Search results

Title: Checkpoint Silencing Regulation by 14-3-3 Proteins.
Creator: Gravenmier, Cutis, College of Medicine
Date Issued: 2013
Identifier: FSU_migr_undergradresearch-0024
Format: Citation

Title: Examination of Nicotine-Induced Alterations in Germ Cell DNA.
Creator: Lopez, Katheryn, Medicine, Biomedical Sciences
Abstract/Description: While evidence from mouse models strongly suggests that prenatal nicotine exposure supports a hyperactive-inattentive phenotype following direct exposure in utero via maternal circulation (Zhu et al 2014), there is little evidence that suggests consequences resulting from indirect exposure of the offspring through a father's use of tobacco products. In order to address the question of the influence of a father smoking on their offspring, we developed a paternal nicotine exposure mouse model...
Show moreWhile evidence from mouse models strongly suggests that prenatal nicotine exposure supports a hyperactive-inattentive phenotype following direct exposure in utero via maternal circulation (Zhu et al 2014), there is little evidence that suggests consequences resulting from indirect exposure of the offspring through a father's use of tobacco products. In order to address the question of the influence of a father smoking on their offspring, we developed a paternal nicotine exposure mouse model in which adult male mice were exposed to nicotine in their drinking water for 12 consecutive weeks.We found that the offspring of these nicotine exposed male mice displayed deficits in working memory and attention, behavioral phenotypes that have been previously linked to ADHD. These intriguing findings were rationale to hypothesize that the fathers' germ cells may have undergone genetic changes as a result of the nicotine exposure and that these changes in the germ cell DNA were the basis for transmission of an ADHD-like phenotype to the offspring.To address these possibilities, we are performing molecular genetic analysis of germ cells and examining gross morphology of the testes of nicotine-exposed fathers to elucidate mechanisms by which paternal nicotine exposure may cause behavioral changes associated with ADHD in the offspring
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Date Issued: 2015
Identifier: FSU_migr_undergradsymposium2015-0025
Format: Citation

Title: The Autolytic Regulation of Human Kallikrein-Related Peptidase 6.
Creator: Blaber, Sachiko, Yoon, Hyesook, Scarisbrick, Isobel, Juliano, Maria, Blaber, Michael
Abstract/Description: Human kallikrein-related peptidase 6 (KLK6) is a member of the kallikrein family of serine-type proteases, characterized as an arginine-specific digestive-type protease capable of degrading a wide-variety of extracellular matrix proteins. KLK6 has been proposed to be a useful biomarker for breast and ovarian cancer prognosis, is abundantly expressed in the CNS and cerebrospinal fluid, and is intimately associated with regions of active inflammatory demyelination in multiple sclerosis (MS)...
Show moreHuman kallikrein-related peptidase 6 (KLK6) is a member of the kallikrein family of serine-type proteases, characterized as an arginine-specific digestive-type protease capable of degrading a wide-variety of extracellular matrix proteins. KLK6 has been proposed to be a useful biomarker for breast and ovarian cancer prognosis, is abundantly expressed in the CNS and cerebrospinal fluid, and is intimately associated with regions of active inflammatory demyelination in multiple sclerosis (MS) lesions. Inhibition of KLK6 results in delayed onset and reduced severity of symptoms associated with experimental autoimmune encephalomyelitis, suggesting a key effector role for this protease in CNS inflammatory disease. KLK6 has been shown to autolytically cleave internally, leading to inactivation and suggesting a negative feedback inhibition control mechanism. Alternatively, the ability of KLK6 to self-activate has also been reported, suggesting a positive feedback activation loop control mechanism. Activation of pro-KLK6 requires hydrolysis after a Lys residue; however, KLK6 exhibits 2 order of magnitude reduced affinity for hydrolysis after Lys versus Arg residues; therefore, the ability to autolytically activate has been called into question. In the present study the catalytic activity of KLK6 toward its pro-sequence and internal autolytic sequence is characterized. The results show that the ability of KLK6 to activate pro-KLK6 is essentially negligible when compared to the rate of the internal autolytic inactivation or to the ability of other proteases to activate pro-KLK6. The results thus show that the primary autolytic regulatory mechanism of KLK6 is negative feedback inhibition, and activation is likely achieved through the action of a separate protease.
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Date Issued: 2007
Identifier: FSU_migr_biomed_faculty_publications-0002, 10.1021/bi6025006, PMC2517904
Format: Citation

Title: Functional Intersection of the Kallikrein-Related Peptidases (KLKs) and Thrombostasis Axis.
Creator: Blaber, Michael, Yoon, Hyesook, Juliano, Maria, Scarisbrick, Isobel, Blaber, Sachiko
Abstract/Description: A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific...
Show moreA large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.
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Date Issued: 2010
Identifier: FSU_migr_biomed_faculty_publications-0018, 10.1515/BC.2010.024, PMC3047482
Format: Citation

Title: X-ray Structure and Biophysical Properties of Rabbit Fibroblast Growth Factor 1.
Creator: Lee, Jihun, Blaber, Sachiko, Irsigler, Andre, Aspinwall, Eric, Blaber, Michael
Abstract/Description: The rabbit is an important and de facto animal model in the study of ischemic disease and angiogenic therapy. Additionally, fibroblast growth factor 1 (FGF-1) is emerging as one of the most important growth factors for novel proangiogenic and pro-arteriogenic therapy. However, despite its significance, the fundamental biophysical properties of rabbit FGF-1, including its X-ray structure, have never been reported. Here, the cloning, crystallization, X-ray structure and determination of the...
Show moreThe rabbit is an important and de facto animal model in the study of ischemic disease and angiogenic therapy. Additionally, fibroblast growth factor 1 (FGF-1) is emerging as one of the most important growth factors for novel proangiogenic and pro-arteriogenic therapy. However, despite its significance, the fundamental biophysical properties of rabbit FGF-1, including its X-ray structure, have never been reported. Here, the cloning, crystallization, X-ray structure and determination of the biophysical properties of rabbit FGF-1 are described. The X-ray structure shows that the amino-acid differences between human and rabbit FGF-1 are solvent-exposed and therefore potentially immunogenic, while the biophysical studies identify differences in thermostability and receptor-binding affinity that distinguish rabbit FGF-1 from human FGF-1.
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Date Issued: 2009
Identifier: FSU_migr_biomed_faculty_publications-0016, 10.1107/S1744309109040287, PMC2777034
Format: Citation

