Search results

Title: Abandoning the Dead Donor Rule?: A National Survey of Public Views on Death and Organ Donation.
Creator: Nair-Collins, Michael, Green, Sydney, Sutin, Angelina
Abstract/Description: Brain dead organ donors are the principal source of transplantable organs. However, it is controversial whether brain death is the same as biological death. Therefore, it is unclear whether organ removal in brain death is consistent with the 'dead donor rule', which states that organ removal must not cause death. Our aim was to evaluate the public's opinion about organ removal if explicitly described as causing the death of a donor in irreversible apneic coma. We conducted a cross-sectional...
Show moreBrain dead organ donors are the principal source of transplantable organs. However, it is controversial whether brain death is the same as biological death. Therefore, it is unclear whether organ removal in brain death is consistent with the 'dead donor rule', which states that organ removal must not cause death. Our aim was to evaluate the public's opinion about organ removal if explicitly described as causing the death of a donor in irreversible apneic coma. We conducted a cross-sectional internet survey of the American public (n=1096). Questionnaire domains included opinions about a hypothetical scenario of organ removal described as causing the death of a patient in irreversible coma, and items measuring willingness to donate organs after death. Some 71% of the sample agreed that it should be legal for patients to donate organs in the scenario described and 67% agreed that they would want to donate organs in a similar situation. Of the 85% of the sample who agreed that they were willing to donate organs after death, 76% agreed that they would donate in the scenario of irreversible coma with organ removal causing death. There appears to be public support for organ donation in a scenario explicitly described as violating the dead donor rule. Further, most but not all people who would agree to donate when organ removal is described as occurring after death would also agree to donate when organ removal is described as causing death in irreversible coma.
Show less
Date Issued: 2014
Identifier: FSU_migr_mhs-0040, 10.1136/medethics-2014-102229
Format: Citation

Title: Allostatic Load and Personality: A 4-Year Longitudinal Study..
Creator: Stephan, Yannick, Sutin, Angelina R, Luchetti, Martina, Terracciano, Antonio
Abstract/Description: Dysregulation across multiple physiological systems, referred to as allostatic load, has pervasive consequences for an individual's health. The present study examined whether allostatic load is associated with personality and personality changes during a 4-year follow-up. A total of 5200 participants aged from 50 to 99 years (59.5% women, mean [standard deviation] age = 66.91 [8.88] years) from the Health and Retirement Study provided data on cardiovascular, metabolic, and immune markers at...
Show moreDysregulation across multiple physiological systems, referred to as allostatic load, has pervasive consequences for an individual's health. The present study examined whether allostatic load is associated with personality and personality changes during a 4-year follow-up. A total of 5200 participants aged from 50 to 99 years (59.5% women, mean [standard deviation] age = 66.91 [8.88] years) from the Health and Retirement Study provided data on cardiovascular, metabolic, and immune markers at baseline and personality both at baseline and at 4 years later. Higher allostatic load was related to higher neuroticism (β = 0.03, p = .042), lower extraversion (β = -0.06, p < .001), and lower conscientiousness (β = -0.06, p < .001) at baseline, and to declines in extraversion (β = -0.03, p = .007), conscientiousness (β = -0.04, p < .001), and agreeableness (β = -0.02, p = .020) over the 4-year period, controlling for demographic covariates. A significant quadratic relation between allostatic load and changes in openness (β = -0.03, p = .002) suggested that openness declines when individuals exceed a high level of cumulative physiological dysregulation. No association was found with changes in neuroticism. Allostatic load is associated with personality change across adulthood and old age. The findings indicate that physiological dysregulation across multiple systems challenges personality stability and is associated with accelerated personality traits change.
Show less
Date Issued: 2016-04-01
Identifier: FSU_pmch_26716813, 10.1097/PSY.0000000000000281, PMC5481782, 26716813, 26716813
Format: Citation

Title: Analyzing State Autism Private Insurance Mandates for Allied Health Services: A Pilot Study..
Creator: Douglas, Megan D, Benevides, Teal W, Carretta, Henry
Abstract/Description: Due to the prevalence, severity, and costs associated with autism spectrum disorders (ASDs), it has become a public health issue. In response, state governments have adopted ASD-specific private insurance mandates requiring coverage of ASD screening, diagnosis, and treatment. Despite rapid uptake of these laws, differences exist in the type and levels of coverage, especially for allied health services including occupational therapy. We piloted a structured legal research methodology to code...
Show moreDue to the prevalence, severity, and costs associated with autism spectrum disorders (ASDs), it has become a public health issue. In response, state governments have adopted ASD-specific private insurance mandates requiring coverage of ASD screening, diagnosis, and treatment. Despite rapid uptake of these laws, differences exist in the type and levels of coverage, especially for allied health services including occupational therapy. We piloted a structured legal research methodology to code ASD insurance mandates that impact allied health service provisions. State private insurance mandates were obtained from WestlawNext. A coding methodology was piloted on 14 states and included variables for age and service limits, treatments covered, and medical necessity. Coding methods were feasible and highly reliable among raters. Ten of 12 states had a coverage mandate, many with specific provisions for allied health providers. A full analysis of all 50 states is warranted to identify provisions affecting allied health providers serving individuals with ASD.
Show less
Date Issued: 2017-10-01
Identifier: FSU_pmch_28874097, 10.1177/1539449217730355, PMC5772933, 28874097, 28874097
Format: Citation

Title: The association of post-discharge adverse events with timely follow-up visits after hospital discharge.
Creator: Tsilimingras, Dennis, Ghosh, Samiran, Duke, Ashley, Zhang, Liying, Carretta, Henry, Schnipper, Jeffrey
Abstract/Description: There has been little research to examine the association of post-discharge adverse events (AEs) with timely follow-up visits after hospital discharge. We aimed to examine whether having a timely follow-up outpatient visit would reduce the risk for post-discharge AEs. This was a methods study of patients at risk for post-discharge AEs from December 2011 through October 2012. Five hundred and forty-five patients who were under the care of hospitalist physicians and were discharged home from a...
Show moreThere has been little research to examine the association of post-discharge adverse events (AEs) with timely follow-up visits after hospital discharge. We aimed to examine whether having a timely follow-up outpatient visit would reduce the risk for post-discharge AEs. This was a methods study of patients at risk for post-discharge AEs from December 2011 through October 2012. Five hundred and forty-five patients who were under the care of hospitalist physicians and were discharged home from a community hospital, spoke English, and could be contacted after discharge were evaluated. The aim of the study was to examine the association of post-discharge AEs with timely follow-up visits after hospital discharge based on structured telephone interviews, health record review, and adjudication by two blinded, trained physicians using a previously established methodology. We observed a higher incidence of AEs with patients that had their first follow-up visit within 7 days after hospital discharge (33.5% vs. 23.0%, p = 0.007). This effect was attenuated somewhat but remained significant when adjusted for several patient factors (adjusted OR 1.33, 95% confidence interval 1.16-2.71). This observational study paradoxically showed an increase in post-discharge AEs with early follow-up, likely a result of confounding by indication and/or information bias that could not be completely adjusted for. This study illustrates the potential hazards with conducting observational studies to determine the efficacy of various transitional care interventions, such as early follow-up, where risk for confounding by indication is high.
Show less
Date Issued: 2017-08-10
Identifier: FSU_pmch_28796810, 10.1371/journal.pone.0182669, PMC5552135, 28796810, 28796810, PONE-D-17-08560
Format: Citation

Title: Asthma 101 for Schools: Successes and Challenges in Transitioning to Online Delivery..
Creator: Nowakowski, Alexandra Catherine Hayes, Carretta, Henry Joseph, Dudley, Julie Kurlfink, Forrest, Jamie R
Abstract/Description: Florida Asthma Program staff worked with evaluators from the Florida State University College of Medicine to assess participation and quality of the American Lung Association's Asthma 101 asthma management education program for school faculty and staff between 2011 and 2014. This included transitioning the program to an online training format for the 2013-2014 school year. Asthma 101 helps school personnel master the basics of asthma physiology and management, with content tailored...
Show moreFlorida Asthma Program staff worked with evaluators from the Florida State University College of Medicine to assess participation and quality of the American Lung Association's Asthma 101 asthma management education program for school faculty and staff between 2011 and 2014. This included transitioning the program to an online training format for the 2013-2014 school year. Asthma 101 helps school personnel master the basics of asthma physiology and management, with content tailored specifically for elementary and secondary educational settings. The program is assessed with questionnaires at multiple timepoints, yielding a quasi-experimental evaluation design. Evaluators reviewed quantitative data from pretests and qualitative and quantitative data from post-program satisfaction questionnaires. Program spreadsheets listing the dates for delivery and number of attendees were also reviewed. Overall, evaluation findings were positive. In the 2011-2012 program year, 16 different course sessions were offered, and more than half of enrolled participants came from Title I schools. A total of 228 people were trained. In the 2012-2013 program year, 19 different course sessions were offered. Enrollment totals (638) and matching pre- and posttest totals (562) soundly exceeded the target metric of 425. At least 170 (27%) of a total of 638 participants could be verified as coming from the target demographic of Title I school faculty and staff. In the 2013-2014 program year, the course was offered online on a rolling basis via the Florida TRAIN course management system. Enrollment remained high and learner outcomes remained consistently strong across all content areas for knowledge and satisfaction. A total of 406 people participated in the training; complete pre- and posttest data were available for 341 of these individuals; and satisfaction data were available for 325. Of the 406 trainees, 199 (49%) reported working for Title I schools. Evaluation yielded very positive results. An overwhelming majority of participants reported finding the course consistently strong across the board and highly impactful for their own ability to help students manage their asthma effectively. Most participants also reported that they would change/improve their asthma management behaviors in the workplace. Recommendations were developed to help expand future program reach.
Show less
Date Issued: 2016-02-01
Identifier: FSU_pmch_26870724, 10.3389/fpubh.2016.00011, PMC4734208, 26870724, 26870724
Format: Citation

Title: Asthma 101 for Schools: Successes and Challenges in Transitioning to Online Delivery.
Creator: Nowakowski, Alexandra Catherine Hayes, Carretta, Henry Joseph, Dudley, Julie Kurlfink, Forrest, Jamie R.
Abstract/Description: Florida Asthma Program staff worked with evaluators from the Florida State UniversityCollege of Medicine to assess participation and quality of the American Lung Association’s Asthma 101 asthma management education program for school faculty and staff between 2011 and 2014. This included transitioning the program to an online training format for the 2013–2014 school year. Asthma 101 helps school personnel master the basics of asthma physiology and management, with content tailored...
Show moreFlorida Asthma Program staff worked with evaluators from the Florida State UniversityCollege of Medicine to assess participation and quality of the American Lung Association’s Asthma 101 asthma management education program for school faculty and staff between 2011 and 2014. This included transitioning the program to an online training format for the 2013–2014 school year. Asthma 101 helps school personnel master the basics of asthma physiology and management, with content tailored specifically for elementary and secondary educational settings. The program is assessed with questionnaires at multiple timepoints, yielding a quasi-experimental evaluation design. Evaluators reviewed quantitative data from pretests and qualitative and quantitative data from post-program satisfaction questionnaires. Program spreadsheets listing the dates for delivery and number of attendees were also reviewed. Overall, evaluation findings were positive. In the 2011–2012 program year, 16 different course sessions were offered, and more than half of enrolled participants came from Title I schools. A total of 228 people were trained. In the 2012–2013 program year, 19 different course sessions were offered. Enrollment totals (638) and matching pre- and post-test totals (562) soundly exceeded the target metric of 425. At least 170 (27%) of a total of 638 participants could be verified as coming from the target demographic of Title I school faculty and staff. In the 2013–2014 program year, the course was offered online on a rolling basis via the Florida TRAIN course management system. Enrollment remained high and learner outcomes remained consistently strong across all content areas for knowledge and satisfaction. A total of 406 people participated in the training; complete pre- and posttest data were available for 341 of these individuals; and satisfaction data were available for 325. Of the 406 trainees, 199 (49%) reported working for Title I schools. Evaluation yielded very positive results. An overwhelming majority of participants reported finding the course consistently strong across the board and highly impactful for their own ability to help students manage their asthma effectively. Most participants also reported that they would change/improve their asthma management behaviors in the workplace. Recommendations were developed to help expand future program reach.
Show less
Date Issued: 2016-02-01
Identifier: FSU_libsubv1_scholarship_submission_1459966472, 10.3389/fpubh.2016.00011
Format: Citation

