Search results

Title: Sanitary pads for men.
Creator: Lipner, Harry
Abstract/Description: Sanitary pads for men are disposable in a storage mode in which they are flat and non-overlapping for easy carrying in pockets. The sanitary pads may be folded in order to form generally semi-cylindrical portions which envelop the wearer's penis and prevent embarrassment to incontinent men. In the storage or carrying mode, the pad may alternately be T-shaped or constructed in a generally rectangular shape. Adhesive means, such as double sided tape, or fabric loop and hook fasteners may be...
Show moreSanitary pads for men are disposable in a storage mode in which they are flat and non-overlapping for easy carrying in pockets. The sanitary pads may be folded in order to form generally semi-cylindrical portions which envelop the wearer's penis and prevent embarrassment to incontinent men. In the storage or carrying mode, the pad may alternately be T-shaped or constructed in a generally rectangular shape. Adhesive means, such as double sided tape, or fabric loop and hook fasteners may be used to secure the pads in proper position. The pads are a layered structure including an inner relatively thick layer of absorbent material, a water barrier layer made of plastic, and an outer relatively thin absorbent layer.
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Date Issued: 1986-03-18
Identifier: FSU_uspto_4576599, 4576599, 505970, 06/609651, 600b83161da1122888348587dc18798c
Format: Citation

Title: Serial bearing assembly.
Creator: Li, Paul Z.
Abstract/Description: Bearing assemblies use serial bearings in order to extend the operational speeds for the bearings. Speed distribution planetary gears are mounted upon an intermediate ring disposed between two other rings. Each of the rings has bearing surfaces which are separated from adjacent bearing surfaces by ball-bearings or other bearings. The planetary gears mesh with gear teeth upon the first and second rings so as to cause rotation of the intermediate ring at a speed intermediate the relative speed...
Show moreBearing assemblies use serial bearings in order to extend the operational speeds for the bearings. Speed distribution planetary gears are mounted upon an intermediate ring disposed between two other rings. Each of the rings has bearing surfaces which are separated from adjacent bearing surfaces by ball-bearings or other bearings. The planetary gears mesh with gear teeth upon the first and second rings so as to cause rotation of the intermediate ring at a speed intermediate the relative speed between the two other rings. The speed distribution planetary gears may be used in a serial thrust bearing assembly serial radial bearing assembly, or a serial radial thrust bearing assembly.
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Date Issued: 1986-10-21
Identifier: FSU_uspto_4618271, 4618271, 533931, 06/807659, 600b83161da1122888348587dc18798c
Format: Citation

Title: Serial safety bearing.
Creator: Li, Paul Z.
Abstract/Description: Serial safety bearing assembly includes two concentric bearing sets and an actuatable device for selectively switching to engage either the inner or the outer of the two concentric bearing sets upon failure of one set or to alternate to first one set and then the other set thus to prolong the working life of the two concentric bearings.
Date Issued: 1987-05-12
Identifier: FSU_uspto_4664539, 4664539, 533931, 06/829080, 600b83161da1122888348587dc18798c
Format: Citation

Title: Method of removing SO.sub.2, NO.sub.X and particles from gas mixtures using streamer corona.
Creator: Mizuno, Akira, Clements, Judson S.
Abstract/Description: A method for converting sulfur dioxide and/or nitrogen oxide gases to acid mist and or particle aerosols is disclosed in which the gases are passed through a streamer corona discharge zone having electrodes of a wire-cylinder or wire-plate geometry.
Date Issued: 1987-09-22
Identifier: FSU_uspto_4695358, 4695358, 586388, 06/796268, 600b83161da1122888348587dc18798c
Format: Citation

Title: Apparatus for measuring fluid flow.
Creator: Li, Paul Z.
Abstract/Description: Apparatus for measuring flow rate and flow direction of a fluid comprises an elongated stem coaxially disposed and supported within an elongated housing, a small diameter spherical probe connected to an end of the stem which projects through an opening in the housing for transmitting to the stem forces exerted on the probe by the flowing fluid, and a sensor for detecting the forces transmitted to the stem and for producing electrical signals representative of a measurement of the flowing...
Show moreApparatus for measuring flow rate and flow direction of a fluid comprises an elongated stem coaxially disposed and supported within an elongated housing, a small diameter spherical probe connected to an end of the stem which projects through an opening in the housing for transmitting to the stem forces exerted on the probe by the flowing fluid, and a sensor for detecting the forces transmitted to the stem and for producing electrical signals representative of a measurement of the flowing fluid. The apparatus may detect forces exerted on the probe in one, two or three orthogonal directions, thereby providing output signals corresponding to the components of a vector representation of the fluid flow.
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Date Issued: 1988-12-06
Identifier: FSU_uspto_4788869, 4788869, 533931, 06/879628, 600b83161da1122888348587dc18798c
Format: Citation

Title: Fermentation of trichoderma reesei and apparatus therefor.
Creator: Cho, Michael Y.
Abstract/Description: A process for producing enzyme cellulases by the fermentation of Trichoderma reesei in an aqueous nutrient medium containing assimilable sources of cellulose, nitrogen, phosphate, magnesium and iron in the presence of an oxygen containing atmosphere and a fermentation apparatus for the aerobic fermentation of microorganisms in a liquid medium at a pressure in excess of about 7 atmospheres. The method comprises fermenting the Trichoderma reesei at a temperature of between about 26.degree. C....
Show moreA process for producing enzyme cellulases by the fermentation of Trichoderma reesei in an aqueous nutrient medium containing assimilable sources of cellulose, nitrogen, phosphate, magnesium and iron in the presence of an oxygen containing atmosphere and a fermentation apparatus for the aerobic fermentation of microorganisms in a liquid medium at a pressure in excess of about 7 atmospheres. The method comprises fermenting the Trichoderma reesei at a temperature of between about 26.degree. C. and 31.degree. C. while maintaining the oxygen containing atmosphere at a pressure of about 1 atmosphere until the Trichoderma reesei enter the late stationary growth phase, thereafter, gradually and steadily increasing the pressure of the oxygen containing atmosphere until it is in excess of about 7 atmospheres and culturing the Trichoderma reesei at said increased pressure and at a temperature of between about 40.degree. C. and about 60.degree. C., thereby resulting in the production of enzyme cellulases by the Trichoderma reesei, and recovering the enzyme cellulases.
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Date Issued: 1990-08-28
Identifier: FSU_uspto_4952505, 4952505, 763646, 07/229823, 600b83161da1122888348587dc18798c
Format: Citation