Title: Activation Profiles of Human Kallikrein-Related Peptidases by Matrix Metalloproteinases.
Creator: Yoon, Hyesook, Blaber, Sachiko, Li, Wu, Scarisbrick, Isobel, Blaber, Michael
Abstract/Description: Abstract The 15 human kallikrein-related peptidases (KLKs) are clinically important biomarkers and therapeutic targets of interest in inflammation, cancer, and neurodegenerative disease. KLKs are secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their amino-terminal pro-peptide, and this is a key step in their functional regulation. Physiologically relevant KLK regulatory cascades of activation have been described in skin...
Show moreAbstract The 15 human kallikrein-related peptidases (KLKs) are clinically important biomarkers and therapeutic targets of interest in inflammation, cancer, and neurodegenerative disease. KLKs are secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their amino-terminal pro-peptide, and this is a key step in their functional regulation. Physiologically relevant KLK regulatory cascades of activation have been described in skin desquamation and semen liquefaction, and work by a large number of investigators has elucidated pairwise and autolytic activation relationships among the KLKs with the potential for more extensive activation cascades. More recent work has asked whether functional intersection of KLKs with other types of regulatory proteases exists. Such studies show a capacity for members of the thrombostasis axis to act as broad activators of pro-KLKs. In the present report, we ask whether such functional intersection is possible between the KLKs and the members of the matrix metalloproteinase (MMP) family by evaluating the ability of the MMPs to activate pro-KLKs. The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression.
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Date Issued: 2013
Identifier: FSU_migr_biomed_faculty_publications-0042, 10.1515/hsz-2012-0249, PMC3709557
Format: Citation

Title: Engineering an Improved Crystal Contact Across a Solvent-Mediated Interface of Human Fibroblast Growth Factor 1.
Creator: Meher, Akshaya, Blaber, Sachiko, Lee, Jihun, Honjo, Ejiro, Kuroki, Ryota, Blaber, Michael
Abstract/Description: Large-volume protein crystals are a prerequisite for neutron diffraction studies and their production represents a bottleneck in obtaining neutron structures. Many protein crystals that permit the collection of high-resolution X-ray diffraction data are inappropriate for neutron diffraction owing to a plate-type morphology that limits the crystal volume. Human fibroblast growth factor 1 crystallizes in a plate morphology that yields atomic resolution X-ray diffraction data but has...
Show moreLarge-volume protein crystals are a prerequisite for neutron diffraction studies and their production represents a bottleneck in obtaining neutron structures. Many protein crystals that permit the collection of high-resolution X-ray diffraction data are inappropriate for neutron diffraction owing to a plate-type morphology that limits the crystal volume. Human fibroblast growth factor 1 crystallizes in a plate morphology that yields atomic resolution X-ray diffraction data but has insufficient volume for neutron diffraction. The thin physical dimension has been identified as corresponding to the b cell edge and the X-ray structure identified a solvent-mediated crystal contact adjacent to position Glu81 that was hypothesized to limit efficient crystal growth in this dimension. In this report, a series of mutations at this crystal contact designed to both reduce side-chain entropy and replace the solvent-mediated interface with direct side-chain contacts are reported. The results suggest that improved crystal growth is achieved upon the introduction of direct crystal contacts, while little improvement is observed with side-chain entropy-reducing mutations alone.
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Date Issued: 2009
Identifier: FSU_migr_biomed_faculty_publications-0017, 10.1107/S1744309109036987, PMC2777043
Format: Citation

Title: Variants of the Serotonin Transporter Gene and NEO-PI-R Neuroticism: No Association in the BLSA and SardiNIA Samples.
Creator: Terracciano, Antonio, Balaci, Lenuta, Thayer, Jason, Scally, Matthew, Kokinos, Sarah, Ferrucci, Luigi, Tanaka, Toshiko, Zonderman, Alan, Sanna, Serena, Olla, Nazario, Zuncheddu,...
Show moreTerracciano, Antonio, Balaci, Lenuta, Thayer, Jason, Scally, Matthew, Kokinos, Sarah, Ferrucci, Luigi, Tanaka, Toshiko, Zonderman, Alan, Sanna, Serena, Olla, Nazario, Zuncheddu, Maria, Naitza, Silvia, Busonero, Fabio, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Costa, Paul
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Abstract/Description: The polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism-related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5-HTTLPR. However, studies that used the NEO-PI-R or related instruments (NEO-PI, NEO-FFI)...
Show moreThe polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism-related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5-HTTLPR. However, studies that used the NEO-PI-R or related instruments (NEO-PI, NEO-FFI) to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia (Italy) that is several times larger than previous samples that used the NEO-PI-R (N = 3,913). The association was also tested in a sample (N = 548) from the Baltimore Longitudinal Study of Aging (BLSA), in which repeated NEO-PI-R assessments were obtained. In the SardiNIA sample, we found no significant association of the 5-HTTLPR genotypes with Neuroticism or its facets (Anxiety, Angry-Hostility, Depression, Self-Consciousness, Impulsiveness, and Vulnerability). In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA (N = 3,972) and nine SNPs in the BLSA (N = 1,182) that map within or near the serotonin transporter gene (SLC6A4), and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits.
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Date Issued: 2009
Identifier: FSU_migr_geriatrics_faculty_publications-0022, 10.1002/ajmg.b.30932
Format: Citation

Title: What is the Best Treatment for an Adult with an Umbilical Hernia?.
Creator: Castro, Robert, Rodríguez, Jose
Abstract/Description: The laparoscopic onlay patch repair is associated with less recurrence, shorter hospital stay, lower wound morbidity, and lower postoperative pain when compared with open suture repair. (SOR B, based on a single cohort study.) Open surgical mesh repair of umbilical hernia is associated with less recurrence than open suture repair, but there is controversy surrounding the infection rates associated with this repair. (SOR B, based on heterogeneous cohort studies.)
Date Issued: 2009
Identifier: FSU_migr_fmr-0016
Format: Citation

Title: What is the Best Treatment for Patients of All Ages with Community-Acquired Pneumonia?.
Creator: Smith, Joshua, Rodríguez, Jose
Abstract/Description: Recommended first-line antibiotic therapy for community-acquired (CA) pneumonia is 5 days of a macrolide in adults and 3 to 5 days of amoxicillin in children. (SOR: C, based on consensus guidelines.) In otherwise healthy adults, there is no clear difference in clinical success rates among beta-lactams, fluoroquinolones, macrolides, and cephalosporins.
Date Issued: 2012
Identifier: FSU_migr_fmr-0033
Format: Citation

Title: What is the Best Nonpharmacologic Therapy for Phantom Limb Pain?.
Creator: Miller, Michelle, Rodríguez, Jose
Abstract/Description: Nonpharmacologic therapies for phantom limb pain (PLP) that have demonstrated some success include motor imagery therapy (SOR C, extrapolated from a randomized controlled trial [RCT] that enrolled a heterogeneous patient sample); Farabloc® (SOR C, based on a single low-quality RCT); and eye movement desensitization and reprocessing (EMDR) in patients who also have depression and posttraumatic stress disorder (SOR C, based on a case series). Evidence is insufficient to support or refute the...
Show moreNonpharmacologic therapies for phantom limb pain (PLP) that have demonstrated some success include motor imagery therapy (SOR C, extrapolated from a randomized controlled trial [RCT] that enrolled a heterogeneous patient sample); Farabloc® (SOR C, based on a single low-quality RCT); and eye movement desensitization and reprocessing (EMDR) in patients who also have depression and posttraumatic stress disorder (SOR C, based on a case series). Evidence is insufficient to support or refute the use of transcutaneous electrical nerve stimulation (TENS), desensitization, scar mobilization, relaxation, or biofeedback.
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Date Issued: 2010
Identifier: FSU_migr_fmr-0020
Format: Citation