Title: Autobiographical Memory and Psychological Distress in a Sample of Upper-Limb Amputees.
Creator: Sutin, Angelina, Luchetti, Martina, Montebarocci, Ornella, Rossi, Nicolino, Cutti, Andrea G.
Abstract/Description: Amputation is a traumatic and life-changing event that can take years to adjust to. The present study (a) examines psychological adjustment in a specific trauma-exposed sample, (b) compares the phenomenology (e.g., vividness) of amputation-related memories to more recent memories, and (c) tests whether memory phenomenology is associated with psychological distress. A total of 24 upper-limb amputees recalled two autobiographical memories–an amputation-related memory and a recent memory–and...
Show moreAmputation is a traumatic and life-changing event that can take years to adjust to. The present study (a) examines psychological adjustment in a specific trauma-exposed sample, (b) compares the phenomenology (e.g., vividness) of amputation-related memories to more recent memories, and (c) tests whether memory phenomenology is associated with psychological distress. A total of 24 upper-limb amputees recalled two autobiographical memories–an amputation-related memory and a recent memory–and rated the phenomenological qualities of each memory, including Vividness, Coherence, Emotional Intensity, Visual Perspective, and Distancing. Participants also completed self-rated measures of psychological distress and personality. The sample was generally well adjusted; participants showed no relevant symptoms of anxiety and depression, and personality scores were similar to the general population. There were no significant differences in phenomenology between the two types of memories recalled. Even though amputation-related memories were, on average, almost 20 years older than the recent memories, they retained their intense phenomenology. Despite the intensity of the memory, none of the phenomenological dimensions were associated with psychological distress. It is worth to further define which dimensions of phenomenology characterize memories of traumatic events, and their association with individuals' psychological reactions.
Show less
Date Issued: 2014-06-12
Identifier: FSU_libsubv1_scholarship_submission_1475156849, 10.1371/journal.pone.0099803
Format: Citation

Title: Autobiographical Memory Phenomenology and Content Mediate Attachment Style and Psychological Distress.
Creator: Sutin, Angelina, Gillath, Omri
Abstract/Description: In two studies, the present research tested the phenomenology and content of autobiographical memory as distinct mediators between attachment avoidance and anxiety and depressive symptoms. In Study 1, participants (N = 454) completed measures of attachment and depressive symptoms in one session, and retrieved and rated two self-defining memories of romantic relationships in a separate session. In Study 2, participants (N = 534) were primed with attachment security, attachment insecurity, or a...
Show moreIn two studies, the present research tested the phenomenology and content of autobiographical memory as distinct mediators between attachment avoidance and anxiety and depressive symptoms. In Study 1, participants (N = 454) completed measures of attachment and depressive symptoms in one session, and retrieved and rated two self-defining memories of romantic relationships in a separate session. In Study 2, participants (N = 534) were primed with attachment security, attachment insecurity, or a control prime and then retrieved and rated a self-defining relationship memory. Memory phenomenology, specifically memory coherence and emotional intensity, mediated the association between attachment avoidance and depressive symptoms, whereas the negative affective content of the memory mediated the association between attachment anxiety and depressive symptoms. Priming attachment security led to retrieval of a more coherent relationship memory, whereas insecurity led to the retrieval of a more incoherent relationship memory. Discussion focuses on the construction and recollection of memories as underlying mechanisms of adult attachment and psychological distress, the importance of memory coherence, and the implications for counseling research and practice.
Show less
Date Issued: 2009
Identifier: FSU_migr_mhs-0034
Format: Citation

Title: Basic Interviewing Skills for Medical Students.
Creator: Gabriel, Joseph, Dutton, Gareth
Abstract/Description: There are three primary purposes to this booklet. The first is to introduce you to the basic tenets of professionalism. The second is to provide an introduction to the general orientation toward patient care that we teach here at the FSU College of Medicine. This is a patient-centered form of care, with an emphasis on the biopsychosocial model of health and illness. The third purpose is to provide an introduction to some of the specific skills necessary to conduct effective patient interviews...
Show moreThere are three primary purposes to this booklet. The first is to introduce you to the basic tenets of professionalism. The second is to provide an introduction to the general orientation toward patient care that we teach here at the FSU College of Medicine. This is a patient-centered form of care, with an emphasis on the biopsychosocial model of health and illness. The third purpose is to provide an introduction to some of the specific skills necessary to conduct effective patient interviews. Although these three areas may seem distinct from one another, in fact they are deeply intertwined. We strongly encourage you to approach these three domains in an integrated fashion. You will have many opportunities to practice the skills described in this booklet. For example, we frequently use role-playing exercises to give you a chance to practice the skills that are necessary to conduct effective medical interviews. In these exercises, you will have the opportunity to interact with your classmates, medical school faculty, and trained "standardized patients" in pre-defined scenarios. Although this might initially feel awkward, research demonstrates that these types of learning experiences can be very valuable for those who take them seriously. The more you practice the more effective you will be when you do the "real thing." You will also be expected to behave in a professional manner from your first day as a medical student. It is important that you take this aspect of your education seriously. Professional behavior is fundamental to good medical practice, and the time to begin acting professionally is now. Your understanding of the skills and approaches outlined in this booklet, and your ability to use them, will be assessed frequently throughout your training as a student at FSU College of Medicine. We are confident that these skills and approaches to the practice of medicine will help you become a confident and effective interviewer.
Show less
Date Issued: 2009
Identifier: FSU_migr_mhs-0005
Format: Citation

Title: BDNF Val66Met is Associated with Introversion and Interacts with 5-HTTLPR to Influence Neuroticism.
Creator: Terracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Deiana, Barbara, Balaci, Lenuta, Sanna, Serena, Olla, Nazario, Maschio, Andrea, Uda, Manuela, Ferrucci, Luigi,...
Show moreTerracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Deiana, Barbara, Balaci, Lenuta, Sanna, Serena, Olla, Nazario, Maschio, Andrea, Uda, Manuela, Ferrucci, Luigi, Schlessinger, David, Costa, Paul
Show less
Abstract/Description: Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurotransmission, and has been linked to neuroticism, a major risk factor for psychiatric disorders. A recent genome-wide association (GWA) scan, however, found the BDNF Val66Met polymorphism (rs6265) associated with extraversion but not with neuroticism. In this study, we examine the links between BDNF and personality traits, assessed using the Revised NEO Personality Inventory (NEO-PI-R), in a sample from SardiNIA ...
Show moreBrain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurotransmission, and has been linked to neuroticism, a major risk factor for psychiatric disorders. A recent genome-wide association (GWA) scan, however, found the BDNF Val66Met polymorphism (rs6265) associated with extraversion but not with neuroticism. In this study, we examine the links between BDNF and personality traits, assessed using the Revised NEO Personality Inventory (NEO-PI-R), in a sample from SardiNIA (n=1560) and the Baltimore Longitudinal Study of Aging (BLSA; n=1131). Consistent with GWA results, we found that BDNF Met carriers were more introverted. By contrast, in both samples and in a meta-analysis inclusive of published data (n=15251), we found no evidence for a main effect of BDNF Val66Met on neuroticism. Finally, on the basis of recent reports of an epistatic effect between BDNF and the serotonin transporter, we explored a Val66Met x 5-HTTLPR interaction in a larger SardiNIA sample (n=2333). We found that 5-HTTLPR LL carriers scored lower on neuroticism in the presence of the BDNF Val variant, but scored higher on neuroticism in the presence of the BDNF Met variant. Our findings support the association between the BDNF Met variant and introversion and suggest that BDNF interacts with the serotonin transporter gene to influence neuroticism.
Show less
Date Issued: 2010
Identifier: FSU_migr_mhs-0029, 10.1038/npp.2009.213
Format: Citation

Title: Brain Death, Paternalism, and the Language of "Death".
Creator: Nair-Collins, Michael
Abstract/Description: The controversy surrounding the dead donor rule and the adequacy of neurological criteria for death continues unabated. However, despite disagreement on fundamental theoretical questions, I argue that there is significant (but not complete) agreement on the permissibility of organ retrieval from heart-beating donors. Many disagreements are rooted in disputes surrounding language meaning and use, rather than the practices of transplant medicine. Thus I suggest that the debate can be fruitfully...
Show moreThe controversy surrounding the dead donor rule and the adequacy of neurological criteria for death continues unabated. However, despite disagreement on fundamental theoretical questions, I argue that there is significant (but not complete) agreement on the permissibility of organ retrieval from heart-beating donors. Many disagreements are rooted in disputes surrounding language meaning and use, rather than the practices of transplant medicine. Thus I suggest that the debate can be fruitfully recast in terms of a dispute about language. Given this recasting, I argue that the language used to describe organ donation is misleading and paternalistic. Finally, I suggest that the near-agreement on the permissibility of heart-beating organ retrieval ought to be reconsidered. If the paternalism is not justified, then either the language used to describe organ transplantation must change radically, or it would seem to follow that much of the transplant enterprise lacks ethical justification.
Show less
Date Issued: 2013
Identifier: FSU_migr_mhs-0038, 10.1353/ken.2013.0002
Format: Citation

Title: Breastfeeding and Adult Personality.
Creator: Sutin, Angelina R, Stephan, Yannick, Terracciano, Antonio
Abstract/Description: Five Factor Model (FFM) personality traits are implicated in long-term health-risk behaviors and outcomes. Less research has addressed how early-life experiences are associated with individual differences in these traits in adulthood. We examine whether having been breastfed is associated with adult personality and well-being in the National Longitudinal Study of Adolescent to Adult Health. At Wave 1, caregivers reported whether the target child had been breastfed. At Wave 4, participants (...
Show moreFive Factor Model (FFM) personality traits are implicated in long-term health-risk behaviors and outcomes. Less research has addressed how early-life experiences are associated with individual differences in these traits in adulthood. We examine whether having been breastfed is associated with adult personality and well-being in the National Longitudinal Study of Adolescent to Adult Health. At Wave 1, caregivers reported whether the target child had been breastfed. At Wave 4, participants (=13,113; 53% female; =28.98) completed measures of psychological functioning. We tested for mean-level differences in the traits by breastfeeding status (yes/no) and by the duration of breastfeeding, controlling for basic demographic factors and early-life factors that could confound the breastfeeding-personality association (e.g., mother education). Participants who had been breastfed scored lower in neuroticism, anxiety, and hostility and higher in openness and optimism than those not breastfed. A curvilinear relation suggested that neuroticism was lowest for those breastfed for 9-12 months and highest for those either breastfed for >24 months or exclusively bottle-fed. Breastfeeding was unrelated to conscientiousness or state psychological functioning. This research suggests long-term psychological benefits to breastfeeding and indicates that early life experiences are associated with traits that are consequential for adult health.
Show less
Date Issued: 2016-09-01
Identifier: FSU_pmch_28966441, 10.1002/per.2030, PMC5614468, 28966441, 28966441
Format: Citation

Title: Caregiver perceptions of childhood weight: demographic moderators and correlates..
Creator: Miller, D, Johnson, W, Miller, M, Miller, J, Sutin, A R
Abstract/Description: To examine whether ethnicity moderates the association between caregiver characteristics and perceptions of childhood weight and whether these perceptions are associated with their child's obesity status. Caregivers recruited from paediatricians' offices (n = 453) completed a survey about childhood health; nurses weighed and measured the children. Caregivers reported their own weight and height, demographic information about their family and made ratings of healthy weight for children in...
Show moreTo examine whether ethnicity moderates the association between caregiver characteristics and perceptions of childhood weight and whether these perceptions are associated with their child's obesity status. Caregivers recruited from paediatricians' offices (n = 453) completed a survey about childhood health; nurses weighed and measured the children. Caregivers reported their own weight and height, demographic information about their family and made ratings of healthy weight for children in general and for their own child in particular. African American caregivers were more likely to view heavier girls as healthier, but this association held only for lower income families or caregivers with higher body mass index. Hispanic caregivers were more likely to misperceive their own child's weight if either the caregiver or the child had a higher body mass index. Parents who perceived heavier weight as healthier or misperceived their own child's weight were more likely to have a child with obesity. This latter association held regardless of ethnicity. The association between ethnicity and perceptions of healthy childhood weight are complex. The relation between caregivers' perceptions of healthy weight and their own child's obesity status, however, was similar regardless of ethnicity.
Show less
Date Issued: 2016-05-01
Identifier: FSU_pmch_26821665, 10.1111/cch.12318, PMC4841719, 26821665, 26821665
Format: Citation