Title: Method for preparation of taxol using an oxazinone.
Creator: Holton, Robert A.
Abstract/Description: Process for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, ethoxyethyl, 2,2,2-trichloroethoxymethyl or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; the contacting of said alcohol and oxazinone being carried out in the presence of a sufficient amount of an activating agent...
Show moreProcess for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, ethoxyethyl, 2,2,2-trichloroethoxymethyl or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; the contacting of said alcohol and oxazinone being carried out in the presence of a sufficient amount of an activating agent under effective conditions to cause the oxazinone to react with the alcohol to form a .beta.-amido ester which is suitable for use as an intermediate in the synthesis of taxol.
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Date Issued: 1991-05-14
Identifier: FSU_uspto_5015744, 5015744, 711524, 07/436235, 600b83161da1122888348587dc18798c
Format: Citation

Title: Method for preparation of taxol using an oxazinone.
Creator: Holton, Robert A.
Abstract/Description: Process for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR.sub.7 wherein R.sub.7 is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R.sub.2 and R.sub.5 are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR.sub.8 wherein R.sub.8 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R.sub.3 and R...
Show moreProcess for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR.sub.7 wherein R.sub.7 is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R.sub.2 and R.sub.5 are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR.sub.8 wherein R.sub.8 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R.sub.3 and R.sub.6 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl and heteroaryl.
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Date Issued: 1992-08-04
Identifier: FSU_uspto_5136060, 5136060, 711524, 07/603041, 600b83161da1122888348587dc18798c
Format: Citation

Title: Method for preparation of taxol using .beta.-lactam.
Creator: Holton, Robert A.
Abstract/Description: A .beta.-lactam of the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, alkyl, acyl, acetal, ethoxyethyl, or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; and process for the preparation of taxol comprising contacting said .beta.-lactam and an alcohol in the presence of an activating agent to provide a taxol intermediate, and converting the intermediate to taxol.
Date Issued: 1992-12-29
Identifier: FSU_uspto_5175315, 5175315, 711524, 07/415028, 600b83161da1122888348587dc18798c
Format: Citation

Title: Specimen holder.
Creator: Rink, William J., Schlenoff, Joseph B., Mathias, Haim H.
Abstract/Description: A specimen holder including a housing having a specimen chamber in it. A window defining a wall of the chamber allows transmission of at least a portion of the x-radiation from X-ray diffraction spectometry apparatus on which the holder is mounted, into the chamber. The housing has a passageway in it opening at one end into the specimen chamber and at the opposite end to outside the housing. A cylindrical specimen mount supports the specimen in the housing is constructed for sealing sliding...
Show moreA specimen holder including a housing having a specimen chamber in it. A window defining a wall of the chamber allows transmission of at least a portion of the x-radiation from X-ray diffraction spectometry apparatus on which the holder is mounted, into the chamber. The housing has a passageway in it opening at one end into the specimen chamber and at the opposite end to outside the housing. A cylindrical specimen mount supports the specimen in the housing is constructed for sealing sliding reception in the passageway such that the specimen mount is rotatable about its longitudinal axis and movable lengthwise of the passageway while maintaining a seal with the passageway for positioning the specimen in the specimen chamber.
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Date Issued: 1993-01-19
Identifier: FSU_uspto_5181233, 5181233, 915738, 07/790203, 600b83161da1122888348587dc18798c
Format: Citation

Title: Method for producing freestanding high Tc superconducting thin films.
Creator: Ng, Hon-Kie, Kilibarda-Dalafave, Snezana
Abstract/Description: A process for producing a freestanding high Tc superconducting thin film is disclosed, which comprises providing a carbon substrate, depositing a high Tc superconducting thin film on the substrate and removing the carbon substrate by converting the carbon substrate to a gaseous composition at a temperature insufficient to cause thermal damage to said superconducting thin film but greater then 500.degree. C. in an oxygen containing atmosphere.
Date Issued: 1993-02-16
Identifier: FSU_uspto_5187147, 5187147, 919692, 07/708186, 600b83161da1122888348587dc18798c
Format: Citation

Title: Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them.
Creator: Holton, Robert A., Nadizadeh, Hossain, Beidiger, Ronald J.
Abstract/Description: A taxane derivative of the formula ##STR1## wherein ##STR2## Z is --OT.sub.1, T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl or monocylic aryl, PA0 R.sub.3 is benzoyl, substituted benzoyl or C.sub.1 -C.sub.6 alkoxycarbonyl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane...
Show moreA taxane derivative of the formula ##STR1## wherein ##STR2## Z is --OT.sub.1, T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl or monocylic aryl, PA0 R.sub.3 is benzoyl, substituted benzoyl or C.sub.1 -C.sub.6 alkoxycarbonyl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
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Date Issued: 1993-07-13
Identifier: FSU_uspto_5227400, 5227400, 711524, 07/862819, 600b83161da1122888348587dc18798c
Format: Citation

Title: Metal alkoxides.
Creator: Holton, Robert A.
Abstract/Description: A metal alkoxide having the following formula: ##STR1## wherein T.sub.1 is hydrogen or a hydroxy protecting group, Z is --OT.sub.2, or --OCOCH.sub.3, T.sub.2 is hydrogen or a hydroxy protecting group, and M is selected from the group comprising Group IA, IIA and transition metals are useful in the preparation of biologically active derivatives of baccatin III and 10-deacetyl baccatin III.
Date Issued: 1993-07-20
Identifier: FSU_uspto_5229526, 5229526, 711524, 07/862778, 600b83161da1122888348587dc18798c
Format: Citation

