OR = 1.23, 95% CI = 1.10-1.38). These associations were mediated, in part, by smoking and body mass index. The findings demonstrate that links between psychological processes and immunity are not limited to acute stressors; stable personality dispositions are associated with a chronic inflammatory state.
Show less - Date Issued
- 2012
- Identifier
- FSU_migr_mhs-0013, 10.1007/s10865-011-9390-0
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- Citation
- Title
- Meta-Analysis of Genome-Wide Association Studies for Personality.
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de Moor, Marleen, Costa, Paul, Terracciano, Antonio, Krueger, Robert F., de Geus, Eco, Toshiko, Tanaka, Penninx, Brenda, Esko, Tönu, Madden, P., Derringer, Jaime, Amin, Najaf,...
Show morede Moor, Marleen, Costa, Paul, Terracciano, Antonio, Krueger, Robert F., de Geus, Eco, Toshiko, Tanaka, Penninx, Brenda, Esko, Tönu, Madden, P., Derringer, Jaime, Amin, Najaf, Willemsen, Gonneke, Hottenga, Jouke-Jan, Distel, M., Uda, Manuela, Sanna, Serena, Spinhoven, Philip, Hartman, Catherina, Sullivan, P., Realo, Anu, Allik, Jüri, Heath, Andrew, Pergadia, M., Agrawal, Arpana, Lin, P., Grucza, Richard, Nutile, Teresa, Ciullo, Marina, Rujescu, Dan, Giegling, Ina, Konte, Bettina, Widen, Elisabeth, Cousminer, D., Eriksson, Johan, Palotie, Aarno, Peltonen, L., Luciano, Michelle, Tenesa, A., Davies, Gail, Lopez, Lorna, Hansell, Narelle, Medland, Sarah, Ferrucci, Luigi, Schlessinger, David, Montgomery, G., Wright, Margeret, Aulchenko, Y., Janssens, A., Oostra, Ben A., Metspalu, Andres, Abecasis, Gonçalo, Deary, Ian J., Räikkönen, K., Bierut, Laura, Martin, Nicholas G., van Duijn, Cornelia, Boomsma, Dorret
Show less - Abstract/Description
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Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17,375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism,...
Show morePersonality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17,375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ≈ 2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P=2.8 × 10(-8) and 3.1 × 10(-8)) and for Conscientiousness in the brain-expressed KATNAL2 gene on 18q21.1 (rs2576037, P=4.9 × 10(-8)). We further conducted a gene-based test that confirmed the association of KATNAL2 to Conscientiousness. In silico replication did not, however, show significant associations of the top SNPs with Openness and Conscientiousness, although the direction of effect of the KATNAL2 SNP on Conscientiousness was consistent in all replication samples. Larger scale GWA studies and alternative approaches are required for confirmation of KATNAL2 as a novel gene affecting Conscientiousness.
Show less - Date Issued
- 2012
- Identifier
- FSU_migr_geriatrics_faculty_publications-0010, 10.1038/mp.2010.128
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- Citation
- Title
- Meta-Analysis and Imputation Refines the Association of 15q25 with Smoking Quantity.
- Creator
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Liu, Jason, Tozzi, Federica, Waterworth, Dawn, Pillai, Sreekumar, Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher, Yuan, Xin, Waeber, Gérard,...
