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Title: Checkpoint Silencing Regulation by 14-3-3 Proteins.
Creator: Gravenmier, Cutis, College of Medicine
Date Issued: 2013
Identifier: FSU_migr_undergradresearch-0024
Format: Citation

Title: Examination of Nicotine-Induced Alterations in Germ Cell DNA.
Creator: Lopez, Katheryn, Medicine, Biomedical Sciences
Abstract/Description: While evidence from mouse models strongly suggests that prenatal nicotine exposure supports a hyperactive-inattentive phenotype following direct exposure in utero via maternal circulation (Zhu et al 2014), there is little evidence that suggests consequences resulting from indirect exposure of the offspring through a father's use of tobacco products. In order to address the question of the influence of a father smoking on their offspring, we developed a paternal nicotine exposure mouse model...
Show moreWhile evidence from mouse models strongly suggests that prenatal nicotine exposure supports a hyperactive-inattentive phenotype following direct exposure in utero via maternal circulation (Zhu et al 2014), there is little evidence that suggests consequences resulting from indirect exposure of the offspring through a father's use of tobacco products. In order to address the question of the influence of a father smoking on their offspring, we developed a paternal nicotine exposure mouse model in which adult male mice were exposed to nicotine in their drinking water for 12 consecutive weeks.We found that the offspring of these nicotine exposed male mice displayed deficits in working memory and attention, behavioral phenotypes that have been previously linked to ADHD. These intriguing findings were rationale to hypothesize that the fathers' germ cells may have undergone genetic changes as a result of the nicotine exposure and that these changes in the germ cell DNA were the basis for transmission of an ADHD-like phenotype to the offspring.To address these possibilities, we are performing molecular genetic analysis of germ cells and examining gross morphology of the testes of nicotine-exposed fathers to elucidate mechanisms by which paternal nicotine exposure may cause behavioral changes associated with ADHD in the offspring
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Date Issued: 2015
Identifier: FSU_migr_undergradsymposium2015-0025
Format: Citation

Title: 24/7 Access: Crafted in 2010 and Built to Last.
Creator: Rosasco, Robyn, Epstein, Susan A.
Abstract/Description: Objectives Our library has provided 24/7 access for student study space since 2010. This service has functioned as anticipated with minor policy breaches in 2010 and 2013. The purpose of this study was to determine how well 24/7 access to our library is working, obtain student feedback on security procedures, and solicit ideas from all stakeholders for future improvements. Methods Stakeholders for 24/7 access to our academic health sciences library include both the service providers (library,...
Show moreObjectives Our library has provided 24/7 access for student study space since 2010. This service has functioned as anticipated with minor policy breaches in 2010 and 2013. The purpose of this study was to determine how well 24/7 access to our library is working, obtain student feedback on security procedures, and solicit ideas from all stakeholders for future improvements. Methods Stakeholders for 24/7 access to our academic health sciences library include both the service providers (library, student affairs, and security/legal personnel) and the service users (first- and second-year medical students and biomedical graduate students). To evaluate the effectiveness of the library's 24/7 access service, the authors conducted a series of free-response interviews with several service provider and user stakeholders to solicit the most detailed feedback possible. The authors also administered a brief survey to determine if students were satisfied with unstaffed access to library study space. The results of stakeholder feedback were used to evaluate the value of our extensive planning for 24/7 access to the library, our thorough and consistent implementation, and our responsiveness to the needs of our students. Results: Our library director invited (via email) 14 student/staff stakeholders to be interviewed by the primary investigator (PI) and co-PI. Three students and three staff members agreed to be interviewed; five interviews were conducted face-to-face and one was conducted by phone. In addition, our library director sent an email invitation to complete a 10-question survey to approximately 500 students; 114 surveys were completed. From the interviews and the survey, shared themes as well as several unique feedback items emerged. In general, the overwhelming response was that the 24/7 service meets the needs of students, providing a secure, consistent study area for students who do not choose to study in another College of Medicine study space, in another campus library, at home, or at another location. Specifically, 90% of the students were not concerned about safety/security issues in the library during unstaffed hours, 82% indicated that the library environment was conducive to studying during unstaffed hours, and 83% felt that the library's orientation on 24/7 policies and procedures has met their needs. Conclusions: Collecting formal feedback on our 24/7 service has validated the time spent in planning, implementation, and responding to student needs, and has also elicited several ideas for improving the 24/7 service. We plan to continue interviewing and surveying 24/7 stakeholders on a yearly basis to solicit current feedback and continually improve the service.
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Date Issued: 2014
Identifier: FSU_migr_medlib_posters-0003
Format: Citation

Title: Aerobic Exercise and Whole-Body Vibration in Offsetting Bone Loss in Older Adults.
Creator: Liu, Pei-Yang, Brummel-Smith, Kenneth, Ilich, Jasminka
Abstract/Description: Osteoporosis and its associated fractures are common complications of aging and most strategies to prevent and/or treat bone loss focused on antiresorptive medications. However, aerobic exercise (AEX) and/or whole-body vibration (WBV) might have beneficial effect on bone mass and provide an alternative approach to increase or maintain bone mineral density (BMD) and reduce the risk of fractures. The purpose of this paper was to investigate the potential benefits of AEX and WBV on BMD in older...
Show moreOsteoporosis and its associated fractures are common complications of aging and most strategies to prevent and/or treat bone loss focused on antiresorptive medications. However, aerobic exercise (AEX) and/or whole-body vibration (WBV) might have beneficial effect on bone mass and provide an alternative approach to increase or maintain bone mineral density (BMD) and reduce the risk of fractures. The purpose of this paper was to investigate the potential benefits of AEX and WBV on BMD in older population and discuss the possible mechanisms of action. Several online databases were utilized and based on the available literature the consensus is that both AEX and WBV may increase spine and femoral BMD in older adults. Therefore, AEX and WBV could serve as nonpharmacological and complementary approaches to increasing/maintaining BMD. However, it is uncertain if noted effects could be permanent and further studies are needed to investigate sustainability of either type of the exercise.
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Date Issued: 2011
Identifier: FSU_migr_geriatrics_faculty_publications-0042, 10.4061/2011/379674
Format: Citation

Title: Activation Profiles of Human Kallikrein-Related Peptidases by Proteases of the Thrombostasis Axis.
Creator: Yoon, Hyesook, Blaber, Sachiko, Evans, D., Trim, Julie, Juliano, Maria, Scarisbrick, Isobel, Blaber, Michael
Abstract/Description: The human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1-15) and are the single largest family of serine proteases. The KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic targets of interest in cancer and neurodegenerative disease. All KLKs appear to be secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their N-terminal pro-peptide. This processing is a key step in the regulation of...
Show moreThe human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1-15) and are the single largest family of serine proteases. The KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic targets of interest in cancer and neurodegenerative disease. All KLKs appear to be secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their N-terminal pro-peptide. This processing is a key step in the regulation of KLK function. Much recent work has been devoted to elucidating the potential for activation cascades between members of the KLK family, with physiologically relevant KLK regulatory cascades now described in skin desquamation and semen liquefaction. Despite this expanding knowledge of KLK regulation, details regarding the potential for functional intersection of KLKs with other regulatory proteases are essentially unknown. To elucidate such interaction potential, we have characterized the ability of proteases associated with thrombostasis to hydrolyze the pro-peptide sequences of the KLK family using a previously described pro-KLK fusion protein system. A subset of positive hydrolysis results were subsequently quantified with proteolytic assays using intact recombinant pro-KLK proteins. Pro-KLK6 and 14 can be activated by both plasmin and uPA, with plasmin being the best activator of pro-KLK6 identified to date. Pro-KLK11 and 12 can be activated by a broad-spectrum of thrombostasis proteases, with thrombin exhibiting a high degree of selectivity for pro-KLK12. The results show that proteases of the thrombostasis family can efficiently activate specific pro-KLKs, demonstrating the potential for important regulatory interactions between these two major protease families.
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Date Issued: 2008
Identifier: FSU_migr_biomed_faculty_publications-0009
Format: Citation

Title: Analysis of the Molecular Pathogenesis of Cardiomyopathy-Causing cTnT Mutants I79N, ΔE96, and ΔK210.
Creator: Bai, Fan, Caster, Hannah, Pinto, Jose, Kawai, Masataka
Abstract/Description: Three troponin T (TnT) mutants that cause hypertrophic, restrictive, and dilated cardiomyopathy (I79N, ΔE96, and ΔK210, respectively), were examined using the thin-filament extraction/reconstitution technique. Effects of Ca(2+), ATP, phosphate, and ADP concentrations on force and its transients were studied at 25°C. Maximal Ca(2+) tension (THC) and Ca(2+)-activatable tension (Tact), respectively, were similar among I79N, ΔE96, and WT, whereas ΔK210 led to a significantly lower THC (∼20% less)...
Show moreThree troponin T (TnT) mutants that cause hypertrophic, restrictive, and dilated cardiomyopathy (I79N, ΔE96, and ΔK210, respectively), were examined using the thin-filament extraction/reconstitution technique. Effects of Ca(2+), ATP, phosphate, and ADP concentrations on force and its transients were studied at 25°C. Maximal Ca(2+) tension (THC) and Ca(2+)-activatable tension (Tact), respectively, were similar among I79N, ΔE96, and WT, whereas ΔK210 led to a significantly lower THC (∼20% less) and Tact (∼25% less) than did WT. In pCa solution containing 8 mM Pi and ionic strength adjusted to 200 mM, the Ca(2+) sensitivity (pCa50) of I79N (5.63 ± 0.02) and ΔE96 (5.60 ± 0.03) was significantly greater than that of WT (5.45 ± 0.04), but the pCa50 of ΔK210 (5.54 ± 0.04) remained similar to that of WT. Five equilibrium constants were deduced using sinusoidal analysis. All three mutants showed significantly lower K0 (ADP association constant) and larger K4 (equilibrium constant of force generation step) relative to the corresponding values for WT. I79N and ΔK210 were associated with a K2 (equilibrium constant of cross-bridge detachment step) significantly lower than that of ΔE96 and WT. These results demonstrated that at pCa 4.66, the force/cross-bridge is ∼18% less in I79N and ∼41% less in ΔK210 than that in WT. These results indicate that the molecular pathogenesis of the cardiac TnT mutation-related cardiomyopathies is different for each mutation.
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Date Issued: 2013
Identifier: FSU_migr_biomed_faculty_publications-0051, 10.1016/j.bpj.2013.04.001
Format: Citation