Title: Characteristics and outcomes of non-Hodgkin's lymphoma patients with leptomeningeal metastases.
Creator: Meng, Xiangrui, Yu, Jingwei, Fan, Qian, Li, Lanfang, Li, Wei, Song, Zheng, Liu, Xianming, Jiang, Yanyang, Gao, Ming, Zhang, Huilai
Abstract/Description: Leptomeningeal metastasis is an uncommon but devastating complication. The incidence of non-Hodgkin's lymphoma has been increasing in recent decades, due to the poor central nervous system penetration of drugs and the prolonged overall survival of patients, leptomeningeal metastases has gradually increased over time. Patients with leptomeningeal metastases have short survival durations and poor quality of life; there are few studies about non-Hodgkin's lymphoma with leptomeningeal metastases....
Show moreLeptomeningeal metastasis is an uncommon but devastating complication. The incidence of non-Hodgkin's lymphoma has been increasing in recent decades, due to the poor central nervous system penetration of drugs and the prolonged overall survival of patients, leptomeningeal metastases has gradually increased over time. Patients with leptomeningeal metastases have short survival durations and poor quality of life; there are few studies about non-Hodgkin's lymphoma with leptomeningeal metastases. We investigated characteristics and outcomes of non-Hodgkin's lymphoma patients with leptomeningeal metastases. This study included 27 non-Hodgkin's lymphoma patients with leptomeningeal metastases diagnosed at Tianjin Medical University Cancer Institute and Hospital between 2013 and 2016. Statistical analysis was performed to investigate the overall survival of non-Hodgkin's lymphoma with leptomeningeal metastases. Diffuse large B cell lymphoma was the most common cancer subtype (21/27, 78%), and more than half of the patients showed extranodal involvement (18/27, 67%). Survival analysis has shown extranodal involvement (P = 0.0205), International Prognostic Index (P = 0.0112), performance status (P < 0.0001), parenchymal involvement (P = 0.0330) and received radiotherapy (P = 0.0056) were predictive factors of prognosis for these patients with leptomeningeal metastases. Cox regression analysis has shown patients with concurrent parenchymal involvement and received radiotherapy are correlated with good prognosis. Given the small number of patients who were included, this study exhibited limitations with respect to analytical power and the random selection of patients. Nevertheless, this investigation revealed characteristics of non-Hodgkin's lymphoma patients with leptomeningeal metastases and suggested that such patients could benefit from multimodal therapy.
Show less
Date Issued: 2018-08-01
Identifier: FSU_pmch_29558001, 10.1007/s10147-018-1268-5, PMC6097078, 29558001, 29558001, 10.1007/s10147-018-1268-5
Format: Citation

Title: Childhood Socioeconomic Status and Stress in Late Adulthood: A Longitudinal Approach to Measuring Allostatic Load..
Creator: Graves, Katelyn Y, Nowakowski, Alexandra C H
Abstract/Description: This study examines how the effects of childhood socioeconomic status (SES) may carry on into late adulthood. We examine how childhood SES affects both perceived stress and allostatic load, which is a cumulative measure of the body's biologic response to chronic stress. We use the National Social Life, Health, and Aging Project, Waves 1 and 2, and suggest a novel method of incorporating a longitudinal allostatic load measure. Individuals who grew up in low SES households have higher...
Show moreThis study examines how the effects of childhood socioeconomic status (SES) may carry on into late adulthood. We examine how childhood SES affects both perceived stress and allostatic load, which is a cumulative measure of the body's biologic response to chronic stress. We use the National Social Life, Health, and Aging Project, Waves 1 and 2, and suggest a novel method of incorporating a longitudinal allostatic load measure. Individuals who grew up in low SES households have higher allostatic load scores in late adulthood, and this association is mediated mostly by educational attainment. The longitudinal allostatic load measure shows similar results to the singular measures and allows us to include 2 time points into one outcome measure. Incorporating 2 separate time points into one measure is important because allostatic load is a measure of cumulative physiological dysregulation, and longitudinal data provide a more comprehensive measure.
Show less
Date Issued: 2017-11-29
Identifier: FSU_pmch_29226194, 10.1177/2333794X17744950, PMC5714076, 29226194, 29226194, 10.1177_2333794X17744950
Format: Citation

Title: Cholesterol, Triglycerides, and the Five-Factor Model of Personality.
Creator: Sutin, Angelina, Terracciano, Antonio, Deiana, Barbara, Uda, Manuela, Schlessinger, David, Lakatta, Edward, Costa, Paul
Abstract/Description: Unhealthy lipid levels are among the leading controllable risk factors for coronary heart disease. To identify the psychological factors associated with dyslipidemia, this study investigates the personality correlates of cholesterol (total, LDL, and HDL) and triglycerides. A community-based sample (N=5532) from Sardinia, Italy, had their cholesterol and triglyceride levels assessed and completed a comprehensive personality questionnaire, the NEO-PI-R. All analyses controlled for age, sex, BMI...
Show moreUnhealthy lipid levels are among the leading controllable risk factors for coronary heart disease. To identify the psychological factors associated with dyslipidemia, this study investigates the personality correlates of cholesterol (total, LDL, and HDL) and triglycerides. A community-based sample (N=5532) from Sardinia, Italy, had their cholesterol and triglyceride levels assessed and completed a comprehensive personality questionnaire, the NEO-PI-R. All analyses controlled for age, sex, BMI, smoking, drinking, hypertension, and diabetes. Low Conscientiousness and traits related to impulsivity were associated with lower HDL cholesterol and higher triglycerides. Compared to the lowest 10%, those who scored in top 10% on Impulsivity had a 2.5 times greater risk of exceeding the clinical threshold for elevated triglycerides (OR=2.51, CI=1.56-4.07). In addition, sex moderated the association between trait depression (a component of Neuroticism) and HDL cholesterol, such that trait depression was associated with lower levels of HDL cholesterol in women but not men. When considering the connection between personality and health, unhealthy lipid profiles may be one intermediate biomarker between personality and morbidity and mortality.
Show less
Date Issued: 2010
Identifier: FSU_migr_mhs-0028, 10.1016/j.biopsycho.2010.01.012
Format: Citation

Title: Chronic Inflammation and Quality of Life in Older Adults: A Cross-Sectional Study Using Biomarkers to Predict Emotional and Relational Outcomes.
Creator: Nowakowski, Alexandra
Abstract/Description: BACKGROUND: This study explores relationships between chronic inflammation and quality of life, making a case for biopsychosocial modeling of these associations. It builds on research from social and clinical disciplines connecting chronic conditions, and inflammatory conditions specifically, to reduced quality of life. METHODS: Data from Wave I of the National Social Life, Health, and Aging Project are modeled using ordinal logistic and ordinary least-squares regression techniques....
Show moreBACKGROUND: This study explores relationships between chronic inflammation and quality of life, making a case for biopsychosocial modeling of these associations. It builds on research from social and clinical disciplines connecting chronic conditions, and inflammatory conditions specifically, to reduced quality of life. METHODS: Data from Wave I of the National Social Life, Health, and Aging Project are modeled using ordinal logistic and ordinary least-squares regression techniques. Inflammation is measured using C-reactive protein; quality of life is conceptualized as happiness with life overall as well as intimate relationships specifically. RESULTS: For most NSHAP participants, chronic inflammation significantly predicts lower odds of reporting high QoL on both emotional and relational measures. Social structural factors do not confound these associations. Inconsistent results for participants with very high (over 6 mg/L) CRP measurements suggest additional social influences. CONCLUSIONS: Findings echo strong theoretical justification for investigating relationships between CRP and QoL in greater detail. Further research should explore possible mediation of these associations by sociomedical sequelae of chronic disease as well as social relationship dynamics. Elaboration is also needed on the mechanisms by which social disadvantage may cause chronic inflammation.
Show less
Date Issued: 2014
Identifier: FSU_migr_mhs-0043, 10.1186/s12955-014-0141-0
Format: Citation

Title: Cognitive Impairment, Dementia, and Personality Stability Among Older Adults.
Creator: Terracciano, Antonio, Stephan, Yannick, Luchetti, Martina, Sutin, Angelina R
Abstract/Description: There is contrasting evidence on personality stability in advanced age, and limited knowledge on the impact of cognitive impairment and dementia on trait stability. Group- and individual-level longitudinal analyses of the five major dimensions of personality assessed twice over 4 years ( N = 9,935) suggest that rank-order stability was progressively lower with advancing age (from r = 0.68 for age 50 to 60 years to r = 0.58 for age >80 years). Stability was low in the dementia group ( r = 0.43...
Show moreThere is contrasting evidence on personality stability in advanced age, and limited knowledge on the impact of cognitive impairment and dementia on trait stability. Group- and individual-level longitudinal analyses of the five major dimensions of personality assessed twice over 4 years ( N = 9,935) suggest that rank-order stability was progressively lower with advancing age (from r = 0.68 for age 50 to 60 years to r = 0.58 for age >80 years). Stability was low in the dementia group ( r = 0.43), and this was not simply due to lower reliability given that internal consistency remained adequate in the dementia group. Among individuals with no cognitive impairment or dementia, there was no association between stability and age ( r = 0.70 even for age >80 years). These results suggest that the lower personality stability in older adults is not due to age but cognitive impairment and dementia.
Show less
Date Issued: 2018-04-01
Identifier: FSU_pmch_29214858, 10.1177/1073191117691844, PMC5725278, 29214858, 29214858
Format: Citation

Title: Community Built Environment Factors and Mobility Around Senior Wellness Centers: The Concept of "Safe Senior Zones".
Creator: Shendell, Derek, Johnson, Matthew, Sanders, Danna, Nowakowski, Alexandra, Yang, Jianhua, Jeffries, Carla, Weisman, Janet, Moulding, Megan
Abstract/Description: The authors investigated built environment (BE) factors in urban neighborhoods in DeKalb County, Georgia. Each volunteering, consenting senior was placed into one of two groups: walking tours outside, then discussions (n=37); and focus group discussions indoors about photographs of BE conditions potentially influencing mobility (n=43). The authors sought to identify BE factors-both real and perceived by participating seniors-related to their ability to walk around senior wellness centers in a...
Show moreThe authors investigated built environment (BE) factors in urban neighborhoods in DeKalb County, Georgia. Each volunteering, consenting senior was placed into one of two groups: walking tours outside, then discussions (n=37); and focus group discussions indoors about photographs of BE conditions potentially influencing mobility (n=43). The authors sought to identify BE factors-both real and perceived by participating seniors-related to their ability to walk around senior wellness centers in a healthy and safe manner. The authors focused specifically on available literature and pilot study data for their concept of "safe senior zones" around senior wellness centers serving urban communities in this article. They also characterized their study population regarding sociodemographic variables and doctor-diagnosed chronic diseases, and types of walking aids reported used to help prevent falls. Their results can inform future applied practice and research on traffic-related exposures and BE factors concerning seniors, and support policy and planning to benefit community environmental public health.
Show less
Date Issued: 2011
Identifier: FSU_migr_mhs-0042
Format: Citation

