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Title: 24/7 Access: Crafted in 2010 and Built to Last.
Creator: Rosasco, Robyn, Epstein, Susan A.
Abstract/Description: Objectives Our library has provided 24/7 access for student study space since 2010. This service has functioned as anticipated with minor policy breaches in 2010 and 2013. The purpose of this study was to determine how well 24/7 access to our library is working, obtain student feedback on security procedures, and solicit ideas from all stakeholders for future improvements. Methods Stakeholders for 24/7 access to our academic health sciences library include both the service providers (library,...
Show moreObjectives Our library has provided 24/7 access for student study space since 2010. This service has functioned as anticipated with minor policy breaches in 2010 and 2013. The purpose of this study was to determine how well 24/7 access to our library is working, obtain student feedback on security procedures, and solicit ideas from all stakeholders for future improvements. Methods Stakeholders for 24/7 access to our academic health sciences library include both the service providers (library, student affairs, and security/legal personnel) and the service users (first- and second-year medical students and biomedical graduate students). To evaluate the effectiveness of the library's 24/7 access service, the authors conducted a series of free-response interviews with several service provider and user stakeholders to solicit the most detailed feedback possible. The authors also administered a brief survey to determine if students were satisfied with unstaffed access to library study space. The results of stakeholder feedback were used to evaluate the value of our extensive planning for 24/7 access to the library, our thorough and consistent implementation, and our responsiveness to the needs of our students. Results: Our library director invited (via email) 14 student/staff stakeholders to be interviewed by the primary investigator (PI) and co-PI. Three students and three staff members agreed to be interviewed; five interviews were conducted face-to-face and one was conducted by phone. In addition, our library director sent an email invitation to complete a 10-question survey to approximately 500 students; 114 surveys were completed. From the interviews and the survey, shared themes as well as several unique feedback items emerged. In general, the overwhelming response was that the 24/7 service meets the needs of students, providing a secure, consistent study area for students who do not choose to study in another College of Medicine study space, in another campus library, at home, or at another location. Specifically, 90% of the students were not concerned about safety/security issues in the library during unstaffed hours, 82% indicated that the library environment was conducive to studying during unstaffed hours, and 83% felt that the library's orientation on 24/7 policies and procedures has met their needs. Conclusions: Collecting formal feedback on our 24/7 service has validated the time spent in planning, implementation, and responding to student needs, and has also elicited several ideas for improving the 24/7 service. We plan to continue interviewing and surveying 24/7 stakeholders on a yearly basis to solicit current feedback and continually improve the service.
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Date Issued: 2014
Identifier: FSU_migr_medlib_posters-0003
Format: Citation

Title: Aerobic Exercise and Whole-Body Vibration in Offsetting Bone Loss in Older Adults.
Creator: Liu, Pei-Yang, Brummel-Smith, Kenneth, Ilich, Jasminka
Abstract/Description: Osteoporosis and its associated fractures are common complications of aging and most strategies to prevent and/or treat bone loss focused on antiresorptive medications. However, aerobic exercise (AEX) and/or whole-body vibration (WBV) might have beneficial effect on bone mass and provide an alternative approach to increase or maintain bone mineral density (BMD) and reduce the risk of fractures. The purpose of this paper was to investigate the potential benefits of AEX and WBV on BMD in older...
Show moreOsteoporosis and its associated fractures are common complications of aging and most strategies to prevent and/or treat bone loss focused on antiresorptive medications. However, aerobic exercise (AEX) and/or whole-body vibration (WBV) might have beneficial effect on bone mass and provide an alternative approach to increase or maintain bone mineral density (BMD) and reduce the risk of fractures. The purpose of this paper was to investigate the potential benefits of AEX and WBV on BMD in older population and discuss the possible mechanisms of action. Several online databases were utilized and based on the available literature the consensus is that both AEX and WBV may increase spine and femoral BMD in older adults. Therefore, AEX and WBV could serve as nonpharmacological and complementary approaches to increasing/maintaining BMD. However, it is uncertain if noted effects could be permanent and further studies are needed to investigate sustainability of either type of the exercise.
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Date Issued: 2011
Identifier: FSU_migr_geriatrics_faculty_publications-0042, 10.4061/2011/379674
Format: Citation

Title: An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model.
Creator: McCrae, Robert R., Scally, Matthew, Terracciano, Antonio, Abecasis, Gonçalo, Costa, Paul
Abstract/Description: There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely unsuccessful search for individual polymorphisms associated with personality traits, the authors identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two thirds of a large (N = 3,972) sample of individuals...
Show moreThere is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely unsuccessful search for individual polymorphisms associated with personality traits, the authors identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two thirds of a large (N = 3,972) sample of individuals from Sardinia who completed the Revised NEO Personality Inventory (P. T. Costa, Jr., & R. R. McCrae, 1992) and were assessed in a genomewide association scan. When MPSs were correlated with the phenotype in the remaining one third of the sample, very small but significant associations were found for 4 of the 5e personality factors when the longest scales were examined. These data suggest that MPSs for Neuroticism, Openness to Experience, Agreeableness, and Conscientiousness (but not Extraversion) contain genetic information that can be refined in future studies, and the procedures described here should be applicable to other quantitative traits.
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Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0015, 10.1037/a0020964
Format: Citation

Title: Activation Profiles of Human Kallikrein-Related Peptidases by Proteases of the Thrombostasis Axis.
Creator: Yoon, Hyesook, Blaber, Sachiko, Evans, D., Trim, Julie, Juliano, Maria, Scarisbrick, Isobel, Blaber, Michael
Abstract/Description: The human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1-15) and are the single largest family of serine proteases. The KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic targets of interest in cancer and neurodegenerative disease. All KLKs appear to be secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their N-terminal pro-peptide. This processing is a key step in the regulation of...
Show moreThe human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1-15) and are the single largest family of serine proteases. The KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic targets of interest in cancer and neurodegenerative disease. All KLKs appear to be secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their N-terminal pro-peptide. This processing is a key step in the regulation of KLK function. Much recent work has been devoted to elucidating the potential for activation cascades between members of the KLK family, with physiologically relevant KLK regulatory cascades now described in skin desquamation and semen liquefaction. Despite this expanding knowledge of KLK regulation, details regarding the potential for functional intersection of KLKs with other regulatory proteases are essentially unknown. To elucidate such interaction potential, we have characterized the ability of proteases associated with thrombostasis to hydrolyze the pro-peptide sequences of the KLK family using a previously described pro-KLK fusion protein system. A subset of positive hydrolysis results were subsequently quantified with proteolytic assays using intact recombinant pro-KLK proteins. Pro-KLK6 and 14 can be activated by both plasmin and uPA, with plasmin being the best activator of pro-KLK6 identified to date. Pro-KLK11 and 12 can be activated by a broad-spectrum of thrombostasis proteases, with thrombin exhibiting a high degree of selectivity for pro-KLK12. The results show that proteases of the thrombostasis family can efficiently activate specific pro-KLKs, demonstrating the potential for important regulatory interactions between these two major protease families.
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Date Issued: 2008
Identifier: FSU_migr_biomed_faculty_publications-0009
Format: Citation

Title: Analysis of the Molecular Pathogenesis of Cardiomyopathy-Causing cTnT Mutants I79N, ΔE96, and ΔK210.
Creator: Bai, Fan, Caster, Hannah, Pinto, Jose, Kawai, Masataka
Abstract/Description: Three troponin T (TnT) mutants that cause hypertrophic, restrictive, and dilated cardiomyopathy (I79N, ΔE96, and ΔK210, respectively), were examined using the thin-filament extraction/reconstitution technique. Effects of Ca(2+), ATP, phosphate, and ADP concentrations on force and its transients were studied at 25°C. Maximal Ca(2+) tension (THC) and Ca(2+)-activatable tension (Tact), respectively, were similar among I79N, ΔE96, and WT, whereas ΔK210 led to a significantly lower THC (∼20% less)...
Show moreThree troponin T (TnT) mutants that cause hypertrophic, restrictive, and dilated cardiomyopathy (I79N, ΔE96, and ΔK210, respectively), were examined using the thin-filament extraction/reconstitution technique. Effects of Ca(2+), ATP, phosphate, and ADP concentrations on force and its transients were studied at 25°C. Maximal Ca(2+) tension (THC) and Ca(2+)-activatable tension (Tact), respectively, were similar among I79N, ΔE96, and WT, whereas ΔK210 led to a significantly lower THC (∼20% less) and Tact (∼25% less) than did WT. In pCa solution containing 8 mM Pi and ionic strength adjusted to 200 mM, the Ca(2+) sensitivity (pCa50) of I79N (5.63 ± 0.02) and ΔE96 (5.60 ± 0.03) was significantly greater than that of WT (5.45 ± 0.04), but the pCa50 of ΔK210 (5.54 ± 0.04) remained similar to that of WT. Five equilibrium constants were deduced using sinusoidal analysis. All three mutants showed significantly lower K0 (ADP association constant) and larger K4 (equilibrium constant of force generation step) relative to the corresponding values for WT. I79N and ΔK210 were associated with a K2 (equilibrium constant of cross-bridge detachment step) significantly lower than that of ΔE96 and WT. These results demonstrated that at pCa 4.66, the force/cross-bridge is ∼18% less in I79N and ∼41% less in ΔK210 than that in WT. These results indicate that the molecular pathogenesis of the cardiac TnT mutation-related cardiomyopathies is different for each mutation.
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Date Issued: 2013
Identifier: FSU_migr_biomed_faculty_publications-0051, 10.1016/j.bpj.2013.04.001
Format: Citation