Title: Absence of Myocardial Thyroid Hormone Inactivating Deiodinase Results in Restrictive Cardiomyopathy in Mice.
Creator: Ueta, Cintia, Oskouei, Behzad, Olivares, Emerson, Pinto, Jose, Correa, Mayrin, Simovic, Gordana, Simonides, Warner, Hare, Joshua, Bianco, Antônio Carlos
Abstract/Description: Cardiac injury induces myocardial expression of the thyroid hormone inactivating type 3 deiodinase (D3), which in turn dampens local thyroid hormone signaling. Here, we show that the D3 gene (Dio3) is a tissue-specific imprinted gene in the heart, and thus, heterozygous D3 knockout (HtzD3KO) mice constitute a model of cardiac D3 inactivation in an otherwise systemically euthyroid animal. HtzD3KO newborns have normal hearts but later develop restrictive cardiomyopathy due to cardiac-specific...
Show moreCardiac injury induces myocardial expression of the thyroid hormone inactivating type 3 deiodinase (D3), which in turn dampens local thyroid hormone signaling. Here, we show that the D3 gene (Dio3) is a tissue-specific imprinted gene in the heart, and thus, heterozygous D3 knockout (HtzD3KO) mice constitute a model of cardiac D3 inactivation in an otherwise systemically euthyroid animal. HtzD3KO newborns have normal hearts but later develop restrictive cardiomyopathy due to cardiac-specific increase in thyroid hormone signaling, including myocardial fibrosis, impaired myocardial contractility, and diastolic dysfunction. In wild-type littermates, treatment with isoproterenol-induced myocardial D3 activity and an increase in the left ventricular volumes, typical of cardiac remodeling and dilatation. Remarkably, isoproterenol-treated HtzD3KO mice experienced a further decrease in left ventricular volumes with worsening of the diastolic dysfunction and the restrictive cardiomyopathy, resulting in congestive heart failure and increased mortality. These findings reveal crucial roles for Dio3 in heart function and remodeling, which may have pathophysiologic implications for human restrictive cardiomyopathy.
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Date Issued: 2012
Identifier: FSU_migr_biomed_faculty_publications-0052, 10.1210/me.2011-1325
Format: Citation

Title: Abandoning the Dead Donor Rule?: A National Survey of Public Views on Death and Organ Donation.
Creator: Nair-Collins, Michael, Green, Sydney, Sutin, Angelina
Abstract/Description: Brain dead organ donors are the principal source of transplantable organs. However, it is controversial whether brain death is the same as biological death. Therefore, it is unclear whether organ removal in brain death is consistent with the 'dead donor rule', which states that organ removal must not cause death. Our aim was to evaluate the public's opinion about organ removal if explicitly described as causing the death of a donor in irreversible apneic coma. We conducted a cross-sectional...
Show moreBrain dead organ donors are the principal source of transplantable organs. However, it is controversial whether brain death is the same as biological death. Therefore, it is unclear whether organ removal in brain death is consistent with the 'dead donor rule', which states that organ removal must not cause death. Our aim was to evaluate the public's opinion about organ removal if explicitly described as causing the death of a donor in irreversible apneic coma. We conducted a cross-sectional internet survey of the American public (n=1096). Questionnaire domains included opinions about a hypothetical scenario of organ removal described as causing the death of a patient in irreversible coma, and items measuring willingness to donate organs after death. Some 71% of the sample agreed that it should be legal for patients to donate organs in the scenario described and 67% agreed that they would want to donate organs in a similar situation. Of the 85% of the sample who agreed that they were willing to donate organs after death, 76% agreed that they would donate in the scenario of irreversible coma with organ removal causing death. There appears to be public support for organ donation in a scenario explicitly described as violating the dead donor rule. Further, most but not all people who would agree to donate when organ removal is described as occurring after death would also agree to donate when organ removal is described as causing death in irreversible coma.
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Date Issued: 2014
Identifier: FSU_migr_mhs-0040, 10.1136/medethics-2014-102229
Format: Citation

Title: ACU Workforce Column: Expanding and Supporting the Health Care Workforce.
Creator: Richert, Amber, Campbell, Kendall, Rodríguez, Jose, Borowsky, Iris, Parikh, Rajesh, Colwell, Ashley
Date Issued: 2013
Identifier: FSU_migr_fmr-0050, 10.1353/hpu.2013.0162
Format: Citation

Title: For Love, Legacy, or Pay: Legal and Pecuniary Aspects of Family Caregiving.
Creator: Kapp, Marshall B.
Abstract/Description: Most caregiving and companionship provided by family members and friends to older individuals in home environments occurs because of the caregiver's feelings of ethical and emotional obligation and attachment. From a legal perspective, though, it might be ill-advised for an informal caregiver to admit such a motivation. Building on a recently published study of relevant litigation, this essay discusses changing cultural and legal aspects of family caregiving when there is some expectation of...
Show moreMost caregiving and companionship provided by family members and friends to older individuals in home environments occurs because of the caregiver's feelings of ethical and emotional obligation and attachment. From a legal perspective, though, it might be ill-advised for an informal caregiver to admit such a motivation. Building on a recently published study of relevant litigation, this essay discusses changing cultural and legal aspects of family caregiving when there is some expectation of pay, property, or future financial legacy in return for the caregiver's present work and sacrifices.
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Date Issued: 2012
Identifier: FSU_migr_medlawcenter_publications-0007
Format: Citation

Title: Four Years of Group Visits Treating Obesity in an Under Served Urban Community: Health not Cosmetics.
Creator: Rodríguez, Jose, Painter, Kimberly, Bent, Gloria
Date Issued: 2007
Identifier: FSU_migr_fmr-0036
Format: Citation

Title: Genetics of Serum BDNF: Meta-analysis of the Val66Met and Genome-wide Association Study.
Creator: Terracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger,...
Show moreTerracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger, David
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Abstract/Description: Abstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of...
Show moreAbstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of serum BDNF to be 0.48 from sib-pairs. There was no association between serum BDNF and Val66Met in the SardiNIA sample and in a meta-analysis of published studies (k = 13 studies, total n = 4727, P = 0.92). Although no genome-wide significant associations were identified, some evidence of association was found in the BDNF gene (rs11030102, P = 0.001) and at two loci (rs7170215, P = 4.8 × 10(-5) and rs11073742 P = 1.2 × 10(-5)) near and within NTRK3 gene, a neurotrophic tyrosine kinase receptor. Conclusions. Our study and meta-analysis of the literature indicate that the BDNF Val66Met variant is not associated with serum BDNF, but other variants in the BDNF and NTRK3 genes might regulate the level of serum BDNF.
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Date Issued: 2011
Identifier: FSU_migr_mhs-0014, 10.3109/15622975.2011.616533
Format: Citation

Title: Genome-Wide Association Scan of Trait Depression.
Creator: Terracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa...
Show moreTerracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa, Paul
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Abstract/Description: BACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a...
Show moreBACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a genetically homogeneous area of Sardinia, Italy (n = 3972) and from the Baltimore Longitudinal Study of Aging in the United States (n = 839). RESULTS: Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷·), a gene involved in circadian rhythm. A plausible biological association was also found with single nucleotide polymorphisms within GRM8 (rs17864092; p = 5 × 10⁻⁶), a metabotropic receptor for glutamate, a major excitatory neurotransmitter in the central nervous system. CONCLUSIONS: These findings suggest shared genetic basis underlying the continuum from personality traits to psychopathology.
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Date Issued: 2010
Identifier: FSU_migr_mhs-0023, 10.1016/j.biopsych.2010.06.030
Format: Citation