Show moreLiu, Jason, Tozzi, Federica, Waterworth, Dawn, Pillai, Sreekumar, Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher, Yuan, Xin, Waeber, Gérard, Vollenweider, Peter, Preisig, Martin, Wareham, Nicholas, Zhao, Jing, Loos, Ruth, Barroso, Inês, Khaw, Kay-Tee, Grundy, Scott M., Barter, Philip, Mahley, Robert, Kesaniemi, Antero, McPherson, Ruth, Vincent, John, Strauss, John, Kennedy, James, Farmer, Anne, McGuffin, Peter, Day, Richard, Matthews, Keith, Bakke, Per, Gulsvik, A. (Amund), Lucae, Susanne, Ising, Marcus, Brueckl, Tanja, Horstmann, Sonja, Wichmann, H.-Erich (Heinz-Erich), Rawal, Rajesh, Dahmen, Norbert, Lamina, Claudia, Polasek, Ozren, Zgaga, Lina, Huffman, Jennifer, Campbell, Susan, Kooner, Jaspal, Chambers, John, Burnett, Mary, Devaney, Joseph, Pichard, Augusto, Kent, Kenneth, Satler, Lowell, Lindsay, Joseph, Waksman, Ron, Epstein, Stephen, Wilson, James F. (James Flett), Wild, Sarah, Campbell, Harry, Vitart, Veronique, Reilly, Muredach, Li, Mingyao, Qu, Liming, Wilensky, Robert, Matthai, William, Hakonarson, Hakon, Rader, Daniel, Franke, Andre, Wittig, Michael, Schäfer, Arne, Uda, Manuela, Terracciano, Antonio, Xiao, Xiangjun, Busonero, Fabio, Scheet, Paul A. (Paul Anthony), Schlessinger, David, St Clair, David, Rujescu, Dan, Abecasis, Gonçalo, Grabe, Hans, Teumer, Alexander, Völzke, Henry, Petersmann, Astrid, John, Ulrich, Rudan, Igor, Hayward, Caroline, Wright, Alan, Kolcic, Ivana, Wright, Benjamin, Thompson, John, Balmforth, Anthony, Hall, A. S. (Alistair Scott), Samani, Nilesh J., Anderson, Carl, Ahmad, Tariq, Mathew, Christopher, Parkes, Miles, Satsangi, Jack, Caulfield, Mark, Munroe, Patricia, Farrall, Martin, Dominiczak, A. F., Worthington, Jane, Thomson, Wendy, Eyre, Steve, Barton, Anne, Mooser, Vincent, Francks, Clyde, Marchini, Jonathan
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Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic...
Show moreSmoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_geriatrics_faculty_publications-0018, 10.1038/ng.572
- Format
- Citation
- Title
- Meta-analysis of Genome-wide Association Studies Identifies Common Variants in CTNNA2 Associated with Excitement-seeking.
- Creator
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Terracciano, Antonio, Esko, Tönu, Sutin, Angelina, de Moor, Marleen, Meirelles, Osorio, Zhu, G., Tanaka, Toshiko, Giegling, Ina, Nutile, Teresa, Realo, Anu, Allik, J., Hansell,...
Show moreTerracciano, Antonio, Esko, Tönu, Sutin, Angelina, de Moor, Marleen, Meirelles, Osorio, Zhu, G., Tanaka, Toshiko, Giegling, Ina, Nutile, Teresa, Realo, Anu, Allik, J., Hansell, Narelle, Wright, Margeret, Montgomery, G., Willemsen, Gonneke, Hottenga, Jouke-Jan, Friedl, M., Ruggiero, D., Sorice, R., Sanna, Serena, Cannas, Alessandra, Räikkönen, K., Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan, Cucca, Francesco, Krueger, Robert F., Lahti, Jari, Luciano, Michelle, Smoller, Jordan W., van Duijn, Cornelia, Abecasis, Gonçalo, Boomsma, Dorret, Ciullo, Marina, Costa, Paul, Ferrucci, Luigi, Martin, Nicholas G., Metspalu, Andres, Rujescu, Dan, Schlessinger, David, Uda, Manuela
Show less - Abstract/Description
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The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To...
Show moreThe tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (N=7860), and combined the results in a meta-analysis. We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 (P=2 × 10(-8)). This single-nucleotide polymorphism maps within the catenin cadherin-associated protein, alpha 2 (CTNNA2) gene, which encodes for a brain-expressed α-catenin critical for synaptic contact. The effect of rs7600563 was in the same direction in all six samples, but did not replicate in additional samples (N=5105). The results provide insight into the genetics of excitement-seeking and risk-taking, and are relevant to hyperactivity, substance use, antisocial and bipolar disorders.