Title: Comparative effectiveness of dual vs. single-action antidepressants on HIV clinical outcomes in HIV-infected people with depression.
Creator: Mills, Jon C, Harman, Jeffrey S, Cook, Robert L, Marlow, Nicole M, Harle, Christopher A, Duncan, R Paul, Gaynes, Bradley N, Pence, Brian W
Abstract/Description: Depression is highly prevalent among people living with HIV/AIDS (PLWHA) and has deleterious effects on HIV clinical outcomes. We examined changes in depression symptoms, viral suppression, and CD4 T cells/μl among PLWHA diagnosed with depression who initiated antidepressant treatment during routine care, and compared the effectiveness of dual-action and single-action antidepressants for improving those outcomes. Comparative effectiveness study of new user dual-action or single-action...
Show moreDepression is highly prevalent among people living with HIV/AIDS (PLWHA) and has deleterious effects on HIV clinical outcomes. We examined changes in depression symptoms, viral suppression, and CD4 T cells/μl among PLWHA diagnosed with depression who initiated antidepressant treatment during routine care, and compared the effectiveness of dual-action and single-action antidepressants for improving those outcomes. Comparative effectiveness study of new user dual-action or single-action antidepressant treatment episodes occurring from 2004 to 2014 obtained from the Center for AIDS Research Network of Integrated Clinical Systems. We identified new user treatment episodes with no antidepressant use in the preceding 90 days. We completed intent-to-treat and per protocol evaluations for the main analysis. Primary outcomes, were viral suppression (HIV viral load <200 copies/ml) and CD4 T cells/μl. In a secondary analysis, we used the Patient Health Questionnaire-9 (PHQ-9) to evaluate changes in depression symptoms and remission (PHQ <5). Generalized estimating equations with inverse probability of treatment weights were fitted to estimate treatment effects. In weighted intent-to-treat analyses, the probability of viral suppression increased 16% after initiating antidepressants [95% confidence interval = (1.12, 1.20)]. We observed an increase of 39 CD4T cells/μl after initiating antidepressants (30, 48). Both the frequency of remission from depression and PHQ-9 scores improved after antidepressant initiation. Comparative effectiveness estimates were null in all models. Initiating antidepressant treatment was associated with improvements in depression, viral suppression, and CD4 T cells/μl, highlighting the health benefits of treating depression in PLWHA. Dual and single-action antidepressants had comparable effectiveness.
Show less
Date Issued: 2017-11-28
Identifier: FSU_pmch_28832409, 10.1097/QAD.0000000000001618, PMC5680130, 28832409, 28832409
Format: Citation

Title: Comparative effectiveness of dual-action versus single-action antidepressants for the treatment of depression in people living with HIV/AIDS.
Creator: Mills, Jon C, Harman, Jeffrey S, Cook, Robert L, Marlow, Nicole M, Harle, Christopher A, Duncan, R Paul, Bengtson, Angela M, Pence, Brian W
Abstract/Description: Depression is the most common psychiatric comorbidity among people living with HIV/AIDS (PLWHA). Little is known about the comparative effectiveness between different types of antidepressants used to treat depression in this population. We compared the effectiveness of dual-action and single-action antidepressants in PLWHA for achieving remission from depression. We used data from the Centers for AIDS Research Network of Integrated Clinic Systems to identify 1175 new user dual-action or...
Show moreDepression is the most common psychiatric comorbidity among people living with HIV/AIDS (PLWHA). Little is known about the comparative effectiveness between different types of antidepressants used to treat depression in this population. We compared the effectiveness of dual-action and single-action antidepressants in PLWHA for achieving remission from depression. We used data from the Centers for AIDS Research Network of Integrated Clinic Systems to identify 1175 new user dual-action or single-action antidepressant treatment episodes occurring from 2005 to 2014 for PLWHA diagnosed with depression. The primary outcome was remission from depression defined as a Patient Health Questionnaire-9 (PHQ-9) score <5. Mean difference in PHQ-9 depressive symptom severity was a secondary outcome. The main approach was an intent-to-treat (ITT) evaluation complemented with a per protocol (PP) sensitivity analysis. Generalized linear models were fitted to estimate treatment effects. In ITT analysis, 32% of the episodes ended in remission for both dual-action and single-action antidepressants. The odds ratio (OR) of remission was 1.02 (95%CI=0.63,1.67). In PP analysis, 40% of dual-action episodes ended in remission compared to 32% in single-action episodes. Dual-action episodes had 1.33 times the odds of remission (95%CI=0.55,3.21), however the result was not statistically significant. Non-significant differences were also observed for depressive symptom severity. Missing data was common but was addressed with inverse probability weights. Results suggest that single-action and dual-action antidepressants are equally effective in PLWHA. Remission was uncommon highlighting the need to identify health service delivery strategies that aid HIV providers in achieving full remission of their patients' depression.
Show less
Date Issued: 2017-06-01
Identifier: FSU_pmch_28340444, 10.1016/j.jad.2017.03.042, PMC5612416, 28340444, 28340444, S0165-0327(16)32306-0
Format: Citation

Title: A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study.
Creator: Haghighi, Mona, Johnson, Suzanne Bennett, Qian, Xiaoning, Lynch, Kristian F., Vehik, Kendra, Huang, Shuai
Abstract/Description: Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper...
Show moreRegression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
Show less
Date Issued: 2016-08-26
Identifier: FSU_libsubv1_wos_000381966300001, 10.1038/srep30828
Format: Citation

Title: A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study.
Creator: Haghighi, Mona, Johnson, Suzanne Bennett, Qian, Xiaoning, Lynch, Kristian F, Vehik, Kendra, Huang, Shuai
Abstract/Description: Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper...
Show moreRegression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
Show less
Date Issued: 2016-08-26
Identifier: FSU_pmch_27561809, 10.1038/srep30828, PMC5000469, 27561809, 27561809, srep30828
Format: Citation

Title: Complementary and Alternative Medicine Use for HIV Management in the State of Florida: Medical Monitoring Project..
Creator: Kelso-Chichetto, Natalie E, Okafor, Chukwuemeka N, Harman, Jeffrey S, Canidate, Shantrel S, Cook, Christa L, Cook, Robert L
Abstract/Description: The aims of this study were to describe complementary and alternative medicine (CAM) use and to assess the relationships between CAM use and antiretroviral therapy (ART) adherence and human immunodeficiency virus (HIV) RNA viral load suppression among a sample of persons living with HIV (PLWH) engaged in care in the state of Florida. The Florida Medical Monitoring Project (n = 803) collected repeated cross-sectional data for surveillance of clinical outcomes among PLWH from 2009 to 2010. Past...
Show moreThe aims of this study were to describe complementary and alternative medicine (CAM) use and to assess the relationships between CAM use and antiretroviral therapy (ART) adherence and human immunodeficiency virus (HIV) RNA viral load suppression among a sample of persons living with HIV (PLWH) engaged in care in the state of Florida. The Florida Medical Monitoring Project (n = 803) collected repeated cross-sectional data for surveillance of clinical outcomes among PLWH from 2009 to 2010. Past-year CAM use specifically for the management of HIV was measured via self-report. Logistic regression models were conducted to assess the effect of CAM use on ART adherence and viral load suppression, controlling for demographic and clinical factors using backwards stepwise deletion of factors with a p-value of >0.25. CAM use was reported in 53.3% (n = 428). In bivariate analysis, CAM use was the highest among those 40-49 years of age (61%; p < 0.05), males (56%; p < 0.01), whites (61%; p = 0.001), and those educated beyond high school (59%; p < 0.05). Among those using CAM, 63% and 37% reported one and two or more CAM modalities, respectively. CAM modalities included biologically based therapies (89%), mind-body medicine/manipulative body-based therapies (30%), spiritual healing (23%), energy therapies (6%), and whole medical systems (6%). In multivariable analyses, any CAM use and number of CAM methods used were not associated with ART adherence. Any CAM use was not associated with detectable viral load (adjusted odds ratio [aOR] 0.81; 95% confidence interval [CI] 0.58-1.12; p = 0.20). Those using two or more methods had significantly decreased risk for detectable viral load (aOR 0.60; 95% CI 0.39-0.92; p < 0.02). CAM use was not associated with negative effects on ART adherence. CAM users were less likely to have detectable viral load compared with non-users. Future research should focus on CAM use among PLWH not engaged in HIV care and the longitudinal patterns of CAM use and possible effects of long-term health outcomes.
Show less
Date Issued: 2016-11-01
Identifier: FSU_pmch_27631385, 10.1089/acm.2016.0190, PMC5116687, 27631385, 27631385
Format: Citation

Title: Correlates and Phenomenology of First and Third Person Memories.
Creator: Sutin, Angelina, Robins, Richard W.
Abstract/Description: The present research addressed fundamental questions about the visual perspective of autobiographical memories: Are stable personality characteristics associated with visual perspective? Does visual perspective influence the memory's phenomenological qualities? Participants in Study 1 (N=1684) completed individual-difference measures and indicated the perspective from which they generally retrieve memories. Participants in Study 2 (N=706) retrieved a memory from their natural or manipulated...
Show moreThe present research addressed fundamental questions about the visual perspective of autobiographical memories: Are stable personality characteristics associated with visual perspective? Does visual perspective influence the memory's phenomenological qualities? Participants in Study 1 (N=1684) completed individual-difference measures and indicated the perspective from which they generally retrieve memories. Participants in Study 2 (N=706) retrieved a memory from their natural or manipulated perspective, rated its phenomenology, and completed the same individual-difference measures. Dissociation and anxiety were associated with third person retrieval style; the Big Five personality traits were primarily unrelated to perspective. Compared to third person memories, naturally occurring first person memories were higher on Vividness, Coherence, Accessibility, Sensory Detail, Emotional Intensity, and Time Perspective, and lower on Distancing; manipulating perspective eliminated these differences. Visual perspective is associated with clinically relevant constructs and, although associated with the memory's phenomenology, perspective does not shape it.
Show less
Date Issued: 2010
Identifier: FSU_migr_mhs-0025, 10.1080/09658211.2010.497765
Format: Citation

Title: Correlates of HPV Knowledge in the Era of HPV Vaccination: A Study of Unvaccinated Young Adult Women.
Creator: Gerend, Mary, Shepherd, Janet
Abstract/Description: Until recently, awareness of the sexually transmitted infection human papillomavirus (HPV)—the virus that causes cervical cancer—was relatively low. The purpose of this study was to identify factors associated with HPV knowledge now that HPV vaccines have become widely available. Young adult women (n = 739; aged 18-26 years) attending Florida State University who had not yet initiated HPV vaccination completed a survey between March-August 2009. The survey assessed HPV awareness, HPV...
Show moreUntil recently, awareness of the sexually transmitted infection human papillomavirus (HPV)—the virus that causes cervical cancer—was relatively low. The purpose of this study was to identify factors associated with HPV knowledge now that HPV vaccines have become widely available. Young adult women (n = 739; aged 18-26 years) attending Florida State University who had not yet initiated HPV vaccination completed a survey between March-August 2009. The survey assessed HPV awareness, HPV knowledge, demographics, socio-political variables, sexual history, and health history variables. Over 97% of participants were aware of HPV prior to study enrollment; however, knowledge of HPV was only moderate. A multivariate regression analysis examining factors related to HPV knowledge revealed five independent correlates: Latina ethnicity, premarital sex values, number of lifetime sexual partners, history of cervical dysplasia, and HIV testing. These variables accounted for 14% of the variance in HPV knowledge. Less knowledge was observed for Latinas and women opposed to premarital sex. Greater knowledge was observed for women who had been tested for HIV and women with more sexual partners or a history of cervical dysplasia. These findings can inform future HPV vaccination campaigns and may be particularly useful in developing interventions for individuals with the largest deficits in HPV knowledge.
Show less
Date Issued: 2011
Identifier: FSU_migr_mhs-0008, 10.1080/03630242.2011.540744
Format: Citation

Title: Cystic Fibrosis Kidney Disease: 10 Tips For Clinicians.
Creator: Nowakowski, Alexandra C. H.
Abstract/Description: Increased longevity in people with cystic fibrosis (CF) means that more people are surviving long enough to develop kidney complications. Nephrologists and their colleagues now face a steep learning curve as many of them encounter patients with CF related kidney disease (CFKD) for the first time. This article presents perspectives from a medical sociologist with CF on what renal health professionals should know about people with CFKD. It outlines challenges that people with CFKD as they age,...
Show moreIncreased longevity in people with cystic fibrosis (CF) means that more people are surviving long enough to develop kidney complications. Nephrologists and their colleagues now face a steep learning curve as many of them encounter patients with CF related kidney disease (CFKD) for the first time. This article presents perspectives from a medical sociologist with CF on what renal health professionals should know about people with CFKD. It outlines challenges that people with CFKD as they age, framing these struggles as opportunities for clinicians to help these unique patients achieve and maintain their best possible quality of life.
Show less
Date Issued: 2018-08-28
Identifier: FSU_libsubv1_wos_000442990600001, 10.3389/fmed.2018.00242
Format: Citation

