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- Title
- Legality, Ethics and Memory: The Role of American Physicians in Post-WWII Germany.
- Creator
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Abel, Liesa A.
- Abstract/Description
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This thesis addresses the responses and subsequent roles of American military physicians in Post- WWII Germany, from March 1945 to January 1950. Physician roles include medical practice both within and outside of their specialties, hospital administration, and work in Prisoner of War (POW) and Displaced Persons (DP) camps. Physicians treated trauma in their patients but also experienced trauma themselves; they also wrestled with conflicting feelings toward German civilians and former Nazis....
Show moreThis thesis addresses the responses and subsequent roles of American military physicians in Post- WWII Germany, from March 1945 to January 1950. Physician roles include medical practice both within and outside of their specialties, hospital administration, and work in Prisoner of War (POW) and Displaced Persons (DP) camps. Physicians treated trauma in their patients but also experienced trauma themselves; they also wrestled with conflicting feelings toward German civilians and former Nazis. Explored here are altruistic motives of physicians who treated POWs and DPs, as well as a contemporary assessment of the significance of their work.
Show less - Date Issued
- 2017-04-28
- Identifier
- FSU_libsubv1_scholarship_submission_1493385335
- Format
- Thesis
- Title
- A Colorful Investigation: Deoxo Rhodamine Spirolactam Ring Opening Rates and The Development of New Rhodamine Dyes based on ESIPT.
- Creator
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Accardo, Joseph, Zhu, Lei
- Abstract/Description
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Deoxo rhodamine spirolactams (DRS) undergo significant fluorescence enhancement when going from their neutral (closed from) to dicationic state (open form). New and existing DRS were synthesized through the reduction of rhodamine spirolactams (RS). The pKa values for the two protonation processes were determined for a set of three DRS, and the overall rates were measured by the stopped-flow method. These compounds exhibited high ring opening rates, up to 104 times as fast as reported RS...
Show moreDeoxo rhodamine spirolactams (DRS) undergo significant fluorescence enhancement when going from their neutral (closed from) to dicationic state (open form). New and existing DRS were synthesized through the reduction of rhodamine spirolactams (RS). The pKa values for the two protonation processes were determined for a set of three DRS, and the overall rates were measured by the stopped-flow method. These compounds exhibited high ring opening rates, up to 104 times as fast as reported RS probes for the same reaction. In addition to the investigation, a fluorescent study of 1,2,3-triazoles is also described, which has fueled the future directions of this study.
Show less - Date Issued
- 2016-04-22
- Identifier
- FSU_libsubv1_scholarship_submission_1461352325
- Format
- Thesis
- Title
- A meal pattern and time-course analysis of estrogen receptor agonists.
- Creator
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Adams, Kia, Butler, Michael, Eckel, Lisa
- Abstract/Description
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Estradiol (E2) is an ovarian hormone that has a well-characterized anorexigenic effect in female animals that was originally believed to be mediated through the activation of nuclear estrogen receptors (ERs). However, recent studies from our lab and others have shown rapid anorexigenic effects after activation of membrane ERs (mERs), such as mER and G-protein coupled estrogen receptor (GPER). The comparative action of the non-selective ER agonist, estradiol benzoate (EB), and the selective ER...
Show moreEstradiol (E2) is an ovarian hormone that has a well-characterized anorexigenic effect in female animals that was originally believed to be mediated through the activation of nuclear estrogen receptors (ERs). However, recent studies from our lab and others have shown rapid anorexigenic effects after activation of membrane ERs (mERs), such as mER and G-protein coupled estrogen receptor (GPER). The comparative action of the non-selective ER agonist, estradiol benzoate (EB), and the selective ER and GPER agonists PPT and G-1, respectively, is poorly understood. In the current study, we analyzed meal patterns after acute administration of each of these agonists in OVX female Long-Evans rats. Both PPT and G-1 produced rapid decreases in food intake within 2 and 1 h, respectively, with associated decreases in the size of the first meal following drug treatment. It was also determined that EB produces a prolonged anorexigenic effect, suppressing food intake for three days beginning 12 h after drug treatment. Overall, these findings provide additional evidence that activation of mERs alone is sufficient to decrease food intake and that mER agonists produce more rapid but more transient effects than the non-selective ER agonist EB.