Title: Absence of Myocardial Thyroid Hormone Inactivating Deiodinase Results in Restrictive Cardiomyopathy in Mice.
Creator: Ueta, Cintia, Oskouei, Behzad, Olivares, Emerson, Pinto, Jose, Correa, Mayrin, Simovic, Gordana, Simonides, Warner, Hare, Joshua, Bianco, Antônio Carlos
Abstract/Description: Cardiac injury induces myocardial expression of the thyroid hormone inactivating type 3 deiodinase (D3), which in turn dampens local thyroid hormone signaling. Here, we show that the D3 gene (Dio3) is a tissue-specific imprinted gene in the heart, and thus, heterozygous D3 knockout (HtzD3KO) mice constitute a model of cardiac D3 inactivation in an otherwise systemically euthyroid animal. HtzD3KO newborns have normal hearts but later develop restrictive cardiomyopathy due to cardiac-specific...
Show moreCardiac injury induces myocardial expression of the thyroid hormone inactivating type 3 deiodinase (D3), which in turn dampens local thyroid hormone signaling. Here, we show that the D3 gene (Dio3) is a tissue-specific imprinted gene in the heart, and thus, heterozygous D3 knockout (HtzD3KO) mice constitute a model of cardiac D3 inactivation in an otherwise systemically euthyroid animal. HtzD3KO newborns have normal hearts but later develop restrictive cardiomyopathy due to cardiac-specific increase in thyroid hormone signaling, including myocardial fibrosis, impaired myocardial contractility, and diastolic dysfunction. In wild-type littermates, treatment with isoproterenol-induced myocardial D3 activity and an increase in the left ventricular volumes, typical of cardiac remodeling and dilatation. Remarkably, isoproterenol-treated HtzD3KO mice experienced a further decrease in left ventricular volumes with worsening of the diastolic dysfunction and the restrictive cardiomyopathy, resulting in congestive heart failure and increased mortality. These findings reveal crucial roles for Dio3 in heart function and remodeling, which may have pathophysiologic implications for human restrictive cardiomyopathy.
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Date Issued: 2012
Identifier: FSU_migr_biomed_faculty_publications-0052, 10.1210/me.2011-1325
Format: Citation

Title: Abandoning the Dead Donor Rule?: A National Survey of Public Views on Death and Organ Donation.
Creator: Nair-Collins, Michael, Green, Sydney, Sutin, Angelina
Abstract/Description: Brain dead organ donors are the principal source of transplantable organs. However, it is controversial whether brain death is the same as biological death. Therefore, it is unclear whether organ removal in brain death is consistent with the 'dead donor rule', which states that organ removal must not cause death. Our aim was to evaluate the public's opinion about organ removal if explicitly described as causing the death of a donor in irreversible apneic coma. We conducted a cross-sectional...
Show moreBrain dead organ donors are the principal source of transplantable organs. However, it is controversial whether brain death is the same as biological death. Therefore, it is unclear whether organ removal in brain death is consistent with the 'dead donor rule', which states that organ removal must not cause death. Our aim was to evaluate the public's opinion about organ removal if explicitly described as causing the death of a donor in irreversible apneic coma. We conducted a cross-sectional internet survey of the American public (n=1096). Questionnaire domains included opinions about a hypothetical scenario of organ removal described as causing the death of a patient in irreversible coma, and items measuring willingness to donate organs after death. Some 71% of the sample agreed that it should be legal for patients to donate organs in the scenario described and 67% agreed that they would want to donate organs in a similar situation. Of the 85% of the sample who agreed that they were willing to donate organs after death, 76% agreed that they would donate in the scenario of irreversible coma with organ removal causing death. There appears to be public support for organ donation in a scenario explicitly described as violating the dead donor rule. Further, most but not all people who would agree to donate when organ removal is described as occurring after death would also agree to donate when organ removal is described as causing death in irreversible coma.
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Date Issued: 2014
Identifier: FSU_migr_mhs-0040, 10.1136/medethics-2014-102229
Format: Citation

Title: For Love, Legacy, or Pay: Legal and Pecuniary Aspects of Family Caregiving.
Creator: Kapp, Marshall B.
Abstract/Description: Most caregiving and companionship provided by family members and friends to older individuals in home environments occurs because of the caregiver's feelings of ethical and emotional obligation and attachment. From a legal perspective, though, it might be ill-advised for an informal caregiver to admit such a motivation. Building on a recently published study of relevant litigation, this essay discusses changing cultural and legal aspects of family caregiving when there is some expectation of...
Show moreMost caregiving and companionship provided by family members and friends to older individuals in home environments occurs because of the caregiver's feelings of ethical and emotional obligation and attachment. From a legal perspective, though, it might be ill-advised for an informal caregiver to admit such a motivation. Building on a recently published study of relevant litigation, this essay discusses changing cultural and legal aspects of family caregiving when there is some expectation of pay, property, or future financial legacy in return for the caregiver's present work and sacrifices.
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Date Issued: 2012
Identifier: FSU_migr_medlawcenter_publications-0007
Format: Citation

Title: Factorial and Construct Validity of the Italian Positive and Negative Affect Schedule (PANAS).
Creator: Terracciano, Antonio, McCrae, Robert R., Costa, Paul
Abstract/Description: This study provides evidence that an Italian version of the Positive and Negative Affect Schedule (PANAS) is a reliable and valid self-report measure. In an Italian sample (N = 600), the PANAS showed solid psychometric properties, and several American findings with the PANAS were replicated. The replicability of the PANAS factor structure was confirmed by high congruence coefficients between the American and Italian varimax solutions. Alternative models were tested with Confirmatory Factor...
Show moreThis study provides evidence that an Italian version of the Positive and Negative Affect Schedule (PANAS) is a reliable and valid self-report measure. In an Italian sample (N = 600), the PANAS showed solid psychometric properties, and several American findings with the PANAS were replicated. The replicability of the PANAS factor structure was confirmed by high congruence coefficients between the American and Italian varimax solutions. Alternative models were tested with Confirmatory Factor Analysis; as in previous studies, the two-factor model achieved the best fit, but absolute fit indices varied with the estimation methods used. The independence/bipolarity issue was also explored: Positive and negative affect scales remain substantially independent after accounting for measurement error and acquiescence. Some predictions from the tripartite model of anxiety and depression were confirmed, and external correlates of the PANAS replicated those found in other languages and cultures. These analyses offer strong support for the construct validity of the Italian PANAS.
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Date Issued: 2003
Identifier: FSU_migr_geriatrics_faculty_publications-0035, 10.1027//1015-5759.19.2.131
Format: Citation

Title: Facets of Personality Linked to Underweight and Overweight.
Creator: Terracciano, Antonio, Sutin, Angelina, McCrae, Robert R., Deiana, Barbara, Ferrucci, Luigi, Schlessinger, David, Uda, Manuela, Costa, Paul
Abstract/Description: OBJECTIVE: Personality traits underlie maladaptive behaviors, and cognitive and emotional disturbances that contribute to major preventable causes of global disease burden. This study examines detailed personality profiles of underweight, normal, and overweight individuals to provide insights into the causes and treatments of abnormal weight. METHODS: More than half of the population from four towns in Sardinia, Italy (n = 5693; age = 14-94 years; mean +/- standard deviation = 43 +/- 17 years...
Show moreOBJECTIVE: Personality traits underlie maladaptive behaviors, and cognitive and emotional disturbances that contribute to major preventable causes of global disease burden. This study examines detailed personality profiles of underweight, normal, and overweight individuals to provide insights into the causes and treatments of abnormal weight. METHODS: More than half of the population from four towns in Sardinia, Italy (n = 5693; age = 14-94 years; mean +/- standard deviation = 43 +/- 17 years) were assessed on multiple anthropometric measures and 30 facets that comprehensively cover the five major dimensions of personality, using the Revised NEO Personality Inventory. RESULTS: High Neuroticism and low Conscientiousness were associated with being underweight and obese, respectively. High Impulsiveness (specifically eating-behavior items) and low Order were associated with body mass index categories of overweight and obese, and with measures of abdominal adiposity (waist and hip circumference). Those scoring in the top 10% of Impulsiveness were about 4 kg heavier than those in the bottom 10%, an effect independent and larger than the FTO genetic variant. Prospective analyses confirmed that Impulsiveness and Order were significant predictors of general and central measures of adiposity assessed 3 years later. CONCLUSIONS: Overweight and obese individuals have difficulty resisting cravings and lack methodical and organized behaviors that might influence diet and weight control. Although individuals' traits have limited impact on the current obesogenic epidemic, personality traits can improve clinical assessment, suggest points of intervention, and help tailor prevention and treatment approaches.
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Date Issued: 2009
Identifier: FSU_migr_mhs-0033, 10.1097/PSY.0b013e3181a2925b
Format: Citation

Title: Eyes on the Prize: The Longitudinal Benefits of Goal Focus on Progress Toward a Weight Loss Goal.
Creator: Conlon, Kyle, Ehrlinger, Joyce, Eibach, Richard, Crescioni, A. Will (Albert William), Alquist, Jessica, Gerend, Mary, Dutton, Gareth
Abstract/Description: Past research suggests that focusing on what has not yet been accomplished (goal focus) signals a lack of progress towards one's high commitment goals and inspires greater motivation than does focusing on what has already been accomplished (accomplishment focus). The present investigation extends this research to a longitudinal, important domain by exploring the consequences of focusing on one's goals versus accomplishments when pursuing a weight loss goal. Participants were tracked over the...
Show morePast research suggests that focusing on what has not yet been accomplished (goal focus) signals a lack of progress towards one's high commitment goals and inspires greater motivation than does focusing on what has already been accomplished (accomplishment focus). The present investigation extends this research to a longitudinal, important domain by exploring the consequences of focusing on one's goals versus accomplishments when pursuing a weight loss goal. Participants were tracked over the course of a 12-week weight loss program that utilized weekly group discussions and a companion website to direct participants' focus toward their end weight loss goal or toward what they had already achieved. Goal-focused participants reported higher levels of commitment to their goal and, ultimately, lost more weight than did accomplishment-focused and no focus control participants. Accomplishment-focused participants did not differ from controls on any measure.
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Date Issued: 2011
Identifier: FSU_migr_mhs-0007, 10.1016/j.jesp.2011.02.005
Format: Citation

Title: Genetics of Serum BDNF: Meta-analysis of the Val66Met and Genome-wide Association Study.
Creator: Terracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger,...
Show moreTerracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger, David
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Abstract/Description: Abstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of...
Show moreAbstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of serum BDNF to be 0.48 from sib-pairs. There was no association between serum BDNF and Val66Met in the SardiNIA sample and in a meta-analysis of published studies (k = 13 studies, total n = 4727, P = 0.92). Although no genome-wide significant associations were identified, some evidence of association was found in the BDNF gene (rs11030102, P = 0.001) and at two loci (rs7170215, P = 4.8 × 10(-5) and rs11073742 P = 1.2 × 10(-5)) near and within NTRK3 gene, a neurotrophic tyrosine kinase receptor. Conclusions. Our study and meta-analysis of the literature indicate that the BDNF Val66Met variant is not associated with serum BDNF, but other variants in the BDNF and NTRK3 genes might regulate the level of serum BDNF.
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Date Issued: 2011
Identifier: FSU_migr_mhs-0014, 10.3109/15622975.2011.616533
Format: Citation

