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參宮の栞
Title
參宮の栞: Sangu no shiori.
Creator
神宮神部署
Abstract/Description
This book provides a detailed description of worship services at Shinto Shrine (Ise shrine) in Ujyamada City (currently the city is named Ise-shi). In the book, general and conscious attitudes, formal worship, the structure of the Shrine, music and performance, festivals, funeral and other services are described and explained. There are also time tables, visitor statistics, and a brief city map.
Identifier
FSU_MSS_1989009_B22_F9_02
Format
Document (PDF)
A comparison of the effects of aesthetically and non-aesthetically illustrated language materials on comprehension of young children
Title
A comparison of the effects of aesthetically and non-aesthetically illustrated language materials on comprehension of young children.
Creator
Zymaris, Angelique K., Florida State University
Abstract/Description
The purpose of this study was to test the alternative hypothesis that subjects who use Aesthetically Illustrated Language Materials (AILM) will have significantly greater mean comprehension scores than subjects who use non-Aesthetically Illustrated Language Materials (non-AILM)., More specifically, five original stories (AILM and non-AILM) with 166 illustrations were developed and used as part of this experiment for the population of interest. A sample of 255 fourth grade students enrolled in...
Show moreThe purpose of this study was to test the alternative hypothesis that subjects who use Aesthetically Illustrated Language Materials (AILM) will have significantly greater mean comprehension scores than subjects who use non-Aesthetically Illustrated Language Materials (non-AILM)., More specifically, five original stories (AILM and non-AILM) with 166 illustrations were developed and used as part of this experiment for the population of interest. A sample of 255 fourth grade students enrolled in the New York City public schools were part of this experiment., The results of a Multivariate Analysis of Variance (MANOVA) supported the alternative hypothesis that there was a significant difference in subjects' mean comprehension scores when using the AILM materials as compared with the control group., The treatment descriptive means, standard deviations, and the MANOVA Sum of Squares were shown to be highly significant (at p value =.00001) in all five AILM treatments., Thus, it is concluded that the AILM method was significantly more effective as compared with the control group., It therefore follows that since AILM helps the student achieve better reading comprehension, its future use would be a valuable contribution to the field of education.
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Date Issued
1988, 1988
Identifier
AAI8819152, 3161609, FSDT3161609, fsu:77810
Format
Document (PDF)
The effects of contingent postural echo on subject preferences in dyadic communication
Title
The effects of contingent postural echo on subject preferences in dyadic communication.
Creator
Zychowski, Mary Ellen., Florida State University
Abstract/Description
This study examined the effect of a postural echo delivered contingent upon selected behaviors and its influence upon a subject's preference on nonsense syllables and objects. The relationship of subject awareness, physiological reactions, and gender differences in reaction to postural echo were also examined., Pilot studies were conducted to produce five nonsense syllables and five common objects with equal probability of being chosen in the experimental studies., Sixty male and 60 female...
Show moreThis study examined the effect of a postural echo delivered contingent upon selected behaviors and its influence upon a subject's preference on nonsense syllables and objects. The relationship of subject awareness, physiological reactions, and gender differences in reaction to postural echo were also examined., Pilot studies were conducted to produce five nonsense syllables and five common objects with equal probability of being chosen in the experimental studies., Sixty male and 60 female subjects were randomly chosen out of a representative sample of undergraduate communication courses and randomly assigned to experimenters for the studies., Experimental Study #1 exposed subjects to five nonsense syllables for multiple thirty second time periods. Unknown to subjects, one of the five nonsense syllables was accompanied by a postural echo. Experimental Study #2 exposed subjects to five objects for single sixty second time periods. Unknown to the subjects, one of the five objects was accompanied by a postural echo., Heart rate of subjects was monitored and recorded throughout the experimental studies., Results showed that a contingent postural echo had no significant effects on subject preferences in dyadic communication. Postural echo operated below the level of awareness and did not exhibit the strength expected from a conditioned reinforcer. Postural echo appears to derive its strength from conversation and the interpersonal interaction but as a technique, in and of itself, postural echo is of questionable value.
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Date Issued
1989, 1989
Identifier
AAI9002946, 3161857, FSDT3161857, fsu:78056
Format
Document (PDF)
tale of two cities: an analysis of factors for Genoese and Venetian expansion during the crusading era, as seen in their naval technology and tradition.
Title
A tale of two cities: an analysis of factors for Genoese and Venetian expansion during the crusading era, as seen in their naval technology and tradition.
Creator
Zwilling, Andrew
Date Issued
2007-02-01
Identifier
160523, FSDT160523, fsu:18950
Format
Document (PDF)
Dissolved Pb And Pb Isotopes In The North Atlantic From The Geovide Transect (geotraces Ga-01) And Their Decadal Evolution
Title
Dissolved Pb And Pb Isotopes In The North Atlantic From The Geovide Transect (geotraces Ga-01) And Their Decadal Evolution.