Show less - Date Issued
- 2017-04-28
- Identifier
- FSU_libsubv1_scholarship_submission_1493409498
- Format
- Thesis
- Title
- Waking Up From the American Dream: Examining Attitudes Toward Economic Mobility Among American Voters.
- Creator
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Adams, Alexander Joshua
- Abstract/Description
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The cultural mythos of the American dream posits that any individual can elevate their socioeconomic status in the United States through hard work, regardless of their original social station. However, economic mobility in the United States has stagnated over the past several decades, making the American Dream more wishful thinking than reality. This study seeks to measure how deeply held American voters’ beliefs are about the American dream. This is accomplished through a survey instrument...
Show moreThe cultural mythos of the American dream posits that any individual can elevate their socioeconomic status in the United States through hard work, regardless of their original social station. However, economic mobility in the United States has stagnated over the past several decades, making the American Dream more wishful thinking than reality. This study seeks to measure how deeply held American voters’ beliefs are about the American dream. This is accomplished through a survey instrument which includes a randomized text which supports either an individualistic, structural, or fatalistic explanation of socioeconomic mobility. A strong belief in the American Dream would indicate a preference for individualistic and fatalistic approaches, rather than structural explanations. By making my survey available on a secure online platform, I have taken a quantitative approach to this question, and have reached a large enough sample size that my results can be considered meaningful.
Show less - Date Issued
- 2019-04-22
- Identifier
- FSU_libsubv1_scholarship_submission_1556028873_4d58380c
- Format
- Thesis
- Title
- The Dorset Chronotope: An Ecocritical Reading of Thomas Hardy's "Jude the Obscure" and "The Mayor of Casterbridge".
- Creator
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Advent, Michael David
- Abstract/Description
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Pre-existing analyses involving Mikhail Bakhtin’s “chronotope”—from the Greek for “time-space”—have dealt with how space-time configurations categorize literature by genre. This means that each genre of literature, generally, has different spatial-temporal frameworks, and therefore, different chronotopes. One of the least studied chronotopes is the idyllic chronotope. Based on pastoral imagery and metaphors, the idyllic chronotope is fundamentally ecocritical: however, many ecocritical...
Show morePre-existing analyses involving Mikhail Bakhtin’s “chronotope”—from the Greek for “time-space”—have dealt with how space-time configurations categorize literature by genre. This means that each genre of literature, generally, has different spatial-temporal frameworks, and therefore, different chronotopes. One of the least studied chronotopes is the idyllic chronotope. Based on pastoral imagery and metaphors, the idyllic chronotope is fundamentally ecocritical: however, many ecocritical studies have not analyzed the use of the idyllic chronotope in a specific author. Accordingly, this project utilizes the idyllic chronotope, through an ecocritical lens, to unpack the spatial-temporal frameworks present in Thomas Hardy’s "Jude the Obscure" and "The Mayor of Casterbridge." In creating “The Dorset Chronotope,” a specific type of idyllic chronotope, this paper argues that the county of Dorset, England, the setting of these two novels, is the primary basis for the space and time characteristics in each respective novel. These spatio-temporal configurations establish relationships between Hardy’s characters and the natural environment, but the way that relationship plays out differs between the novels. For "Jude," these chronotopic relationships are inherently concerned with travel and movement; for "Mayor", the chronotopic relationships reveals the interconnected and circular relationship between the present and the past. Ultimately, “The Dorset Chronotope” inspires a new conversation concerning Hardy’s use of space and time and gives insight into Hardy’s perception of humanity interacting with the surrounding world: that is, that Hardy fundamentally believes in a deterministic world.
Show less - Date Issued
- 2019-04-15
- Identifier
- FSU_libsubv1_scholarship_submission_1556112013_16ef57b6
- Format
- Thesis
- Title
- The Effect of the Center of Academic Retention and Enhancement on the College Enrollment of Black Undergraduate Students at the Florida State University.