Title: Ethnicity, Education, and the Temporal Stability of Personality Traits In the East Baltimore Epidemiologic Catchment Area Study.
Creator: Löckenhoff, Corinna, Terracciano, Antonio, Bienvenu, O. Joseph, Patriciu, Nicholas, Nestadt, Gerald, McCrae, Robert R., Eaton, William W., Costa, Paul
Abstract/Description: We examined the influence of age, gender, Black vs. White ethnicity, and education on five indices of personality stability and change across an average interval of 8 years in the East Baltimore Epidemiologic Catchment Area study. In the full sample (n = 505, aged 30-88), examination of structural, rank-order, ipsative, and mean level stability, as well as indices of reliable change suggested that NEO-PI-R personality traits showed moderate to high levels of stability over time. There were...
Show moreWe examined the influence of age, gender, Black vs. White ethnicity, and education on five indices of personality stability and change across an average interval of 8 years in the East Baltimore Epidemiologic Catchment Area study. In the full sample (n = 505, aged 30-88), examination of structural, rank-order, ipsative, and mean level stability, as well as indices of reliable change suggested that NEO-PI-R personality traits showed moderate to high levels of stability over time. There were few age and gender effects on temporal stability but rank-order, ipsative, and mean level stability were lower among Blacks and individuals with lower education. Future research should explore additional demographic predictors of temporal plasticity in a diverse range of samples, and employ observer ratings to assess personality.
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Date Issued: 2008
Identifier: FSU_migr_geriatrics_faculty_publications-0028, 10.1016/j.jrp.2007.09.004
Format: Citation

Title: Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment.
Creator: Krenzer, Stefanie, Peterziel, Heike, Mauch, Cornelia, Blaber, Sachiko, Blaber, Michael, Angel, Peter, Hess, Jochen
Abstract/Description: Cutaneous malignant melanoma is an aggressive disease of poor prognosis. Clinical and experimental studies have provided major insight into the pathogenesis of the disease, including the functional interaction between melanoma cells and surrounding keratinocytes, fibroblasts, and immune cells. Nevertheless, patients with metastasized melanoma have a very poor prognosis and are largely refractory to clinical therapies. Hence, diagnostic tools to monitor melanoma development, as well as...
Show moreCutaneous malignant melanoma is an aggressive disease of poor prognosis. Clinical and experimental studies have provided major insight into the pathogenesis of the disease, including the functional interaction between melanoma cells and surrounding keratinocytes, fibroblasts, and immune cells. Nevertheless, patients with metastasized melanoma have a very poor prognosis and are largely refractory to clinical therapies. Hence, diagnostic tools to monitor melanoma development, as well as therapeutic targets, are urgently needed. We investigated the expression pattern of the kallikrein-related peptidase 6 (KLK6) in human melanoma tissue sections throughout tumor development. Although KLK6 was not detectable in tumor cells, we found strong KLK6 protein expression in keratinocytes and stromal cells located adjacent to benign nevi, primary melanomas, and cutaneous metastatic lesions, suggesting a paracrine function of extracellular KLK6 during neoplastic transformation and malignant progression. Accordingly, recombinant Klk6 protein significantly induced melanoma cell migration and invasion accompanied by an accelerated intracellular Ca(2+) flux. We could further demonstrate that KLK6-induced intracellular Ca(2+) flux and tumor cell invasion critically depends on the protease-activated receptor 1 (PAR1). Our data provide experimental evidence that specific inhibition of the KLK6-PAR1 axis may interfere with the deleterious effect of tumor-microenvironment interaction and represent a potential option for translational melanoma research.
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Date Issued: 2011
Identifier: FSU_migr_biomed_faculty_publications-0024, 10.1038/jid.2011.190
Format: Citation

Title: Geriatric Depression: Do Older Persons Have a Right to Be Unhappy?.
Creator: Kapp, Marshall B.
Abstract/Description: Clinical depression is a serious medical problem in the older population. Although it is considered to be highly treatable, physicians and other health care professionals often are criticized for doing an inadequate job of recognizing, and then treating, depression in older persons. They are routinely exhorted to improve their performance by being more aggressive in recognizing and intervening with this clinical condition. Yet, the mandate to provide aggressive treatment of depression is not...
Show moreClinical depression is a serious medical problem in the older population. Although it is considered to be highly treatable, physicians and other health care professionals often are criticized for doing an inadequate job of recognizing, and then treating, depression in older persons. They are routinely exhorted to improve their performance by being more aggressive in recognizing and intervening with this clinical condition. Yet, the mandate to provide aggressive treatment of depression is not always uncontroversial. Rather, medical intervention for older patients may raise a number of challenging legal, as well as ethical, questions. Using a case example, this article outlines some of the salient legal issues implicated by an older person's right to be and act depressed and the exceptions to that right.
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Date Issued: 2002
Identifier: FSU_migr_medlawcenter_publications-0002
Format: Citation

Title: GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment.
Creator: Rietveld, Cornelius, Medland, Sarah, Derringer, Jaime, Yang, Jian, Esko, Tönu, Martin, Nicolas, Westra, Harm-Jan, Shakhbazov, Konstantin, Abdellaoui, Abdel, Agrawal, Arpana,...
Show moreRietveld, Cornelius, Medland, Sarah, Derringer, Jaime, Yang, Jian, Esko, Tönu, Martin, Nicolas, Westra, Harm-Jan, Shakhbazov, Konstantin, Abdellaoui, Abdel, Agrawal, Arpana, Albrecht, Eva, Alizadeh, Behrooz, Amin, Najaf, Barnard, John, Baumeister, Sebastian, Benke, Kelly, Bielak, Lawrence, Boatman, Jeffrey A., Boyle, Patricia, Davies, Gail, de Leeuw, Christiaan, Eklund, Niina, Evans, Daniel, Ferhmann, Rudolf, Fischer, Krista, Gieger, Christian, Gjessing, Håkon K, Hägg, Sara, Harris, Jennifer, Hayward, Caroline, Holzapfel, Christina, Ibrahim-Verbaas, Carla, Ingelsson, Erik, Jacobsson, Bo, Joshi, Peter, Jugessur, Astanand, Kaakinen, Marika, Kanoni, Stavroula, Karjalainen, Juha, Kolcic, Ivana, Kristiansson, Kati, Kutalik, Zoltán, Lahti, Jari, Lee, Sang, Lin, Peng, Lind, Penelope, Liu, Yongmei, Lohman, Kurt, Loitfelder, Marisa, McMahon, George, Vidal, Pedro, Meirelles, Osorio, Milani, Lili, Myhre, Ronny, Nuotio, Marja-Liisa, Oldmeadow, Christopher, Petrovic, Katja, Peyrot, Wouter, Polasek, Ozren, Quaye, Lydia, Reinmaa, Eva, Rice, John, Rizzi, Thais, Schmidt, Helena, Schmidt, Reinhold, Smith, Albert, Smith, Jennifer, Tanaka, Toshiko, Terracciano, Antonio, van der Loos, Matthijs, Vitart, Veronique, Völzke, Henry, Wellmann, Jürgen, Yu, Lei, Zhao, Wei, Allik, Jüri, Attia, John, Bandinelli, Stefania, Bastardot, François, Beauchamp, Jonathan, Bennett, David, Berger, Klaus, Bierut, Laura, Boomsma, Dorret, Bültmann, Ute, Campbell, Harry, Chabris, Christopher, Cherkas, Lynn, Chung, Mina, Cucca, Francesco, de Andrade, Mariza, De Jager, Philip, De Neve, Jan-Emmanuel, Deary, Ian J., Dedoussis, George, Deloukas, Panos, Dimitriou, Maria, Eiríksdóttir, Guðny, Elderson, Martin, Eriksson, Johan, Evans, David, Faul, Jessica, Ferrucci, Luigi, Garcia, Melissa, Grönberg, Henrik, Guðnason, Vilmundur, Hall, Per, Harris, Juliette, Harris, Tamara, Hastie, Nicholas, Heath, Andrew, Hernandez, Dena, Hoffmann, Wolfgang, Hofman, Adriaan, Holle, Rolf, Holliday, Elizabeth, Hottenga, Jouke-Jan, Iacono, William, Illig, Thomas, Järvelin, Marjo-Riitta, Kähönen, Mika, Kaprio, Jaakko, Kirkpatrick, Robert, Kowgier, Matthew, Latvala, Antti, Launer, Lenore, Lawlor, Debbie, Lehtimäki, Terho, Li, Jingmei, Lichtenstein, Paul, Lichtner, Peter, Liewald, David, Madden, Pamela, Magnusson, Patrik, Mäkinen, Tomi, Masala, Marco, McGue, Matthew, Metspalu, Andres, Mielck, Andreas, Miller, Michael, Montgomery, Grant, Mukherjee, Sutapa, Nyholt, Dale, Oostra, Ben A., Palmer, Lyle, Palotie, Aarno, Penninx, Brenda, Perola, Markus, Peyser, Patricia, Preisig, Martin, Räikkönen, Katri, Raitakari, Olli, Realo, Anu, Ring, Susan, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sarin, Antti-Pekka, Schlessinger, David, Scott, Rodney, Snieder, Harold, St Pourcain, Beate, Starr, John M., Sul, Jae, Surakka, Ida, Svento, Rauli, Teumer, Alexander, Tiemeier, Henning, van Rooij, Frank, Van Wagoner, David, Vartiainen, Erkki, Viikari, Jorma, Vollenweider, Peter, Vonk, Judith, Waeber, Gérard, Weir, David, Wichmann, H.-Erich (Heinz-Erich), Widen, Elisabeth, Willemsen, Gonneke, Wilson, James F. (James Flett), Wright, Alan, Conley, Dalton, Smith, George Davey, Franke, Lude, Groenen, Patrick, Hofman, Albert, Johannesson, Magnus, Kardia, Sharon, Krueger, Robert F., Laibson, David, Martin, Nicholas G., Meyer, Michelle, Posthuma, Danielle, Thurik, A. R. (A. Roy), Timpson, Nicholas, Uitterlinden, André G., van Duijn, Cornelia, Visscher, Peter, Benjamin, Daniel, Cesarini, David, Koellinger, Philipp
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Abstract/Description: A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2%...
Show moreA genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
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Date Issued: 2013
Identifier: FSU_migr_geriatrics_faculty_publications-0007, 10.1126/science.1235488
Format: Citation