Show less - Date Issued
- 2011
- Identifier
- FSU_migr_mhs-0018, 10.1038/tp.2011.42
- Format
- Citation
- Title
- Neuroticism, Depressive Symptoms, and Serum BDNF.
- Creator
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Terracciano, Antonio, Lobina, Monia, Piras, Maria, Mulas, Antonella, Cannas, Alessandra, Meirelles, Osorio, Sutin, Angelina, Zonderman, Alan, Uda, Manuela, Crisponi, Laura,...
Show moreTerracciano, Antonio, Lobina, Monia, Piras, Maria, Mulas, Antonella, Cannas, Alessandra, Meirelles, Osorio, Sutin, Angelina, Zonderman, Alan, Uda, Manuela, Crisponi, Laura, Schlessinger, David
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OBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. We test whether serum and plasma levels of BDNF are associated with trait neuroticism and its facets and with state measures of depressive symptoms. METHODS: In a community-based cohort (N = 2099), we measured serum and plasma BDNF concentrations and administered the Revised NEO Personality Inventory and the Center for Epidemiological Studies...
Show moreOBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. We test whether serum and plasma levels of BDNF are associated with trait neuroticism and its facets and with state measures of depressive symptoms. METHODS: In a community-based cohort (N = 2099), we measured serum and plasma BDNF concentrations and administered the Revised NEO Personality Inventory and the Center for Epidemiological Studies Depression Scale. Covariates included age, sex, cigarette smoking, obesity, and antidepressant use. RESULTS: Serum BDNF concentrations were inversely related to neuroticism (r = -0.074, p < .001), in particular the depression facet (r = -0.08, p < .001). Lower BDNF concentrations were also associated with severe depressive symptoms (Center for Epidemiological Studies Depression Scale ≥ 28; odds ratio = 0.906; 95% confidence interval = 0.851-0.965). The association of serum BDNF with neuroticism was independent of depressive symptoms, indicating that serum BDNF might represent a biological correlate of neuroticism and not just of transient depressive states. Plasma BDNF was not associated with measures of depression. CONCLUSIONS: Our study suggests that lower serum BDNF is associated with both a dispositional vulnerability to depression and acute depressive states in the general population.
Show less - Date Issued
- 2011
- Identifier
- FSU_migr_mhs-0019, 10.1097/PSY.0b013e3182306a4f
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- Citation
- Title
- Cholesterol, Triglycerides, and the Five-Factor Model of Personality.
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Sutin, Angelina, Terracciano, Antonio, Deiana, Barbara, Uda, Manuela, Schlessinger, David, Lakatta, Edward, Costa, Paul
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Unhealthy lipid levels are among the leading controllable risk factors for coronary heart disease. To identify the psychological factors associated with dyslipidemia, this study investigates the personality correlates of cholesterol (total, LDL, and HDL) and triglycerides. A community-based sample (N=5532) from Sardinia, Italy, had their cholesterol and triglyceride levels assessed and completed a comprehensive personality questionnaire, the NEO-PI-R. All analyses controlled for age, sex, BMI...
Show moreUnhealthy lipid levels are among the leading controllable risk factors for coronary heart disease. To identify the psychological factors associated with dyslipidemia, this study investigates the personality correlates of cholesterol (total, LDL, and HDL) and triglycerides. A community-based sample (N=5532) from Sardinia, Italy, had their cholesterol and triglyceride levels assessed and completed a comprehensive personality questionnaire, the NEO-PI-R. All analyses controlled for age, sex, BMI, smoking, drinking, hypertension, and diabetes. Low Conscientiousness and traits related to impulsivity were associated with lower HDL cholesterol and higher triglycerides. Compared to the lowest 10%, those who scored in top 10% on Impulsivity had a 2.5 times greater risk of exceeding the clinical threshold for elevated triglycerides (OR=2.51, CI=1.56-4.07). In addition, sex moderated the association between trait depression (a component of Neuroticism) and HDL cholesterol, such that trait depression was associated with lower levels of HDL cholesterol in women but not men. When considering the connection between personality and health, unhealthy lipid profiles may be one intermediate biomarker between personality and morbidity and mortality.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_mhs-0028, 10.1016/j.biopsycho.2010.01.012
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- Citation
- Title
- Personality and Metabolic Syndrome.