Title: Genome-Wide Association Scan of Trait Depression.
Creator: Terracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa...
Show moreTerracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa, Paul
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Abstract/Description: BACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a...
Show moreBACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a genetically homogeneous area of Sardinia, Italy (n = 3972) and from the Baltimore Longitudinal Study of Aging in the United States (n = 839). RESULTS: Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷·), a gene involved in circadian rhythm. A plausible biological association was also found with single nucleotide polymorphisms within GRM8 (rs17864092; p = 5 × 10⁻⁶), a metabotropic receptor for glutamate, a major excitatory neurotransmitter in the central nervous system. CONCLUSIONS: These findings suggest shared genetic basis underlying the continuum from personality traits to psychopathology.
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Date Issued: 2010
Identifier: FSU_migr_mhs-0023, 10.1016/j.biopsych.2010.06.030
Format: Citation

Title: Ethnicity, Education, and the Temporal Stability of Personality Traits In the East Baltimore Epidemiologic Catchment Area Study.
Creator: Löckenhoff, Corinna, Terracciano, Antonio, Bienvenu, O. Joseph, Patriciu, Nicholas, Nestadt, Gerald, McCrae, Robert R., Eaton, William W., Costa, Paul
Abstract/Description: We examined the influence of age, gender, Black vs. White ethnicity, and education on five indices of personality stability and change across an average interval of 8 years in the East Baltimore Epidemiologic Catchment Area study. In the full sample (n = 505, aged 30-88), examination of structural, rank-order, ipsative, and mean level stability, as well as indices of reliable change suggested that NEO-PI-R personality traits showed moderate to high levels of stability over time. There were...
Show moreWe examined the influence of age, gender, Black vs. White ethnicity, and education on five indices of personality stability and change across an average interval of 8 years in the East Baltimore Epidemiologic Catchment Area study. In the full sample (n = 505, aged 30-88), examination of structural, rank-order, ipsative, and mean level stability, as well as indices of reliable change suggested that NEO-PI-R personality traits showed moderate to high levels of stability over time. There were few age and gender effects on temporal stability but rank-order, ipsative, and mean level stability were lower among Blacks and individuals with lower education. Future research should explore additional demographic predictors of temporal plasticity in a diverse range of samples, and employ observer ratings to assess personality.
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Date Issued: 2008
Identifier: FSU_migr_geriatrics_faculty_publications-0028, 10.1016/j.jrp.2007.09.004
Format: Citation

Title: Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment.
Creator: Krenzer, Stefanie, Peterziel, Heike, Mauch, Cornelia, Blaber, Sachiko, Blaber, Michael, Angel, Peter, Hess, Jochen
Abstract/Description: Cutaneous malignant melanoma is an aggressive disease of poor prognosis. Clinical and experimental studies have provided major insight into the pathogenesis of the disease, including the functional interaction between melanoma cells and surrounding keratinocytes, fibroblasts, and immune cells. Nevertheless, patients with metastasized melanoma have a very poor prognosis and are largely refractory to clinical therapies. Hence, diagnostic tools to monitor melanoma development, as well as...
Show moreCutaneous malignant melanoma is an aggressive disease of poor prognosis. Clinical and experimental studies have provided major insight into the pathogenesis of the disease, including the functional interaction between melanoma cells and surrounding keratinocytes, fibroblasts, and immune cells. Nevertheless, patients with metastasized melanoma have a very poor prognosis and are largely refractory to clinical therapies. Hence, diagnostic tools to monitor melanoma development, as well as therapeutic targets, are urgently needed. We investigated the expression pattern of the kallikrein-related peptidase 6 (KLK6) in human melanoma tissue sections throughout tumor development. Although KLK6 was not detectable in tumor cells, we found strong KLK6 protein expression in keratinocytes and stromal cells located adjacent to benign nevi, primary melanomas, and cutaneous metastatic lesions, suggesting a paracrine function of extracellular KLK6 during neoplastic transformation and malignant progression. Accordingly, recombinant Klk6 protein significantly induced melanoma cell migration and invasion accompanied by an accelerated intracellular Ca(2+) flux. We could further demonstrate that KLK6-induced intracellular Ca(2+) flux and tumor cell invasion critically depends on the protease-activated receptor 1 (PAR1). Our data provide experimental evidence that specific inhibition of the KLK6-PAR1 axis may interfere with the deleterious effect of tumor-microenvironment interaction and represent a potential option for translational melanoma research.
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Date Issued: 2011
Identifier: FSU_migr_biomed_faculty_publications-0024, 10.1038/jid.2011.190
Format: Citation

Title: Five-Factor Model Personality Traits and the Retirement Transition: Longitudinal and Cross-Sectional Associations.
Creator: Löckenhoff, Corinna, Terracciano, Antonio, Costa, Paul
Abstract/Description: The authors examined associations between 5-factor personality traits and retirement in a diverse community sample. Longitudinal analyses (n = 367) compared personality trajectories of participants who remained employed and participants who retired. Personality at baseline did not predict future retirement, but compared to participants who remained employed, retirees increased in Agreeableness and decreased in Activity, a facet of Extraversion. In cross-sectional analyses among retirees (n =...
Show moreThe authors examined associations between 5-factor personality traits and retirement in a diverse community sample. Longitudinal analyses (n = 367) compared personality trajectories of participants who remained employed and participants who retired. Personality at baseline did not predict future retirement, but compared to participants who remained employed, retirees increased in Agreeableness and decreased in Activity, a facet of Extraversion. In cross-sectional analyses among retirees (n = 144), those low in Neuroticism and high in Extraversion reported higher retirement satisfaction, and those high in Extraversion reported higher postretirement activity levels. Findings suggest that the trait perspective contributes to the understanding of the retirement process.
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Date Issued: 2009
Identifier: FSU_migr_geriatrics_faculty_publications-0024, 10.1037/a0015121
Format: Citation

Title: Five-Factor Personality Traits and Age Trajectories of Self-Rated Health: The Role of Question Framing.
Creator: Löckenhoff, Corinna, Terracciano, Antonio, Ferrucci, Luigi, Costa, Paul
Abstract/Description: We examined the influence of personality traits on mean levels and age trends in 4 single-item measures of self-rated health: general rating, comparison to age peers, comparison to past health, and expectations for future health. Community-dwelling participants (N = 1,683) completed 7,474 self-rated health assessments over a period of up to 19 years. In hierarchical linear modeling analyses, age-associated declines differed across the 4 health items. Across age groups, high Neuroticism and...
Show moreWe examined the influence of personality traits on mean levels and age trends in 4 single-item measures of self-rated health: general rating, comparison to age peers, comparison to past health, and expectations for future health. Community-dwelling participants (N = 1,683) completed 7,474 self-rated health assessments over a period of up to 19 years. In hierarchical linear modeling analyses, age-associated declines differed across the 4 health items. Across age groups, high Neuroticism and low Conscientiousness, low Extraversion, and low Openness were associated with worse health ratings, with notable differences across the 4 health items. Furthermore, high Neuroticism predicted steeper declines in health ratings involving temporal comparisons. We consider theoretical implications regarding the mechanisms behind associations among personality traits and self-rated health.
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Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0011, 10.1111/j.1467-6494.2011.00724.x
Format: Citation

Title: Five-Factor Model Personality Profiles of Drug Users.
Creator: Terracciano, Antonio, Löckenhoff, Corinna, Crum, Rosa, Bienvenu, O. Joseph, Costa, Paul
Abstract/Description: BACKGROUND: Personality traits are considered risk factors for drug use, and, in turn, the psychoactive substances impact individuals' traits. Furthermore, there is increasing interest in developing treatment approaches that match an individual's personality profile. To advance our knowledge of the role of individual differences in drug use, the present study compares the personality profile of tobacco, marijuana, cocaine, and heroin users and non-users using the wide spectrum Five-Factor...
Show moreBACKGROUND: Personality traits are considered risk factors for drug use, and, in turn, the psychoactive substances impact individuals' traits. Furthermore, there is increasing interest in developing treatment approaches that match an individual's personality profile. To advance our knowledge of the role of individual differences in drug use, the present study compares the personality profile of tobacco, marijuana, cocaine, and heroin users and non-users using the wide spectrum Five-Factor Model (FFM) of personality in a diverse community sample. METHOD: Participants (N = 1,102; mean age = 57) were part of the Epidemiologic Catchment Area (ECA) program in Baltimore, MD, USA. The sample was drawn from a community with a wide range of socio-economic conditions. Personality traits were assessed with the Revised NEO Personality Inventory (NEO-PI-R), and psychoactive substance use was assessed with systematic interview. RESULTS: Compared to never smokers, current cigarette smokers score lower on Conscientiousness and higher on Neuroticism. Similar, but more extreme, is the profile of cocaine/heroin users, which score very high on Neuroticism, especially Vulnerability, and very low on Conscientiousness, particularly Competence, Achievement-Striving, and Deliberation. By contrast, marijuana users score high on Openness to Experience, average on Neuroticism, but low on Agreeableness and Conscientiousness. CONCLUSION: In addition to confirming high levels of negative affect and impulsive traits, this study highlights the links between drug use and low Conscientiousness. These links provide insight into the etiology of drug use and have implications for public health interventions.
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Date Issued: 2008
Identifier: FSU_migr_geriatrics_faculty_publications-0027, 10.1186/1471-244X-8-22
Format: Citation

Title: Geriatric Depression: Do Older Persons Have a Right to Be Unhappy?.
Creator: Kapp, Marshall B.
Abstract/Description: Clinical depression is a serious medical problem in the older population. Although it is considered to be highly treatable, physicians and other health care professionals often are criticized for doing an inadequate job of recognizing, and then treating, depression in older persons. They are routinely exhorted to improve their performance by being more aggressive in recognizing and intervening with this clinical condition. Yet, the mandate to provide aggressive treatment of depression is not...
Show moreClinical depression is a serious medical problem in the older population. Although it is considered to be highly treatable, physicians and other health care professionals often are criticized for doing an inadequate job of recognizing, and then treating, depression in older persons. They are routinely exhorted to improve their performance by being more aggressive in recognizing and intervening with this clinical condition. Yet, the mandate to provide aggressive treatment of depression is not always uncontroversial. Rather, medical intervention for older patients may raise a number of challenging legal, as well as ethical, questions. Using a case example, this article outlines some of the salient legal issues implicated by an older person's right to be and act depressed and the exceptions to that right.
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Date Issued: 2002
Identifier: FSU_migr_medlawcenter_publications-0002
Format: Citation