- Creator
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Brown, Keturah, African-American Studies
- Abstract/Description
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College enrollment rates into institutions of higher education have increased over the last thirty years for Black high school graduates (Insitute of Education Science, 2011). However, there are many college enrollment factors that influence a student's decision to attend a college or university. This study sought to determine the most influential college enrollment factors that affect the decision of Black undergraduates to enroll at FSU. Specifically, the study analyzed the role that the...
Show moreCollege enrollment rates into institutions of higher education have increased over the last thirty years for Black high school graduates (Insitute of Education Science, 2011). However, there are many college enrollment factors that influence a student's decision to attend a college or university. This study sought to determine the most influential college enrollment factors that affect the decision of Black undergraduates to enroll at FSU. Specifically, the study analyzed the role that the Center of Academic Retention and Enhancement, a summer bridge program at the Florida State University, plays in the enrollment of Black undergraduate students. A survey questionnaire was developed and distributed to Black undergraduate students at Florida State University that asked questions concerning the importance of various college enrollment factors. The study found that "Financial Aid: Scholarships and Grants" was the most important college enrollment factor. The C.A.R.E Program was also influential in the decision of the majority of C.A.R.E students to attend FSU. Based off of the findings from the survey, it is evident that the C.A.R.E Program is a vital instrument in the recruitment of Black undergraduate students to FSU and to the academic success of those students throughout their college career.
Show less - Date Issued
- 2012
- Identifier
- FSU_migr_uhm-0099
- Format
- Thesis
- Title
- Oxytocin and metabolic tissue: An analysis of OXTR in skeletal muscle and lipid size and density in surrounding adipose tissue.
- Creator
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Aiken, Romy Maxine, Greenwood, Maria, Hammock, Elizabeth
- Abstract/Description
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The neuropeptide oxytocin (OXT) is most commonly associated with parturition, lactation, and social behavior but also modulates eating behaviors and homeostatic metabolic processes. Existing research relating metabolic disorders to OXT suggest a role for OXT in regulating the physiology of metabolic tissues. The implications of this role are relevant to Prader-Willi Syndrome (PWS), a genetic disorder which includes a deficit of OXT-producing neurons in the paraventricular nucleus of the...
Show moreThe neuropeptide oxytocin (OXT) is most commonly associated with parturition, lactation, and social behavior but also modulates eating behaviors and homeostatic metabolic processes. Existing research relating metabolic disorders to OXT suggest a role for OXT in regulating the physiology of metabolic tissues. The implications of this role are relevant to Prader-Willi Syndrome (PWS), a genetic disorder which includes a deficit of OXT-producing neurons in the paraventricular nucleus of the hypothalamus, obesity, hypotonia, and hyperphagia. The purpose of this study is to assess the presence of oxytocin receptors (OXTR) in the skeletal muscles of neonatal OXTR wildtype and knockout mice and consider genotype-dependent differences in surrounding adipose tissue. Image analysis for OXTR in muscle was performed on archived autoradiographic samples and associated anatomical cresyl violet stains from 20 μm sagittal slices of postnatal day 0 (P0) whole body OXTR wild-type (WT) and OXTR knock-out (KO) mice. Quantification of radioligand binding in regions of interest (forelimb, hindlimb, and masseter muscles) revealed higher OXTR binding in OXTR-KO males than wildtype males across regions while OXTR-WT females demonstrate higher binding across regions than wildtype males. BODIPY lipid staining of neonatal OXTR-WT and OXTR-KO mice suggest density of lipid droplets in adipose tissue above forelimb does not differ between knock-outs and wildtypes. Failed immunofluorescence staining of EGFP-OXTR transgene positive and negative P0 mice fixed with liquid and vapor paraformaldehyde (PFA) prompted investigation of vapor fixation protocol to optimize endogenous fluorescence. Endogenous fluorescence in trigeminal ganglion of OXTR-EGFP transgene positive and negative mice fixed for varying incubation periods was inconclusive and requires further investigation.