Title: Functional Role of Kallikrein 6 in Regulating Immune Cell Survival.
Creator: Scarisbrick, Isobel, Epstein, Benjamin, Cloud, Beth, Yoon, Hyesook, Wu, Jianmin, Renner, Danielle, Blaber, Sachiko, Blaber, Michael, Vandell, Alexander, Bryson, Alexandra
Abstract/Description: BACKGROUND: Kallikrein 6 (KLK6) is a newly identified member of the kallikrein family of secreted serine proteases that prior studies indicate is elevated at sites of central nervous system (CNS) inflammation and which shows regulated expression with T cell activation. Notably, KLK6 is also elevated in the serum of multiple sclerosis (MS) patients however its potential roles in immune function are unknown. Herein we specifically examine whether KLK6 alters immune cell survival and the...
Show moreBACKGROUND: Kallikrein 6 (KLK6) is a newly identified member of the kallikrein family of secreted serine proteases that prior studies indicate is elevated at sites of central nervous system (CNS) inflammation and which shows regulated expression with T cell activation. Notably, KLK6 is also elevated in the serum of multiple sclerosis (MS) patients however its potential roles in immune function are unknown. Herein we specifically examine whether KLK6 alters immune cell survival and the possible mechanism by which this may occur. METHODOLOGY/PRINCIPAL FINDINGS: Using murine whole splenocyte preparations and the human Jurkat T cell line we demonstrate that KLK6 robustly supports cell survival across a range of cell death paradigms. Recombinant KLK6 was shown to significantly reduce cell death under resting conditions and in response to camptothecin, dexamethasone, staurosporine and Fas-ligand. Moreover, KLK6-over expression in Jurkat T cells was shown to generate parallel pro-survival effects. In mixed splenocyte populations the vigorous immune cell survival promoting effects of KLK6 were shown to include both T and B lymphocytes, to occur with as little as 5 minutes of treatment, and to involve up regulation of the pro-survival protein B-cell lymphoma-extra large (Bcl-XL), and inhibition of the pro-apoptotic protein Bcl-2-interacting mediator of cell death (Bim). The ability of KLK6 to promote survival of splenic T cells was also shown to be absent in cell preparations derived from PAR1 deficient mice. CONCLUSION/SIGNIFICANCE: KLK6 promotes lymphocyte survival by a mechanism that depends in part on activation of PAR1. These findings point to a novel molecular mechanism regulating lymphocyte survival that is likely to have relevance to a range of immunological responses that depend on apoptosis for immune clearance and maintenance of homeostasis.
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Date Issued: 2011
Identifier: FSU_migr_biomed_faculty_publications-0022, 10.1371/journal.pone.0018376
Format: Citation

Title: Functional Effects of a Restrictive-Cardiomyopathy-Linked Cardiac Troponin I Mutation (R145W) in Transgenic Mice.
Creator: Wen, Yuhui, Xu, Yuanyuan, Wang, Yingcai, Pinto, Jose, Potter, James, Kerrick, W.
Abstract/Description: The human cardiac troponin I (hcTnI) mutation R145W has been associated with restrictive cardiomyopathy. In this study, simultaneous measurements of ATPase activity and force in skinned papillary fibers from hcTnI R145W transgenic mice (Tg-R145W) were explored. Tg-R145W fibers showed an approximately 13-16% increase in maximal Ca(2+)-activated force and ATPase activity compared to hcTnI wild-type transgenic mice. The force-generating cross-bridge turnover rate (g) and the energy cost (ATPase...
Show moreThe human cardiac troponin I (hcTnI) mutation R145W has been associated with restrictive cardiomyopathy. In this study, simultaneous measurements of ATPase activity and force in skinned papillary fibers from hcTnI R145W transgenic mice (Tg-R145W) were explored. Tg-R145W fibers showed an approximately 13-16% increase in maximal Ca(2+)-activated force and ATPase activity compared to hcTnI wild-type transgenic mice. The force-generating cross-bridge turnover rate (g) and the energy cost (ATPase/force) were the same in all groups of fibers. Also, the Tg-R145W fibers showed a large increase in the Ca(2+) sensitivity of both force development and ATPase. In intact fibers, the mutation caused prolonged force and intracellular [Ca(2+)] transients and increased time to peak force. Analysis of force and Ca(2+) transients showed that there was a 40% increase in peak force in Tg-R145W muscles, which was likely due to the increased Ca(2+) transient duration. The above cited results suggest that: (1) there would be an increase in resistance to ventricular filling during diastole resulting from the prolonged force and Ca(2+) transients that would result in a decrease in ventricular filling (diastolic dysfunction); and (2) there would be a large (approximately 53%) increase in force during systole, which may help to partly compensate for diastolic dysfunction. These functional results help to explain the mechanisms by which these mutations give rise to a restrictive phenotype.
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Date Issued: 2009
Identifier: FSU_migr_biomed_faculty_publications-0060, 10.1016/j.jmb.2009.07.080
Format: Citation

Title: A Legal Approach to the Use of Human Biological Materials for Research Purposes.
Creator: Kapp, Marshall B.
Abstract/Description: Human Biological Materials (HBM) come from individuals in a variety of circumstances. The use of HBM for research purposes raises a host of difficult ethical questions. The law is important in this arena because, in most cases, legal principles significantly influence the making of ethical choices. Following a general overview of research regulation in the United States generally and a few comments on the relevance of international statements for this country, this article explores several...
Show moreHuman Biological Materials (HBM) come from individuals in a variety of circumstances. The use of HBM for research purposes raises a host of difficult ethical questions. The law is important in this arena because, in most cases, legal principles significantly influence the making of ethical choices. Following a general overview of research regulation in the United States generally and a few comments on the relevance of international statements for this country, this article explores several specific legal issues, and their ethical implications, related to the obtaining and handling of HBM for research purposes, namely: informed consent; privacy; and commercial or ownership (property) interests in HBM. The article concludes that, although the realistic liability risks are low, the law's important role in characterizing the rights and responsibilities involved will be very influential in shaping the ways that the chasm between science and ethics is resolved within the context of the use of human tissue for research purposes.
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Date Issued: 2012
Identifier: FSU_migr_medlawcenter_publications-0004
Format: Citation

Title: Legal Issues Arising in the Process of Determining Decisional Capacity in Older Persons.
Creator: Kapp, Marshall B.
Abstract/Description: There is an increasing incidence of dementia, depression and other affective disorders, delirium, and other mental health problems such as psychoses among older individuals in the United States. Because the severity of mental illness, in terms of cognitive and behavioral impairment and therefore the illness' impact on functional ability, varies for different patients at different times along a continuum, there is not an automatic correlation between an older person's clinical diagnosis and a...
Show moreThere is an increasing incidence of dementia, depression and other affective disorders, delirium, and other mental health problems such as psychoses among older individuals in the United States. Because the severity of mental illness, in terms of cognitive and behavioral impairment and therefore the illness' impact on functional ability, varies for different patients at different times along a continuum, there is not an automatic correlation between an older person's clinical diagnosis and a dichotomous determination that the individual does or does not possess sufficient present capacity to personally make various sorts of fundamental life decisions. Decisional capacity assessment in the aged carries important implications both for the official adjudication of legal competence and for patient/client management in the vast majority of cases involving "bumbling through." There exists many salient, but generally overlooked, legal and ethical concerns immersed in the health care or human services provider's attempt to evaluate the decisional capacity of a particular older patient/client. This article surveys the most important of those concerns, which arise before we ever get to the point of applying assessment data to the relevant legal and ethical standards of decisional capacity.
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Date Issued: 2010
Identifier: FSU_migr_medlawcenter_publications-0003
Format: Citation

Title: A Letter to the Editor: Under-Represented Minority Faculty in Academic Medical Centers.
Creator: Campbell, Kendall
Date Issued: 2013
Identifier: FSU_migr_fmr-0042
Format: Citation

Title: Making Medical Decisions for Someone Else: A Florida Handbook.
Creator: Kapp, Marshall B.
Abstract/Description: If you make health care decisions for another adult person—or might at some future point—this handbook is for you. Learn what it means to become a "health care substitute."
Date Issued: 2011
Identifier: FSU_migr_medlawcenter_publications-0001
Format: Citation