Title: Fear, Anger, Fruits, and Veggies: Interactive Effects of Emotion and Message Framing on Health Behavior.
Creator: Gerend, Mary, Maner, Jon
Abstract/Description: Objective: Message framing is a theoretically grounded health communication strategy designed to motivate action by emphasizing the benefits of engaging in a particular behavior (gains) or the costs of failing to engage in the behavior (losses). This study investigated whether the effectiveness of a framed message depends on the emotional state of the message recipient. We examined effects of fear versus anger, emotions that frequently occur within the context of health decision-making....
Show moreObjective: Message framing is a theoretically grounded health communication strategy designed to motivate action by emphasizing the benefits of engaging in a particular behavior (gains) or the costs of failing to engage in the behavior (losses). This study investigated whether the effectiveness of a framed message depends on the emotional state of the message recipient. We examined effects of fear versus anger, emotions that frequently occur within the context of health decision-making. Methods: Undergraduate students (N = 133) were randomly assigned to complete a fear or anger induction task after which they read a gain- or loss-framed pamphlet promoting fruit and vegetable consumption. Fruit and vegetable intake (servings per day) was subsequently assessed over the following two weeks. Results: As predicted, a significant frame by emotion interaction was observed, such that participants in the fear condition reported eating more servings of fruits and vegetables after exposure to a loss-framed message than to a gain-framed message. In contrast, participants in the anger condition reported eating (marginally) more servings of fruits and vegetables after exposure to a gain-framed message than to a loss-framed message. That is, greater increases in fruit and vegetable intake from baseline to follow-up were observed when frame was matched to participants' emotional state than when it was mismatched. Conclusion: The effectiveness of framed health communications depends on the message recipient's current emotional state. Affective factors that are incidental to the behavior recommended in a health communication can affect the relative success of gain- and loss-framed appeals.
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Date Issued: 2011
Identifier: FSU_migr_mhs-0006, 10.1037/a0021981
Format: Citation

Title: GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment.
Creator: Rietveld, Cornelius, Medland, Sarah, Derringer, Jaime, Yang, Jian, Esko, Tönu, Martin, Nicolas, Westra, Harm-Jan, Shakhbazov, Konstantin, Abdellaoui, Abdel, Agrawal, Arpana,...
Show moreRietveld, Cornelius, Medland, Sarah, Derringer, Jaime, Yang, Jian, Esko, Tönu, Martin, Nicolas, Westra, Harm-Jan, Shakhbazov, Konstantin, Abdellaoui, Abdel, Agrawal, Arpana, Albrecht, Eva, Alizadeh, Behrooz, Amin, Najaf, Barnard, John, Baumeister, Sebastian, Benke, Kelly, Bielak, Lawrence, Boatman, Jeffrey A., Boyle, Patricia, Davies, Gail, de Leeuw, Christiaan, Eklund, Niina, Evans, Daniel, Ferhmann, Rudolf, Fischer, Krista, Gieger, Christian, Gjessing, Håkon K, Hägg, Sara, Harris, Jennifer, Hayward, Caroline, Holzapfel, Christina, Ibrahim-Verbaas, Carla, Ingelsson, Erik, Jacobsson, Bo, Joshi, Peter, Jugessur, Astanand, Kaakinen, Marika, Kanoni, Stavroula, Karjalainen, Juha, Kolcic, Ivana, Kristiansson, Kati, Kutalik, Zoltán, Lahti, Jari, Lee, Sang, Lin, Peng, Lind, Penelope, Liu, Yongmei, Lohman, Kurt, Loitfelder, Marisa, McMahon, George, Vidal, Pedro, Meirelles, Osorio, Milani, Lili, Myhre, Ronny, Nuotio, Marja-Liisa, Oldmeadow, Christopher, Petrovic, Katja, Peyrot, Wouter, Polasek, Ozren, Quaye, Lydia, Reinmaa, Eva, Rice, John, Rizzi, Thais, Schmidt, Helena, Schmidt, Reinhold, Smith, Albert, Smith, Jennifer, Tanaka, Toshiko, Terracciano, Antonio, van der Loos, Matthijs, Vitart, Veronique, Völzke, Henry, Wellmann, Jürgen, Yu, Lei, Zhao, Wei, Allik, Jüri, Attia, John, Bandinelli, Stefania, Bastardot, François, Beauchamp, Jonathan, Bennett, David, Berger, Klaus, Bierut, Laura, Boomsma, Dorret, Bültmann, Ute, Campbell, Harry, Chabris, Christopher, Cherkas, Lynn, Chung, Mina, Cucca, Francesco, de Andrade, Mariza, De Jager, Philip, De Neve, Jan-Emmanuel, Deary, Ian J., Dedoussis, George, Deloukas, Panos, Dimitriou, Maria, Eiríksdóttir, Guðny, Elderson, Martin, Eriksson, Johan, Evans, David, Faul, Jessica, Ferrucci, Luigi, Garcia, Melissa, Grönberg, Henrik, Guðnason, Vilmundur, Hall, Per, Harris, Juliette, Harris, Tamara, Hastie, Nicholas, Heath, Andrew, Hernandez, Dena, Hoffmann, Wolfgang, Hofman, Adriaan, Holle, Rolf, Holliday, Elizabeth, Hottenga, Jouke-Jan, Iacono, William, Illig, Thomas, Järvelin, Marjo-Riitta, Kähönen, Mika, Kaprio, Jaakko, Kirkpatrick, Robert, Kowgier, Matthew, Latvala, Antti, Launer, Lenore, Lawlor, Debbie, Lehtimäki, Terho, Li, Jingmei, Lichtenstein, Paul, Lichtner, Peter, Liewald, David, Madden, Pamela, Magnusson, Patrik, Mäkinen, Tomi, Masala, Marco, McGue, Matthew, Metspalu, Andres, Mielck, Andreas, Miller, Michael, Montgomery, Grant, Mukherjee, Sutapa, Nyholt, Dale, Oostra, Ben A., Palmer, Lyle, Palotie, Aarno, Penninx, Brenda, Perola, Markus, Peyser, Patricia, Preisig, Martin, Räikkönen, Katri, Raitakari, Olli, Realo, Anu, Ring, Susan, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sarin, Antti-Pekka, Schlessinger, David, Scott, Rodney, Snieder, Harold, St Pourcain, Beate, Starr, John M., Sul, Jae, Surakka, Ida, Svento, Rauli, Teumer, Alexander, Tiemeier, Henning, van Rooij, Frank, Van Wagoner, David, Vartiainen, Erkki, Viikari, Jorma, Vollenweider, Peter, Vonk, Judith, Waeber, Gérard, Weir, David, Wichmann, H.-Erich (Heinz-Erich), Widen, Elisabeth, Willemsen, Gonneke, Wilson, James F. (James Flett), Wright, Alan, Conley, Dalton, Smith, George Davey, Franke, Lude, Groenen, Patrick, Hofman, Albert, Johannesson, Magnus, Kardia, Sharon, Krueger, Robert F., Laibson, David, Martin, Nicholas G., Meyer, Michelle, Posthuma, Danielle, Thurik, A. R. (A. Roy), Timpson, Nicholas, Uitterlinden, André G., van Duijn, Cornelia, Visscher, Peter, Benjamin, Daniel, Cesarini, David, Koellinger, Philipp
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Abstract/Description: A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2%...
Show moreA genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
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Date Issued: 2013
Identifier: FSU_migr_geriatrics_faculty_publications-0007, 10.1126/science.1235488
Format: Citation

Title: Functional Role of Kallikrein 6 in Regulating Immune Cell Survival.
Creator: Scarisbrick, Isobel, Epstein, Benjamin, Cloud, Beth, Yoon, Hyesook, Wu, Jianmin, Renner, Danielle, Blaber, Sachiko, Blaber, Michael, Vandell, Alexander, Bryson, Alexandra
Abstract/Description: BACKGROUND: Kallikrein 6 (KLK6) is a newly identified member of the kallikrein family of secreted serine proteases that prior studies indicate is elevated at sites of central nervous system (CNS) inflammation and which shows regulated expression with T cell activation. Notably, KLK6 is also elevated in the serum of multiple sclerosis (MS) patients however its potential roles in immune function are unknown. Herein we specifically examine whether KLK6 alters immune cell survival and the...
Show moreBACKGROUND: Kallikrein 6 (KLK6) is a newly identified member of the kallikrein family of secreted serine proteases that prior studies indicate is elevated at sites of central nervous system (CNS) inflammation and which shows regulated expression with T cell activation. Notably, KLK6 is also elevated in the serum of multiple sclerosis (MS) patients however its potential roles in immune function are unknown. Herein we specifically examine whether KLK6 alters immune cell survival and the possible mechanism by which this may occur. METHODOLOGY/PRINCIPAL FINDINGS: Using murine whole splenocyte preparations and the human Jurkat T cell line we demonstrate that KLK6 robustly supports cell survival across a range of cell death paradigms. Recombinant KLK6 was shown to significantly reduce cell death under resting conditions and in response to camptothecin, dexamethasone, staurosporine and Fas-ligand. Moreover, KLK6-over expression in Jurkat T cells was shown to generate parallel pro-survival effects. In mixed splenocyte populations the vigorous immune cell survival promoting effects of KLK6 were shown to include both T and B lymphocytes, to occur with as little as 5 minutes of treatment, and to involve up regulation of the pro-survival protein B-cell lymphoma-extra large (Bcl-XL), and inhibition of the pro-apoptotic protein Bcl-2-interacting mediator of cell death (Bim). The ability of KLK6 to promote survival of splenic T cells was also shown to be absent in cell preparations derived from PAR1 deficient mice. CONCLUSION/SIGNIFICANCE: KLK6 promotes lymphocyte survival by a mechanism that depends in part on activation of PAR1. These findings point to a novel molecular mechanism regulating lymphocyte survival that is likely to have relevance to a range of immunological responses that depend on apoptosis for immune clearance and maintenance of homeostasis.
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Date Issued: 2011
Identifier: FSU_migr_biomed_faculty_publications-0022, 10.1371/journal.pone.0018376
Format: Citation