Show less - Date Issued
- 2019-08-02
- Identifier
- FSU_libsubv1_scholarship_submission_1564745984_47eee70d
- Format
- Thesis
- Title
- Examining Factors Influencing the Differential Reporting of Suicide Attempt History Among Undergraduates at Elevated Suicide Risk.
- Creator
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Albury, Evan Ann
- Abstract/Description
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Prior studies suggest that individuals may respond inconsistently to different assessments of suicide attempt (SA) history; yet, little is known regarding why inconsistent reporting of SA history may occur. The overarching goal of this study was to examine factors that influence whether individuals consistently respond to different self-report measures designed to assess SA history. Undergraduate students (N = 141) who reported a lifetime history of suicidal ideation completed three different...
Show morePrior studies suggest that individuals may respond inconsistently to different assessments of suicide attempt (SA) history; yet, little is known regarding why inconsistent reporting of SA history may occur. The overarching goal of this study was to examine factors that influence whether individuals consistently respond to different self-report measures designed to assess SA history. Undergraduate students (N = 141) who reported a lifetime history of suicidal ideation completed three different self-report measures of SA history: the (1) Beck Scale for Suicide Ideation (BSS), (2) Suicidal Behaviors Questionnaire—Revised (SBQ-R), and (3) Self-Injurious Thoughts and Behaviors Interview-Short Form (SITBI-SF), as well as indices of clinical severity, personality traits, and impulsivity. All measures were administered in a randomized order to control for potential order effects. Descriptive statistics and one-way ANOVAs were used to test study aims. Of the sample, 75.2% of participants denied an SA history across all three measures, 16.3% reported an SA across all measures (“consistent responders”), and 8.5% responded inconsistently to SA history measures (“inconsistent responders”). One-way ANOVAs did not reveal any statistically significant differences in clinical severity, personality traits, or impulsivity between consistent and inconsistent responders; however, medium effects were observed when comparing consistent and inconsistent responders on levels of conscientiousness, neuroticism/emotional stability, sensation-seeking, and self-reported future likelihood of making an SA. Findings from this study underscore a need for increased efforts to improve SA history assessments and to identify whether personality and clinical characteristics might play a role in inconsistent reporting of SA history among young adults.
Show less - Date Issued
- 2019-04-05
- Identifier
- FSU_libsubv1_scholarship_submission_1554472661_917b066f
- Format
- Thesis
- Title
- Investigating circadian modulation of consummatory learning using a classical paradigm in Aplysia.
- Creator
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Allem, Alyssa D.
- Abstract/Description
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The circadian system is an endogenous system of oscillators that rhythmically regulate many biological processes. Memory formation is a prominent process influenced by the circadian clock. Learning and memory are vital processes for any organism to make predictions about certain aspects of their environment. Aplysia have been a significant model organism for studying memory and circadian rhythms, as they demonstrate certain behaviors with fluctuation based on the time of day. Aplysia...
Show moreThe circadian system is an endogenous system of oscillators that rhythmically regulate many biological processes. Memory formation is a prominent process influenced by the circadian clock. Learning and memory are vital processes for any organism to make predictions about certain aspects of their environment. Aplysia have been a significant model organism for studying memory and circadian rhythms, as they demonstrate certain behaviors with fluctuation based on the time of day. Aplysia californica is a diurnal species that only sleeps at night, similar to humans, meaning that they would presumably feed during the day. In previous studies, feeding behavior of Aplysia has provided a great model system for investigating consummatory learning, as new learning paradigms that focus on biting activity have emerged to study classical conditioning in Aplysia. However, there has been a lack in research investigating the circadian aspects of consummatory feeding behaviors in Aplysia and whether or not consummatory learning is shaped by circadian oscillators. This study focused on characterizing consummatory feeding behaviors in Aplysia using a behavioral biting assay time course and it was concluded that biting response is regulated by the circadian clock. However, associative paradigms that measure biting response may not be suitable to investigate circadian modulation of learning and memory. Determining how the circadian clock regulates biting activity is valuable to A. californica’s use as a model organism for studying the circadian modulation of learning.