Title: Certain alkoxy substituted taxanes and pharmaceutical compositions containing them.
Creator: Holton, Robert A., Beidiger, Ronald J.
Abstract/Description: A taxane derivative of the formula ##STR1## wherein R.sub.1 is phenyl or substituted phenyl, PA0 R.sub.3 is CH.sub.3 O--, or CH.sub.3 CH.sub.2 O--, PA0 Z is --OT.sub.1, PA0 T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2. PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl or monocylic aryl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of...
Show moreA taxane derivative of the formula ##STR1## wherein R.sub.1 is phenyl or substituted phenyl, PA0 R.sub.3 is CH.sub.3 O--, or CH.sub.3 CH.sub.2 O--, PA0 Z is --OT.sub.1, PA0 T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2. PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl or monocylic aryl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
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Date Issued: 1993-09-07
Identifier: FSU_uspto_5243045, 5243045, 711524, 07/863198, 600b83161da1122888348587dc18798c
Format: Citation

Title: Certain substituted taxanes and pharmaceutical compositions containing them.
Creator: Holton, Robert A., Nadizadeh, Hossain, Beidiger, Ronald J., Kim, Seokchan
Abstract/Description: A taxane derivative of the formula ##STR1## wherein R.sub.1 and R.sub.3 are independently selected from the group comprising phenyl, naphthalene, C.sub.6 H.sub.5 CHCH--, and ##STR2## provided, however, R.sub.1 and R.sub.3 are not both phenyl; PA0 Q is CH.sub.3 --, (CH.sub.3).sub.3 C--, CH.sub.3 O--, Cl, Br, F, NO.sub.2, ##STR3## Z is --OT.sub.1, T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6...
Show moreA taxane derivative of the formula ##STR1## wherein R.sub.1 and R.sub.3 are independently selected from the group comprising phenyl, naphthalene, C.sub.6 H.sub.5 CHCH--, and ##STR2## provided, however, R.sub.1 and R.sub.3 are not both phenyl; PA0 Q is CH.sub.3 --, (CH.sub.3).sub.3 C--, CH.sub.3 O--, Cl, Br, F, NO.sub.2, ##STR3## Z is --OT.sub.1, T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl or monocylic aryl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
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Date Issued: 1993-10-05
Identifier: FSU_uspto_5250683, 5250683, 711524, 07/863451, 600b83161da1122888348587dc18798c
Format: Citation

Title: Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones.
Creator: Holton, Robert A.
Abstract/Description: A process for preparing taxane derivatives taxol by providing a metal alkoxide having the bi, tri-, or tetracyclic taxane nucleus, reacting the metal alkoxide with an oxazinone to form an intermediate, and converting the intermediate to the taxane derivative.
Date Issued: 1993-10-19
Identifier: FSU_uspto_5254703, 5254703, 711524, 07/863829, 600b83161da1122888348587dc18798c
Format: Citation

Title: Low self-absorbing, intrinsically scintillating polymers.
Creator: Schlenoff, Joseph B., Dharia, Jayesh, Johnson, Kurtis F.
Abstract/Description: Polymers containing covalently-bonded, low self-absorbing, scintillating chromophores, polymerizable chromophores of the formula: ##STR1## wherein R.sub.1 is vinyl, .alpha.-methyl vinyl, vinyl phenyl, or vinyl benzyl, and R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo, or ether, and a process for the preparation of polymers containing low self-absorbing, scintillating chromophores.
Date Issued: 1993-11-02
Identifier: FSU_uspto_5258478, 5258478, 915739, 07/874748, 600b83161da1122888348587dc18798c
Format: Citation

Title: Metal alkoxides.
Creator: Holton, Robert A.
Abstract/Description: A metal alkoxide having the following formula: ##STR1## wherein T.sub.1 is hydrogen or a hydroxy protecting group, Z is --OT.sub.2, or --OCOCH.sub.3, T.sub.2 is hydrogen or a hydroxy protecting group, and M is selected from the group comprising Group IA, IIA and transition metals are useful in the preparation of biologically active derivatives of baccatin III and 10-deacetyl baccatin III.
Date Issued: 1993-12-28
Identifier: FSU_uspto_5274124, 5274124, 711524, 07/949066, 600b83161da1122888348587dc18798c
Format: Citation

Title: Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them.
Creator: Holton, Robert A., Nadizadeh, Hossain, Rengan, Kasthuri
Abstract/Description: Taxane derivatives of the formula ##STR1## wherein R.sub.1 is phenyl or p-nitrophenyl, PA1 R.sub.3 is furyl or thienyl, PA1 T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA1 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or monocylic aryl, PA1 Ac is acetyl, and PA1 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor...
Show moreTaxane derivatives of the formula ##STR1## wherein R.sub.1 is phenyl or p-nitrophenyl, PA1 R.sub.3 is furyl or thienyl, PA1 T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA1 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or monocylic aryl, PA1 Ac is acetyl, and PA1 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
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Date Issued: 1994-02-01
Identifier: FSU_uspto_5283253, 5283253, 711524, 07/975723, 600b83161da1122888348587dc18798c
Format: Citation

Title: Butenyl substituted taxanes and pharmaceutical compositions containing them.
Creator: Holton, Robert A., Nadizadeh, Hossain
Abstract/Description: Taxane derivatives of the formula ##STR1## wherein R.sub.1 is butenyl, PA0 R.sub.3 is phenyl, PA0 T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or monocylic aryl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
Date Issued: 1994-02-08
Identifier: FSU_uspto_5284864, 5284864, 711524, 07/975705, 600b83161da1122888348587dc18798c
Format: Citation