Title: What is the Best Treatment for Postinfluenza Pneumonia?.
Creator: Smith, Joshua, Rodríguez, Jose
Abstract/Description: Cefotaxime, ceftriaxone, and respiratory fluoroquinolones are recommended for influenza-associated pneumonia. Oseltamivir and zanamivir can be used to reduce viral shedding in hospitalized patients with influenza, with or without pneumonia. (SOR C, based on consensus guidelines.) Early treatment of the influenza infection with oseltamivir or inhaled zanamivir is recommended for prevention of postinfluenza pneumonia. (SOR A, based on a meta-analysis.)
Date Issued: 2010
Identifier: FSU_migr_fmr-0027
Format: Citation

Title: What is the Best Treatment for Symptomatic PVD in the Elderly?.
Creator: LeFranc, Noemi, Rodríguez, Jose
Abstract/Description: In patients with peripheral vascular disease (PVD), a structured exercise program improves walking distances and is relatively low risk and low cost. Lipid-lowering therapy reduces the risk of cardiovascular events and also increases walking distances. Cilostazol and naftidrofuryl improve walking distance, but add an additional expense. Angioplasty appears to improve walking distance better than exercise at 6 months, but not at 2 or 6 years. (SOR A, based on a systematic reviews.)
Date Issued: 2010
Identifier: FSU_migr_fmr-0026
Format: Citation

Title: What is the Best Prophylaxis for Menstrual Migraine?.
Creator: Barrie, Jamie, Rodríguez, Jose
Abstract/Description: Oral naratriptan results in slightly fewer headache days than placebo in patients with menstrual migraines. (SOR A, based on consistent randomized controlled trials [RCTs].) Naproxen and magnesium therapy are also more effective than placebo. (SOR B, based on single small RCTs.) Frovatriptan may reduce the severity of pain better than transdermal estrogens and naproxen (SOR C, based on a single open-label comparison study), but has not been studied in comparison with a placebo.
Date Issued: 2008
Identifier: FSU_migr_fmr-0008
Format: Citation

Title: What is the Best Treatment for Exercise-Induced Asthma?.
Creator: Rodríguez, Jose, Gonzalez, David
Abstract/Description: Patients using the leukotriene inhibitor montelukast require less frequent use of rescue medication than patients using the long-acting beta-agonist salmeterol. (SOR B, based on a single randomized controlled trial [RCT]). No studies have compared short-acting beta-agonists with either leukotriene inhibitors or long-acting beta-agonists.
Date Issued: 2008
Identifier: FSU_migr_fmr-0004
Format: Citation

Title: What is the Best Treatment for Graves' Disease in Women Trying to Become Pregnant?.
Creator: Pearcy, Amanda, Rodríguez, Jose
Abstract/Description: It is recommended that pregnant women with Graves' disease and thyroid-stimulating hormone (TSH) antibodies be treated with an antithyroid drug, whereas those without TSH antibodies should simply be observed. Radioiodine treatment with iodine-131 (I-131) is contraindicated when a woman is attempting pregnancy and during pregnancy. Propylthiouracil (PTU) is the first-line drug therapy during the first trimester. (SOR B, from an evidence-based guideline.)
Date Issued: 2010
Identifier: FSU_migr_fmr-0025
Format: Citation

Title: Visual Perspective and Genetics: A Commentary on Lemogne and Colleagues.
Creator: Sutin, Angelina
Abstract/Description: Lemogne and colleagues offer an interesting extension to their previous work on visual perspective and depression: Individuals at-risk for depression (defined as higher scores on Harm Avoidance), without a history of mood disorders, report retrieval of positive memories from the 3rd person perspective. Their findings suggest that the retrieval of positive experiences from the 3rd person perspective may be a risk-factor for depression, not just a lingering consequence of it. Their study,...
Show moreLemogne and colleagues offer an interesting extension to their previous work on visual perspective and depression: Individuals at-risk for depression (defined as higher scores on Harm Avoidance), without a history of mood disorders, report retrieval of positive memories from the 3rd person perspective. Their findings suggest that the retrieval of positive experiences from the 3rd person perspective may be a risk-factor for depression, not just a lingering consequence of it. Their study, however, also reports a genetic association in a severely underpowered sample. Rather than focusing on gene x environment interactions, which large, well-powered studies on related phenotypes have failed to detect, a greater understanding of the phenomenology of visual perspective may be a more fruitful avenue for future research.
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Date Issued: 2009
Identifier: FSU_migr_mhs-0032, 10.1016/j.concog.2009.05.002
Format: Citation

Title: Washing Feet and Clipping Toenails: The Servanthood of a Family Physician.
Creator: Campbell, Kendall
Date Issued: 2014
Identifier: FSU_migr_fmr-0055
Format: Citation

Title: Underrepresented Minority Faculty in Academic Medicine: A Systematic Review of URM Faculty Development.
Creator: Rodríguez, Jose, Campbell, Kendall, Fogarty, John, Williams, Roxann
Abstract/Description: BACKGROUND AND OBJECTIVES: Retention and recruitment of minority faculty members continues to be a concern of medical schools because there is higher attrition and talent loss among this group. While much has been written, there has not been a systematic review published on this topic. This is the first study to use evidence-based medicine (EBM) criteria and apply it to this issue. METHODS: We searched MEDLINE, Web of Knowledge, ProQuest, and Google Scholar for papers relating to the...
Show moreBACKGROUND AND OBJECTIVES: Retention and recruitment of minority faculty members continues to be a concern of medical schools because there is higher attrition and talent loss among this group. While much has been written, there has not been a systematic review published on this topic. This is the first study to use evidence-based medicine (EBM) criteria and apply it to this issue. METHODS: We searched MEDLINE, Web of Knowledge, ProQuest, and Google Scholar for papers relating to the recruitment and retention of minority faculty. We then graded the evidence using the EBM criteria as defined by the American Academy of Family Physicians. The same criteria were applied to extract evidence-based observations of problems in recruitment and retention for minority faculty. RESULTS: Of the 548 studies identified and reviewed, 11 met inclusion criteria for this literature review. This article presents the data from the reviewed papers that described or evaluated minority faculty development programs. Faculty development programs in 15 different institutions showed mentoring and faculty development for minority faculty could increase retention, academic productivity, and promotion rates for this group. ConclusionS: For medical schools to be successful in retention and recruitment of minority medical school faculty, specific programs need to be in place. Overall evidence is strong that faculty development programs and mentoring programs increase retention, productivity, and promotion for this group of medical faculty. This paper is a call to action for more faculty development and mentorship programs to reduce the disparities that exist between minority faculty and all other faculty members.
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Date Issued: 2014
Identifier: FSU_migr_fmr-0049
Format: Citation