Title: Functional Effects of a Restrictive-Cardiomyopathy-Linked Cardiac Troponin I Mutation (R145W) in Transgenic Mice.
Creator: Wen, Yuhui, Xu, Yuanyuan, Wang, Yingcai, Pinto, Jose, Potter, James, Kerrick, W.
Abstract/Description: The human cardiac troponin I (hcTnI) mutation R145W has been associated with restrictive cardiomyopathy. In this study, simultaneous measurements of ATPase activity and force in skinned papillary fibers from hcTnI R145W transgenic mice (Tg-R145W) were explored. Tg-R145W fibers showed an approximately 13-16% increase in maximal Ca(2+)-activated force and ATPase activity compared to hcTnI wild-type transgenic mice. The force-generating cross-bridge turnover rate (g) and the energy cost (ATPase...
Show moreThe human cardiac troponin I (hcTnI) mutation R145W has been associated with restrictive cardiomyopathy. In this study, simultaneous measurements of ATPase activity and force in skinned papillary fibers from hcTnI R145W transgenic mice (Tg-R145W) were explored. Tg-R145W fibers showed an approximately 13-16% increase in maximal Ca(2+)-activated force and ATPase activity compared to hcTnI wild-type transgenic mice. The force-generating cross-bridge turnover rate (g) and the energy cost (ATPase/force) were the same in all groups of fibers. Also, the Tg-R145W fibers showed a large increase in the Ca(2+) sensitivity of both force development and ATPase. In intact fibers, the mutation caused prolonged force and intracellular [Ca(2+)] transients and increased time to peak force. Analysis of force and Ca(2+) transients showed that there was a 40% increase in peak force in Tg-R145W muscles, which was likely due to the increased Ca(2+) transient duration. The above cited results suggest that: (1) there would be an increase in resistance to ventricular filling during diastole resulting from the prolonged force and Ca(2+) transients that would result in a decrease in ventricular filling (diastolic dysfunction); and (2) there would be a large (approximately 53%) increase in force during systole, which may help to partly compensate for diastolic dysfunction. These functional results help to explain the mechanisms by which these mutations give rise to a restrictive phenotype.
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Date Issued: 2009
Identifier: FSU_migr_biomed_faculty_publications-0060, 10.1016/j.jmb.2009.07.080
Format: Citation

Title: A Legal Approach to the Use of Human Biological Materials for Research Purposes.
Creator: Kapp, Marshall B.
Abstract/Description: Human Biological Materials (HBM) come from individuals in a variety of circumstances. The use of HBM for research purposes raises a host of difficult ethical questions. The law is important in this arena because, in most cases, legal principles significantly influence the making of ethical choices. Following a general overview of research regulation in the United States generally and a few comments on the relevance of international statements for this country, this article explores several...
Show moreHuman Biological Materials (HBM) come from individuals in a variety of circumstances. The use of HBM for research purposes raises a host of difficult ethical questions. The law is important in this arena because, in most cases, legal principles significantly influence the making of ethical choices. Following a general overview of research regulation in the United States generally and a few comments on the relevance of international statements for this country, this article explores several specific legal issues, and their ethical implications, related to the obtaining and handling of HBM for research purposes, namely: informed consent; privacy; and commercial or ownership (property) interests in HBM. The article concludes that, although the realistic liability risks are low, the law's important role in characterizing the rights and responsibilities involved will be very influential in shaping the ways that the chasm between science and ethics is resolved within the context of the use of human tissue for research purposes.
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Date Issued: 2012
Identifier: FSU_migr_medlawcenter_publications-0004
Format: Citation

Title: Legal Issues Arising in the Process of Determining Decisional Capacity in Older Persons.
Creator: Kapp, Marshall B.
Abstract/Description: There is an increasing incidence of dementia, depression and other affective disorders, delirium, and other mental health problems such as psychoses among older individuals in the United States. Because the severity of mental illness, in terms of cognitive and behavioral impairment and therefore the illness' impact on functional ability, varies for different patients at different times along a continuum, there is not an automatic correlation between an older person's clinical diagnosis and a...
Show moreThere is an increasing incidence of dementia, depression and other affective disorders, delirium, and other mental health problems such as psychoses among older individuals in the United States. Because the severity of mental illness, in terms of cognitive and behavioral impairment and therefore the illness' impact on functional ability, varies for different patients at different times along a continuum, there is not an automatic correlation between an older person's clinical diagnosis and a dichotomous determination that the individual does or does not possess sufficient present capacity to personally make various sorts of fundamental life decisions. Decisional capacity assessment in the aged carries important implications both for the official adjudication of legal competence and for patient/client management in the vast majority of cases involving "bumbling through." There exists many salient, but generally overlooked, legal and ethical concerns immersed in the health care or human services provider's attempt to evaluate the decisional capacity of a particular older patient/client. This article surveys the most important of those concerns, which arise before we ever get to the point of applying assessment data to the relevant legal and ethical standards of decisional capacity.
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Date Issued: 2010
Identifier: FSU_migr_medlawcenter_publications-0003
Format: Citation

Title: Making Medical Decisions for Someone Else: A Florida Handbook.
Creator: Kapp, Marshall B.
Abstract/Description: If you make health care decisions for another adult person—or might at some future point—this handbook is for you. Learn what it means to become a "health care substitute."
Date Issued: 2011
Identifier: FSU_migr_medlawcenter_publications-0001
Format: Citation

Title: Longevity Candidate Genes and Their Association with Personality Traits in the Elderly.
Creator: Luciano, Michelle, Lopez, Lorna, de Moor, Marleen, Harris, Sarah, Davies, Gail, Nutile, Teresa, Krueger, Robert F., Esko, Tönu, Schlessinger, David, Toshiko, Tanaka, Derringer,...
Show moreLuciano, Michelle, Lopez, Lorna, de Moor, Marleen, Harris, Sarah, Davies, Gail, Nutile, Teresa, Krueger, Robert F., Esko, Tönu, Schlessinger, David, Toshiko, Tanaka, Derringer, Jaime, Realo, Anu, Hansell, Narelle, Pergadia, Michele, Pesonen, Anu-Katriina, Sanna, Serena, Terracciano, Antonio, Madden, Pamela, Penninx, Brenda, Spinhoven, Philip, Hartman, Catherina, Oostra, Ben A., Janssens, A., Eriksson, Johan, Starr, John M., Cannas, Alessandra, Ferrucci, Luigi, Metspalu, Andres, Wright, Margeret, Heath, Andrew, van Duijn, Cornelia, Bierut, Laura, Raikkonen, Katri, Martin, Nicholas G., Ciullo, Marina, Rujescu, Dan, Boomsma, Dorret, Deary, Ian J.
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Abstract/Description: Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A,...
Show moreHuman longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P < 0.0002), but there was an over-representation of nominally significant (P < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17,106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged >60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.
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Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0013, 10.1002/ajmg.b.32013
Format: Citation

Title: Longitudinal Trajectories in Guilford-Zimmerman Temperament Survey Data: Results from the Baltimore Longitudinal Study of Aging.
Creator: Terracciano, Antonio, McCrae, Robert R., Costa, Paul
Abstract/Description: We examined developmental trends in personality traits over a 42-year time period by using data from the Baltimore Longitudinal Study on Aging (N = 2,359; individuals aged 17-98), collected from 1958 to 2002. Hierarchical linear modeling analyses revealed cumulative mean-level changes averaging about 0.5 SD across adulthood. Scales related to extraversion showed distinct developmental patterns: General Activity declined from age 60 to 90; Restraint increased; Ascendance peaked around age 60;...
Show moreWe examined developmental trends in personality traits over a 42-year time period by using data from the Baltimore Longitudinal Study on Aging (N = 2,359; individuals aged 17-98), collected from 1958 to 2002. Hierarchical linear modeling analyses revealed cumulative mean-level changes averaging about 0.5 SD across adulthood. Scales related to extraversion showed distinct developmental patterns: General Activity declined from age 60 to 90; Restraint increased; Ascendance peaked around age 60; and Sociability declined slightly. Scales related to neuroticism showed curvilinear declines up to age 70 and increases thereafter. Scales related to agreeableness and openness changed little; Masculinity declined linearly. We found significant individual variability in change. Although intercepts differed, trajectories were similar for men and women. Attrition and death had no effect on slopes. This study highlights the use of lower order traits in providing a more nuanced picture of developmental change.
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Date Issued: 2006
Identifier: FSU_migr_geriatrics_faculty_publications-0031
Format: Citation

Title: Libraries for New Medical Schools: The Creation of a Network for Identifying and Supporting the Needs of 21st Century Medical Schools.
Creator: Boilard, David, Dexter, Nadine, Doyle, Jacqueline, Rand, Debra, Shearer, Barbara
Abstract/Description: As new medical schools are developing, new academic libraries must also be created to support the schools' missions, faculty, students, and curricula. The formation of a network of these new and emerging academic health sciences libraries is described. In June 2012, the First Symposium on Creating New Academic Health Sciences Libraries was held in Orlando, Florida. Sponsored by the Association of Academic Health Sciences Libraries (AAHSL), this inaugural Symposium brought together...
Show moreAs new medical schools are developing, new academic libraries must also be created to support the schools' missions, faculty, students, and curricula. The formation of a network of these new and emerging academic health sciences libraries is described. In June 2012, the First Symposium on Creating New Academic Health Sciences Libraries was held in Orlando, Florida. Sponsored by the Association of Academic Health Sciences Libraries (AAHSL), this inaugural Symposium brought together representatives from 16 new schools to discuss planning needed for the LCME process for library services and resources, to discuss experiences and challenges, and to share visions of 'born digital' libraries. Because this is a priority initiative of the AAHSL, the Association will continue to support members of this group by providing information and additional networking opportunities.
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Date Issued: 2012
Identifier: FSU_migr_medlib_posters-0001
Format: Citation

Title: How Long Should Antibiotic Therapy Be Continued for an Uncomplicated, Symptomatic Lower UTI in an Elderly Woman?.
Creator: Radkay, Lisa, Rodríguez, Jose
Abstract/Description: Elderly women with symptomatic lower urinary tract infections (UTIs) should be treated for 3 to 6 days with oral antibiotics. This duration provides better short-term outcomes than 1-day therapy and has long-term outcomes equivalent to 7- to 14-day therapy. (SOR B, based on a systematic review of heterogeneous RCTs.)
Date Issued: 2010
Identifier: FSU_migr_fmr-0028
Format: Citation