Show less - Date Issued
- 2016-12-06
- Identifier
- FSU_libsubv1_scholarship_submission_1481005091
- Format
- Thesis
- Title
- Characterization of small molecule inhibitors of Zika Virus infection.
- Creator
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Allen, Chase Terrance
- Abstract/Description
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Zika virus (ZIKV) is a mosquito-transmitted positive RNA sense virus that has spread rapidly in the past year, prompting the World Health Organization (WHO), on 1 February 2016, to announce that the association of Zika infection with clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern1. The state of emergency eventually ended in November of 2016; however, given the global health concern posed by this virus, a large-scale...
Show moreZika virus (ZIKV) is a mosquito-transmitted positive RNA sense virus that has spread rapidly in the past year, prompting the World Health Organization (WHO), on 1 February 2016, to announce that the association of Zika infection with clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern1. The state of emergency eventually ended in November of 2016; however, given the global health concern posed by this virus, a large-scale effort to identify drugs for treating ZIKV and combatting its continued spread is of utmost importance. There are currently no drugs or vaccines for the treatment or prevention of ZIKV infection, although at least one vaccine study is scheduled for stage II/IIb clinical trials. This vaccine is currently being developed by the National Institute of Allergy and Infectious Diseases (NIAID), a branch of the National Institutes of Health (NIH). Although this vaccine study is underway, it is still highly advantageous to have small molecule inhibitors because whether or not this vaccination will produce susceptibilities to secondary flavivirus infections is still unknown42. The urgency that this situation provides led us and others to look to test preexisting drugs for efficacy against ZIKV infection. In attempt to close this gap in treatment and prevention we, in collaboration with Dr. Wei Zheng and others at the National Center for Advanced Translational Sciences (NCATS), previously reported a screen of 6,000 compounds for anti-ZIKV activity. In this study, we identified several compounds with sub-micromolar anti-ZIKV activity in a cell-culture based model, including the FDA approved anthelmintic drug Niclosamide. Niclosamide proved to be capable of inhibiting ZIKV replication at ~0.2μM concentrations, in vitro, when added either before or after ZIKV exposure2. In order to pursue additional potential drugs, our collaborative efforts have, in total, screened over 80,000 compounds for anti-ZIKV activity. Of these, we have selected several compounds for characterization, based on multiple factors: initial antiviral activity in a ZIKV viral protein (non-structural protein 1) detection assay, cytotoxicity profiles, and US Food and Drug Administration (FDA) approval status or previous in vivo safety profiles via human clinical trials. Attempts to further characterize the anthelmintic drug Niclosamide as well as efforts to identify several more compounds for antiviral activity were explored in a cell culture based ZIKV model for efficacy against ZIKV infection and drug anti-ZIKV mechanism of action. My results demonstrate the efficacy of these screening techniques, identify potential compounds for anti-ZIKV drug development, and provide preliminary insights on the selected drug mechanisms of action.
Show less - Date Issued
- 2017-04-27
- Identifier
- FSU_libsubv1_scholarship_submission_1493319376
- Format
- Thesis
- Title
- Syntaxin3 is Essential for Photoreceptor Survival in Zebrafish.
- Creator
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Allen, Dylan Michael
- Abstract/Description
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SNARE proteins are essential for membrane fusion in eukaryotes. Syntaxin binding proteins (STXBP) mediate SNARE-dependent vesicular binding to the plasma membrane. A mutation was previously isolated in stxbp1b resulting in rapid degeneration of retinal photoreceptors. I hypothesize that Stx3, a member of the SNARE complex, is also essential for photoreceptor survival. Mutations were induced in stx3 by injecting gRNA targeting exon 2 and mRNA encoding Cas9 into 1-cell stage zebrafish embryos....