Title: What Are the Best Nonpharmacologic Treatments for Urinary Incontinence in Women?.
Creator: Rojas, Christine, Rodríguez, Jose
Abstract/Description: Pelvic floor muscle training (PFMT) is superior to no treatment or inactive controls, and is effective in nonpregnant, pregnant, and postpartum women. (SOR A, based on meta-analyses.) The clinical value of habit retraining, timed voiding, or mechanical devices for treatment of urinary incontinence is unknown.
Date Issued: 2009
Identifier: FSU_migr_fmr-0013
Format: Citation

Title: What Are the Risks of Oral Contraceptives in Patients with Cardiovascular Disease Risk Factors?.
Creator: Love, Kaitlin, Miller, Michelle, Pemberton, Kenisha, Rodríguez, Jose
Abstract/Description: Women who smoke, have hypertension, hyperlipidemia, or factor V Leiden deficiency and take oral contraception (OC) are at increased risk of myocardial infarction (MI). Third-generation OCs and low-dose OCs are not associated with increased MI risk in women with or without other cardiovascular (CV) risk factors (SOR B, systematic review of cohort studies). OCs are contraindicated in women with preexisting congestive heart failure or CV disease, but may be used in otherwise healthy women with...
Show moreWomen who smoke, have hypertension, hyperlipidemia, or factor V Leiden deficiency and take oral contraception (OC) are at increased risk of myocardial infarction (MI). Third-generation OCs and low-dose OCs are not associated with increased MI risk in women with or without other cardiovascular (CV) risk factors (SOR B, systematic review of cohort studies). OCs are contraindicated in women with preexisting congestive heart failure or CV disease, but may be used in otherwise healthy women with diabetes, hypertension, or hyperlipidemia (SOR C, evidence-based guidelines derived from consensus and expert opinion).
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Date Issued: 2013
Identifier: FSU_migr_fmr-0047
Format: Citation

Title: What Are the Causes of Systolic Murmurs in Young Children?.
Creator: Goodwin, Meredith, Dexter, Nadine, Rodríguez, Jose
Abstract/Description: Innocent or functional murmurs are the most common, present at some point in 50% to 90% of children, typically between 2 and 7 years of age. (SOR B, based on a cohort study.) Systolic murmurs due to systemic diseases or infections are the next most common, with anemia being the most frequent cause. (SOR C, based on a narrative review.) Congenital heart disease is the least common cause of a systolic murmur, occurring in less than 1% of the general population. (SOR B, based on a systematic...
Show moreInnocent or functional murmurs are the most common, present at some point in 50% to 90% of children, typically between 2 and 7 years of age. (SOR B, based on a cohort study.) Systolic murmurs due to systemic diseases or infections are the next most common, with anemia being the most frequent cause. (SOR C, based on a narrative review.) Congenital heart disease is the least common cause of a systolic murmur, occurring in less than 1% of the general population. (SOR B, based on a systematic review of cohort studies.)
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Date Issued: 2010
Identifier: FSU_migr_fmr-0019
Format: Citation

Title: What Common Food Additives Can Cause Acute, Nonallergic Symptoms?.
Creator: Rodríguez, Jose, Campbell, Sara Chelland, Gallard, Javier
Abstract/Description: Aspartame may be associated with headaches in susceptible individuals (SOR B, based on a small crossover study.) Monosodium glutamate (MSG) is associated with a range of constitutional symptoms; however, with blinding, responses to MSG are rarely consistent. (SOR B, based on a randomized controlled trial [RCT].)
Date Issued: 2010
Identifier: FSU_migr_fmr-0022
Format: Citation

Title: What Are Effective Treatments for Painful Varicose Veins?.
Creator: Gonzalez, David, Rodríguez, Jose
Abstract/Description: Several ablative therapies are effective. However, endovenous laser ablation (EVLA) has a higher 5-year success rate than surgical stripping, ultrasound-guided foam sclerotherapy (UGFS), and radiofre-quency ablation (RFA). EVLA is also associated with less postoperative pain, and results a faster improvement in health-related quality of life when compared with surgery. (SOR A, based on a meta-analysis.) Compression stockings are not as effective as ablative therapy. (SOR A, based on a meta...
Show moreSeveral ablative therapies are effective. However, endovenous laser ablation (EVLA) has a higher 5-year success rate than surgical stripping, ultrasound-guided foam sclerotherapy (UGFS), and radiofre-quency ablation (RFA). EVLA is also associated with less postoperative pain, and results a faster improvement in health-related quality of life when compared with surgery. (SOR A, based on a meta-analysis.) Compression stockings are not as effective as ablative therapy. (SOR A, based on a meta-analysis.)
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Date Issued: 2010
Identifier: FSU_migr_fmr-0029
Format: Citation

Title: What Can Be Done to Slow Progression of Dementia in the Elderly?.
Creator: Parker, Alex, Rodríguez, Jose
Abstract/Description: Cholinesterase inhibitors alone or in combination with memantine delay the rate of nursing home admissions among elderly patients with Alzheimer's disease (AD), but have no statistical influence on mortality. (SOR B, based on an observational study.) Cholinesterase inhibitors are associated with small improvements in cognition and function in patients with AD when compared with placebo (SOR A, based on a meta-analysis.) The total societal medical cost of donepezil therapy is comparable to the...
Show moreCholinesterase inhibitors alone or in combination with memantine delay the rate of nursing home admissions among elderly patients with Alzheimer's disease (AD), but have no statistical influence on mortality. (SOR B, based on an observational study.) Cholinesterase inhibitors are associated with small improvements in cognition and function in patients with AD when compared with placebo (SOR A, based on a meta-analysis.) The total societal medical cost of donepezil therapy is comparable to the cost of placebo. (SOR B, based on 1 randomized controlled trial [RCT].)
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Date Issued: 2009
Identifier: FSU_migr_fmr-0015
Format: Citation

Title: What Are the Best Treatments for Reducing Pain Due to Compression Fractures?.
Creator: Bada, Alvaro, Rodríguez, Jose
Abstract/Description: The answer remains unclear. Nasal salmon calcitonin is effective for analgesia of vertebral compression fractures (SOR A, based on a systematic review of randomized controlled trials [RCTs]). Although percutaneous vertebroplasty is slightly more effective than balloon kyphoplasty for reducing pain, it also has a higher refracture rate (SOR A, based on a meta-analysis). Isometric back-extensor muscle strengthening and proprioceptive postural retraining is more effective for prolonging time...
Show moreThe answer remains unclear. Nasal salmon calcitonin is effective for analgesia of vertebral compression fractures (SOR A, based on a systematic review of randomized controlled trials [RCTs]). Although percutaneous vertebroplasty is slightly more effective than balloon kyphoplasty for reducing pain, it also has a higher refracture rate (SOR A, based on a meta-analysis). Isometric back-extensor muscle strengthening and proprioceptive postural retraining is more effective for prolonging time between refractures if there has not been a vertebroplasty (SOR B, based on a case series).
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Date Issued: 2009
Identifier: FSU_migr_fmr-0009
Format: Citation