Title: Superconductive alloys having bifurcated critical current density and method of preparation.
Creator: Testardi, Louis R., Hascicek, Yusuf S.
Abstract/Description: A device having superconductive and resistive states including an element comprising a high temperature superconductive material having a first (high) state with a first (high) critical current density and having a second (low) state with a second (low) critical current density, wherein the second (low) critical current density is less than the first (high) critical current density. A transient pulse generator applies a transient pulse to the element. The transient pulse changes the state of...
Show moreA device having superconductive and resistive states including an element comprising a high temperature superconductive material having a first (high) state with a first (high) critical current density and having a second (low) state with a second (low) critical current density, wherein the second (low) critical current density is less than the first (high) critical current density. A transient pulse generator applies a transient pulse to the element. The transient pulse changes the state of the element between the first (high) and second (low) states, the element being superconductive in the first (high) state, and the element being resistive in the second (low) state. A YBa.sub.2 Cu.sub.3 O.sub.7-x or YBa.sub.2 Cu.sub.3 O.sub.7-x -Ag compound exhibiting bifurcation of its critical current density versus temperature curve. A process for the production of a YBa.sub.2 Cu.sub.3 O.sub.7-x or YBa.sub.2 Cu.sub.3 O.sub.7-x -Ag superconducting material which exhibits bifurcation in its critical current density versus temperature curve. The process involves the provision of the appropriate powder or mix of powders, pressing the powder to form the desired specimen, sintering the specimen at a sufficient temperature for a sufficient time to achieve fusion of the powder, heat treating the sintered specimen, and subjecting the specimen to an oxygenation process.
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Date Issued: 1994-02-15
Identifier: FSU_uspto_5286710, 5286710, 846000, 07/644175, 600b83161da1122888348587dc18798c
Format: Citation

Title: Method for preparation of taxol.
Creator: Holton, Robert A.
Abstract/Description: A .beta.-lactam of the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, alkyl, acyl, acetal, ethoxyethyl, or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; and process for the preparation of taxol comprising contacting said .beta.-lactam and an alcohol in the presence of an activating agent to provide a taxol intermediate, and converting the intermediate to taxol.
Date Issued: 1994-08-09
Identifier: FSU_uspto_5336785, 5336785, 711524, 07/968003, 600b83161da1122888348587dc18798c
Format: Citation

Title: Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof.
Creator: Holton, Robert A., Somoza, Carmen
Abstract/Description: A process for the preparation of a 10-desacetoxy and 10-desoxy tetracyclic taxane in which a tetracyclic taxane having a C10 hydroxy or acetoxy substituent is reacted with samarium diiodide.
Date Issued: 1994-08-16
Identifier: FSU_uspto_5338872, 5338872, 711524, 08/005229, 600b83161da1122888348587dc18798c
Format: Citation

Title: 10-desacetoxytaxol derivatives.
Creator: Farina, Vittorio, Holton, Robert A., Chen, Shu-Hui
Abstract/Description: The present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have the formula ##STR1## wherein R.sub.2 is hydrogen, hydroxy or a protected hydroxy group; R.sub.3 and R.sub.4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, --SH, --NH.sub.2, or --NR.sub.8 R.sub.9 ; R.sub.5 is R.sub.10, or --OR.sub.10 ; R.sub.6 and R.sub.7 are independently hydrogen, alkyl, or aryl; R.sub.8 and R.sub.9 are independently...
Show moreThe present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have the formula ##STR1## wherein R.sub.2 is hydrogen, hydroxy or a protected hydroxy group; R.sub.3 and R.sub.4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, --SH, --NH.sub.2, or --NR.sub.8 R.sub.9 ; R.sub.5 is R.sub.10, or --OR.sub.10 ; R.sub.6 and R.sub.7 are independently hydrogen, alkyl, or aryl; R.sub.8 and R.sub.9 are independently hydrogen, alkyl, alkenyl, alkynyl, or aryl; and R.sub.10 is alkoxy, alkyl, alkenyl, alkynl, or aryl.
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Date Issued: 1994-09-27
Identifier: FSU_uspto_5350866, 5350866, 691280, 07/949449, 600b83161da1122888348587dc18798c
Format: Citation

Title: Oxazinone compounds for the preparation of taxol.
Creator: Holton, Robert A.
Abstract/Description: Process for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR.sub.7 wherein R.sub.7 is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R.sub.2 and R.sub.5 are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR.sub.8 wherein R.sub.8 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R.sub.3 and R...
Show moreProcess for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR.sub.7 wherein R.sub.7 is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R.sub.2 and R.sub.5 are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR.sub.8 wherein R.sub.8 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R.sub.3 and R.sub.6 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl and heteroaryl.
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Date Issued: 1995-01-24
Identifier: FSU_uspto_5384399, 5384399, 711524, 07/898438, 600b83161da1122888348587dc18798c
Format: Citation

Title: Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups.
Creator: Holton, Robert A., Kim, Seokchan
Abstract/Description: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R.sub.7 COO- and/or R.sub.8 COO-, respectively, wherein R.sub.7 and R.sub.8 are independently H,...
Show moreProcess for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R.sub.7 COO- and/or R.sub.8 COO-, respectively, wherein R.sub.7 and R.sub.8 are independently H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, moncyclic aryl, or monocyclic heteroaryl.
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Date Issued: 1995-03-21
Identifier: FSU_uspto_5399726, 5399726, 711524, 08/010798, 600b83161da1122888348587dc18798c
Format: Citation

Title: Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes.
Creator: Holton, Robert A., Somoza, Carmen, Kim, Hyeong B., Shindo, Mitsuru, Biediger, Ronald J., Boatman, P. Douglas, Smith, Chase C., Liang, Feng, Murthi, Krishna K.
Abstract/Description: Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.
Date Issued: 1995-04-11
Identifier: FSU_uspto_5405972, 5405972, 711524, 08/189058, 600b83161da1122888348587dc18798c
Format: Citation