Show moreSNARE proteins are essential for membrane fusion in eukaryotes. Syntaxin binding proteins (STXBP) mediate SNARE-dependent vesicular binding to the plasma membrane. A mutation was previously isolated in stxbp1b resulting in rapid degeneration of retinal photoreceptors. I hypothesize that Stx3, a member of the SNARE complex, is also essential for photoreceptor survival. Mutations were induced in stx3 by injecting gRNA targeting exon 2 and mRNA encoding Cas9 into 1-cell stage zebrafish embryos. Embryos and adults were genotyped using PCR and DNA sequencing. Retinal phenotypes were characterized for visual deficits using the optokinetic reflex (OKR). Histological sections were immunolabeled for photoreceptor-specific antigens. Using this approach, I isolated novel alleles of stx3. One allele is predicted to result in a frame shift mutation and premature stop codon. 25% of the offspring from matings between 2 heterozygous carriers of the novel stx3 allele failed to display an OKR. Larvae lacking an OKR were homozygous for the mutation, and immunolabeling revealed photoreceptor degeneration. These data show that the SNARE complex is essential for photoreceptor survival in the developing zebrafish retina. Supported by the NIH and FSU.
Show less - Date Issued
- 2018-10-2018
- Identifier
- FSU_libsubv1_scholarship_submission_1533830132_1751809e
- Format
- Thesis
- Title
- Perceptions of Racism Among College Students: Race, Gender, and the Influence of Social Media.
- Creator
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Amaya, Kristen
- Abstract/Description
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This thesis analyzes internal perceptions of institutional racism among undergraduate college students. The research examines the degree to which students perceive the issue of institutional racism to be an existing and pressing problem in our society today. The paper explores how students' perceptions of racism may be influenced by their race, gender, and social attitudes. The thesis also analyzes how students' perceptions of racism are mediated by access and exposure to the vast amounts of...
Show moreThis thesis analyzes internal perceptions of institutional racism among undergraduate college students. The research examines the degree to which students perceive the issue of institutional racism to be an existing and pressing problem in our society today. The paper explores how students' perceptions of racism may be influenced by their race, gender, and social attitudes. The thesis also analyzes how students' perceptions of racism are mediated by access and exposure to the vast amounts of political information available on social media sites such as Twitter and Facebook. A survey of 110 college students was conducted and both quantitative and qualitative data were collected. Quantitative results suggest that students' awareness of racial inequality and racial discrimination were not influenced by race or gender identity but were influenced by their social attitudes and the nature of their social media use. Qualitative results provide an in-depth analysis of students' personal opinions about racism and suggest an overall awareness of the issue, but nonetheless polarized views.
Show less - Date Issued
- 2017-12-11
- Identifier
- FSU_libsubv1_scholarship_submission_1513037496_a2cdd06a
- Format
- Thesis
- Title
- Analysis of the 1st–3rd December 2018 South Georgia and North Florida Flooding Event.
- Creator
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Anand, Michael Andrew
- Abstract/Description
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The purpose of this project is to determine what caused the 3-day heavy rainfall event in the North Florida and South Georgia region from December 1st through December 3rd, 2018 as well as why it was climatologically abnormal for the month of December. This will be done by 1. Determining the surface features and fronts responsible for providing the lift and moisture to help produce the heavy rainfall, 2. Analyzing upper-air data as a second way to identify the systems and to see what the...
Show moreThe purpose of this project is to determine what caused the 3-day heavy rainfall event in the North Florida and South Georgia region from December 1st through December 3rd, 2018 as well as why it was climatologically abnormal for the month of December. This will be done by 1. Determining the surface features and fronts responsible for providing the lift and moisture to help produce the heavy rainfall, 2. Analyzing upper-air data as a second way to identify the systems and to see what the atmospheric column was like in terms of moisture content and instability to produce the heavy rainfall in the region, and 3. Examining in-depth the radar loops from the four radar sites in the area to show how the event unfolded. This will also serve as a visual explanation for why certain areas received significantly more rainfall than others.In the end, by showing the overall synoptic setup and radar imagery that caused the heavy rainfall event over our region, the results will serve as an example for future winter flash flood events if they were to occur again.
Show less - Date Issued
- 2020-04-01
- Identifier
- FSU_libsubv1_scholarship_submission_1585775676_7e9026f0
- Format
- Thesis