Title: What Are the Most Effective Methods for Managing General Psychosocial Stress?.
Creator: Rodby, Katherine, Rodríguez, Jose
Abstract/Description: Mindfulness-based stress reduction (MBSR), cognitive-behavioral stress reduction (CBSR), and somatic relaxation are all effective therapies for psychosocial stress. Exercise also reduces stress and improves mental health (SOR B, based on small randomized controlled trials [RCTs]). Anxiolytic agents and antidepressants may be used in refractory cases. (SOR C, expert opinion.)
Date Issued: 2009
Identifier: FSU_migr_fmr-0011
Format: Citation

Title: Plasma BDNF Concentration, Val66Met Genetic Variant and Depression-Related Personality Traits.
Creator: Terracciano, Antonio, Martin, B., Ansari, D., Tanaka, Toshiko, Ferrucci, Luigi, Maudsley, S., Mattson, M., Costa, Paul
Abstract/Description: Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a relatively large community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examine whether BDNF plasma concentration is associated with the Val66Met functional polymorphism of the BDNF gene (n = 335) and with depression-related...
Show moreBrain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a relatively large community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examine whether BDNF plasma concentration is associated with the Val66Met functional polymorphism of the BDNF gene (n = 335) and with depression-related personality traits assessed with the NEO-PI-R (n = 391). Plasma concentration of BDNF was not associated with the Val66Met variant in either men or women. However, in men, but not in women, BDNF plasma level was associated with personality traits linked to depression. Contrary to the notion that low BDNF is associated with negative outcomes, we found lower plasma levels in men who score lower on depression and vulnerability to stress (two facets of Neuroticism) and higher on Conscientiousness and Extraversion. These findings challenge the prevailing hypothesis that lower peripheral levels of BDNF are a marker of depression.
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Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0016, 10.1111/j.1601-183X.2010.00579.x
Format: Citation

Title: Professor Gert's Views on Death: An Analysis and Critique.
Creator: Nair-Collins, Michael
Abstract/Description: In this paper I analyze and critique Gert's views on death, tracing the evolution of his ideas throughout his career. I argue that the definitions-criteria-tests framework that he and his colleagues introduced, along with their approach to death as a biological phenomenon to be understood in biological terms, are immensely important and largely correct. However, there is no scientific justification for claiming that brain-dead bodies are biologically dead bodies. Furthermore, continuing to...
Show moreIn this paper I analyze and critique Gert's views on death, tracing the evolution of his ideas throughout his career. I argue that the definitions-criteria-tests framework that he and his colleagues introduced, along with their approach to death as a biological phenomenon to be understood in biological terms, are immensely important and largely correct. However, there is no scientific justification for claiming that brain-dead bodies are biologically dead bodies. Furthermore, continuing to use the language of "death" to describe such bodies as a matter of public policy constitutes paternalism. I use Gert's analysis of the justification of paternalism to argue that the paternalism inherent in the language of "death" is unjustified.
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Date Issued: 2013
Identifier: FSU_migr_mhs-0037
Format: Citation

Title: Sex Differences in Resting-State Neural Correlates of Openness to Experience Among Older Adults.
Creator: Sutin, Angelina, Beason-Held, Lori, Resnick, Susan M., Costa, Paul
Abstract/Description: We investigated sex differences in the resting-state neural correlates of Openness to Experience, a universal personality trait defined by cognitive flexibility, attention to feelings, creativity, and preference for novelty. Using resting-state positron-emission tomography from 100 older individuals (>55 years of age), we identified associations between Openness and resting-state regional cerebral blood flow that replicated across 2 assessments of the same sample, approximately 2 years apart....
Show moreWe investigated sex differences in the resting-state neural correlates of Openness to Experience, a universal personality trait defined by cognitive flexibility, attention to feelings, creativity, and preference for novelty. Using resting-state positron-emission tomography from 100 older individuals (>55 years of age), we identified associations between Openness and resting-state regional cerebral blood flow that replicated across 2 assessments of the same sample, approximately 2 years apart. Openness correlated positively with prefrontal activity in women, anterior cingulate activity in men, and orbitofrontal activity in both sexes, which suggests that areas linked to cognitive flexibility (women), monitoring processes (men), and reward and emotional processing (both) underlie individual differences in Openness. The results challenge the implicit assumption that the same trait will rely on the same neural mechanisms across all who express it.
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Date Issued: 2009
Identifier: FSU_migr_mhs-0031, 10.1093/cercor/bhp066
Format: Citation

Title: Sex-Specific Correlates of Walking Speed in a Wide Age-Ranged Population.
Creator: Tolea, Magdalena, Costa, Paul, Terracciano, Antonio, Griswold, Michael, Simonsick, Eleanor M., Najjar, Samer, Scuteri, Angelo, Deiana, Barbara, Orrù, Marco, Masala, Marco, Uda,...
Show moreTolea, Magdalena, Costa, Paul, Terracciano, Antonio, Griswold, Michael, Simonsick, Eleanor M., Najjar, Samer, Scuteri, Angelo, Deiana, Barbara, Orrù, Marco, Masala, Marco, Uda, Manuela, Schlessinger, David, Ferrucci, Luigi
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Abstract/Description: The goals of this cross-sectional study were to explore correlates of walking speed in a large wide age-ranged population and to identify factors affecting lower walking speed at older ages. Participants were 3,872 community-dwelling adults in the first follow-up of the SardiNIA study who completed a 4-m walking test. Sex-specific correlates of walking speed included marital status, height, waist circumference, pulse wave velocity, comorbidity, subjective health, strength, and personality....
Show moreThe goals of this cross-sectional study were to explore correlates of walking speed in a large wide age-ranged population and to identify factors affecting lower walking speed at older ages. Participants were 3,872 community-dwelling adults in the first follow-up of the SardiNIA study who completed a 4-m walking test. Sex-specific correlates of walking speed included marital status, height, waist circumference, pulse wave velocity, comorbidity, subjective health, strength, and personality. Effect modifiers of the age-walking speed association included extraversion (<55 >years, p = .019) and education (<55 >years, p = .021; > or =55 years, p = .012) in women, and openness (<55 >years, p = .005), waist circumference (<55 >years, p = .010), and subjective health (<55 >years, p = .014) in men. The strong impact of personality suggests that certain personality traits may be associated with behaviors that affect physical performance and condition the reduced mobility mostly at younger ages. If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention.
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Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0020, 10.1093/geronb/gbp130
Format: Citation