Creator
Zurbrick, Cheryl M., Boyle, Edward A., Kayser, Richard J., Reuer, Matthew K., Wu, Jinfeng, Planquette, Helene, Shelley, Rachel, Boutorh, Julia, Cheize, Marie, Contreira,...
Show moreZurbrick, Cheryl M., Boyle, Edward A., Kayser, Richard J., Reuer, Matthew K., Wu, Jinfeng, Planquette, Helene, Shelley, Rachel, Boutorh, Julia, Cheize, Marie, Contreira, Leonardo, Barraqueta, Jan-Lukas Menzel, Lacan, Francois, Sarthou, Geraldine
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Abstract/Description
During the 2014 GEOVIDE transect, seawater samples were collected for dissolved Pb and Pb isotope analysis. These samples provide a high-resolution "snapshot" of the source regions for the present Pb distribution in the North Atlantic Ocean. Some of these stations were previously occupied for Pb from as early as 1981, and we compare the 2014 data with these older data, some of which are reported here for the first time. Lead concentrations were highest in subsurface Mediterranean Water (MW)...
Show moreDuring the 2014 GEOVIDE transect, seawater samples were collected for dissolved Pb and Pb isotope analysis. These samples provide a high-resolution "snapshot" of the source regions for the present Pb distribution in the North Atlantic Ocean. Some of these stations were previously occupied for Pb from as early as 1981, and we compare the 2014 data with these older data, some of which are reported here for the first time. Lead concentrations were highest in subsurface Mediterranean Water (MW) near the coast of Portugal, which agrees well with other recent observations by the US GEOTRACES program (Noble et al., 2015). The recently formed Labrador Sea Water (LSW) between Greenland and Nova Scotia is much lower in Pb concentration than the older LSW found in the West European Basin due to decreases in Pb emissions into the atmosphere during the past 20 years. Comparison of North Atlantic data from 1989 to 2014 shows decreasing Pb concentrations consistent with decreased anthropogenic inputs, active scavenging, and advection/convection. Although the isotopic composition of northern North Atlantic seawater appears more homogenous compared to previous decades, a clear spatiotemporal trend in isotope ratios is evident over the past 15 years and implies that small changes to atmospheric Pb emissions continue. Emissions data indicate that the relative proportions of US and European Pb sources to the ocean have been relatively uniform during the past 2 decades, while aerosol data may suggest a greater relative proportion of natural mineral Pb. Using our measurements in conjunction with emissions inventories, we support the findings of previous atmospheric analyses that a significant portion of the Pb deposited to the ocean in 2014 was natural, although it is obscured by the much greater solubility of anthropogenic aerosols over natural ones.
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Date Issued
2018-08-22
Identifier
FSU_libsubv1_wos_000442399400004, 10.5194/bg-15-4995-2018
Format
Citation
RADICAL REACTIONS ON SILICA SURFACES AZOCUMENE
Title
RADICAL REACTIONS ON SILICA SURFACES AZOCUMENE.
Creator
ZUPANCIC, JOSEPH JAMES., The Florida State University
Date Issued
1978, 1978
Identifier
AAI7917097, 2989137, FSDT2989137, fsu:73644
Format
Document (PDF)
Cadherin 6 is activated by Epstein-Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma.
Title
Cadherin 6 is activated by Epstein-Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma.
Creator
Zuo, L-L, Zhang, J, Liu, L-Z, Zhou, Q, Du, S-J, Xin, S-Y, Ning, Z-P, Yang, J, Yu, H-B, Yue, W-X, Wang, J, Zhu, F-X, Li, G-Y, Lu, J-H
Abstract/Description
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy, which is notorious among head-and-neck cancers with its metastatic feature. Epstein-Barr virus (EBV) infection plays a fundamental role in NPC development with the mechanism is not well understood. Here we demonstrate that EBV oncoprotein LMP1 drives EMT and metastasis of NPC by reactivating the adhesion molecule, cadherin 6 (CDH6), which normally occurs in embryogenesis with unknown role in NPC. CDH6 was found to be upregulated in...
Show moreNasopharyngeal carcinoma (NPC) is an epithelial malignancy, which is notorious among head-and-neck cancers with its metastatic feature. Epstein-Barr virus (EBV) infection plays a fundamental role in NPC development with the mechanism is not well understood. Here we demonstrate that EBV oncoprotein LMP1 drives EMT and metastasis of NPC by reactivating the adhesion molecule, cadherin 6 (CDH6), which normally occurs in embryogenesis with unknown role in NPC. CDH6 was found to be upregulated in LMP1-positive NPC tissues, and was identified as a target of the epithelium-specific miR-203. LMP1-activated NF-κB transcriptionally repressed the miR-203 expression by binding to the promoter region of miR-203 gene. CDH6 activation in turn induced EMT and promoted metastasis in NPC. CDH6 depletion, NF-κB inhibitor and miR-203 overexpression were able to impair the EMT effects. The miR-203 downregulation in NPC tissues was strongly associated with metastasis clinically. The CDH6 activator, Runt-related transcription factor 2 (RUNX2), was also activated by EBV in the event. For both CDH6 and RUNX2 are components at TGF-β downstream, CDH6 became a node protein for the interplay of multiple signalings including NF-κB and TGF-β. Therefore, the switch-on of miR-203 was important for nasopharyngeal epithelial cells to maintain normal phenotype. This study demonstrates that EBV has evolved sophisticated strategies by driving epithelial cells to obtain malignant features, particularly in NPC metastasis, providing novel biomarkers for the therapy and prognosis of EBV-associated NPC.