Title: Species-specific DNA probes for vibrio vulnificus methods and kits.
Creator: Reeves, Robert H., Bennison, Brenda W., LaRock, Paul A.
Abstract/Description: The present invention relates to species-specific DNA probes specific for Vibrio vulnificus and Vibrio cholerae. The DNA probes of the present invention specifically detects Vibrio vulnificus or Vibrio cholerae in a mixed bacterial sample based on unique ribosomal RNA nucleotide sequences. When the DNA probes of the present invention are tagged with a labeled molecule such as a fluorescent label, it affords direct and immediate visualization of individual bacterial cells, and a rapid method...
Show moreThe present invention relates to species-specific DNA probes specific for Vibrio vulnificus and Vibrio cholerae. The DNA probes of the present invention specifically detects Vibrio vulnificus or Vibrio cholerae in a mixed bacterial sample based on unique ribosomal RNA nucleotide sequences. When the DNA probes of the present invention are tagged with a labeled molecule such as a fluorescent label, it affords direct and immediate visualization of individual bacterial cells, and a rapid method of detection of bacterial infection in humans and shellfish without culturing.
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Date Issued: 1995-06-20
Identifier: FSU_uspto_5426025, 5426025, 1078215, 07/891987, 600b83161da1122888348587dc18798c
Format: Citation

Title: Preparation of substituted isoserine esters using .beta.-lactams and metal or ammonium alkoxides.
Creator: Holton, Robert A.
Abstract/Description: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a .beta.-lactam.
Date Issued: 1995-07-04
Identifier: FSU_uspto_5430160, 5430160, 711524, 08/034247, 600b83161da1122888348587dc18798c
Format: Citation

Title: Mercaptosulfide metalloproteinase inhibitors.
Creator: Schwartz, Martin A., Van Wart, Harold Edgar
Abstract/Description: Novel mercaptosulfide matrix metalloproteinase inhibitors of the Formula I, ##STR1## wherein: n is 0 or 1; PA1 R.sup.1 is selected from the group consisting of hydrogen, lower alkyl, amino lower alkyl, carbamoyl lower alkyl, PhtN(lower alkyl), TsNH(lower alkyl); and PA1 R.sup.2 is selected from the group consisting of hydrogen, lower alkyl, amino lower alkyl, carbamoyl lower alkyl, PhtN(lower alkyl), TsNH (lower alkyl); or PA1 R.sup.1 and R.sup.2 together are --CH.sub.2 --CH.sub.2 --CH.sub.2 ...
Show moreNovel mercaptosulfide matrix metalloproteinase inhibitors of the Formula I, ##STR1## wherein: n is 0 or 1; PA1 R.sup.1 is selected from the group consisting of hydrogen, lower alkyl, amino lower alkyl, carbamoyl lower alkyl, PhtN(lower alkyl), TsNH(lower alkyl); and PA1 R.sup.2 is selected from the group consisting of hydrogen, lower alkyl, amino lower alkyl, carbamoyl lower alkyl, PhtN(lower alkyl), TsNH (lower alkyl); or PA1 R.sup.1 and R.sup.2 together are --CH.sub.2 --CH.sub.2 --CH.sub.2 --; PA1 R.sup.3 is selected from the group consisting of hydrogen, lower alkyl, aralkyl and heteroaralkyl; and PA1 R.sup.4 is selected from the group consisting of hydrogen, lower alkyl, amino lower-alkyl, guanyl lower-alkyl, imidazoylalkyl, aralkyl and 2-indolylmethyl; and PA1 R.sup.5 is selected from the group consisting of lower alkyl, aralkyl and --CH(R.sup.6)--C(O)NH.sub.2, PA1 wherein PA2 R.sup.6 is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, imidazoylalkyl, hydroxymethyl, 1-hydroxyethyl, mercapto lower-alkyl, and methylthio lower-alkyl; or a pharmaceutically acceptable ester, ether or salt thereof, useful for treating diseases and disease conditions associated with matrix metalloproteinase modulation.
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Date Issued: 1995-10-03
Identifier: FSU_uspto_5455262, 5455262, 89928, 08/132414, 600b83161da1122888348587dc18798c
Format: Citation

Title: Method of producing superconductor which exhibits critical current density bifurcation.
Creator: Testardi, Louis R., Hascicek, Yusuf S.
Abstract/Description: A process for the production of a YBa.sub.2 Cu.sub.3 O.sub.7-x or YBa.sub.2 Cu.sub.3 O.sub.7-x -AgO superconductor includes: providing the appropriate powder or mix of powders, pressing the powder to form the desired specimen, sintering the specimen to achieve fusion of the powder, heat treating the sintered specimen, and subjecting the specimen to an oxygenation process. The material exhibits bifurcation in its critical current density versus temperature curve.
Date Issued: 1995-11-07
Identifier: FSU_uspto_5464813, 5464813, 846000, 08/152322, 600b83161da1122888348587dc18798c
Format: Citation

Title: Preparation of substituted isoserine esters using metal alkoxides and .beta .
Creator: Holton, Robert A.
Abstract/Description: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a .beta.-lactam.
Date Issued: 1995-11-14
Identifier: FSU_uspto_5466834, 5466834, 711524, 08/314532, 600b83161da1122888348587dc18798c
Format: Citation

Title: Solid scintillators for detecting radioactive ions in solution.
Creator: Schlenoff, Joseph B.
Abstract/Description: A scintillator for absorbing and concentrating radioactive ions within a solution, the scintillator including a solid scintillator and an ionic layer on a surface of and in contact with the solid scintillator. When radioactive ions are absorbed by the ionic layer, the scintillator acts as a light source.
Date Issued: 1995-11-14
Identifier: FSU_uspto_5466930, 5466930, 915739, 08/200213, 600b83161da1122888348587dc18798c
Format: Citation