Title: Should Coenzyme Q10 Be Used to Lower Blood Pressure in Asymptomatic Patients?.
Creator: Barker, Daniella, Rodríguez, Jose
Abstract/Description: Coenzyme Q10 (CoQ10) may lower systolic and diastolic blood pressures in patients with primary hypertension, but is not recommended as an antihypertensive treatment (SOR: C, systematic review of low-quality RCTs using disease-oriented outcomes).
Date Issued: 2013
Identifier: FSU_migr_fmr-0046
Format: Citation

Title: Spermitin: A Novel Mitochondrial Protein in Drosophila Spermatids.
Creator: Chen, Jieyan, Megraw, Timothy
Abstract/Description: Mitochondria, important energy centers in the cell, also control sperm cell morphogenesis.Drosophila spermatids have a remarkably large mitochondrial formation called the nebenkern. Immediately following meiosis during sperm development, the mitochondria in the spermatid fuse together into two large aggregates which then wrap around one another to produce the spherical nebenkern: a giant mitochondrion about 6 micrometers in diameter. The fused mitochondria play an important role in sperm tail...
Show moreMitochondria, important energy centers in the cell, also control sperm cell morphogenesis.Drosophila spermatids have a remarkably large mitochondrial formation called the nebenkern. Immediately following meiosis during sperm development, the mitochondria in the spermatid fuse together into two large aggregates which then wrap around one another to produce the spherical nebenkern: a giant mitochondrion about 6 micrometers in diameter. The fused mitochondria play an important role in sperm tail elongation by providing a structural platform to support the elongation of sperm cells. We have identified a novel testis-specific protein, Spermitin (Sprn), a protein with a Pleckstrin homology-like (PH) domain related to Ran-binding protein 1 at its C-terminus. Fluorescence microscopy showed that Sprn localizes at mitochondria in transfected Kc167 cells, and in the nebenkern throughout spermatid morphogenesis. The role of Sprn is unclear, as sprn mutant males are fertile, and have sperm tail length comparable to the wild-type.
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Date Issued: 2014
Identifier: FSU_migr_biomed_faculty_publications-0049, 10.1371/journal.pone.0108802
Format: Citation

Title: The Validity and Structure of Culture-Level Personality Scores: Data from Ratings of Young Adolescents.
Creator: McCrae, Robert R., Terracciano, Antonio, De Fruyt, Filip, De Bolle, Marleen, Gelfand, Michele J., Costa, Paul
Abstract/Description: We examined properties of culture-level personality traits in ratings of targets (N=5,109) ages 12 to 17 in 24 cultures. Aggregate scores were generalizable across gender, age, and relationship groups and showed convergence with culture-level scores from previous studies of self-reports and observer ratings of adults, but they were unrelated to national character stereotypes. Trait profiles also showed cross-study agreement within most cultures, 8 of which had not previously been studied....
Show moreWe examined properties of culture-level personality traits in ratings of targets (N=5,109) ages 12 to 17 in 24 cultures. Aggregate scores were generalizable across gender, age, and relationship groups and showed convergence with culture-level scores from previous studies of self-reports and observer ratings of adults, but they were unrelated to national character stereotypes. Trait profiles also showed cross-study agreement within most cultures, 8 of which had not previously been studied. Multidimensional scaling showed that Western and non-Western cultures clustered along a dimension related to Extraversion. A culture-level factor analysis replicated earlier findings of a broad Extraversion factor but generally resembled the factor structure found in individuals. Continued analysis of aggregate personality scores is warranted.
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Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0017, 10.1111/j.1467-6494.2010.00634.x
Format: Citation

Title: What is the Best Treatment for an Adult Whose Asthma Exacerbation Has Not Completely Responded to 5 Days of Oral Corticosteroids?.
Creator: Hofmann, Mikel, Rodríguez, Jose, Klatt, Carolyn
Abstract/Description: Current guidelines recommend that patients with acute asthma exacerbations be treated with systemic corticosteroids for 5 to 10 days, so continued steroid therapy is an option. However, limited evidence suggests that a 2-week course of oral steroids may be no more effective than a 1-week course (SOR C, based on a single small randomized controlled trial with a trend favoring prolonged therapy).
Date Issued: 2008
Identifier: FSU_migr_fmr-0007
Format: Citation

Title: What is the Role of Carbohydrate-Restricted Diets for Patients with Obesity-Related Diseases (Hyperlipidemia, Diabetes, Hypertension, etc)?.
Creator: Nagy, Suzanne, Soberon, Angelica, Rodríguez, Jose
Abstract/Description: Compared with low-fat diets, carbohydrate-restricted diets (eg, Atkins) produce more weight loss in the short term (at 6 months but not at 1 year) and produce a greater reduction in glycosylated hemoglobin (HbA1C). (SOR A, based on a meta-analysis.) However, no studies have been published with more than 1 year duration or have focused on patient-oriented outcomes. The American Diabetes Association now recommends either low-carbohydrate or low-fat calorie-restricted diets for weight loss over...
Show moreCompared with low-fat diets, carbohydrate-restricted diets (eg, Atkins) produce more weight loss in the short term (at 6 months but not at 1 year) and produce a greater reduction in glycosylated hemoglobin (HbA1C). (SOR A, based on a meta-analysis.) However, no studies have been published with more than 1 year duration or have focused on patient-oriented outcomes. The American Diabetes Association now recommends either low-carbohydrate or low-fat calorie-restricted diets for weight loss over the short term. (SOR C, based on expert opinion.)
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Date Issued: 2008
Identifier: FSU_migr_fmr-0006
Format: Citation

Title: When is Heparin Indicated for the Management of Acute Stroke?.
Creator: Murphy, Shelley, Rodríguez, Jose
Abstract/Description: Heparin does not appear to improve overall outcomes when used for ischemic stroke or within the first 2 weeks of a cardioembolic stroke. (SOR B, extrapolated from meta-analyses of multiple heparinoids.)
Date Issued: 2009
Identifier: FSU_migr_fmr-0018
Format: Citation

Title: Which is the Best Surgical Incision/Technique for Cesarean Section?.
Creator: LeFranc, Noemi, Rodríguez, Jose
Abstract/Description: The Joel-Cohen skin incision is associated with less fever, pain, analgesic use, and blood loss, as well as shorter surgeries and hospital stays when compared with the Pfannenstiel skin incision (SOR: A, based on a systematic review). For uterine incision, the answer is no clear, but blunt dissection is associated with less blood loss when compared with sharp dissection (SOR: A, based on a systematic review and subsequent RCT). Cephalad-caudad blunt dissection appears safer than transverse...
Show moreThe Joel-Cohen skin incision is associated with less fever, pain, analgesic use, and blood loss, as well as shorter surgeries and hospital stays when compared with the Pfannenstiel skin incision (SOR: A, based on a systematic review). For uterine incision, the answer is no clear, but blunt dissection is associated with less blood loss when compared with sharp dissection (SOR: A, based on a systematic review and subsequent RCT). Cephalad-caudad blunt dissection appears safer than transverse blunt dissection (SOR: B, based on 1 RCT).
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Date Issued: 2010
Identifier: FSU_migr_fmr-0030
Format: Citation