Title: Depressive Symptoms Are Associated with Weight Gain Among Women.
Creator: Sutin, Angelina, Zonderman, Alan
Abstract/Description: BACKGROUND: Many studies have linked depression and obesity; few have more than two assessments of depressive symptoms and adiposity to address the potential bidirectional relationship between adiposity and depressive symptoms from young adulthood through old age. We tested whether baseline depressive symptoms are associated with changes in weight, whether baseline adiposity is associated with changes in depressive symptoms, and whether these associations vary by sex.MethodParticipants (n...
Show moreBACKGROUND: Many studies have linked depression and obesity; few have more than two assessments of depressive symptoms and adiposity to address the potential bidirectional relationship between adiposity and depressive symptoms from young adulthood through old age. We tested whether baseline depressive symptoms are associated with changes in weight, whether baseline adiposity is associated with changes in depressive symptoms, and whether these associations vary by sex.MethodParticipants (n=2251; 47% female) were from the Baltimore Longitudinal Study of Aging (BLSA). Using hierarchical linear modeling (HLM) on 30 years of data, the trajectory of adiposity and depressive symptoms over adulthood was estimated from >10 000 observations (mean=4.5 assessments per participant) of body mass index (BMI; kg/m2), waist circumference and hip circumference and >10 000 observations (mean=4.5 assessments per participant) of the Center for Epidemiological Studies Depression Scale (CES-D). Baseline depressive symptoms and adiposity were then tested as predictors of the trajectory of adiposity and depressive symptoms respectively. Additional analyses tested for sex-specific associations. RESULTS: Sex moderated the association between depressive symptoms and weight gain such that women who experienced depressed affect had greater increases in BMI (binteraction=0.12, s.e.=0.04), waist (binteraction=0.22, s.e.=0.10) and hip circumference (binteraction=0.20, s.e.=0.07) across the adult lifespan, controlling for relevant demographic and behavioral covariates. Baseline adiposity was unrelated to the trajectory of depressive symptoms (median b=0.00) for both sexes. CONCLUSIONS: Women who experience symptoms of depression tend to gain more weight across adulthood than men who experience such symptoms. Whether an individual was normal weight or overweight was unrelated to changes in depressive symptoms across adulthood.
Show less
Date Issued: 2012
Identifier: FSU_migr_mhs-0012, 10.1017/S0033291712000566
Format: Citation

Title: The Detroit Young Adult Asthma Project: Proposal For A Multicomponent Technology Intervention For African American Emerging Adults With Asthma.
Creator: MacDonell, Karen, Naar, Sylvie, Gibson-Scipio, Wanda, Bruzzese, Jean-Marie, Wang, Bo, Brody, Aaron
Abstract/Description: Background: Racial and ethnic minority youth have poorer asthma status than white youth, even after controlling for socioeconomic variables. Proper use of asthma controller medications is critical in reducing asthma mortality and morbidity. The clinical consequences of poor asthma management include increased illness complications, excessive functional morbidity, and fatal asthma attacks. There are significant limitations in research on interventions to improve asthma management in racial...
Show moreBackground: Racial and ethnic minority youth have poorer asthma status than white youth, even after controlling for socioeconomic variables. Proper use of asthma controller medications is critical in reducing asthma mortality and morbidity. The clinical consequences of poor asthma management include increased illness complications, excessive functional morbidity, and fatal asthma attacks. There are significant limitations in research on interventions to improve asthma management in racial minority populations, particularly minority adolescents and young adults, although illness management tends to deteriorate after adolescence during emerging adulthood, the unique developmental period beyond adolescence but before adulthood. Objective: The objective of the pilot study was to test the feasibility, acceptability, and signals of efficacy of an intervention targeting adherence to controller medication in African American youth (ages 18-29) with asthma. All elements of the protocol were piloted in a National Heart, Lung, and Blood Institute (NHLBI)-funded pilot study (1R34HL107664 MacDonell). Results suggested feasibility and acceptability of the protocol as well as proof of concept. We are now ready to test the intervention in a larger randomized clinical trial. Methods: The proposed study will include 192 African American emerging adults with moderate to severe persistent asthma and low controller medication adherence recruited from clinic, emergency department, and community settings. Half of the sample will be randomized to receive a multicomponent technology-based intervention targeting adherence to daily controller medication. The multicomponent technology-based intervention consists of 2 components: (1) 2 sessions of computer-delivered motivational interviewing targeting medication adherence and (2) individualized text messaging focused on medication adherence between the sessions. Text messages will be individualized based on ecological momentary assessment. The remaining participants will complete a series of computer-delivered asthma education modules matched for length, location, and method of delivery of the intervention session. Control participants will also receive text messages between intervention sessions. Message content will be the same for all control participants and contain general facts about asthma (not tailored). Results: It is hypothesized that youth randomized to multicomponent technology-based intervention will show improvements in medication adherence (primary outcome) and asthma control (secondary outcome) compared with comparison condition at all postintervention follow-ups (3, 6, 9, and 12 months). The proposed study was funded by NHLBI from September 1, 2016 through August 31, 2021. Conclusions: This project will test a brief, technology-based intervention specifically targeting adherence to asthma controller medications in an under-researched population, African American emerging adults. If successful, our multicomponent technology-based intervention aimed at improving adherence to asthma medications has the potential to improve quality of life of minority emerging adults with asthma at relatively low cost. It could eventually be integrated into clinical settings and practice to reach a large number of emerging adults with asthma.
Show less
Date Issued: 2018-05-01
Identifier: FSU_libsubv1_wos_000433883200011, 10.2196/resprot.8872
Format: Citation

Title: Developing Asthma-Friendly Childcare Centers with Online Training and Evaluation.
Creator: Nowakowski, Alexandra Catherine Hayes, Carretta, Henry Joseph, Pineda, Nicole, Dudley, Julie Kurlfink, Forrest, Jamie R.
Abstract/Description: In 2011, the Florida Asthma Coalition (FAC) began offering its Asthma-Friendly Childcare Center (AFCC) training online. This course teaches childcare center employees the fundamentals of effective asthma management. It covers basic asthma physiology, ways to recognize asthma attacks, techniques to help children experiencing attacks, and strategies to create healthy environments for asthmatics. A team of health services researchers evaluated both years of the online training. Evaluators used a...
Show moreIn 2011, the Florida Asthma Coalition (FAC) began offering its Asthma-Friendly Childcare Center (AFCC) training online. This course teaches childcare center employees the fundamentals of effective asthma management. It covers basic asthma physiology, ways to recognize asthma attacks, techniques to help children experiencing attacks, and strategies to create healthy environments for asthmatics. A team of health services researchers evaluated both years of the online training. Evaluators used a quasi-experimental design with pretest, posttest, and follow-up assessment. Questions measured knowledge gain and retention, user satisfaction, and implementation of management strategies. Over 650 people from nearly all 67 Florida counties took AFCC training online between 2011 and 2013. Test scores improved by a minimum of 11% points in all program years evaluated. Gains in both knowledge and confidence were substantial and highly significant across years. While individual trainees did forget some content on follow-up, they seemed to retain the specific messages most relevant for their own workplaces. Most trainees also planned to implement multiple management strategies recommended by the training. A large majority of participants rated the training as excellent on all quality metrics, including relevance of content and time efficiency of the online format. Nearly all respondents perceived the training as useful for both providing improved care and fulfilling licensure or certification requirements. Many participants also indicated that their centers would pursue formal certification as AFCCs via the program offered by FAC. The online AFCC course performed strongly in its first years, yielding both high participant satisfaction and substantial improvement in workplace asthma management activity. This training holds promise for introducing and improving multidimensional asthma management strategies at childcare facilities nationwide.
Show less
Date Issued: 2016-03-16
Identifier: FSU_libsubv1_scholarship_submission_1459958642, 10.3389/fpubh.2016.00039
Format: Citation

Title: Developing Asthma-Friendly Childcare Centers with Online Training and Evaluation.
Creator: Nowakowski, Alexandra Catherine Hayes, Carretta, Henry Joseph, Pineda, Nicole, Dudley, Julie Kurlfink, Forrest, Jamie R
Abstract/Description: In 2011, the Florida Asthma Coalition (FAC) began offering its Asthma-Friendly Childcare Center (AFCC) training online. This course teaches childcare center employees the fundamentals of effective asthma management. It covers basic asthma physiology, ways to recognize asthma attacks, techniques to help children experiencing attacks, and strategies to create healthy environments for asthmatics. A team of health services researchers evaluated both years of the online training. Evaluators used a...
Show moreIn 2011, the Florida Asthma Coalition (FAC) began offering its Asthma-Friendly Childcare Center (AFCC) training online. This course teaches childcare center employees the fundamentals of effective asthma management. It covers basic asthma physiology, ways to recognize asthma attacks, techniques to help children experiencing attacks, and strategies to create healthy environments for asthmatics. A team of health services researchers evaluated both years of the online training. Evaluators used a quasi-experimental design with pretest, posttest, and follow-up assessment. Questions measured knowledge gain and retention, user satisfaction, and implementation of management strategies. Over 650 people from nearly all 67 Florida counties took AFCC training online between 2011 and 2013. Test scores improved by a minimum of 11% points in all program years evaluated. Gains in both knowledge and confidence were substantial and highly significant across years. While individual trainees did forget some content on follow-up, they seemed to retain the specific messages most relevant for their own workplaces. Most trainees also planned to implement multiple management strategies recommended by the training. A large majority of participants rated the training as excellent on all quality metrics, including relevance of content and time efficiency of the online format. Nearly all respondents perceived the training as useful for both providing improved care and fulfilling licensure or certification requirements. Many participants also indicated that their centers would pursue formal certification as AFCCs via the program offered by FAC. The online AFCC course performed strongly in its first years, yielding both high participant satisfaction and substantial improvement in workplace asthma management activity. This training holds promise for introducing and improving multidimensional asthma management strategies at childcare facilities nationwide.
Show less
Date Issued: 2016-03-16
Identifier: FSU_pmch_27014676, 10.3389/fpubh.2016.00039, PMC4792866, 27014676, 27014676
Format: Citation

Title: Disparities in Infant Mortality by Race Among Hispanic and Non-Hispanic Infants.
Creator: Rice, Whitney S, Goldfarb, Samantha S, Brisendine, Anne E, Burrows, Stevie, Wingate, Martha S
Abstract/Description: U.S.-born Hispanic infants have a well-documented health advantage relative to other minority groups. However, little published research has examined racial heterogeneity within the Hispanic population, in relation to health outcomes. The current study aims to explore possible implications of racial identification for the health of U.S. born Hispanic compared to non-Hispanic infants. Methods Data were drawn from 2007 to 2008 NCHS Cohort Linked Live Birth-Infant Death Files, restricted to...
Show moreU.S.-born Hispanic infants have a well-documented health advantage relative to other minority groups. However, little published research has examined racial heterogeneity within the Hispanic population, in relation to health outcomes. The current study aims to explore possible implications of racial identification for the health of U.S. born Hispanic compared to non-Hispanic infants. Methods Data were drawn from 2007 to 2008 NCHS Cohort Linked Live Birth-Infant Death Files, restricted to deliveries of Hispanic black, Hispanic white, non-Hispanic black (NHB) and non-Hispanic white mothers (NHW) (n = 7,901,858). Adjusted odds ratios for first week mortality, neonatal, postneonatal, and overall infant mortality were calculated for each group, using NHW as the reference group. A distinct health gradient was observed in which NHB infants (n = 1,250,222) had the highest risk of first week (aOR 2.29, CI 2.21-2.37), neonatal (aOR 2.23, CI 2.17-2.30), postneonatal (aOR 1.74, CI 1.68-1.81), and infant mortality (aOR 2.05, CI 2.00-2.10) compared to NHW infants (n = 4,578,150). Hispanic black infants (n = 84,377) also experienced higher risk of first-week (aOR 1.28 (1.12-1.47), neonatal (aOR .27, CI 1.13-1.44), postneonatal (aOR 1.34, CI 1.15-1.56), and infant mortality (aOR 1.30, CI 1.18-1.43) compared to both NHW and Hispanic white infants (n = 1,989,109). Conclusions for Practice: Risk of infant mortality varies among Hispanic infants by race, with poorer outcomes experienced by Hispanic black infants. Compared to non-Hispanic infants of the same race, Hispanic black infants experience a smaller health disadvantage and Hispanic white infants have better or similar infant health outcomes. Our findings suggest implications of racial heterogeneity on infant health outcomes, and provide insight into the role of race as a social construct.
Show less
Date Issued: 2017-07-01
Identifier: FSU_pmch_28197819, 10.1007/s10995-017-2290-3, PMC5498242, 28197819, 28197819, 10.1007/s10995-017-2290-3
Format: Citation