Title: Libraries for New Medical Schools: The Creation of a Network for Identifying and Supporting the Needs of 21st Century Medical Schools.
Creator: Boilard, David, Dexter, Nadine, Doyle, Jacqueline, Rand, Debra, Shearer, Barbara
Abstract/Description: As new medical schools are developing, new academic libraries must also be created to support the schools' missions, faculty, students, and curricula. The formation of a network of these new and emerging academic health sciences libraries is described. In June 2012, the First Symposium on Creating New Academic Health Sciences Libraries was held in Orlando, Florida. Sponsored by the Association of Academic Health Sciences Libraries (AAHSL), this inaugural Symposium brought together...
Show moreAs new medical schools are developing, new academic libraries must also be created to support the schools' missions, faculty, students, and curricula. The formation of a network of these new and emerging academic health sciences libraries is described. In June 2012, the First Symposium on Creating New Academic Health Sciences Libraries was held in Orlando, Florida. Sponsored by the Association of Academic Health Sciences Libraries (AAHSL), this inaugural Symposium brought together representatives from 16 new schools to discuss planning needed for the LCME process for library services and resources, to discuss experiences and challenges, and to share visions of 'born digital' libraries. Because this is a priority initiative of the AAHSL, the Association will continue to support members of this group by providing information and additional networking opportunities.
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Date Issued: 2012
Identifier: FSU_migr_medlib_posters-0001
Format: Citation

Title: How Long Should Antibiotic Therapy Be Continued for an Uncomplicated, Symptomatic Lower UTI in an Elderly Woman?.
Creator: Radkay, Lisa, Rodríguez, Jose
Abstract/Description: Elderly women with symptomatic lower urinary tract infections (UTIs) should be treated for 3 to 6 days with oral antibiotics. This duration provides better short-term outcomes than 1-day therapy and has long-term outcomes equivalent to 7- to 14-day therapy. (SOR B, based on a systematic review of heterogeneous RCTs.)
Date Issued: 2010
Identifier: FSU_migr_fmr-0028
Format: Citation

Title: How Are Thyroid Function Tests Altered by Thyroid Replacement Medications?.
Creator: Shah, Shawn, Rodríguez, Jose
Abstract/Description: Small changes in the dosing of levothyroxine (±25 mcg) are associated with large changes in serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations, but not with measurable changes in hypothyroid symptoms, well-being, or quality of life. (SOR: B, based on a single RCT.) Taking levothyroxine while fasting is associated with a higher serum FT4 and lower serum TSH compared with administration after a meal, but these differences are small. (SOR: C, based on a single RCT...
Show moreSmall changes in the dosing of levothyroxine (±25 mcg) are associated with large changes in serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations, but not with measurable changes in hypothyroid symptoms, well-being, or quality of life. (SOR: B, based on a single RCT.) Taking levothyroxine while fasting is associated with a higher serum FT4 and lower serum TSH compared with administration after a meal, but these differences are small. (SOR: C, based on a single RCT using disease-oriented outcomes.)
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Date Issued: 2010
Identifier: FSU_migr_fmr-0032
Format: Citation

Title: Impact of a Creative Arts Journal on a Medical School Community: A Qualitative Study.
Creator: Rodríguez, Jose, Welch, Tana, Edwards, Janine C.
Abstract/Description: The Florida State University College of Medicine (FSUCOM) has created a new creative arts journal called HEAL: Humanism Evolving through Arts and Literature. This study was designed to evaluate the influence creative arts publications may have on students, faculty, and staff of a medical school. The investigators randomly selected 17 participants from 25 volunteers in the HEAL project who agreed to be interviewed. They used consensual qualitative research methods to analyze the data,...
Show moreThe Florida State University College of Medicine (FSUCOM) has created a new creative arts journal called HEAL: Humanism Evolving through Arts and Literature. This study was designed to evaluate the influence creative arts publications may have on students, faculty, and staff of a medical school. The investigators randomly selected 17 participants from 25 volunteers in the HEAL project who agreed to be interviewed. They used consensual qualitative research methods to analyze the data, identifying major areas of impact HEAL had on the faculty, students, and staff. Three major themes were identified: Strengthening Professional Relationships (SPR), Educational Enhancement (EE), and Self-Expression (SE). The following sub-themes were identified: SPR—changed perceptions; SE—artistic self-expression; EE—faculty example, and positive reinforcement of career choice. HEAL is perceived as a valuable part of medical education, and the identified themes can be tested in further research.
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Date Issued: 2012
Identifier: FSU_migr_fmr-0048, 10.1080/08893675.2012.736179
Format: Citation

Title: Kallikrein 6 is a Novel Molecular Trigger of Reactive Astrogliosis.
Creator: Scarisbrick, Isobel, Radulovic, Maja, Burda, Joshua, Larson, Nadya, Blaber, Sachiko, Giannini, Caterina, Blaber, Michael, Vandell, Alexander
Abstract/Description: Kallikrein-related peptidase 6 (KLK6) is a trypsin-like serine protease upregulated at sites of central nervous system (CNS) injury, including de novo expression by reactive astrocytes, yet its physiological actions are largely undefined. Taken with recent evidence that KLK6 activates G-protein-coupled protease-activated receptors (PARs), we hypothesized that injury-induced elevations in KLK6 contribute to the development of astrogliosis and that this occurs in a PAR-dependent fashion. Using...
Show moreKallikrein-related peptidase 6 (KLK6) is a trypsin-like serine protease upregulated at sites of central nervous system (CNS) injury, including de novo expression by reactive astrocytes, yet its physiological actions are largely undefined. Taken with recent evidence that KLK6 activates G-protein-coupled protease-activated receptors (PARs), we hypothesized that injury-induced elevations in KLK6 contribute to the development of astrogliosis and that this occurs in a PAR-dependent fashion. Using primary murine astrocytes and the Neu7 astrocyte cell line, we show that KLK6 causes astrocytes to transform from an epitheliod to a stellate morphology and to secrete interleukin 6 (IL-6). By contrast, KLK6 reduced expression of glial fibrillary acidic protein (GFAP). The stellation-promoting activities of KLK6 were shown to be dependent on activation of the thrombin receptor, PAR1, as a PAR1-specific inhibitor, SCH79797, blocked KLK6-induced morphological changes. The ability of KLK6 to promote astrocyte stellation was also shown to be linked to activation of protein kinase C (PKC). These studies indicate that KLK6 is positioned to serve as a molecular trigger of select physiological processes involved in the development of astrogliosis and that this is likely to occur at least in part by activation of the G-protein-coupled receptor, PAR1.
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Date Issued: 2012
Identifier: FSU_migr_biomed_faculty_publications-0030, 10.1515/hsz-2011-0241
Format: Citation

Title: Hypothalamic-Pituitary Function in Brain Death: A Review.
Creator: Nair-Collins, Michael, Northrup, Jesse, Olcese, James
Abstract/Description: The Uniform Determination of Death Act (UDDA) states that an individual is dead when "all functions of the entire brain" have ceased irreversibly. However, it has been questioned whether some functions of the hypothalamus, particularly osmoregulation, can continue after the clinical diagnosis of brain death (BD). In order to learn whether parts of the hypothalamus can continue to function after the diagnosis of BD, we performed 2 separate systematic searches of the MEDLINE database,...
Show moreThe Uniform Determination of Death Act (UDDA) states that an individual is dead when "all functions of the entire brain" have ceased irreversibly. However, it has been questioned whether some functions of the hypothalamus, particularly osmoregulation, can continue after the clinical diagnosis of brain death (BD). In order to learn whether parts of the hypothalamus can continue to function after the diagnosis of BD, we performed 2 separate systematic searches of the MEDLINE database, corresponding to the functions of the posterior and anterior pituitary. No meta-analysis is possible due to nonuniformity in the clinical literature. However, some modest generalizations can reasonably be drawn from a narrative review and from anatomic considerations that explain why these findings should be expected. We found evidence suggesting the preservation of hypothalamic function, including secretion of hypophysiotropic hormones, responsiveness to anterior pituitary stimulation, and osmoregulation, in a substantial proportion of patients declared dead by neurological criteria. We discuss several possible explanations for these findings. We conclude by suggesting that additional clinical research with strict inclusion criteria is necessary and further that a more nuanced and forthright public dialogue is needed, particularly since standard diagnostic practices and the UDDA may not be entirely in accord.
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Date Issued: 2014
Identifier: FSU_migr_mhs-0041, 10.1177/0885066614527410
Format: Citation

Title: Humans Are Mortal?!: I'm Calling My Attorney.
Creator: Kapp, Marshall B.
Date Issued: 2010
Identifier: FSU_migr_medlawcenter_presentations-0002
Format: Citation

Title: Increasing our Library's Value with DALRs.
Creator: Epstein, Susan A.
Abstract/Description: Increasing our Library's Value with DALRs The Maguire Medical Library (MML) at the Florida State University has been developing a unique service for faculty and other researchers who need advanced, long-term assistance using a variety of library resources. Because such research projects typically involve formulating various search strategies, searching several library databases in-depth, and collecting, managing and sharing citations, the MML DALR program uses a team approach to meet...
Show moreIncreasing our Library's Value with DALRs The Maguire Medical Library (MML) at the Florida State University has been developing a unique service for faculty and other researchers who need advanced, long-term assistance using a variety of library resources. Because such research projects typically involve formulating various search strategies, searching several library databases in-depth, and collecting, managing and sharing citations, the MML DALR program uses a team approach to meet researchers' needs. With a team approach, the time and skills of librarians, researchers in the College of Medicine's academic departments, and associates for library research embedded within each department complement each other efficiently and effectively. The poster describes how the research team concept evolved, and features examples of the project documentation, such as the participation requirements for the departmental associates for library research (DALRs). Viewers of this poster will hopefully be able to determine if a team approach to library research might be useful in their own work environments.
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Date Issued: 2013
Identifier: FSU_migr_medlib_posters-0004
Format: Citation