Title: Sulfoximine and suldodiimine matrix metalloproteinase inhibitors.
Creator: Schwartz, Martin A., Van Wart, Harold Edgar
Abstract/Description: Novel sulfoximine and sulfodiimine matrix metalloproteinase inhibitors of the formula, ##STR1## wherein: R.sup.1 is selected from the group consisting of lower-alkyl, hydroxy lower-alkyl, amino lower-alkyl, carbamoyl lower-alkyl, lower-alkyl carbonyl, lower-alkyoxyalkyl, aralkyl and heteroaralkyl; PA1 X is NH or O; PA1 R.sup.2 is selected from the group consisting of hydrogen, lower-alkyl and aralkyl; PA1 R.sup.3 is selected from the group consisting of hydrogen, lower-alkyl, amino lower...
Show moreNovel sulfoximine and sulfodiimine matrix metalloproteinase inhibitors of the formula, ##STR1## wherein: R.sup.1 is selected from the group consisting of lower-alkyl, hydroxy lower-alkyl, amino lower-alkyl, carbamoyl lower-alkyl, lower-alkyl carbonyl, lower-alkyoxyalkyl, aralkyl and heteroaralkyl; PA1 X is NH or O; PA1 R.sup.2 is selected from the group consisting of hydrogen, lower-alkyl and aralkyl; PA1 R.sup.3 is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, aralkyl and heteroaralkyl; and PA1 R.sup.4 is selected from the group consisting of lower alkyl, aralkyl and --CH(R.sup.5)--C(O)NH.sub.2, PA2 wherein R.sup.5 is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, imidazoylalkyl, hydroxymethyl, 1-hydroxyethyl, mercapto lower-alkyl, and methylthio lower-alkyl; useful for modulating physiological functions or treating diseases and disease conditions associated with matrix metalloproteinase modulation.
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Date Issued: 1995-11-28
Identifier: FSU_uspto_5470834, 5470834, 89928, 08/132411, 600b83161da1122888348587dc18798c
Format: Citation

Title: Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them.
Creator: Holton, Robert A., Rengan, Kasthuri
Abstract/Description: Taxane derivatives having a 3' pyridyl substituted C13 side chain.
Date Issued: 1996-02-06
Identifier: FSU_uspto_5489601, 5489601, 711524, 08/095085, 600b83161da1122888348587dc18798c
Format: Citation

Title: Fuzzy expert system learning network.
Creator: Narita, Kazunari, Lacher, Robert Christopher
Abstract/Description: " In the present invention, prior art techniques are extended to allow application of the backpropagation learning technique to artificial neural networks derived from fuzzy expert system rule-bases. A method in accordance with the invention, referred to herein as a Fuzzy Expert Network (FEN), is implemented in a programmed machine such as a computer to provide automated learning of both ""fine"" and ""coarse"" knowledge in a network of artificial neural objects (ANOs) implementing fuzzy...
Show more" In the present invention, prior art techniques are extended to allow application of the backpropagation learning technique to artificial neural networks derived from fuzzy expert system rule-bases. A method in accordance with the invention, referred to herein as a Fuzzy Expert Network (FEN), is implemented in a programmed machine such as a computer to provide automated learning of both ""fine"" and ""coarse"" knowledge in a network of artificial neural objects (ANOs) implementing fuzzy modeling rules. Through application of the FEN method, an event-driven fuzzy expert network comprising acyclically connected ANOs derived from fuzzy modelling rules may be implemented. Neural objects implement one or more fuzzy combining and defuzzification rules and use backpropagation of error techniques to implement learning. As in prior art, the FEN allows each ANO to adjust its input weight parameters--""fine"" knowledge learning. Unlike prior art, the FEN allows each ANO to modify its internal parameters--""coarse"" knowledge learning. This latter action means that individual ANOs have the capability to modify the parameters of the fuzzy rule's membership function upon which they are based. In this way the FEN is able to change the structure of its encoded knowledge over time, making it a more adaptable architecture for autonomous and/or adaptable control systems. Simulation results showing the FEN's learning and adaptability behavior are given. "
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Date Issued: 1996-06-04
Identifier: FSU_uspto_5524176, 5524176, 1144144, 08/205483, 600b83161da1122888348587dc18798c
Format: Citation

Title: Heteroaryl substituted oxazinone compounds for the preparation of taxol.
Creator: Holton, Robert A.
Abstract/Description: Process for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR.sub.7 wherein R.sub.7 is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R.sub.2 and R.sub.5 are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR.sub.8 wherein R.sub.8 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R.sub.3 and R...
Show moreProcess for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR.sub.7 wherein R.sub.7 is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R.sub.2 and R.sub.5 are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR.sub.8 wherein R.sub.8 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R.sub.3 and R.sub.6 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl and heteroaryl.
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Date Issued: 1996-07-02
Identifier: FSU_uspto_5532363, 5532363, 711524, 08/335495, 600b83161da1122888348587dc18798c
Format: Citation

Title: .beta.-lactams as taxol intermediates N-acylated.
Creator: Holton, Robert A.
Abstract/Description: .beta.-lactam compounds which are reacted with a metal alkoxide for preparing N-acyl, N-sulfonyl and phosphoryl substituted isoserine esters.
Date Issued: 1996-07-23
Identifier: FSU_uspto_5539103, 5539103, 711524, 08/351532, 600b83161da1122888348587dc18798c
Format: Citation

Title: Proton-transfer, low self-absorbing chromophores for use in scintillators.
Creator: Schlenoff, Joseph B., Gao, Feng (Frank), Dharia, Jayesh, Johnson, Kurtis F.
Abstract/Description: Proton-transfer, low self-absorbing chromophores of the formula: ##STR1## wherein R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo or an ether group, R.sub.4 is O or N--H, and R.sub.5 is thienyl, naphthyl, furanyl, pyrrolyl, phenyl vinyl, diphenyl vinyl, phenyl ethynyl, hydroxy chromonyl phenyl, didecyloxy hydroxy chromonyl phenyl, phenyl or ##STR2## wherein R.sub.1 is vinyl, vinyl phenyl, vinyl benzyl, alkyl ethenyl, or alkyl phenyl ethenyl, provided that when...
Show moreProton-transfer, low self-absorbing chromophores of the formula: ##STR1## wherein R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo or an ether group, R.sub.4 is O or N--H, and R.sub.5 is thienyl, naphthyl, furanyl, pyrrolyl, phenyl vinyl, diphenyl vinyl, phenyl ethynyl, hydroxy chromonyl phenyl, didecyloxy hydroxy chromonyl phenyl, phenyl or ##STR2## wherein R.sub.1 is vinyl, vinyl phenyl, vinyl benzyl, alkyl ethenyl, or alkyl phenyl ethenyl, provided that when R.sub.5 is phenyl and R.sub.2 and R.sub.3 are hydrogen, R.sub.4 is N--H.
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Date Issued: 1996-09-03
Identifier: FSU_uspto_5552551, 5552551, 915739, 08/096956, 600b83161da1122888348587dc18798c
Format: Citation