Title: Do the 'brain dead' merely appear to be alive?.
Creator: Nair-Collins, Michael, Miller, Franklin G
Abstract/Description: The established view regarding 'brain death' in medicine and medical ethics is that patients determined to be dead by neurological criteria are dead in terms of a biological conception of death, not a philosophical conception of personhood, a social construction or a legal fiction. Although such individuals show apparent signs of being alive, in reality they are (biologically) dead, though this reality is masked by the intervention of medical technology. In this article, we argue that an...
Show moreThe established view regarding 'brain death' in medicine and medical ethics is that patients determined to be dead by neurological criteria are dead in terms of a biological conception of death, not a philosophical conception of personhood, a social construction or a legal fiction. Although such individuals show apparent signs of being alive, in reality they are (biologically) dead, though this reality is masked by the intervention of medical technology. In this article, we argue that an appeal to the distinction between appearance and reality fails in defending the view that the 'brain dead' are dead. Specifically, this view relies on an inaccurate and overly simplistic account of the role of medical technology in the physiology of a 'brain dead' patient. We conclude by offering an explanation of why the conventional view on 'brain death', though mistaken, continues to be endorsed in light of its connection to organ transplantation and the dead donor rule.
Show less
Date Issued: 2017-11-01
Identifier: FSU_pmch_28848063, 10.1136/medethics-2016-103867, PMC5749302, 28848063, 28848063, medethics-2016-103867
Format: Citation

Title: Does Knowing Hurt? Perceiving Oneself as Overweight Predicts Future Physical Health and Well-Being.
Creator: Daly, Michael, Robinson, Eric, Sutin, Angelina R
Abstract/Description: Identifying oneself as being overweight may be associated with adverse health outcomes, yet prospective tests of this possibility are lacking. Over 7 years, we examined associations between perceptions of being overweight and subsequent health in a sample of 3,582 U.S. adults. Perceiving oneself as being overweight predicted longitudinal declines in subjective health ( d = -0.22, p
Show moreIdentifying oneself as being overweight may be associated with adverse health outcomes, yet prospective tests of this possibility are lacking. Over 7 years, we examined associations between perceptions of being overweight and subsequent health in a sample of 3,582 U.S. adults. Perceiving oneself as being overweight predicted longitudinal declines in subjective health ( d = -0.22, p < .001), increases in depressive symptoms ( d = 0.09, p < .05), and raised levels of physiological dysregulation ( d = 0.24, p < .001), as gauged by clinical indicators of cardiovascular, inflammatory, and metabolic functioning. These associations remained after controlling for a range of potential confounders and were observed irrespective of whether perceptions of being overweight were accurate or inaccurate. This research highlights the possibility that identifying oneself as overweight may act independently of body mass index to contribute to unhealthy profiles of physiological functioning and impaired health over time. These findings underscore the importance of evaluating whether weight-feedback interventions may have unforeseen adverse consequences.
Show less
Date Issued: 2017-07-01
Identifier: FSU_pmch_28504919, 10.1177/0956797617696311, PMC6052963, 28504919, 28504919
Format: Citation

Title: The Effect of Birth Cohort on Well-Being: The Legacy of Economic Hard Times.
Creator: Sutin, Angelina, Terracciano, Antonio, Milaneschi, Yuri, An, Yang, Ferrucci, Luigi, Zonderman, Alan
Abstract/Description: In the present research, we examined the effects of age, cohort, and time of measurement on well-being across adulthood. Cross-sectional and longitudinal analyses of two independent samples-one with more than 10,000 repeated assessments across 30 years (mean assessments per participant = 4.44, SD = 3.47) and one with nationally representative data-suggested that well-being declines with age. This decline, however, reversed when we controlled for birth cohort. That is, once we accounted for...
Show moreIn the present research, we examined the effects of age, cohort, and time of measurement on well-being across adulthood. Cross-sectional and longitudinal analyses of two independent samples-one with more than 10,000 repeated assessments across 30 years (mean assessments per participant = 4.44, SD = 3.47) and one with nationally representative data-suggested that well-being declines with age. This decline, however, reversed when we controlled for birth cohort. That is, once we accounted for the fact that older cohorts had lower levels of well-being, all cohorts increased in well-being with age relative to their own baseline. Participants tested more recently had higher well-being, but time of measurement, unlike cohort, did not change the shape of the trajectory. Although well-being increased with age for everyone, cohorts that lived through the economic challenges of the early 20th century had lower well-being than those born during more prosperous times.
Show less
Date Issued: 2013
Identifier: FSU_migr_mhs-0010, 10.1177/0956797612459658
Format: Citation

Title: Effect of Digoxin Use Among Medicaid Enrollees With Atrial Fibrillation.
Creator: Adedinsewo, Demilade, Xu, Junjun, Agasthi, Pradyumna, Oderinde, Adesoji, Adekeye, Oluwatoyosi, Sachdeva, Rajesh, Rust, George, Onwuanyi, Anekwe
Abstract/Description: Recently published analysis of contemporary atrial fibrillation (AF) cohorts showed an association between digoxin and increased mortality and hospitalizations; however, other studies have demonstrated conflicting results. Many AF cohort studies did not or were unable to examine racial differences. Our goal was to examine risk factors for hospitalizations and mortality with digoxin use in a diverse real-world AF patient population and evaluate racial differences. We performed a retrospective...
Show moreRecently published analysis of contemporary atrial fibrillation (AF) cohorts showed an association between digoxin and increased mortality and hospitalizations; however, other studies have demonstrated conflicting results. Many AF cohort studies did not or were unable to examine racial differences. Our goal was to examine risk factors for hospitalizations and mortality with digoxin use in a diverse real-world AF patient population and evaluate racial differences. We performed a retrospective cohort analysis of claims data for Medicaid beneficiaries, aged 18 to 64 years, with incident diagnosis of AF in 2008 with follow-up until December 31, 2009. We created Kaplan-Meier curves and constructed multivariable Cox proportional hazard models for mortality and hospitalization. We identified 11 297 patients with an incident diagnosis of AF in 2008, of those, 1401 (12.4%) were on digoxin. Kaplan-Meier analysis demonstrated an increased risk of hospitalization with digoxin use overall and within race and heart failure groups. In adjusted models, digoxin was associated with an increased risk of hospitalization (adjusted hazard ratio, 1.54; 95% confidence interval, 1.39-1.70) and mortality (adjusted hazard ratio, 1.50; 95% confidence interval, 1.05-2.13). Overall, blacks had a higher risk of hospitalization but similar mortality when compared with whites regardless of digoxin use. We found no significant interaction between race and digoxin use for mortality (=0.4437) and hospitalization (=0.7122). Our study demonstrates an overall increased risk of hospitalizations and mortality with digoxin use but no racial/ethnic differences in outcomes were observed. Further studies including minority populations are needed to critically evaluate these associations.
Show less
Date Issued: 2017-05-01
Identifier: FSU_pmch_28500174, 10.1161/CIRCEP.116.004573, PMC5522586, 28500174, 28500174, CIRCEP.116.004573
Format: Citation

Title: Exploring Black-white Differences In The Relationship Between Inflammation And Timing Of Menopause.
Creator: Nowakowski, Alexandra C. H., Graves, Katelyn Y.
Abstract/Description: Understanding the biosocial context of menopausal timing offers insight into social and health inequalities. Prior research on inflammatory chronic conditions suggests that inflammation may predict how early women experience menopause. We explore the ability of black race to moderate the overall relationship between chronic inflammation and timing of menopause. We use data from the National Social Life, Health, and Aging Project on inflammation, age of last menstruation, and race as well as...
Show moreUnderstanding the biosocial context of menopausal timing offers insight into social and health inequalities. Prior research on inflammatory chronic conditions suggests that inflammation may predict how early women experience menopause. We explore the ability of black race to moderate the overall relationship between chronic inflammation and timing of menopause. We use data from the National Social Life, Health, and Aging Project on inflammation, age of last menstruation, and race as well as relevant social and medical covariates. We conduct event history modeling to predict age at menopause by inflammatory biomarker levels. Using interaction analysis, we investigate whether being black may shape the overall relationship between inflammation status and menopause timing. Our analyses find no significant statistical interactions between black race and inflammation in predicting menopausal onset. However, we do identify independent correlational relationships between inflammation and black race (r = 0.136) and between menopausal timing and black race (r =-0.129) as well as inflammation (r= -0.138) that emerge as significant in corresponding regression models. We conclude that race probably does not moderate associations between inflammation and menopause. Yet, we also note that the original parameter estimate for black race's impact on menopausal onset (HR= 1.29, p < 0.05) becomes non-significant in a model that includes inflammation (HR= 1.06, p< 0.01). To translate our findings into policy and practice implications, we present alternate conceptualizations of black-white disparity in the inflammation-menopause relationship and recommend future research using mediation modeling.
Show less
Date Issued: 2017-06
Identifier: FSU_libsubv1_wos_000406795600011, 10.1007/s40615-016-0241-0
Format: Set of related objects

Title: Eyes on the Prize: The Longitudinal Benefits of Goal Focus on Progress Toward a Weight Loss Goal.
Creator: Conlon, Kyle, Ehrlinger, Joyce, Eibach, Richard, Crescioni, A. Will (Albert William), Alquist, Jessica, Gerend, Mary, Dutton, Gareth
Abstract/Description: Past research suggests that focusing on what has not yet been accomplished (goal focus) signals a lack of progress towards one's high commitment goals and inspires greater motivation than does focusing on what has already been accomplished (accomplishment focus). The present investigation extends this research to a longitudinal, important domain by exploring the consequences of focusing on one's goals versus accomplishments when pursuing a weight loss goal. Participants were tracked over the...
Show morePast research suggests that focusing on what has not yet been accomplished (goal focus) signals a lack of progress towards one's high commitment goals and inspires greater motivation than does focusing on what has already been accomplished (accomplishment focus). The present investigation extends this research to a longitudinal, important domain by exploring the consequences of focusing on one's goals versus accomplishments when pursuing a weight loss goal. Participants were tracked over the course of a 12-week weight loss program that utilized weekly group discussions and a companion website to direct participants' focus toward their end weight loss goal or toward what they had already achieved. Goal-focused participants reported higher levels of commitment to their goal and, ultimately, lost more weight than did accomplishment-focused and no focus control participants. Accomplishment-focused participants did not differ from controls on any measure.
Show less
Date Issued: 2011
Identifier: FSU_migr_mhs-0007, 10.1016/j.jesp.2011.02.005
Format: Citation

Title: Facets of Conscientiousness and risk of dementia.
Creator: Sutin, A R, Stephan, Y, Terracciano, A
Abstract/Description: Multiple studies have found Conscientiousness to be protective against dementia. The purpose of this study is to identify which specific aspects, or facets, of Conscientiousness are most protective against cognitive impairment and whether these associations are moderated by demographic factors and/or genetic risk. Health and Retirement Study participants were selected for analysis if they completed the facets of Conscientiousness measure, scored in the range of normal cognitive functioning at...
Show moreMultiple studies have found Conscientiousness to be protective against dementia. The purpose of this study is to identify which specific aspects, or facets, of Conscientiousness are most protective against cognitive impairment and whether these associations are moderated by demographic factors and/or genetic risk. Health and Retirement Study participants were selected for analysis if they completed the facets of Conscientiousness measure, scored in the range of normal cognitive functioning at the baseline personality assessment, and had at least one follow-up assessment of cognition over the up to 6-year follow-up (N = 11 181). Cox regression was used to test for risk of incident dementia and risk of incident cognitive impairment not dementia (CIND). Over the follow-up, 278 participants developed dementia and 2186 participants developed CIND. The facet of responsibility had the strongest and most consistent association with dementia risk: every standard deviation increase in this facet was associated with a nearly 35% decreased risk of dementia; self-control and industriousness were also protective. Associations were generally similar when controlling for clinical, behavioral, and genetic risk factors. These three facets were also independent predictors of decreased risk of CIND. The present research indicates that individuals who see themselves as responsible, able to control their behavior, and hard workers are less likely to develop CIND or dementia and that these associations persist after accounting for some common clinical, behavioral, and genetic risk factors.
Show less
Date Issued: 2018-04-01
Identifier: FSU_pmch_28874220, 10.1017/S0033291717002306, PMC5839940, 28874220, 28874220, S0033291717002306
Format: Citation