Title: Kallikreins are Associated with Secondary Progressive Multiple Sclerosis and Promote Neurodegeneration.
Creator: Scarisbrick, Isobel, Linbo, Rachel, Vandell, Alexander, Keegan, Mark, Blaber, Sachiko, Blaber, Michael, Sneve, Diane, Lucchinetti, Claudia F., Rodriguez, Moses, Diamandis,...
Show moreScarisbrick, Isobel, Linbo, Rachel, Vandell, Alexander, Keegan, Mark, Blaber, Sachiko, Blaber, Michael, Sneve, Diane, Lucchinetti, Claudia F., Rodriguez, Moses, Diamandis, Eleftherios P.
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Abstract/Description: Tissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 10 were determined in 35 MS patients and 62 controls by quantitative fluorometric ELISA. Serum levels were then correlated with Expanded Disability Status Scale (EDSS) scores...
Show moreTissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 10 were determined in 35 MS patients and 62 controls by quantitative fluorometric ELISA. Serum levels were then correlated with Expanded Disability Status Scale (EDSS) scores determined at the time of serological sampling or at last clinical follow-up. Serum levels of KLK1 and KLK6 were elevated in MS patients (p
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Date Issued: 2008
Identifier: FSU_migr_biomed_faculty_publications-0008
Format: Citation

Title: Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians.
Creator: Pilia, Giuseppe, Chen, Wei-Min, Scuteri, Angelo, Orrú, Marco, Albai, Giuseppe, Dei, Mariano, Lai, Sandra, Usala, Gianluca, Lai, Monica, Loi, Paola, Mameli, Cinzia, Vacca,...
Show morePilia, Giuseppe, Chen, Wei-Min, Scuteri, Angelo, Orrú, Marco, Albai, Giuseppe, Dei, Mariano, Lai, Sandra, Usala, Gianluca, Lai, Monica, Loi, Paola, Mameli, Cinzia, Vacca, Loredana, Deiana, Manila, Olla, Nazario, Masala, Marco, Cao, Antonio, Najjar, Samer, Terracciano, Antonio, Nedorezov, Timur, Sharov, Alexei, Zonderman, Alan, Abecasis, Gonçalo, Costa, Paul, Lakatta, Edward, Schlessinger, David
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Abstract/Description: In family studies, phenotypic similarities between relatives yield information on the overall contribution of genes to trait variation. Large samples are important for these family studies, especially when comparing heritability between subgroups such as young and old, or males and females. We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for...
Show moreIn family studies, phenotypic similarities between relatives yield information on the overall contribution of genes to trait variation. Large samples are important for these family studies, especially when comparing heritability between subgroups such as young and old, or males and females. We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, focusing on facets of personality and cardiovascular function. We also summarize results of bivariate analyses for all pairs of traits and of heterogeneity analyses for each trait. We found a significant genetic component for every trait. On average, genetic effects explained 40% of the variance for 38 blood tests, 51% for five anthropometric measures, 25% for 20 measures of cardiovascular function, and 19% for 35 personality traits. Four traits showed significant evidence for an X-linked component. Bivariate analyses suggested overlapping genetic determinants for many traits, including multiple personality facets and several traits related to the metabolic syndrome; but we found no evidence for shared genetic determinants that might underlie the reported association of some personality traits and cardiovascular risk factors. Models allowing for heterogeneity suggested that, in this cohort, the genetic variance was typically larger in females and in younger individuals, but interesting exceptions were observed. For example, narrow heritability of blood pressure was approximately 26% in individuals more than 42 y old, but only approximately 8% in younger individuals. Despite the heterogeneity in effect sizes, the same loci appear to contribute to variance in young and old, and in males and females. In summary, we find significant evidence for heritability of many medically important traits, including cardiovascular function and personality. Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits.
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Date Issued: 2006
Identifier: FSU_migr_geriatrics_faculty_publications-0033, 10.1371/journal.pgen.0020132
Format: Citation

Title: Rater Wealth Predicts Perceptions of Outgroup Competence.
Creator: Chan, Wayne, McCrae, Robert R., Rogers, Darrin, Weimer, Amy, Greenberg, David, Terracciano, Antonio
Abstract/Description: National income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of...
Show moreNational income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of interpersonal warmth on the culture level. In conclusion, raters' economic wealth, either nationally or individually, is significantly associated with perception of outgroup members, supporting the notion that ingroup conditions or stereotypes function as frames of reference in evaluating outgroup traits.
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Date Issued: 2011
Identifier: FSU_migr_geriatrics_faculty_publications-0012, 10.1016/j.jrp.2011.08.001
Format: Citation

Title: Interventions for Heart Failure.
Creator: Glickman, Michael, Rodríguez, Jose
Abstract/Description: The following interventions improve important outcomes in patients with systolic heart failure (all SORs: A, based on meta-analyses): • Angiotensin converting enzyme (ACE) inhibitors reduce mortality, repeat myocardial infarction (MI), and hospitalization rates • Beta-blockers and aldosterone blockers reduce mortality and hospitalization rates • Diuretics reduce mortality and hospitalization rates and improve exercise capacity • Digitalis treatment decreases hospitalization rates and clinical...
Show moreThe following interventions improve important outcomes in patients with systolic heart failure (all SORs: A, based on meta-analyses): • Angiotensin converting enzyme (ACE) inhibitors reduce mortality, repeat myocardial infarction (MI), and hospitalization rates • Beta-blockers and aldosterone blockers reduce mortality and hospitalization rates • Diuretics reduce mortality and hospitalization rates and improve exercise capacity • Digitalis treatment decreases hospitalization rates and clinical deterioration • Aerobic exercise rehabilitation of at least 6 months in duration decreases hospitalization rates and improves quality of life. The following intervention improves important outcomes in African American patients with systolic heart failure (SOR: B, based on a single RCT): • Isosorbide dinitrate and hydralazine combination therapy reduces mortality and hospitalization rates and improves quality of life.
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Date Issued: 2011
Identifier: FSU_migr_fmr-0034
Format: Citation

Title: How Safe and Effective is Pramlintide in Improving Long-Term Glycemic Control and Weight Loss in Patients with Type 2 Diabetes Mellitus Receiving Insulin?.
Creator: Iyengar, Sanjana, Love, Kaitlin, Bauerband, Brian, Rodríguez, Jose
Date Issued: 2013
Identifier: FSU_migr_fmr-0052
Format: Citation

Title: Inner City Community Oriented Primary Care to Improve Medical Student Skills and Combat Obesity.
Creator: Rodríguez, Jose, Fornari, Alice
Abstract/Description: Background: Efforts to increase medical student knowledge regarding obesity are needed in medical school curriculum. This article examines a third year medical student intervention utilizing obesity group visits. Description: In our third-year family medicine clerkship, we implemented the Health not Cosmetics pilot intervention as part of a Community Oriented Primary Care experience. The intervention consisted of weekly group visits run by third and fourth year medical students to teach...
Show moreBackground: Efforts to increase medical student knowledge regarding obesity are needed in medical school curriculum. This article examines a third year medical student intervention utilizing obesity group visits. Description: In our third-year family medicine clerkship, we implemented the Health not Cosmetics pilot intervention as part of a Community Oriented Primary Care experience. The intervention consisted of weekly group visits run by third and fourth year medical students to teach lifestyle modification. To evaluate the intervention, medical students filled out an anonymous departmental evaluation form and patients were surveyed using a short questionnaire during a group visit. Evaluation: Medical students rated the intervention as meeting or exceeding expectations and as improving Community Oriented Primary Care skills, especially in the following areas: identifying community needs, participating in an intervention, collecting data and presenting results. Patients adopted more active lifestyles and healthier eating habits. Conclusion: This intervention was well received by medical students and patients.
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Date Issued: 2006
Identifier: FSU_migr_fmr-0002
Format: Citation

Title: Information Use Environments of African-American Dementia Caregivers Over the Course of Cognitive-Behavioral Therapy for Depression.
Creator: Kazmer, Michelle M., Glueckauf, Robert L., Ma, Jinxuan, Burnett, Kathleen
Abstract/Description: Caregivers of older adults with dementia face significant challenges associated with their care recipients' condition and with their own mental and physical well-being. Qualitative research data were collected via interviews with caregivers who participated in the African-American Alzheimer's Caregiver Training and Support (ACTS) research project. Analysis of these data with a focus on information use indicated that participating caregivers' information use environments were shaped by key...
Show moreCaregivers of older adults with dementia face significant challenges associated with their care recipients' condition and with their own mental and physical well-being. Qualitative research data were collected via interviews with caregivers who participated in the African-American Alzheimer's Caregiver Training and Support (ACTS) research project. Analysis of these data with a focus on information use indicated that participating caregivers' information use environments were shaped by key individuals, settings, and information sources. These included the ACTS counselors, ACTS intervention guidebook, fellow caregivers, use of a personal calendar/datebook, and the identification of key problems and development of goals to help ameliorate those problems. CBT groups fostered sharing, synthesizing, and validating information about dementia caregiving and dementia care resources; the ACTS CBT guidebook served as an important physical touchstone of reliable and portable information. Understanding the specific needs, behaviors, and constraints of African-American caregivers is important to the future development of information components of tailored, depression-reduction interventions.
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Date Issued: 2013
Identifier: FSU_migr_slis_faculty_publications-0016, 10.1016/j.lisr.2013.02.003
Format: Citation