- Creator
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Sutin, Angelina, Costa, Paul, Uda, Manuela, Ferrucci, Luigi, Schlessinger, David, Terracciano, Antonio
- Abstract/Description
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The prevalence of metabolic syndrome has paralleled the sharp increase in obesity. Given its tremendous physical, emotional, and financial burden, it is of critical importance to identify who is most at risk and the potential points of intervention. Psychological traits, in addition to physiological and social risk factors, may contribute to metabolic syndrome. The objective of the present research is to test whether personality traits are associated with metabolic syndrome in a large...
Show moreThe prevalence of metabolic syndrome has paralleled the sharp increase in obesity. Given its tremendous physical, emotional, and financial burden, it is of critical importance to identify who is most at risk and the potential points of intervention. Psychological traits, in addition to physiological and social risk factors, may contribute to metabolic syndrome. The objective of the present research is to test whether personality traits are associated with metabolic syndrome in a large community sample. Participants (N = 5,662) from Sardinia, Italy, completed a comprehensive personality questionnaire, the NEO-PI-R, and were assessed on all components of metabolic syndrome (waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure, and fasting glucose). Logistic regressions were used to predict metabolic syndrome from personality traits, controlling for age, sex, education, and current smoking status. Among adults over age 45 (n = 2,419), Neuroticism and low Agreeableness were associated with metabolic syndrome, whereas high Conscientiousness was protective. Individuals who scored in the top 10% on Conscientiousness were approximately 40% less likely to have metabolic syndrome (OR = 0.61, 95% CI = 0.41-0.92), whereas those who scored in the lowest 10% on Agreeableness were 50% more likely to have it (OR = 1.53, 95% CI = 1.09-2.16). At the facet level, traits related to impulsivity and hostility were the most strongly associated with metabolic syndrome. The present research indicates that those with fewer psychological resources are more vulnerable to metabolic syndrome and suggests a psychological component to other established risk factors.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_mhs-0020, 10.1007/s11357-010-9153-9
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- Citation
- Title
- Personality Traits Prospectively Predict Verbal Fluency in a Lifespan Sample.
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Sutin, Angelina, Terracciano, Antonio, Kitner-Triolo, Melissa, Uda, Manuela, Schlessinger, David, Zonderman, Alan
- Abstract/Description
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In a community-dwelling sample (N = 4,790; age range 14-94), we examined whether personality traits prospectively predicted performance on a verbal fluency task. Open, extraverted, and emotionally stable participants had better verbal fluency. At the facet level, dispositionally happy and self-disciplined participants retrieved more words; those prone to anxiety and depression and those who were deliberative retrieved fewer words. Education moderated the association between conscientiousness...
Show moreIn a community-dwelling sample (N = 4,790; age range 14-94), we examined whether personality traits prospectively predicted performance on a verbal fluency task. Open, extraverted, and emotionally stable participants had better verbal fluency. At the facet level, dispositionally happy and self-disciplined participants retrieved more words; those prone to anxiety and depression and those who were deliberative retrieved fewer words. Education moderated the association between conscientiousness and fluency such that participants with lower education performed better on the fluency task if they were also conscientious. Age was not a moderator at the domain level, indicating that the personality-fluency associations were consistent across the life span. A disposition toward emotional vulnerability and being less open, less happy, and undisciplined may be detrimental to cognitive performance.
Show less - Date Issued
- 2011
- Identifier
- FSU_migr_mhs-0015, 10.1037/a0024276
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- Citation