Title: .beta.-lactams used in preparing taxol.
Creator: Holton, Robert A.
Abstract/Description: A .beta.-lactam of the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, alkyl, acyl, acetal, ethoxyethyl, or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; and the enantiomers and diastereomers thereof.
Date Issued: 1996-11-12
Identifier: FSU_uspto_5574156, 5574156, 711524, 08/254561, 600b83161da1122888348587dc18798c
Format: Citation

Title: Method and apparatus for broadband decoupling in nuclear magnetic resonance with chirp pulses.
Creator: Bodenhausen, Geoffrey, Fu, Riqiang
Abstract/Description: Methods and apparatus for broadband decoupling in nuclear magnetic resonance with chirp and other RF pulses are disclosed. Such methods may include the step of positioning the sample in a static magnetic field. Additional steps may define a first cycle of pulses, such as chirp pulses, wherein at least two of the pulses have a different initial phase angle from each other and may define a second cycle of pulses wherein at least two of the pulses in the second cycle have an initial phase angle...
Show moreMethods and apparatus for broadband decoupling in nuclear magnetic resonance with chirp and other RF pulses are disclosed. Such methods may include the step of positioning the sample in a static magnetic field. Additional steps may define a first cycle of pulses, such as chirp pulses, wherein at least two of the pulses have a different initial phase angle from each other and may define a second cycle of pulses wherein at least two of the pulses in the second cycle have an initial phase angle different from the initial phase angles of the pulses in the first cycle. Further steps may repeatedly generate a supercycle of the first and second cycles to produce pulses for inverting the longitudinal magnetization in the sample and may also detect the signals emitted by the sample in response to inversion of the longitudinal magnetization. Alternatively, the chirp pulses in the first and second cycles may be defined to sweep a bandwidth of 100 kHz or more. The first and second cycles may also be defined to include linear frequency modulated RF pulses wherein each of the RF pulses has an amplitude which is substantially constant during at least about 50% of the pulses. Apparatus for performing the disclosed methods is also disclosed. Other methods and apparatus are also disclosed.
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Date Issued: 1996-12-03
Identifier: FSU_uspto_5581182, 5581182, 697108, 08/504171, 600b83161da1122888348587dc18798c
Format: Citation

Title: Metalorganic chemical vapor deposition method for depositing f-series metal or nitrogen and metal amides for use in mocvd.
Creator: Rees, Jr., William S.
Abstract/Description: A metalorganic chemical vapor deposition (MOCVD) method for depositing an F-series metal onto a semiconductor or other substrate or for incorporating nitrogen as a p-type dopant in Group II-VI semiconductor materials. The MOCVD method utilizes an F-series metal amide or zinc amide composition as the source compound for the F-series metal or nitrogen, respectively. Novel erbium amide and zinc amide compositions are disclosed along with methods for preparing the metal amide compositions.
Date Issued: 1996-12-10
Identifier: FSU_uspto_5583205, 5583205, 708303, 08/151500, 600b83161da1122888348587dc18798c
Format: Citation

Title: Taxane and baccatin III analogs bearing new C2 and C4 functional groups.
Creator: Holton, Robert A., Kim, Seokchan
Abstract/Description: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R.sub.7 COO-- and/or R.sub.8 COO--, respectively, wherein R.sub.7 and R.sub.8 are independently H...
Show moreProcess for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R.sub.7 COO-- and/or R.sub.8 COO--, respectively, wherein R.sub.7 and R.sub.8 are independently H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.2 alkenyl, C.sub.2 -C.sub.6 alkynyl, moncyclic aryl, or monocyclic heteroaryl.
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Date Issued: 1996-12-24
Identifier: FSU_uspto_5587489, 5587489, 711524, 08/372103, 600b83161da1122888348587dc18798c
Format: Citation

Title: Species-specific DNA probes for vibrio cholerae and methods.
Creator: Reeves, Robert H., Bennison, Brenda W., LaRock, Paul A.
Abstract/Description: The present invention relates to species-specific DNA probes specific for Vibrio vulnificus and Vibrio cholerae. The DNA probes of the present invention specifically detects Vibrio vulnificus or Vibrio cholerae in a mixed bacterial sample based on unique ribosomal RNA nucleotide sequences. When the DNA probes of the present invention are tagged with a labeled molecule such as a fluorescent label, it affords direct and immediate visualization of individual bacterial cells, and a rapid method...
Show moreThe present invention relates to species-specific DNA probes specific for Vibrio vulnificus and Vibrio cholerae. The DNA probes of the present invention specifically detects Vibrio vulnificus or Vibrio cholerae in a mixed bacterial sample based on unique ribosomal RNA nucleotide sequences. When the DNA probes of the present invention are tagged with a labeled molecule such as a fluorescent label, it affords direct and immediate visualization of individual bacterial cells, and a rapid method of detection of bacterial infection in humans and shellfish without culturing.
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Date Issued: 1997-03-04
Identifier: FSU_uspto_5607835, 5607835, 1078215, 08/473589, 600b83161da1122888348587dc18798c
Format: Citation