Title: What is the Most Effective Treatment for Bell's Palsy Among Patients with Diabetes?.
Creator: Gonzalez, David, Rodríguez, Jose, Talbot, Richard
Abstract/Description: Patients with Bell's palsy have higher cure rates when treated with oral prednisolone within 72 hours of onset (SOR B, based on a single randomized controlled trial), but it is unclear what effect this therapy would have on patients with diabetes. Intravenous lipo-prostaglandin E1 (lipo-PGE1) may be an alternative to steroid therapy for Bell's palsy that does not effect blood glucose levels. (SOR C, based on a single small cohort study.)
Date Issued: 2010
Identifier: FSU_migr_fmr-0024
Format: Citation

Title: The University of Florida's Commitment to Recruit Family Physicians.
Creator: Cotter, Shenary, Campbell, Kendall, Curry, R.
Abstract/Description: At the University of Florida, we enthusiastically educate and encourage students about family medicine. Communities in which family physicians practice are healthier, and relationships patients have with their family physicians are some of the most rewarding. We demonstrate this to UF students in a variety of settings and interactions with our faculty throughout their entire four-year medical education. Paramount to our efforts are personal interactions with core faculty members enthusiastic...
Show moreAt the University of Florida, we enthusiastically educate and encourage students about family medicine. Communities in which family physicians practice are healthier, and relationships patients have with their family physicians are some of the most rewarding. We demonstrate this to UF students in a variety of settings and interactions with our faculty throughout their entire four-year medical education. Paramount to our efforts are personal interactions with core faculty members enthusiastic about family medicine and teaching. Students participate in a wide range of clinical settings, providing the full complement of family medicine. They encounter faculty members whose focus is hospital medicine, procedures, sports medicine, women's health, student health, ambulatory care, urgent care, academic medicine and underserved care. The diversity of our faculty provides students insight into the many opportunities available in family medicine. Targeted student activities throughout medical school help spark and maintain student interest in family medicine.
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Date Issued: 2009
Identifier: FSU_migr_fmr-0039
Format: Citation

Title: Training Medical Students to Recognize and Address Health Disparities.
Creator: Campbell, Kendall
Abstract/Description: As the U.S. population grows more diverse, it is becoming more and more important for medical schools to address health disparities, underserved populations and cultural competency. The growing population places increasing demands on our health care system and requires our medical schools to produce more culturally competent, health disparity-minded physicians. The 16th Report of the Council on Graduate Medical Education suggests that the demand for physicians after 2015 will be greater than...
Show moreAs the U.S. population grows more diverse, it is becoming more and more important for medical schools to address health disparities, underserved populations and cultural competency. The growing population places increasing demands on our health care system and requires our medical schools to produce more culturally competent, health disparity-minded physicians. The 16th Report of the Council on Graduate Medical Education suggests that the demand for physicians after 2015 will be greater than the supply. The persons most impacted will be those who are underserved.
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Date Issued: 2009
Identifier: FSU_migr_fmr-0040
Format: Citation

Title: Trait Antagonism and the Progression of Arterial Thickening: Women with Antagonistic Traits Have Similar Carotid Arterial Thickness as Men.
Creator: Sutin, Angelina, Scuteri, Angelo, Lakatta, Edward, Tarasov, Kirill, Ferrucci, Luigi, Costa, Paul, Schlessinger, David, Uda, Manuela, Terracciano, Antonio
Abstract/Description: A large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based sample from Sardinia, Italy (n=5614), this study examined how trait antagonism (low agreeableness) and its facets are associated with carotid artery intima-media thickness, a measure of arterial thickening. Controlling for demographic and cardiovascular risk...
Show moreA large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based sample from Sardinia, Italy (n=5614), this study examined how trait antagonism (low agreeableness) and its facets are associated with carotid artery intima-media thickness, a measure of arterial thickening. Controlling for demographic and cardiovascular risk factors, low agreeableness and, in particular, low straightforwardness and low compliance, were associated with greater carotid thickening, measured concurrently and prospectively, and with increases in intima-media thickness over 3 years. Indeed, those in the bottom 10% of agreeableness had a 40% increase in risk for elevated intima-media thickness. Although men have thicker arterial walls, women with antagonistic traits had similar carotid thickening as antagonistic men. Antagonistic individuals, especially those who are manipulative and aggressive, have greater increases in arterial thickening, independent of traditional cardiovascular risk factors.
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Date Issued: 2010
Identifier: FSU_migr_mhs-0022, 10.1161/HYPERTENSIONAHA.110.155317
Format: Citation

Title: Trait Dissociation and the Subjective Affective, Motivational, and Phenomenological Experience of Self-Defining Memories.
Creator: Sutin, Angelina, Stockdale, Gary
Abstract/Description: The present research reports 2 studies that examine the relation between nonpathological trait dissociation and the subjective affect, motivation, and phenomenology of self-defining memories. In Study 1 (N=293), participants retrieved and rated the emotional and motivational experience of a general and a positive and negative achievement-related memory. Study 2 (N=449) extended these ratings to relationship-related memories and the phenomenological experience of the memory. Dissociation was...
Show moreThe present research reports 2 studies that examine the relation between nonpathological trait dissociation and the subjective affect, motivation, and phenomenology of self-defining memories. In Study 1 (N=293), participants retrieved and rated the emotional and motivational experience of a general and a positive and negative achievement-related memory. Study 2 (N=449) extended these ratings to relationship-related memories and the phenomenological experience of the memory. Dissociation was associated with incongruent affect in valenced memories (e.g., positive affect in a negative memory) and memories that were visually incoherent and saturated with power motivation, hubristic pride, and shame, regardless of valence or domain. The present findings demonstrate that autobiographical memories, which integrate emotional, motivational, and phenomenological components, reflect the emotional and motivational processes inherent to dissociation.
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Date Issued: 2011
Identifier: FSU_migr_mhs-0017, 10.1111/j.1467-6494.2010.00708.x
Format: Citation

Title: What Methods Are Effective for Reducing the Incidence of Dental Caries?.
Creator: Gaar, Micah, Rodríguez, Jose, Alexiev, Elena
Abstract/Description: Fluoride mouth rinses and fluoride toothpastes used regularly at home reduce the incidence of dental caries about 25%. (SOR A, based on systematic reviews of RCTs.) Professionally applied fluoride varnishes reduce carries by about 50%. (SOR A, based on systematic reviews of RCTs.) Pit and fissure sealants provide additional protection beyond fluoride varnishes. (SOR B, based on a meta-analysis with a small number of patients.)
Date Issued: 2010
Identifier: FSU_migr_fmr-0023
Format: Citation