Title: How Are Thyroid Function Tests Altered by Thyroid Replacement Medications?.
Creator: Shah, Shawn, Rodríguez, Jose
Abstract/Description: Small changes in the dosing of levothyroxine (±25 mcg) are associated with large changes in serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations, but not with measurable changes in hypothyroid symptoms, well-being, or quality of life. (SOR: B, based on a single RCT.) Taking levothyroxine while fasting is associated with a higher serum FT4 and lower serum TSH compared with administration after a meal, but these differences are small. (SOR: C, based on a single RCT...
Show moreSmall changes in the dosing of levothyroxine (±25 mcg) are associated with large changes in serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations, but not with measurable changes in hypothyroid symptoms, well-being, or quality of life. (SOR: B, based on a single RCT.) Taking levothyroxine while fasting is associated with a higher serum FT4 and lower serum TSH compared with administration after a meal, but these differences are small. (SOR: C, based on a single RCT using disease-oriented outcomes.)
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Date Issued: 2010
Identifier: FSU_migr_fmr-0032
Format: Citation

Title: Impact of a Creative Arts Journal on a Medical School Community: A Qualitative Study.
Creator: Rodríguez, Jose, Welch, Tana, Edwards, Janine C.
Abstract/Description: The Florida State University College of Medicine (FSUCOM) has created a new creative arts journal called HEAL: Humanism Evolving through Arts and Literature. This study was designed to evaluate the influence creative arts publications may have on students, faculty, and staff of a medical school. The investigators randomly selected 17 participants from 25 volunteers in the HEAL project who agreed to be interviewed. They used consensual qualitative research methods to analyze the data,...
Show moreThe Florida State University College of Medicine (FSUCOM) has created a new creative arts journal called HEAL: Humanism Evolving through Arts and Literature. This study was designed to evaluate the influence creative arts publications may have on students, faculty, and staff of a medical school. The investigators randomly selected 17 participants from 25 volunteers in the HEAL project who agreed to be interviewed. They used consensual qualitative research methods to analyze the data, identifying major areas of impact HEAL had on the faculty, students, and staff. Three major themes were identified: Strengthening Professional Relationships (SPR), Educational Enhancement (EE), and Self-Expression (SE). The following sub-themes were identified: SPR—changed perceptions; SE—artistic self-expression; EE—faculty example, and positive reinforcement of career choice. HEAL is perceived as a valuable part of medical education, and the identified themes can be tested in further research.
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Date Issued: 2012
Identifier: FSU_migr_fmr-0048, 10.1080/08893675.2012.736179
Format: Citation

Title: Kallikrein 6 is a Novel Molecular Trigger of Reactive Astrogliosis.
Creator: Scarisbrick, Isobel, Radulovic, Maja, Burda, Joshua, Larson, Nadya, Blaber, Sachiko, Giannini, Caterina, Blaber, Michael, Vandell, Alexander
Abstract/Description: Kallikrein-related peptidase 6 (KLK6) is a trypsin-like serine protease upregulated at sites of central nervous system (CNS) injury, including de novo expression by reactive astrocytes, yet its physiological actions are largely undefined. Taken with recent evidence that KLK6 activates G-protein-coupled protease-activated receptors (PARs), we hypothesized that injury-induced elevations in KLK6 contribute to the development of astrogliosis and that this occurs in a PAR-dependent fashion. Using...
Show moreKallikrein-related peptidase 6 (KLK6) is a trypsin-like serine protease upregulated at sites of central nervous system (CNS) injury, including de novo expression by reactive astrocytes, yet its physiological actions are largely undefined. Taken with recent evidence that KLK6 activates G-protein-coupled protease-activated receptors (PARs), we hypothesized that injury-induced elevations in KLK6 contribute to the development of astrogliosis and that this occurs in a PAR-dependent fashion. Using primary murine astrocytes and the Neu7 astrocyte cell line, we show that KLK6 causes astrocytes to transform from an epitheliod to a stellate morphology and to secrete interleukin 6 (IL-6). By contrast, KLK6 reduced expression of glial fibrillary acidic protein (GFAP). The stellation-promoting activities of KLK6 were shown to be dependent on activation of the thrombin receptor, PAR1, as a PAR1-specific inhibitor, SCH79797, blocked KLK6-induced morphological changes. The ability of KLK6 to promote astrocyte stellation was also shown to be linked to activation of protein kinase C (PKC). These studies indicate that KLK6 is positioned to serve as a molecular trigger of select physiological processes involved in the development of astrogliosis and that this is likely to occur at least in part by activation of the G-protein-coupled receptor, PAR1.
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Date Issued: 2012
Identifier: FSU_migr_biomed_faculty_publications-0030, 10.1515/hsz-2011-0241
Format: Citation

Title: The Italian Version of the NEO PI-R: Conceptual and Empirical Support for the Use of Targeted Rotation.
Creator: Terracciano, Antonio
Abstract/Description: Earlier cross-cultural research on replicability of the Revised NEO Personality Inventory (NEO-PI-R) suggested that personality trait structure is universal, but a recent study using an Italian translation has challenged this position. The present article reexamines the psychometric properties of the Italian NEO-PI-R and discusses the importance of orthogonal Procrustes rotation when the replicability of complex factor structures is tested. The arguments are supported by data from a slightly...
Show moreEarlier cross-cultural research on replicability of the Revised NEO Personality Inventory (NEO-PI-R) suggested that personality trait structure is universal, but a recent study using an Italian translation has challenged this position. The present article reexamines the psychometric properties of the Italian NEO-PI-R and discusses the importance of orthogonal Procrustes rotation when the replicability of complex factor structures is tested. The arguments are supported by data from a slightly modified translation of the NEO-PI-R, which was administered to 575 Italian subjects. These data show a close replication of the American normative factor structure when targeted rotation is used. Further, the validity of the Italian NEO-PI-R is supported by external correlates, such as demographic variables (age, sex, education), depression, and affect scales.
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Date Issued: 2003
Identifier: FSU_migr_geriatrics_faculty_publications-0037, 10.1016/S0191-8869(03)00035-7
Format: Citation

Title: Hypothalamic-Pituitary Function in Brain Death: A Review.
Creator: Nair-Collins, Michael, Northrup, Jesse, Olcese, James
Abstract/Description: The Uniform Determination of Death Act (UDDA) states that an individual is dead when "all functions of the entire brain" have ceased irreversibly. However, it has been questioned whether some functions of the hypothalamus, particularly osmoregulation, can continue after the clinical diagnosis of brain death (BD). In order to learn whether parts of the hypothalamus can continue to function after the diagnosis of BD, we performed 2 separate systematic searches of the MEDLINE database,...
Show moreThe Uniform Determination of Death Act (UDDA) states that an individual is dead when "all functions of the entire brain" have ceased irreversibly. However, it has been questioned whether some functions of the hypothalamus, particularly osmoregulation, can continue after the clinical diagnosis of brain death (BD). In order to learn whether parts of the hypothalamus can continue to function after the diagnosis of BD, we performed 2 separate systematic searches of the MEDLINE database, corresponding to the functions of the posterior and anterior pituitary. No meta-analysis is possible due to nonuniformity in the clinical literature. However, some modest generalizations can reasonably be drawn from a narrative review and from anatomic considerations that explain why these findings should be expected. We found evidence suggesting the preservation of hypothalamic function, including secretion of hypophysiotropic hormones, responsiveness to anterior pituitary stimulation, and osmoregulation, in a substantial proportion of patients declared dead by neurological criteria. We discuss several possible explanations for these findings. We conclude by suggesting that additional clinical research with strict inclusion criteria is necessary and further that a more nuanced and forthright public dialogue is needed, particularly since standard diagnostic practices and the UDDA may not be entirely in accord.
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Date Issued: 2014
Identifier: FSU_migr_mhs-0041, 10.1177/0885066614527410
Format: Citation

Title: Humans Are Mortal?!: I'm Calling My Attorney.
Creator: Kapp, Marshall B.
Date Issued: 2010
Identifier: FSU_migr_medlawcenter_presentations-0002
Format: Citation

Title: Individual Difference Variables, Affective Differentiation, and the Structures of Affect.
Creator: Terracciano, Antonio, McCrae, Robert R., Hagemann, Dirk, Costa, Paul
Abstract/Description: Methodological arguments are usually invoked to explain variations in the structure of affect. Using self-rated affect from Italian samples (N=600), we show that individual difference variables related to affective differentiation can moderate the observed structure. Indices of circumplexity and congruence coefficients to the hypothesized target were used to quantify the observed structures. Results did not support the circumplex model as a universal structure. A circular structure with axes...
Show moreMethodological arguments are usually invoked to explain variations in the structure of affect. Using self-rated affect from Italian samples (N=600), we show that individual difference variables related to affective differentiation can moderate the observed structure. Indices of circumplexity and congruence coefficients to the hypothesized target were used to quantify the observed structures. Results did not support the circumplex model as a universal structure. A circular structure with axes of activation and valence was approximated only among more affectively differentiated groups: students and respondents with high scores on Openness to Feelings and measures of negative emotionality. A different structure, with unipolar Positive Affect and Negative Affect factors, was observed among adults and respondents with low Openness to Feelings and negative emotionality. The observed structure of affect will depend in part on the nature of the sample studied.
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Date Issued: 2003
Identifier: FSU_migr_geriatrics_faculty_publications-0036
Format: Citation

Title: Increasing our Library's Value with DALRs.
Creator: Epstein, Susan A.
Abstract/Description: Increasing our Library's Value with DALRs The Maguire Medical Library (MML) at the Florida State University has been developing a unique service for faculty and other researchers who need advanced, long-term assistance using a variety of library resources. Because such research projects typically involve formulating various search strategies, searching several library databases in-depth, and collecting, managing and sharing citations, the MML DALR program uses a team approach to meet...
Show moreIncreasing our Library's Value with DALRs The Maguire Medical Library (MML) at the Florida State University has been developing a unique service for faculty and other researchers who need advanced, long-term assistance using a variety of library resources. Because such research projects typically involve formulating various search strategies, searching several library databases in-depth, and collecting, managing and sharing citations, the MML DALR program uses a team approach to meet researchers' needs. With a team approach, the time and skills of librarians, researchers in the College of Medicine's academic departments, and associates for library research embedded within each department complement each other efficiently and effectively. The poster describes how the research team concept evolved, and features examples of the project documentation, such as the participation requirements for the departmental associates for library research (DALRs). Viewers of this poster will hopefully be able to determine if a team approach to library research might be useful in their own work environments.
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Date Issued: 2013
Identifier: FSU_migr_medlib_posters-0004
Format: Citation