Title: Is Laparoscopic or Open Surgery Better to Prevent Recurrence of an Inguinal Hernia in an Adult Man?: Update.
Creator: Bada, Alvaro, Rodríguez, Jose
Abstract/Description: The risk of recurrence of inguinal hernia is reduced by the use of synthetic mesh, but does not depend on the specific surgical procedure. Compared with the open approach, laparoscopy requires a longer operation (15 minutes longer on average), but decreases recovery time and reduces persistent pain and numbness. (SOR A, based on a systematic review.) Recurrence rates with laparoscopic inguinal hernia repair are highly operator dependent. (SOR A, based on 2 large randomized controlled trials ...
Show moreThe risk of recurrence of inguinal hernia is reduced by the use of synthetic mesh, but does not depend on the specific surgical procedure. Compared with the open approach, laparoscopy requires a longer operation (15 minutes longer on average), but decreases recovery time and reduces persistent pain and numbness. (SOR A, based on a systematic review.) Recurrence rates with laparoscopic inguinal hernia repair are highly operator dependent. (SOR A, based on 2 large randomized controlled trials [RCTs].)
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Date Issued: 2009
Identifier: FSU_migr_fmr-0012
Format: Citation

Title: Is Uterine Artery Embolization (UAE) Safe and Effective for Treatment of Uterine Fibroids?.
Creator: Davis, Laura, Provost, Bridgette, Rodríguez, Jose
Abstract/Description: Compared with hysterectomy or myomectomy, UAE for treating fibroids results in similar patient satisfaction. UAE is associated with fewer blood transfusions, shorter hospital stays, and quicker resumption of normal activities than surgical treatment. However, patients undergoing UAE are more likely to require further intervention at 2 and 5 years and are more likely to have minor complications than patients treated surgically (SOR: A, systematic review of RCTs).
Date Issued: 2012
Identifier: FSU_migr_fmr-0044
Format: Citation

Title: Health Literacy as a Tool to Improve the Public Understanding of Alzheimer's Disease.
Creator: Kobylarz, Fred, Pomidor, Alice, Pleasant, Andrew F.
Abstract/Description: The ultimate goal of health literacy is to improve care by enhancing the patient's quality of life, maximizing clinical outcomes, and reducing inequities in health. Successful restructuring of the healthcare system to make it more effective, efficient, and equitable demands that health literacy be integrated as a key source of theoretical and empirical data regarding patients' needs and wishes. This applies across the life course, but it is especially true for the increasing numbers of older...
Show moreThe ultimate goal of health literacy is to improve care by enhancing the patient's quality of life, maximizing clinical outcomes, and reducing inequities in health. Successful restructuring of the healthcare system to make it more effective, efficient, and equitable demands that health literacy be integrated as a key source of theoretical and empirical data regarding patients' needs and wishes. This applies across the life course, but it is especially true for the increasing numbers of older adults who must deal with the medical care system the most, yet often comprehend medical information the least. Nearly nine out of ten people in the United States do not have the level of proficiency in health literacy skills necessary to successfully navigate the healthcare system. According to the National Assessment of Adult Literacy (NAAL), populations overrepresented at the lowest levels of health literacy (below basic level) in the United States include people over age 65, those who did not graduate from high school, persons who did not speak English before starting school, people who have poor health status, those who are of racial and ethnic minority groups, and individuals without medical insurance. An increasing number of efforts are ongoing across the United States and internationally to address health literacy. Significant national initiatives include Healthy People 2010, the Joint Commission's report "Improving Health Literacy to Protect Patient Safety," and the U.S. Department of Heath and Human Services Office of the Surgeon General's "Workshop on Improving Health Literacy." Other organizations attempting to address health literacy include the American Medical Association and the Partnership for Clear Health Communication. Many organizations are launching successful health literacy–based interventions such as the Canyon Ranch Institute's Life Enhancement Program, an integrated approach to prevention and wellness. Additionally, there are a growing number of curricula addressing health literacy being developed by a wide range of organizations and individuals. Equally significant efforts are ongoing in a number of countries around the world, particularly Canada, Australia, and Switzerland. The purposes of this article are to familiarize readers with the concept of health literacy; demonstrate how health literacy can serve as a tool to improve the public's understanding of Alzheimer's disease (AD), the seventh leading cause of death; and suggest generally applicable strategies for clinicians.
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Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0041
Format: Citation

Title: Health Care Technology, Health Care Rationing, and Older Americans: Enough Already?.
Creator: Kapp, Marshall B.
Abstract/Description: This is a book review essay, using Daniel Callahan's 2009 book, "Taming the Beloved Beast: How Medical Technology Costs Are Destroying Our Health Care System," as the jumping off point. Kapp takes strong issue with Callahan's proposal that health care costs can best be contained by the federal government setting and enforcing strict controls on the development and use of medical technology, with patients' chronological age acting as the main criterion for distribution of scarce medical...
Show moreThis is a book review essay, using Daniel Callahan's 2009 book, "Taming the Beloved Beast: How Medical Technology Costs Are Destroying Our Health Care System," as the jumping off point. Kapp takes strong issue with Callahan's proposal that health care costs can best be contained by the federal government setting and enforcing strict controls on the development and use of medical technology, with patients' chronological age acting as the main criterion for distribution of scarce medical resources.
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Date Issued: 2010
Identifier: FSU_migr_medlawcenter_publications-0006
Format: Citation

Title: Is Calcitonin Useful for Reducing the Pain of Acute Osteoporotic Fractures?.
Creator: Parker, Alex, Soberon, Angelica, Rodríguez, Jose
Abstract/Description: Calcitonin has been shown to improve acute pain at rest in patients with osteoporotic vertebral fractures, when compared with placebo, and reduce the use of other analgesic medications (SOR A, based on a meta-analysis of randomized controlled trials [RCTs]). However, calcitonin is not superior to placebo in patients with hip fracture who have undergone surgical repair. (SOR B, based on an RCT.)
Date Issued: 2009
Identifier: FSU_migr_fmr-0017
Format: Citation

Title: Late Onset Sporadic Dilated Cardiomyopathy Caused by a Cardiac Troponin T Mutation.
Creator: Morales, Ana, Pinto, Jose, Siegfried, Jill, Li, Duanxiang, Norton, Nadine, Hofmeyer, Mark, Vallin, Marta, Morales, Azorides R., Potter, James, Hershberger, Ray
Abstract/Description: Mutations in TNNT2, encoding cardiac troponin T, commonly shows early onset, aggressive dilated cardiomyopathy (DCM). This observation may influence the decision of whether to undertake clinical genetic testing for TNNT2 in later onset DCM. Further, the trigger for late onset DCM remains enigmatic. A 70-year-old woman, previously healthy with a left ventricular ejection fraction of 50%-55% at age 69, presented with DCM of unknown cause and a 4-month history progressive heart failure requiring...
Show moreMutations in TNNT2, encoding cardiac troponin T, commonly shows early onset, aggressive dilated cardiomyopathy (DCM). This observation may influence the decision of whether to undertake clinical genetic testing for TNNT2 in later onset DCM. Further, the trigger for late onset DCM remains enigmatic. A 70-year-old woman, previously healthy with a left ventricular ejection fraction of 50%-55% at age 69, presented with DCM of unknown cause and a 4-month history progressive heart failure requiring cardiac transplantation. Clinical genetic testing revealed a novel TNNT2 R139H mutation but no relevant variants in 18 other DCM genes. Her explanted heart showed partial fatty replacement in the right ventricle. Sequencing for five arrhythmogenic right ventricular dysplasia genes was negative. Functional studies in porcine cardiac skinned fibers reconstituted with the mutant R139H troponin T protein showed decreased Ca(2+) sensitivity at pH 7, characteristic of DCM. Because fatty infiltration may acidify the myocellular environment, maximal force development examined at pH 6.5 was diminished, suggesting a possible environmental trigger. We conclude that the TNNT2 R139H mutation was likely to be disease causing. Further, later age of onset may not be relevant to exclude genetic testing for TNNT2 mutations.
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Date Issued: 2010
Identifier: FSU_migr_biomed_faculty_publications-0054, 10.1111/j.1752-8062.2010.00228.x
Format: Citation

Title: Medical Decision-Making for Incapacitated Elders: A 'Therapeutic Interests' Standard.
Creator: Kapp, Marshall B.
Abstract/Description: Some older individuals lack sufficient present cognitive and/or emotional ability to make and express autonomous decisions personally. In those situations, health care providers routinely turn to available formal or informal surrogates who often must apply the best interests standard in making decisions for the incapacitated person. This article contends that defining the best interests standard of surrogate decision making for older adults in terms of optimal or ideal choices (truly the...
Show moreSome older individuals lack sufficient present cognitive and/or emotional ability to make and express autonomous decisions personally. In those situations, health care providers routinely turn to available formal or informal surrogates who often must apply the best interests standard in making decisions for the incapacitated person. This article contends that defining the best interests standard of surrogate decision making for older adults in terms of optimal or ideal choices (truly the patient's "best" interests) frequently sets out an unrealizable goal for surrogates to satisfy. Instead, a decision-making standard based on the incapacitated person's "therapeutic" interests is more realistic and hence more honest to adopt and apply from legal, ethical, and medical perspectives.
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Date Issued: 2010
Identifier: FSU_migr_medlawcenter_publications-0009
Format: Citation