Title: What Question Set is Most Effective to Screen Chronic Pain Patients for Potential Opioid Abuse?.
Creator: Rodríguez, Jose, Gonzalez, David
Abstract/Description: The Screener and Opioid Assessment Measure for Patients with Chronic Pain (SOAAP) and the Opioid Risk Tool (ORT) are both validated tools that screen for future problems with prescription opioids. The ORT has been more rigorously studied and is able to identify low-, moderate-, and high-risk populations. (SOR B, based on a single validating cohort study.)
Date Issued: 2008
Identifier: FSU_migr_fmr-0005
Format: Citation

Title: What Health Education Interventions Reduce the Progression of Prediabetes to Overt Diabetes in High-Risk Groups?.
Creator: Fabrizi, Meghan, Rodríguez, Jose
Date Issued: 2013
Identifier: FSU_migr_fmr-0053
Format: Citation

Title: What Therapies Are Effective for Relief of Chronic Vertigo Symptoms?.
Creator: Crawford, Veronita, Rodríguez, Jose
Abstract/Description: For unilateral peripheral vestibular dysfunction, vestibular rehabilitation (VR) improves subjective dizziness. In benign paroxysmal positional vertigo (BPPV), canalith repositioning maneuvers are associated with excellent short-term relief. (SOR A, based on a systematic review.) In patients with Ménière's disease, instruction in VR and symptom control are equally effective; the Meniett device can produce symptom relief in refractory cases. (SOR B, based on randomized controlled trials [RCTs]...
Show moreFor unilateral peripheral vestibular dysfunction, vestibular rehabilitation (VR) improves subjective dizziness. In benign paroxysmal positional vertigo (BPPV), canalith repositioning maneuvers are associated with excellent short-term relief. (SOR A, based on a systematic review.) In patients with Ménière's disease, instruction in VR and symptom control are equally effective; the Meniett device can produce symptom relief in refractory cases. (SOR B, based on randomized controlled trials [RCTs].) Antihistamines, anticholinergics, benzodiazepines, diuretics, calcium channel blockers, and topiramate may also help relieve symptoms. (SOR C, based on expert opinion.)
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Date Issued: 2009
Identifier: FSU_migr_fmr-0010
Format: Citation

Title: What Treatments Are Effective for Nickel Allergy?.
Creator: Lesnick, Joseph, Rodríguez, Jose
Abstract/Description: Preventing further exposure is clearly important. Postexposure, topical tacrolimus and topical steroids improve symptoms of nickel allergy better than placebo (SOR: B, 2 small RCTs).
Date Issued: 2013
Identifier: FSU_migr_fmr-0045
Format: Citation

Title: What Treatments Are Effective for Symptomatic Benign Orthostatic Hypotension?.
Creator: Caporasco, Anthony, Chhabra, Ruchi, Qureshi, Hina, Rodríguez, Jose, Hitchcock, Kristin
Abstract/Description: Increased salt intake, compression stockings, and midodrine can reduce symptoms related to benign orthostatic hypotension. (SOR B, based on a single study of each intervention.) Counterpressure measures are safe, easy, reliable strategies to prevent syncope. (SOR A, based on 2 randomized controlled trials [RCTs] and a case series.) Drugs contributing to benign orthostatic hypotension should be discontinued or replaced if possible. (SOR C, based on expert opinion.)
Date Issued: 2009
Identifier: FSU_migr_fmr-0014
Format: Citation

Title: The personality domains and styles of the five-factor model are related to incident depression in Medicare recipients aged 65 to 100.
Creator: Weiss, Alexander, Sutin, Angelina, Duberstein, Paul Raphael, Friedman, Bruce, Bagby, R. Michael, Costa, Paul
Abstract/Description: OBJECTIVES: Few prospective studies have examined personality and depression in older adults. The authors investigated whether the Five-Factor Model of personality traits-Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness-and trait combinations (styles) are related to incident major or minor depression. PARTICIPANTS/SETTING: Prospective data were gathered on a community sample of 512 older adults with disability and a history of significant health care...
Show moreOBJECTIVES: Few prospective studies have examined personality and depression in older adults. The authors investigated whether the Five-Factor Model of personality traits-Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness-and trait combinations (styles) are related to incident major or minor depression. PARTICIPANTS/SETTING: Prospective data were gathered on a community sample of 512 older adults with disability and a history of significant health care utilization who were enrolled in a Medicare Demonstration Project. MEASUREMENTS: Depression and personality traits and styles were assessed at baseline; depression was assessed again at approximately 12 and 22 months. DESIGN: Participants who developed incident major depression were compared with those free of depression at all three assessments. Similar analyses were done for minor depression. RESULTS: High Neuroticism and low Conscientiousness were risk factors for both major and minor depression. Combinations of high Neuroticism with low or high Extraversion or high Openness conferred risk for major depression. Other novel findings for major depression revealed new trait combinations of low Conscientiousness with low or high Extraversion, high Openness, or low Agreeableness. Three trait combinations, all involving low Conscientiousness, predicted risk for minor depression: high Neuroticism, high Agreeableness, and low Openness. CONCLUSION: The present findings highlight the importance of examining combinations of personality traits or personality styles when identifying those who are most at-risk for geriatric depression. Since other personality domains may modify the risk related to high Neuroticism and low Conscientiousness, the prevention, diagnosis, and treatment of depression could be greatly improved by assessing older patients not only on all five domains of personality but in terms of their combinations.
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Date Issued: 2009
Identifier: FSU_migr_mhs-0035
Format: Citation

Department of Family Medicine and Rural Health (55)	+ -
Department of Behavioral Sciences and Social Medicine (39)	+ -
Department of Geriatrics (38)	+ -
Department of Biomedical Sciences (29)	+ -
Center for Innovative Collaboration in Medicine and Law (12)	+ -

Department of Clinical Sciences (1)	+ -
Department of Nutrition, Food and Exercise Sciences (1)	+ -
School of Information Faculty Scholarship (1)	+ -
Showcase of Undergraduate Research Excellence (1)	+ -
2015 (1)	+ -

Psychology (64)	+ -
Psychiatry (57)	+ -
Diseases (48)	+ -
Human behavior (43)	+ -
Social aspects (43)	+ -

Personality (42)	+ -
Mental health (34)	+ -
Social psychiatry (25)	+ -
Cardiovascular system (24)	+ -
Biochemistry (21)	+ -
Genetics (21)	+ -
Social sciences (21)	+ -
Cytology (19)	+ -
Geriatrics (19)	+ -
Developmental biology (18)	+ -
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Physiology (18)	+ -
Public health (18)	+ -
Clinical biochemistry (17)	+ -
Biophysics (16)	+ -
Mental illness (16)	+ -
Molecular biology (16)	+ -
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Symptoms (16)	+ -
Chemicals (15)	+ -
Amino acids (14)	+ -
Drugs (14)	+ -
Peptides (14)	+ -
Proteins (14)	+ -

Terracciano, Antonio (52)	+ -
Rodríguez, Jose (46)	+ -
Costa, Paul (37)	+ -
Sutin, Angelina (29)	+ -
Ferrucci, Luigi (22)	+ -

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