Title: Kallikreins are Associated with Secondary Progressive Multiple Sclerosis and Promote Neurodegeneration.
Creator: Scarisbrick, Isobel, Linbo, Rachel, Vandell, Alexander, Keegan, Mark, Blaber, Sachiko, Blaber, Michael, Sneve, Diane, Lucchinetti, Claudia F., Rodriguez, Moses, Diamandis,...
Show moreScarisbrick, Isobel, Linbo, Rachel, Vandell, Alexander, Keegan, Mark, Blaber, Sachiko, Blaber, Michael, Sneve, Diane, Lucchinetti, Claudia F., Rodriguez, Moses, Diamandis, Eleftherios P.
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Abstract/Description: Tissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 10 were determined in 35 MS patients and 62 controls by quantitative fluorometric ELISA. Serum levels were then correlated with Expanded Disability Status Scale (EDSS) scores...
Show moreTissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 10 were determined in 35 MS patients and 62 controls by quantitative fluorometric ELISA. Serum levels were then correlated with Expanded Disability Status Scale (EDSS) scores determined at the time of serological sampling or at last clinical follow-up. Serum levels of KLK1 and KLK6 were elevated in MS patients (p
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Date Issued: 2008
Identifier: FSU_migr_biomed_faculty_publications-0008
Format: Citation

Title: Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians.
Creator: Pilia, Giuseppe, Chen, Wei-Min, Scuteri, Angelo, Orrú, Marco, Albai, Giuseppe, Dei, Mariano, Lai, Sandra, Usala, Gianluca, Lai, Monica, Loi, Paola, Mameli, Cinzia, Vacca,...
Show morePilia, Giuseppe, Chen, Wei-Min, Scuteri, Angelo, Orrú, Marco, Albai, Giuseppe, Dei, Mariano, Lai, Sandra, Usala, Gianluca, Lai, Monica, Loi, Paola, Mameli, Cinzia, Vacca, Loredana, Deiana, Manila, Olla, Nazario, Masala, Marco, Cao, Antonio, Najjar, Samer, Terracciano, Antonio, Nedorezov, Timur, Sharov, Alexei, Zonderman, Alan, Abecasis, Gonçalo, Costa, Paul, Lakatta, Edward, Schlessinger, David
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Abstract/Description: In family studies, phenotypic similarities between relatives yield information on the overall contribution of genes to trait variation. Large samples are important for these family studies, especially when comparing heritability between subgroups such as young and old, or males and females. We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for...
Show moreIn family studies, phenotypic similarities between relatives yield information on the overall contribution of genes to trait variation. Large samples are important for these family studies, especially when comparing heritability between subgroups such as young and old, or males and females. We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, focusing on facets of personality and cardiovascular function. We also summarize results of bivariate analyses for all pairs of traits and of heterogeneity analyses for each trait. We found a significant genetic component for every trait. On average, genetic effects explained 40% of the variance for 38 blood tests, 51% for five anthropometric measures, 25% for 20 measures of cardiovascular function, and 19% for 35 personality traits. Four traits showed significant evidence for an X-linked component. Bivariate analyses suggested overlapping genetic determinants for many traits, including multiple personality facets and several traits related to the metabolic syndrome; but we found no evidence for shared genetic determinants that might underlie the reported association of some personality traits and cardiovascular risk factors. Models allowing for heterogeneity suggested that, in this cohort, the genetic variance was typically larger in females and in younger individuals, but interesting exceptions were observed. For example, narrow heritability of blood pressure was approximately 26% in individuals more than 42 y old, but only approximately 8% in younger individuals. Despite the heterogeneity in effect sizes, the same loci appear to contribute to variance in young and old, and in males and females. In summary, we find significant evidence for heritability of many medically important traits, including cardiovascular function and personality. Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits.
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Date Issued: 2006
Identifier: FSU_migr_geriatrics_faculty_publications-0033, 10.1371/journal.pgen.0020132
Format: Citation

Title: Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers.
Creator: Hartz, Sarah, Short, Susan, Saccone, Nancy, Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah, Sun, Juzhong, Chen,...
Show moreHartz, Sarah, Short, Susan, Saccone, Nancy, Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah, Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Gubjartsson, Daniel, Hansel, Nadia, Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikäinen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Rosenberger, Albert, Scheet, Paul A. (Paul Anthony), Shaffer, John, Teumer, Alexander, Thompson, John, Vink, Jacqueline, Vogelzangs, Nicole, Wenzlaff, Angela, Wheeler, William, Xiao, Xiangjun, Yang, Bao-Zhu, Aggen, Steven, Balmforth, Anthony, Baumeister, Sebastian, Beaty, Terri H., Bennett, Siiri, Bergen, Andrew, Boyd, Heather, Broms, Ulla, Campbell, Harry, Chatterjee, Nilanjan, Chen, Jingchun, Cheng, Yu-Ching, Cichon, Sven, Couper, David, Cucca, Francesco, Dick, Danielle M. (Danielle Marie), Foroud, Tatiana, Furberg, Helena, Giegling, Ina, Gu, Fangyi, Hall, A. S. (Alistair Scott), Hällfors, Jenni, Han, Shizhong, Hartmann, Annette, Hayward, Caroline, Heikkilä, Kauko, Hewitt, John K., Hottenga, Jouke-Jan, Jensen, Majken, Jousilahti, Pekka, Kaakinen, Marika, Kittner, Steven, Konte, Bettina, Korhonen, Tellervo, Landi, Maria-Teresa, Laatikainen, Tiina, Leppert, Mark, Levy, Steven, Mathias, Rasika, McNeil, Daniel, Medland, Sarah, Montgomery, Grant, Muley, Thomas, Murray, Tanda, Nauck, Matthias, North, Kari, Pergadia, Michele, Polasek, Ozren, Ramos, Erin Michele, Ripatti, Samuli, Risch, Angela, Ruczinski, Ingo, Rudan, Igor, Salomaa, Veikko, Schlessinger, David, Styrkársdóttir, Unnur, Terracciano, Antonio, Uda, Manuela, Willemsen, Gonneke, Wu, Xifeng, Abecasis, Gonçalo, Barnes, Kathleen, Bickeböller, Heike, Boerwinkle, Eric, Boomsma, Dorret, Caporaso, Neil, Duan, Jubao, Edenberg, Howard, Francks, Clyde, Gejman, Pablo, Gelernter, Joel, Grabe, Hans, Hops, Hyman, Jarvelin, Marjo-Riitta, Viikari, Jorma, Kähönen, Mika, Kendler, Kenneth S., Lehtimäki, Terho, Levinson, Douglas, Marazita, Mary, Marchini, Jonathan, Melbye, Mads, Mitchell, Braxton, Murray, Jeffrey, Nöthen, Markus, Penninx, Brenda, Raitakari, Olli, Rietschel, Marcella, Rujescu, Dan, Samani, Nilesh J., Sanders, Alan, Schwartz, Ann, Shete, Sanjay, Shi, Jianxin, Spitz, Margaret R., Stefansson, Kari, Swan, Gary, Thorgeirsson, Thorgeir, Völzke, Henry, Wei, Qingyi, Wichmann, H.-Erich (Heinz-Erich), Amos, Christopher I., Breslau, Naomi, Cannon, Dale S., Ehringer, Marissa, Grucza, Richard, Hatsukami, Dorothy, Heath, Andrew, Johnson, Eric, Kaprio, Jaakko, Madden, Pamela, Martin, Nicholas G., Stevens, Victoria, Stitzel, Jerry, Weiss, Robert, Kraft, Peter, Bierut, Laura
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Abstract/Description: CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally...
Show moreCONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13,843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19,505) (P = .01). CONCLUSION: These results highlight an increased genetic vulnerability to smoking in early-onset smokers.
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Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0040, 10.1001/archgenpsychiatry.2012.124
Format: Citation

Title: Hierarchical Linear Modeling Analyses of the NEO-PI-R Scales in the Baltimore Longitudinal Study of Aging.
Creator: Terracciano, Antonio, McCrae, Robert R., Brant, Larry, Costa, Paul
Abstract/Description: The authors examined age trends in the 5 factors and 30 facets assessed by the Revised NEO Personality Inventory in Baltimore Longitudinal Study of Aging data (N=1,944; 5,027 assessments) collected between 1989 and 2004. Consistent with cross-sectional results, hierarchical linear modeling analyses showed gradual personality changes in adulthood: a decline in Neuroticism up to age 80, stability and then decline in Extraversion, decline in Openness, increase in Agreeableness, and increase in...
Show moreThe authors examined age trends in the 5 factors and 30 facets assessed by the Revised NEO Personality Inventory in Baltimore Longitudinal Study of Aging data (N=1,944; 5,027 assessments) collected between 1989 and 2004. Consistent with cross-sectional results, hierarchical linear modeling analyses showed gradual personality changes in adulthood: a decline in Neuroticism up to age 80, stability and then decline in Extraversion, decline in Openness, increase in Agreeableness, and increase in Conscientiousness up to age 70. Some facets showed different curves from the factor they define. Birth cohort effects were modest, and there were no consistent Gender x Age interactions. Significant nonnormative changes were found for all 5 factors; they were not explained by attrition but might be due to genetic factors, disease, or life experience.
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Date Issued: 2005
Identifier: FSU_migr_geriatrics_faculty_publications-0030, 10.1037/0882-7974.20.3.493
Format: Citation

Title: High Neuroticism and Low Conscientiousness Are Associated with Interleukin-6.
Creator: Sutin, Angelina, Terracciano, Antonio, Deiana, Barbara, Naitza, Silvia, Ferrucci, Luigi, Uda, Manuela, Schlessinger, David, Costa, Paul
Abstract/Description: BACKGROUND: High Neuroticism and low Conscientiousness are frequently implicated in health-risk behaviors, such as smoking and overeating, as well as health outcomes, including mortality. Their associations with physiological markers of morbidity and mortality, such as inflammation, are less well documented. The present research examines the association between the five major dimensions of personality and interleukin-6 (IL-6), a pro-inflammatory cytokine often elevated in patients with...
Show moreBACKGROUND: High Neuroticism and low Conscientiousness are frequently implicated in health-risk behaviors, such as smoking and overeating, as well as health outcomes, including mortality. Their associations with physiological markers of morbidity and mortality, such as inflammation, are less well documented. The present research examines the association between the five major dimensions of personality and interleukin-6 (IL-6), a pro-inflammatory cytokine often elevated in patients with chronic morbidity and frailty. METHOD: A population-based sample (n=4923) from four towns in Sardinia, Italy, had their levels of IL-6 measured and completed a comprehensive personality questionnaire, the NEO-PI-R. Analyses controlled for factors known to have an effect on IL-6: age; sex; smoking; weight; aspirin use; disease burden. RESULTS: High Neuroticism and low Conscientiousness were both associated with higher levels of IL-6. The findings remained significant after controlling for the relevant covariates. Similar results were found for C-reactive protein, a related marker of chronic inflammation. Further, smoking and weight partially mediated the association between impulsivity-related traits and higher IL-6 levels. Finally, logistic regressions revealed that participants either in the top 10% of the distribution of Neuroticism or the bottom 10% of conscientiousness had an approximately 40% greater risk of exceeding clinically relevant thresholds of IL-6. CONCLUSIONS: Consistent with the literature on personality and self-reported health, individuals high on Neuroticism or low on Conscientiousness show elevated levels of this inflammatory cytokine. Identifying critical medical biomarkers associated with personality may help to elucidate the physiological mechanisms responsible for the observed connections between personality traits and physical health.
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Date Issued: 2010
Identifier: FSU_migr_mhs-0026, 10.1017/S0033291709992029
Format: Citation