Title: Medical-Legal Literature 2010-2011: Top Ten Hits.
Creator: Kapp, Marshall B.
Date Issued: 2011
Identifier: FSU_migr_medlawcenter_presentations-0001
Format: Citation

Title: Mobile Health Unit for Obesity Education: Attitudes and Perceptions Among Local Homeless Residents.
Creator: Soberon, Angelica, Brown, L., Rodríguez, Jose
Abstract/Description: Objective: Poverty is a risk factor for obesity. Using homelessness as a marker for poverty, we examined the prevalence of obesity in Leon County, Florida's homeless population to determine their attitudes and perceptions towards the disease. Methods: Our medical team equipped a mobile health unit with educational material before visiting homeless shelters, health fairs and shopping areas in Northwest Florida. Participants at these sites completed a short survey and our staff calculated Body...
Show moreObjective: Poverty is a risk factor for obesity. Using homelessness as a marker for poverty, we examined the prevalence of obesity in Leon County, Florida's homeless population to determine their attitudes and perceptions towards the disease. Methods: Our medical team equipped a mobile health unit with educational material before visiting homeless shelters, health fairs and shopping areas in Northwest Florida. Participants at these sites completed a short survey and our staff calculated Body Mass Index (BMI). The team also distributed lifestyle modification and obesity patient education. BMI and survey responses were compared and analyzed using statistical software. Results: Subjects were assigned to one of two groups: the homeless group or the "all others" group. The homeless group's responses and BMIs were compared to the "all others" group. Weight status in the homeless group was distributed as follows: normal weight (48.3%), overweight (39.7%) and obese (12.1%). The distribution among all other participants was: normal weight (34.8%), overweight (25.8%), and obese (39.3%). Homeless participants overestimated their BMI category as often as all others, were less likely to participate in weight loss interventions, and less likely to recognize overweight and obesity as a problem. Conclusion: Medical practitioners need to recognize the role of patients' attitudes about weight loss and clarify definitions of exercise. Obesity is less prevalent among the homeless; however, the same obesity trends exist. In addition, we learned that the homeless are eager to learn about obesity and healthy lifestyles, but may not be as willing to attempt interventions that have worked in other populations. Mobile health units can be used to reach out to them.
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Date Issued: 2009
Identifier: FSU_migr_fmr-0035
Format: Citation

Title: Meta-Analysis and Imputation Refines the Association of 15q25 with Smoking Quantity.
Creator: Liu, Jason, Tozzi, Federica, Waterworth, Dawn, Pillai, Sreekumar, Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher, Yuan, Xin, Waeber, Gérard,...
Show moreLiu, Jason, Tozzi, Federica, Waterworth, Dawn, Pillai, Sreekumar, Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher, Yuan, Xin, Waeber, Gérard, Vollenweider, Peter, Preisig, Martin, Wareham, Nicholas, Zhao, Jing, Loos, Ruth, Barroso, Inês, Khaw, Kay-Tee, Grundy, Scott M., Barter, Philip, Mahley, Robert, Kesaniemi, Antero, McPherson, Ruth, Vincent, John, Strauss, John, Kennedy, James, Farmer, Anne, McGuffin, Peter, Day, Richard, Matthews, Keith, Bakke, Per, Gulsvik, A. (Amund), Lucae, Susanne, Ising, Marcus, Brueckl, Tanja, Horstmann, Sonja, Wichmann, H.-Erich (Heinz-Erich), Rawal, Rajesh, Dahmen, Norbert, Lamina, Claudia, Polasek, Ozren, Zgaga, Lina, Huffman, Jennifer, Campbell, Susan, Kooner, Jaspal, Chambers, John, Burnett, Mary, Devaney, Joseph, Pichard, Augusto, Kent, Kenneth, Satler, Lowell, Lindsay, Joseph, Waksman, Ron, Epstein, Stephen, Wilson, James F. (James Flett), Wild, Sarah, Campbell, Harry, Vitart, Veronique, Reilly, Muredach, Li, Mingyao, Qu, Liming, Wilensky, Robert, Matthai, William, Hakonarson, Hakon, Rader, Daniel, Franke, Andre, Wittig, Michael, Schäfer, Arne, Uda, Manuela, Terracciano, Antonio, Xiao, Xiangjun, Busonero, Fabio, Scheet, Paul A. (Paul Anthony), Schlessinger, David, St Clair, David, Rujescu, Dan, Abecasis, Gonçalo, Grabe, Hans, Teumer, Alexander, Völzke, Henry, Petersmann, Astrid, John, Ulrich, Rudan, Igor, Hayward, Caroline, Wright, Alan, Kolcic, Ivana, Wright, Benjamin, Thompson, John, Balmforth, Anthony, Hall, A. S. (Alistair Scott), Samani, Nilesh J., Anderson, Carl, Ahmad, Tariq, Mathew, Christopher, Parkes, Miles, Satsangi, Jack, Caulfield, Mark, Munroe, Patricia, Farrall, Martin, Dominiczak, A. F., Worthington, Jane, Thomson, Wendy, Eyre, Steve, Barton, Anne, Mooser, Vincent, Francks, Clyde, Marchini, Jonathan
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Abstract/Description: Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic...
Show moreSmoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
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Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0018, 10.1038/ng.572
Format: Citation

Title: Medical Concerns in HIV-Positive Aging.
Creator: Simone, Mark, Appelbaum, Jonathan
Abstract/Description: The management and prognosis of HIV disease has changed dramatically since the introduction of combination HIV antiretroviral therapy in 1996. Thus, the number of older adults with HIV is increasing partly because people with HIV are living longer. At the same time, the rates of new HIV cases in older adults (usually defined as people over the age of 50) are also increasing. Currently, about 25 percent of all patients living with HIV are older than 50, and by 2015 adults older than 50 will...
Show moreThe management and prognosis of HIV disease has changed dramatically since the introduction of combination HIV antiretroviral therapy in 1996. Thus, the number of older adults with HIV is increasing partly because people with HIV are living longer. At the same time, the rates of new HIV cases in older adults (usually defined as people over the age of 50) are also increasing. Currently, about 25 percent of all patients living with HIV are older than 50, and by 2015 adults older than 50 will account for 50 percent of the population living with HIV.1 These trends make understanding the medical challenges of HIV in older adults more important than ever. This article reviews the special issues associated with HIV and AIDS in an older population.
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Date Issued: 2009
Identifier: FSU_migr_clinicalsciences_faculty_publications-0001
Format: Citation

Title: Molecular and Functional Characterization of Novel Hypertrophic Cardiomyopathy Susceptibility Mutations in TNNC1-encoded Troponin C.
Creator: Landstrom, Andrew, Parvatiyar, Michelle, Pinto, Jose, Marquardt, Michelle, Bos, J., Tester, David, Ommen, Steve, Potter, James, Ackerman, Michael
Abstract/Description: Hypertrophic Cardiomyopathy (HCM) is a common primary cardiac disorder defined by a hypertrophied left ventricle, is one of the main causes of sudden death in young athletes, and has been associated with mutations in most sarcomeric proteins (tropomyosin, troponin T and I, and actin, etc.). Many of these mutations appear to affect the functional properties of cardiac troponin C (cTnC), i.e., by increasing the Ca(2+)-sensitivity of contraction, a hallmark of HCM, yet surprisingly, prior to...
Show moreHypertrophic Cardiomyopathy (HCM) is a common primary cardiac disorder defined by a hypertrophied left ventricle, is one of the main causes of sudden death in young athletes, and has been associated with mutations in most sarcomeric proteins (tropomyosin, troponin T and I, and actin, etc.). Many of these mutations appear to affect the functional properties of cardiac troponin C (cTnC), i.e., by increasing the Ca(2+)-sensitivity of contraction, a hallmark of HCM, yet surprisingly, prior to this report, cTnC had not been classified as a HCM-susceptibility gene. In this study, we show that mutations occurring in the human cTnC (HcTnC) gene (TNNC1) have the same prevalence (~0.4%) as well established HCM-susceptibility genes that encode other sarcomeric proteins. Comprehensive open reading frame/splice site mutation analysis of TNNC1 performed on 1025 unrelated HCM patients enrolled over the last 10 years revealed novel missense mutations in TNNC1: A8V, C84Y, E134D, and D145E. Functional studies with these recombinant HcTnC HCM mutations showed increased Ca(2+) sensitivity of force development (A8V, C84Y and D145E) and force recovery (A8V and D145E). These results are consistent with the HCM functional phenotypes seen with other sarcomeric-HCM mutations (E134D showed no changes in these parameters). This is the largest cohort analysis of TNNC1 in HCM that details the discovery of at least three novel HCM-associated mutations and more strongly links TNNC1 to HCM along with functional evidence that supports a central role for its involvement in the disease. This study may help to further define TNNC1 as an HCM-susceptibility gene, a classification that has already been established for the other members of the troponin complex.
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Date Issued: 2008
Identifier: FSU_migr_biomed_faculty_publications-0058, 10.1016/j.yjmcc.2008.05.003
Format: Citation

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