Title: Facets of Personality Linked to Underweight and Overweight.
Creator: Terracciano, Antonio, Sutin, Angelina, McCrae, Robert R., Deiana, Barbara, Ferrucci, Luigi, Schlessinger, David, Uda, Manuela, Costa, Paul
Abstract/Description: OBJECTIVE: Personality traits underlie maladaptive behaviors, and cognitive and emotional disturbances that contribute to major preventable causes of global disease burden. This study examines detailed personality profiles of underweight, normal, and overweight individuals to provide insights into the causes and treatments of abnormal weight. METHODS: More than half of the population from four towns in Sardinia, Italy (n = 5693; age = 14-94 years; mean +/- standard deviation = 43 +/- 17 years...
Show moreOBJECTIVE: Personality traits underlie maladaptive behaviors, and cognitive and emotional disturbances that contribute to major preventable causes of global disease burden. This study examines detailed personality profiles of underweight, normal, and overweight individuals to provide insights into the causes and treatments of abnormal weight. METHODS: More than half of the population from four towns in Sardinia, Italy (n = 5693; age = 14-94 years; mean +/- standard deviation = 43 +/- 17 years) were assessed on multiple anthropometric measures and 30 facets that comprehensively cover the five major dimensions of personality, using the Revised NEO Personality Inventory. RESULTS: High Neuroticism and low Conscientiousness were associated with being underweight and obese, respectively. High Impulsiveness (specifically eating-behavior items) and low Order were associated with body mass index categories of overweight and obese, and with measures of abdominal adiposity (waist and hip circumference). Those scoring in the top 10% of Impulsiveness were about 4 kg heavier than those in the bottom 10%, an effect independent and larger than the FTO genetic variant. Prospective analyses confirmed that Impulsiveness and Order were significant predictors of general and central measures of adiposity assessed 3 years later. CONCLUSIONS: Overweight and obese individuals have difficulty resisting cravings and lack methodical and organized behaviors that might influence diet and weight control. Although individuals' traits have limited impact on the current obesogenic epidemic, personality traits can improve clinical assessment, suggest points of intervention, and help tailor prevention and treatment approaches.
Show less
Date Issued: 2009
Identifier: FSU_migr_mhs-0033, 10.1097/PSY.0b013e3181a2925b
Format: Citation

Title: Factors associated with longitudinal food record compliance in a paediatric cohort study.
Creator: Yang, Jimin, Lynch, Kristian F., Uusitalo, Ulla M., Foterek, Kristina, Hummel, Sandra, Silvis, Katherine, Aronsson, Carin Andren, Riikonen, Anne, Rewers, Marian, She, Jin-Xiong,...
Show moreYang, Jimin, Lynch, Kristian F., Uusitalo, Ulla M., Foterek, Kristina, Hummel, Sandra, Silvis, Katherine, Aronsson, Carin Andren, Riikonen, Anne, Rewers, Marian, She, Jin-Xiong, Ziegler, Anette G., Simell, Olli G., Toppari, Jorma, Hagopian, William A., Lernmark, Ake, Akolkar, Beena, Krischer, Jeffrey P., Norris, Jill M., Virtanen, Suvi M., Johnson, Suzanne B.
Show less
Abstract/Description: Objective Non-compliance with food record submission can induce bias in nutritional epidemiological analysis and make it difficult to draw inference from study findings. We examined the impact of demographic, lifestyle and psychosocial factors on such non-compliance during the first 3 years of participation in a multidisciplinary prospective paediatric study. Design The Environmental Determinants of Diabetes in the Young (TEDDY) study collects a 3 d food record quarterly during the first year...
Show moreObjective Non-compliance with food record submission can induce bias in nutritional epidemiological analysis and make it difficult to draw inference from study findings. We examined the impact of demographic, lifestyle and psychosocial factors on such non-compliance during the first 3 years of participation in a multidisciplinary prospective paediatric study. Design The Environmental Determinants of Diabetes in the Young (TEDDY) study collects a 3 d food record quarterly during the first year of life and semi-annually thereafter. High compliance with food record completion was defined as the participating families submitting one or more days of food record at every scheduled clinic visit. Setting Three centres in the USA (Colorado, Georgia/Florida and Washington) and three in Europe (Finland, Germany and Sweden). Subjects Families who finished the first 3 years of TEDDY participation (n 8096). Results High compliance was associated with having a single child, older maternal age, higher maternal education and father responding to study questionnaires. Families showing poor compliance were more likely to be living far from the study centres, from ethnic minority groups, living in a crowded household and not attending clinic visits regularly. Postpartum depression, maternal smoking behaviour and mother working outside the home were also independently associated with poor compliance. Conclusions These findings identified specific groups for targeted strategies to encourage completion of food records, thereby reducing potential bias in multidisciplinary collaborative research.
Show less
Date Issued: 2016-04
Identifier: FSU_libsubv1_wos_000372820100005, 10.1017/S1368980015001883
Format: Citation

Title: Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful?.
Creator: Smith, Laura B, Liu, Xiang, Johnson, Suzanne Bennett, Tamura, Roy, Elding Larsson, Helena, Ahmed, Simi, Veijola, Riitta, Haller, Michael J, Akolkar, Beena, Hagopian, William A,...
Show moreSmith, Laura B, Liu, Xiang, Johnson, Suzanne Bennett, Tamura, Roy, Elding Larsson, Helena, Ahmed, Simi, Veijola, Riitta, Haller, Michael J, Akolkar, Beena, Hagopian, William A, Rewers, Marian J, Krischer, Jeffrey, Steck, Andrea K
Show less
Abstract/Description: Diagnosis of type 1 diabetes often causes a negative psychological impact on families. We examined whether parents and children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study differ in their psychological adjustment to diabetes diagnosis compared to children diagnosed with diabetes in the community. TEDDY follows 8676 children at genetic risk for type 1 diabetes from birth. Fifty-four TEDDY children diagnosed with diabetes and 54 age-matched community...
Show moreDiagnosis of type 1 diabetes often causes a negative psychological impact on families. We examined whether parents and children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study differ in their psychological adjustment to diabetes diagnosis compared to children diagnosed with diabetes in the community. TEDDY follows 8676 children at genetic risk for type 1 diabetes from birth. Fifty-four TEDDY children diagnosed with diabetes and 54 age-matched community control children diagnosed with diabetes were enrolled. Participants were aged 3 to 10 years and study visits occurred at 3, 6, and 12 months postdiagnosis. Psychological measures included an adapted diabetes-specific State Anxiety Inventory, the Pediatric Quality of Life Inventory-Diabetes Module, and the Pediatric Inventory for Parents, which measures frequency and difficulty of parenting stress. A generalized estimating equation analysis based on a difference score between TEDDY children and community controls found no significant differences between TEDDY parents and community controls on parent diabetes-specific anxiety (P = .30). However, TEDDY children exhibited better diabetes-specific quality of life (P = .03) and TEDDY parents reported lower frequency (P = .004) and difficulty (P = .008) of parenting stress compared to community controls. Children diagnosed with at-risk for type 1 diabetes who have previously enrolled in research monitoring have improved diabetes quality of life and lower parenting stress postdiagnosis compared to children diagnosed in the community. Families in follow-up studies may be more prepared if their child is diagnosed with diabetes.
Show less
Date Issued: 2018-08-01
Identifier: FSU_pmch_29577538, 10.1111/pedi.12674, PMC6030424, 29577538, 29577538
Format: Citation

Title: Fear, Anger, Fruits, and Veggies: Interactive Effects of Emotion and Message Framing on Health Behavior.
Creator: Gerend, Mary, Maner, Jon
Abstract/Description: Objective: Message framing is a theoretically grounded health communication strategy designed to motivate action by emphasizing the benefits of engaging in a particular behavior (gains) or the costs of failing to engage in the behavior (losses). This study investigated whether the effectiveness of a framed message depends on the emotional state of the message recipient. We examined effects of fear versus anger, emotions that frequently occur within the context of health decision-making....
Show moreObjective: Message framing is a theoretically grounded health communication strategy designed to motivate action by emphasizing the benefits of engaging in a particular behavior (gains) or the costs of failing to engage in the behavior (losses). This study investigated whether the effectiveness of a framed message depends on the emotional state of the message recipient. We examined effects of fear versus anger, emotions that frequently occur within the context of health decision-making. Methods: Undergraduate students (N = 133) were randomly assigned to complete a fear or anger induction task after which they read a gain- or loss-framed pamphlet promoting fruit and vegetable consumption. Fruit and vegetable intake (servings per day) was subsequently assessed over the following two weeks. Results: As predicted, a significant frame by emotion interaction was observed, such that participants in the fear condition reported eating more servings of fruits and vegetables after exposure to a loss-framed message than to a gain-framed message. In contrast, participants in the anger condition reported eating (marginally) more servings of fruits and vegetables after exposure to a gain-framed message than to a loss-framed message. That is, greater increases in fruit and vegetable intake from baseline to follow-up were observed when frame was matched to participants' emotional state than when it was mismatched. Conclusion: The effectiveness of framed health communications depends on the message recipient's current emotional state. Affective factors that are incidental to the behavior recommended in a health communication can affect the relative success of gain- and loss-framed appeals.
Show less
Date Issued: 2011
Identifier: FSU_migr_mhs-0006, 10.1037/a0021981
Format: Citation

Title: The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study..
Creator: Roth, Roswith, Baxter, Judith, Vehik, Kendra, Hopkins, Diane, Killian, Michael, Gesualdo, Patricia, Melin, Jessica, Simell, Barbara, Strauss, Elisabeth, Lernmark, Åke, Johnson,...
Show moreRoth, Roswith, Baxter, Judith, Vehik, Kendra, Hopkins, Diane, Killian, Michael, Gesualdo, Patricia, Melin, Jessica, Simell, Barbara, Strauss, Elisabeth, Lernmark, Åke, Johnson, Suzanne Bennett
Show less
Abstract/Description: Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes...
Show moreSaliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre- and post-blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting adherence, and sufficiency of saliva sample for cortisol determination. Collection of saliva samples in a diverse pediatric population is feasible. Establishing non-invasive and acceptable methods for collecting physiological parameters of stress will allow better exploration of determinants of health in this important population.
Show less
Date Issued: 2017-07-01
Identifier: FSU_pmch_28555778, 10.1002/dev.21523, PMC5502734, 28555778, 28555778
Format: Citation

Title: Feeling Older and the Development of Cognitive Impairment and Dementia.
Creator: Stephan, Yannick, Sutin, Angelina R, Luchetti, Martina, Terracciano, Antonio
Abstract/Description: Subjective age is a biopsychosocial marker of aging associated with a range of outcomes in old age. In the domain of cognition, feeling older than one's chronological age is related to lower cognitive performance and steeper cognitive decline among older adults. The present study examines whether an older subjective age is associated with the risk of incident cognitive impairment and dementia. Participants were 5,748 individuals aged 65 years and older drawn from the Health and Retirement...
Show moreSubjective age is a biopsychosocial marker of aging associated with a range of outcomes in old age. In the domain of cognition, feeling older than one's chronological age is related to lower cognitive performance and steeper cognitive decline among older adults. The present study examines whether an older subjective age is associated with the risk of incident cognitive impairment and dementia. Participants were 5,748 individuals aged 65 years and older drawn from the Health and Retirement Study. Measures of subjective age, cognition, and covariates were obtained at baseline, and follow-up cognition was assessed over a 2- to 4-year period. Only participants without cognitive impairment were included at baseline. At follow-up, participants were classified into one of the three categories: normal functioning, cognitive impairment without dementia (CIND), and dementia. An older subjective age at baseline was associated with higher likelihood of CIND (odds ratio [OR] = 1.18; 1.09-1.28) and dementia (OR = 1.29; 1.02-1.63) at follow-up, controlling for chronological age, other demographic factors, and baseline cognition. Physical inactivity and depressive symptoms partly accounted for these associations. An older subjective age is a marker of individuals' risk of subsequent cognitive impairment and dementia.
Show less
Date Issued: 2017-10-01
Identifier: FSU_pmch_27436103, 10.1093/geronb/gbw085, PMC5927095, 27436103, 27436103, gbw085
Format: Citation