Title: Impulsivity-Related Traits Are Associated with Higher White Blood Cell Counts.
Creator: Sutin, Angelina, Milaneschi, Yuri, Cannas, Alessandra, Ferrucci, Luigi, Uda, Manuela, Schlessinger, David, Zonderman, Alan, Terracciano, Antonio
Abstract/Description: A chronically elevated white blood cell (WBC) count is a risk factor for morbidity and mortality. The present research tests whether facets of impulsivity-impulsiveness, excitement-seeking, self-discipline, and deliberation-are associated with chronically elevated WBC counts. Community-dwelling participants (N = 5,652) from Sardinia, Italy, completed a standard personality questionnaire and provided blood samples concurrently and again 3 years later. Higher scores on impulsivity, in...
Show moreA chronically elevated white blood cell (WBC) count is a risk factor for morbidity and mortality. The present research tests whether facets of impulsivity-impulsiveness, excitement-seeking, self-discipline, and deliberation-are associated with chronically elevated WBC counts. Community-dwelling participants (N = 5,652) from Sardinia, Italy, completed a standard personality questionnaire and provided blood samples concurrently and again 3 years later. Higher scores on impulsivity, in particular impulsiveness and excitement-seeking, were related to higher total WBC counts and higher lymphocyte counts at both time points. Impulsiveness was a predictor of chronic inflammation: for every standard deviation difference in this trait, there was an almost 25% higher risk of elevated WBC counts at both time points (OR = 1.23, 95% CI = 1.10-1.38). These associations were mediated, in part, by smoking and body mass index. The findings demonstrate that links between psychological processes and immunity are not limited to acute stressors; stable personality dispositions are associated with a chronic inflammatory state.
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Date Issued: 2012
Identifier: FSU_migr_mhs-0013, 10.1007/s10865-011-9390-0
Format: Citation

Title: Rater Wealth Predicts Perceptions of Outgroup Competence.
Creator: Chan, Wayne, McCrae, Robert R., Rogers, Darrin, Weimer, Amy, Greenberg, David, Terracciano, Antonio
Abstract/Description: National income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of...
Show moreNational income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of interpersonal warmth on the culture level. In conclusion, raters' economic wealth, either nationally or individually, is significantly associated with perception of outgroup members, supporting the notion that ingroup conditions or stereotypes function as frames of reference in evaluating outgroup traits.
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Date Issued: 2011
Identifier: FSU_migr_geriatrics_faculty_publications-0012, 10.1016/j.jrp.2011.08.001
Format: Citation

Title: Intra-Individual Change in Personality Stability and Age.
Creator: Terracciano, Antonio, McCrae, Robert R., Costa, Paul
Abstract/Description: The stability of individual differences in personality traits is typically examined at the group level with test-retest correlations across two assessments. For 684 subjects (age range 17-76) we computed individual coefficients from three sequential assessments to evaluate intra-individual (i.e., within-person) change in stability over time. For both trait and profile (ipsative) stability, results indicate that intra-individual stability increases up to age 30 and then plateaus. Neither...
Show moreThe stability of individual differences in personality traits is typically examined at the group level with test-retest correlations across two assessments. For 684 subjects (age range 17-76) we computed individual coefficients from three sequential assessments to evaluate intra-individual (i.e., within-person) change in stability over time. For both trait and profile (ipsative) stability, results indicate that intra-individual stability increases up to age 30 and then plateaus. Neither demographic variables (sex, ethnicity, education, and secular trends), nor the standing on the five major dimensions of personality, were predictors of change in trait stability. Contrary to results from studies of adolescents, personality "maturity" was unrelated to personality stability in adulthood. These findings support the notion that personality stability plateaus early in adulthood.
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Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0019, 10.1016/j.jrp.2009.09.006
Format: Citation

Title: Interventions for Heart Failure.
Creator: Glickman, Michael, Rodríguez, Jose
Abstract/Description: The following interventions improve important outcomes in patients with systolic heart failure (all SORs: A, based on meta-analyses): • Angiotensin converting enzyme (ACE) inhibitors reduce mortality, repeat myocardial infarction (MI), and hospitalization rates • Beta-blockers and aldosterone blockers reduce mortality and hospitalization rates • Diuretics reduce mortality and hospitalization rates and improve exercise capacity • Digitalis treatment decreases hospitalization rates and clinical...
Show moreThe following interventions improve important outcomes in patients with systolic heart failure (all SORs: A, based on meta-analyses): • Angiotensin converting enzyme (ACE) inhibitors reduce mortality, repeat myocardial infarction (MI), and hospitalization rates • Beta-blockers and aldosterone blockers reduce mortality and hospitalization rates • Diuretics reduce mortality and hospitalization rates and improve exercise capacity • Digitalis treatment decreases hospitalization rates and clinical deterioration • Aerobic exercise rehabilitation of at least 6 months in duration decreases hospitalization rates and improves quality of life. The following intervention improves important outcomes in African American patients with systolic heart failure (SOR: B, based on a single RCT): • Isosorbide dinitrate and hydralazine combination therapy reduces mortality and hospitalization rates and improves quality of life.
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Date Issued: 2011
Identifier: FSU_migr_fmr-0034
Format: Citation

Title: How Safe and Effective is Pramlintide in Improving Long-Term Glycemic Control and Weight Loss in Patients with Type 2 Diabetes Mellitus Receiving Insulin?.
Creator: Iyengar, Sanjana, Love, Kaitlin, Bauerband, Brian, Rodríguez, Jose
Date Issued: 2013
Identifier: FSU_migr_fmr-0052
Format: Citation

Title: Information Use Environments of African-American Dementia Caregivers Over the Course of Cognitive-Behavioral Therapy for Depression.
Creator: Kazmer, Michelle M., Glueckauf, Robert L., Ma, Jinxuan, Burnett, Kathleen
Abstract/Description: Caregivers of older adults with dementia face significant challenges associated with their care recipients' condition and with their own mental and physical well-being. Qualitative research data were collected via interviews with caregivers who participated in the African-American Alzheimer's Caregiver Training and Support (ACTS) research project. Analysis of these data with a focus on information use indicated that participating caregivers' information use environments were shaped by key...
Show moreCaregivers of older adults with dementia face significant challenges associated with their care recipients' condition and with their own mental and physical well-being. Qualitative research data were collected via interviews with caregivers who participated in the African-American Alzheimer's Caregiver Training and Support (ACTS) research project. Analysis of these data with a focus on information use indicated that participating caregivers' information use environments were shaped by key individuals, settings, and information sources. These included the ACTS counselors, ACTS intervention guidebook, fellow caregivers, use of a personal calendar/datebook, and the identification of key problems and development of goals to help ameliorate those problems. CBT groups fostered sharing, synthesizing, and validating information about dementia caregiving and dementia care resources; the ACTS CBT guidebook served as an important physical touchstone of reliable and portable information. Understanding the specific needs, behaviors, and constraints of African-American caregivers is important to the future development of information components of tailored, depression-reduction interventions.
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Date Issued: 2013
Identifier: FSU_migr_slis_faculty_publications-0016, 10.1016/j.lisr.2013.02.003
Format: Citation

Title: Is Laparoscopic or Open Surgery Better to Prevent Recurrence of an Inguinal Hernia in an Adult Man?: Update.
Creator: Bada, Alvaro, Rodríguez, Jose
Abstract/Description: The risk of recurrence of inguinal hernia is reduced by the use of synthetic mesh, but does not depend on the specific surgical procedure. Compared with the open approach, laparoscopy requires a longer operation (15 minutes longer on average), but decreases recovery time and reduces persistent pain and numbness. (SOR A, based on a systematic review.) Recurrence rates with laparoscopic inguinal hernia repair are highly operator dependent. (SOR A, based on 2 large randomized controlled trials ...
Show moreThe risk of recurrence of inguinal hernia is reduced by the use of synthetic mesh, but does not depend on the specific surgical procedure. Compared with the open approach, laparoscopy requires a longer operation (15 minutes longer on average), but decreases recovery time and reduces persistent pain and numbness. (SOR A, based on a systematic review.) Recurrence rates with laparoscopic inguinal hernia repair are highly operator dependent. (SOR A, based on 2 large randomized controlled trials [RCTs].)
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Date Issued: 2009
Identifier: FSU_migr_fmr-0012
Format: Citation

Department of Family Medicine and Rural Health (41)	+ -
Department of Behavioral Sciences and Social Medicine (38)	+ -
Department of Geriatrics (37)	+ -
Department of Biomedical Sciences (29)	+ -
Center for Innovative Collaboration in Medicine and Law (11)	+ -

Maguire Medical Library (7)	+ -
Department of Nutrition, Food and Exercise Sciences (1)	+ -
School of Information Faculty Scholarship (1)	+ -

Psychology (62)	+ -
Psychiatry (56)	+ -
Human behavior (41)	+ -
Personality (41)	+ -
Social aspects (41)	+ -

Diseases (40)	+ -
Mental health (32)	+ -
Social psychiatry (23)	+ -
Cardiovascular system (22)	+ -
Genetics (21)	+ -
Biochemistry (20)	+ -
Social sciences (20)	+ -
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Developmental biology (18)	+ -
Geriatrics (18)	+ -
Physiology (18)	+ -
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Biophysics (16)	+ -
Mental illness (16)	+ -
Molecular biology (16)	+ -
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Amino acids (14)	+ -
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Proteins (14)	+ -
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Genomics (13)	+ -
Cardiology (11)	+ -

Terracciano, Antonio (50)	+ -
Rodríguez, Jose (39)	+ -
Costa, Paul (36)	+ -
Sutin, Angelina (28)	+ -
Ferrucci, Luigi (22)	+ -

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