Title: Synthetic process for the preparation of tricyclic and tetracyclic taxanes.
Creator: Holton, Robert A., Somoza, Carmen, Kim, Hyeong B., Shindo, Mitsuru, Biediger, Ronald J., Boatman, P. Douglas, Smith, Chase C., Liang, Feng, Murthi, Krishna K.
Abstract/Description: Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.
Date Issued: 1997-04-08
Identifier: FSU_uspto_5618952, 5618952, 711524, 08/383956, 600b83161da1122888348587dc18798c
Format: Citation

Title: Enhanced flux pinning in superconductors by embedding carbon nanotubes with BSCCO materials.
Creator: Fossheim, Kristian, Ebbesen, Thomas W.
Abstract/Description: Enhanced flux pinning in superconductors is achieved by embedding carbon nanotubes into a superconducting matrix. The carbon nanotubes simulate the structure, size and shape of heavy ion induced columnar defects in a superconductor such as Bi.sub.2 Sr.sub.2 CaCu.sub.2 O.sub.8+x. The nanotubes survive at treatment temperatures of up to approximately 800.degree. C. both in oxygen containing and in inert atmospheres. The superconducting matrix with nanotubes is heat treated at a lower...
Show moreEnhanced flux pinning in superconductors is achieved by embedding carbon nanotubes into a superconducting matrix. The carbon nanotubes simulate the structure, size and shape of heavy ion induced columnar defects in a superconductor such as Bi.sub.2 Sr.sub.2 CaCu.sub.2 O.sub.8+x. The nanotubes survive at treatment temperatures of up to approximately 800.degree. C. both in oxygen containing and in inert atmospheres. The superconducting matrix with nanotubes is heat treated at a lower temperature than the temperature used to treat the best case pure superconductor material.
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Date Issued: 1997-05-06
Identifier: FSU_uspto_5627140, 5627140, 1210140, 08/445366, 3e498511f06dc249bfff6c3d97d82422
Format: Citation

Title: Tricyclic and tetracyclic taxanes.
Creator: Holton, Robert A., Somoza, Carmen, Kim, Hyeong B., Shindo, Mitsuru, Biediger, Ronald J., Boatman, P. Douglas, Smith, Chase C., Liang, Feng, Murthi, Krishna K.
Abstract/Description: The synthesis of taxol and other tricyclic and tetracyclic taxanes.
Date Issued: 1997-06-10
Identifier: FSU_uspto_5637732, 5637732, 711524, 08/383775, 600b83161da1122888348587dc18798c
Format: Citation

Title: Process for the preparation of 10-desacetoxybaccatin III.
Creator: Holton, Robert A., Somoza, Carmen
Abstract/Description: A process for abstracting a C10 hydroxy, acyloxy or sulfonyloxy substituent from a taxane in which the C10 hydroxy, acyloxy or sulfonyloxy substituted taxane is reacted with samarium diiodide.
Date Issued: 1997-08-05
Identifier: FSU_uspto_5654447, 5654447, 711524, 08/500868, 600b83161da1122888348587dc18798c
Format: Citation

Title: Radiosensitizing diamines and their pharmaceutical preparations.
Creator: Hofer, Kurt G., Yang, Li-Xi
Abstract/Description: A compound comprising a diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula ##STR1## wherein A comprises a carbon chain having from about 2-10 carbons in the chain, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are H, or T, T is ##STR2## wherein A' comprises a carbon chain having from about 1-8 carbons in the chain, R.sup.5 is H, lower alkyl, or halo, and R.sup.6 is H, lower alkyl, halo...
Show moreA compound comprising a diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula ##STR1## wherein A comprises a carbon chain having from about 2-10 carbons in the chain, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are H, or T, T is ##STR2## wherein A' comprises a carbon chain having from about 1-8 carbons in the chain, R.sup.5 is H, lower alkyl, or halo, and R.sup.6 is H, lower alkyl, halo or nitro, provided that at least one of R.sup.1 and R.sup.2, and at least one of R.sup.3 and R.sup.4 is T. Intermediates for, pharmaceutical compositions containing, methods for making and methods for using such compounds to radiosensitize and kill hypoxic tumor cells are also provided.
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Date Issued: 1997-12-23
Identifier: FSU_uspto_5700825, 5700825, 7999, 08/414272, 600b83161da1122888348587dc18798c
Format: Citation

Title: Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them.
Creator: Holton, Robert A., Nadizadeh, Hossain, Rengan, Kasthuri, Tao, Chunlin
Abstract/Description: Taxane derivatives having an amino substituted C13 side chain.
Date Issued: 1998-01-20
Identifier: FSU_uspto_5710287, 5710287, 711524, 08/462122, 600b83161da1122888348587dc18798c
Format: Citation

utility (462)	+ -
design (3)	+ -

Holton, Robert A. (101)	+ -
Schlenoff, Joseph B. (34)	+ -
Wang, Ben (26)	+ -
Li, Hui (23)	+ -
Liang, Zhiyong (20)	+ -

Somoza, Carmen (20)	+ -
Zhang, Chun Hua (20)	+ -
Chai, Ki-byung (19)	+ -
Nadizadeh, Hossain (17)	+ -
Suzuki, Yukio (16)	+ -
Blaber, Michael (15)	+ -
Shindo, Mitsuru (15)	+ -
Steurer, Mischa (15)	+ -
Tatcho, Passinam (15)	+ -
Alabugin, Igor V. (13)	+ -
Haik, Yousef (11)	+ -
Liang, Feng (11)	+ -
Roux, Kenneth H. (11)	+ -
Sathe, Shridhar K. (11)	+ -
Tao, Chunlin (11)	+ -
Teuber, Suzanne S. (11)	+ -
Rengan, Kasthuri (10)	+ -
Vu, Phong H. (10)	+ -
Edrington, Chris S. (9)	+ -
Salmani, Mohamadamin (9)	+ -
Biediger, Ronald J. (8)	+ -
Boatman, P. Douglas (8)	+ -
Murthi, Krishna K. (8)	+ -
Smith, Chase C. (8)	+ -
Chen, Ching-Jen (7)	+ -

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