Title: First 200 Robotic General Surgery Cases in a Community Hospital: A Retrospective Cohort Study.
Creator: Oviedo, Rodolfo, Brownstein, Naomi, Smith, SchMiyah, Robertson, Jarrod, Nair-Collins, Sangeeta
Abstract/Description: Background and Objectives: A retrospective series and learning curve of the first 101 robotic general surgery cases from a single surgeon in a small community hospital has been previously reported. This study serves as a continuation and offers a more detailed statistical analysis while demonstrating the efficacy and safety of a general surgery robotics program in a community hospital with quality assessment measures. Methods: Measurements included total operative time, console time,...
Show moreBackground and Objectives: A retrospective series and learning curve of the first 101 robotic general surgery cases from a single surgeon in a small community hospital has been previously reported. This study serves as a continuation and offers a more detailed statistical analysis while demonstrating the efficacy and safety of a general surgery robotics program in a community hospital with quality assessment measures. Methods: Measurements included total operative time, console time, conversion rates, complications, surgical site infections, surgical site occurrences, length of stay, and patient demographics. Descriptive statistics were included for all variables. Linear regression was used to test the hypothesis of a learning curve, reflected by a decrease in console time with experience. Results: Between March 2014 and February 2017, 200 robotic general surgery cases were performed by a single surgeon in a 266-bed community hospital, including laparoscopic cholecystectomies; ventral, incisional, and umbilical hernia repairs; colorectal; foregut and bariatric; inguinal hernia repairs; and miscellaneous procedures. One hundred and ninety-eight of the cases (99%) were completed robotically. Thirteen patients were readmitted within 30 days, and 21 had complications (11%). There were no mortalities, and all complications were resolved positively. The mean operative and console times of all 200 cases were 214.8 and 105.7 minutes, respectively. Decreased console time was significantly associated with increasing case load, even after controlling for surgery type. Conclusion: With increased operative volume, general surgeons who utilize the robotic platform can improve operative outcomes, decrease operative times and perform increasingly complicated procedures while maintaining low complication rates.
Show less
Date Issued: 2018-08-08
Identifier: FSU_libsubv1_scholarship_submission_1536177251_40501fac
Format: Citation

Title: The Five-Factor Model of Personality and Physical Inactivity: A Meta-Analysis of 16 Samples..
Creator: Sutin, Angelina R, Stephan, Yannick, Luchetti, Martina, Artese, Ashley, Oshio, Atsushi, Terracciano, Antonio
Abstract/Description: A sedentary lifestyle is harmful for health; personality traits may contribute to physical (in)activity. With participant-level data from 16 samples (>125,000), we examined the personality correlates of physical inactivity, frequency of physical activity, and sedentary behavior (in a subset of samples). Lower Neuroticism and higher Conscientiousness were associated with more physical activity and less inactivity and sedentary behavior. Extraversion and Openness were also associated with more...
Show moreA sedentary lifestyle is harmful for health; personality traits may contribute to physical (in)activity. With participant-level data from 16 samples (>125,000), we examined the personality correlates of physical inactivity, frequency of physical activity, and sedentary behavior (in a subset of samples). Lower Neuroticism and higher Conscientiousness were associated with more physical activity and less inactivity and sedentary behavior. Extraversion and Openness were also associated with more physical activity and less inactivity, but these traits were mostly unrelated to specific sedentary behaviors (e.g., TV watching). The results generally did not vary by age or sex. The findings support the notion that the interest, motivational, emotional, and interpersonal processes assessed by five-factor model traits partly shape the individual's engagement in physical activity.
Show less
Date Issued: 2016-08-01
Identifier: FSU_pmch_29056783, 10.1016/j.jrp.2016.05.001, PMC5650243, 29056783, 29056783
Format: Citation

Title: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Creator: Okbay, Aysu, Baselmans, Bart M L, De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G, Fontana, Mark Alan, Meddens, S Fleur W, Linnér, Richard Karlsson, Rietveld, Cornelius...
Show moreOkbay, Aysu, Baselmans, Bart M L, De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G, Fontana, Mark Alan, Meddens, S Fleur W, Linnér, Richard Karlsson, Rietveld, Cornelius A, Derringer, Jaime, Gratten, Jacob, Lee, James J, Liu, Jimmy Z, de Vlaming, Ronald, Ahluwalia, Tarunveer S, Buchwald, Jadwiga, Cavadino, Alana, Frazier-Wood, Alexis C, Furlotte, Nicholas A, Garfield, Victoria, Geisel, Marie Henrike, Gonzalez, Juan R, Haitjema, Saskia, Karlsson, Robert, van der Laan, Sander W, Ladwig, Karl-Heinz, Lahti, Jari, van der Lee, Sven J, Lind, Penelope A, Liu, Tian, Matteson, Lindsay, Mihailov, Evelin, Miller, Michael B, Minica, Camelia C, Nolte, Ilja M, Mook-Kanamori, Dennis, van der Most, Peter J, Oldmeadow, Christopher, Qian, Yong, Raitakari, Olli, Rawal, Rajesh, Realo, Anu, Rueedi, Rico, Schmidt, Börge, Smith, Albert V, Stergiakouli, Evie, Tanaka, Toshiko, Taylor, Kent, Thorleifsson, Gudmar, Wedenoja, Juho, Wellmann, Juergen, Westra, Harm-Jan, Willems, Sara M, Zhao, Wei, Amin, Najaf, Bakshi, Andrew, Bergmann, Sven, Bjornsdottir, Gyda, Boyle, Patricia A, Cherney, Samantha, Cox, Simon R, Davies, Gail, Davis, Oliver S P, Ding, Jun, Direk, Nese, Eibich, Peter, Emeny, Rebecca T, Fatemifar, Ghazaleh, Faul, Jessica D, Ferrucci, Luigi, Forstner, Andreas J, Gieger, Christian, Gupta, Richa, Harris, Tamara B, Harris, Juliette M, Holliday, Elizabeth G, Hottenga, Jouke-Jan, De Jager, Philip L, Kaakinen, Marika A, Kajantie, Eero, Karhunen, Ville, Kolcic, Ivana, Kumari, Meena, Launer, Lenore J, Franke, Lude, Li-Gao, Ruifang, Liewald, David C, Koini, Marisa, Loukola, Anu, Marques-Vidal, Pedro, Montgomery, Grant W, Mosing, Miriam A, Paternoster, Lavinia, Pattie, Alison, Petrovic, Katja E, Pulkki-Råback, Laura, Quaye, Lydia, Räikkönen, Katri, Rudan, Igor, Scott, Rodney J, Smith, Jennifer A, Sutin, Angelina R, Trzaskowski, Maciej, Vinkhuyzen, Anna E, Yu, Lei, Zabaneh, Delilah, Attia, John R, Bennett, David A, Berger, Klaus, Bertram, Lars, Boomsma, Dorret I, Snieder, Harold, Chang, Shun-Chiao, Cucca, Francesco, Deary, Ian J, van Duijn, Cornelia M, Eriksson, Johan G, Bültmann, Ute, de Geus, Eco J C, Groenen, Patrick J F, Gudnason, Vilmundur, Hansen, Torben, Hartman, Catharine A, Haworth, Claire M A, Hayward, Caroline, Heath, Andrew C, Hinds, David A, Hyppönen, Elina, Iacono, William G, Järvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Kaprio, Jaakko, Kardia, Sharon L R, Keltikangas-Järvinen, Liisa, Kraft, Peter, Kubzansky, Laura D, Lehtimäki, Terho, Magnusson, Patrik K E, Martin, Nicholas G, McGue, Matt, Metspalu, Andres, Mills, Melinda, de Mutsert, Renée, Oldehinkel, Albertine J, Pasterkamp, Gerard, Pedersen, Nancy L, Plomin, Robert, Polasek, Ozren, Power, Christine, Rich, Stephen S, Rosendaal, Frits R, den Ruijter, Hester M, Schlessinger, David, Schmidt, Helena, Svento, Rauli, Schmidt, Reinhold, Alizadeh, Behrooz Z, Sørensen, Thorkild I A, Spector, Tim D, Starr, John M, Stefansson, Kari, Steptoe, Andrew, Terracciano, Antonio, Thorsteinsdottir, Unnur, Thurik, A Roy, Timpson, Nicholas J, Tiemeier, Henning, Uitterlinden, André G, Vollenweider, Peter, Wagner, Gert G, Weir, David R, Yang, Jian, Conley, Dalton C, Smith, George Davey, Hofman, Albert, Johannesson, Magnus, Laibson, David I, Medland, Sarah E, Meyer, Michelle N, Pickrell, Joseph K, Esko, Tõnu, Krueger, Robert F, Beauchamp, Jonathan P, Koellinger, Philipp D, Benjamin, Daniel J, Bartels, Meike, Cesarini, David
Show less
Abstract/Description: Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with...
Show moreVery few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Show less
Date Issued: 2016-06-01
Identifier: FSU_pmch_27089181, 10.1038/ng.3552, PMC4884152, 27089181, 27089181, ng.3552
Format: Citation

Title: Genetics of Serum BDNF: Meta-analysis of the Val66Met and Genome-wide Association Study.
Creator: Terracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger,...
Show moreTerracciano, Antonio, Piras, Maria, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina, Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger, David
Show less
Abstract/Description: Abstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of...
Show moreAbstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS). Methods. In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS. Results. We estimated the heritability of serum BDNF to be 0.48 from sib-pairs. There was no association between serum BDNF and Val66Met in the SardiNIA sample and in a meta-analysis of published studies (k = 13 studies, total n = 4727, P = 0.92). Although no genome-wide significant associations were identified, some evidence of association was found in the BDNF gene (rs11030102, P = 0.001) and at two loci (rs7170215, P = 4.8 × 10(-5) and rs11073742 P = 1.2 × 10(-5)) near and within NTRK3 gene, a neurotrophic tyrosine kinase receptor. Conclusions. Our study and meta-analysis of the literature indicate that the BDNF Val66Met variant is not associated with serum BDNF, but other variants in the BDNF and NTRK3 genes might regulate the level of serum BDNF.
Show less
Date Issued: 2011
Identifier: FSU_migr_mhs-0014, 10.3109/15622975.2011.616533
Format: Citation

Title: Genome-Wide Association Scan of Trait Depression.
Creator: Terracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa...
Show moreTerracciano, Antonio, Tanaka, Toshiko, Sutin, Angelina, Sanna, Serena, Deiana, Barbara, Lai, Sandra, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo, Ferrucci, Luigi, Costa, Paul
Show less
Abstract/Description: BACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a...
Show moreBACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a genetically homogeneous area of Sardinia, Italy (n = 3972) and from the Baltimore Longitudinal Study of Aging in the United States (n = 839). RESULTS: Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷·), a gene involved in circadian rhythm. A plausible biological association was also found with single nucleotide polymorphisms within GRM8 (rs17864092; p = 5 × 10⁻⁶), a metabotropic receptor for glutamate, a major excitatory neurotransmitter in the central nervous system. CONCLUSIONS: These findings suggest shared genetic basis underlying the continuum from personality traits to psychopathology.
Show less
Date Issued: 2010
Identifier: FSU_migr_mhs-0023, 10.1016/j.biopsych.2010.06.030
Format: Citation

Department of Geriatrics (21)	+ -
Department of Family Medicine and Rural Health (3)	+ -
Department of Psychology (2)	+ -
Department of Statistics (2)	+ -
Department of Urban and Regional Planning (2)	+ -

College of Criminology and Criminal Justice (1)	+ -
Department of Biomedical Sciences (1)	+ -
Department of Family and Child Sciences (1)	+ -
Department of Sociology (1)	+ -
Program in Neuroscience (1)	+ -

Humans (48)	+ -
Female (42)	+ -
Male (40)	+ -
Medical sciences (39)	+ -
Psychology (31)	+ -

Psychiatry (28)	+ -
Adult (23)	+ -
Human behavior (21)	+ -
Mental health (21)	+ -
Middle Aged (19)	+ -
Social psychiatry (17)	+ -
Personality (16)	+ -
Longitudinal Studies (15)	+ -
Young Adult (15)	+ -
Adolescent (14)	+ -
Aged (14)	+ -
Social aspects (14)	+ -
Mental illness (12)	+ -
United States (11)	+ -
Aged, 80 and over (8)	+ -
Child (8)	+ -
Child, Preschool (8)	+ -
Risk Factors (8)	+ -
Cross-Sectional Studies (7)	+ -
Diseases (7)	+ -
Health (7)	+ -
Medicine (7)	+ -
Parents/psychology (7)	+ -
Physiology (7)	+ -
Infant (6)	+ -

text (130)	+ -
journal article (79)	+ -
conference poster (1)	+ -
working paper (1)	+ -

Search In

Pages

Pages

Sort Results By:

Narrow results by:

Collection

Topical Subject

Genre

Type of Resource

Language

Creator

Format

Found In

Owner