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Date Issued
2017-12-22
Identifier
FSU_pmch_29284791, 10.1038/s41389-017-0005-7, PMC5865538, 29284791, 29284791, 10.1038/s41389-017-0005-7
Format
Citation
AN INFERENTIAL METHOD FOR DOMAIN REFERENCED TESTS
Title
AN INFERENTIAL METHOD FOR DOMAIN REFERENCED TESTS.
Creator
ZUNIGA-MOLINA, LEONEL., The Florida State University
Date Issued
1979, 1979
Identifier
AAI8001120, 2989304, FSDT2989304, fsu:73811
Format
Document (PDF)
RELATIONSHIP BETWEEN MATERNAL BEHAVIOR AND ATTITUDES TOWARD FAMILY LIFE
Title
RELATIONSHIP BETWEEN MATERNAL BEHAVIOR AND ATTITUDES TOWARD FAMILY LIFE.
Creator
ZUNICH, MICHAEL., The Florida State University
Date Issued
1959, 1959
Identifier
AAI5906928, 2984883, FSDT2984883, fsu:69332
Format
Document (PDF)
LUMINESCENCE SPECTRA OF TRANSITION-METAL COMPLEXES
Title
LUMINESCENCE SPECTRA OF TRANSITION-METAL COMPLEXES.
Creator
ZULOAGA, FERNANDO., The Florida State University
Date Issued
1966, 1966
Identifier
AAI6605464, 2985447, FSDT2985447, fsu:69956
Format
Document (PDF)
RESOURCE SCARCITIES AND FOREIGN CONFLICT OF MAJOR POWERS, 1925-1939
Title
RESOURCE SCARCITIES AND FOREIGN CONFLICT OF MAJOR POWERS, 1925-1939.
Creator
ZUK, GARY., Florida State University
Abstract/Description
Choucri and North are among the few foreign conflict analysts to systematically specify domestic and international determinants of major power international expansion and conflict. They argue that major powers characterized by a growing population, technology, and military capability along with an increasing reliance upon external supplies of raw materials, when denied access to such products will acquire sovereignity over resource producing territories and in the process become more conflict...
Show moreChoucri and North are among the few foreign conflict analysts to systematically specify domestic and international determinants of major power international expansion and conflict. They argue that major powers characterized by a growing population, technology, and military capability along with an increasing reliance upon external supplies of raw materials, when denied access to such products will acquire sovereignity over resource producing territories and in the process become more conflict oriented than their major power counterparts., This perspective is both plausible and well rooted in the literature. However, because Choucri and North omitted the key resource scarcity concept from their model they were unable to directly evaluate their thesis. Consequently, its reassessment is justified and necessary., The period chosen for this purpose, the interwar years, was selected for several reasons. First, foreign policy analysts have long argued that strategic material shortages played a crucial part in the territorial expansion and foreign conflict directed plans and policies of Italy, and especially Germany and Japan during the time. Second, Choucri and North consider the period a legitimate and intriguing testing ground for their thesis. Finally, empirically oriented foreign conflict analysts have largely overlooked the period. Not much is known, then, about the foreign conflict dynamics of the major powers during the period., It was found that the territorial expanding and foreign conflict-oriented powers had international access to needed resources (especially petroleum) but chose to acquire territories and wage interstate conflict in any event. Yet these territories could do little to satisfy the resource needs of the expanding powers. Indeed the most important international strategic material suppliers were sovereign nations, notably the United States, and the Soviet Union, whose products were all too readily available to the expanding powers. Consequently, the Choucri-North framework, with its emphasis upon resource shortages being the catalyst of international expansion and conflict, does not advance our understanding of the major power international expansion and conflict dynamics in the period between the First and Second World Wars.
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Date Issued
1983, 1983
Identifier
AAI8329431, 3085688, FSDT3085688, fsu:75178
Format
Document (PDF)
impact of education on sexual behavior in sub-Saharan Africa
Title
The impact of education on sexual behavior in sub-Saharan Africa: A review of the evidence.
Creator
Zuilkowski, Stephanie, Jukes, Matthew C. H.
Abstract/Description
Many studies have attempted to determine the relationship between education and HIV status. However, a complete and causal understanding of this relationship requires analysis of its mediating pathways, focusing on sexual behaviors. We developed a series of hypotheses based on the differential effect of educational attainment on three sexual behaviors. We tested our predictions in a systematic literature review including 65 articles reporting associations between three specific sexual...
Show moreMany studies have attempted to determine the relationship between education and HIV status. However, a complete and causal understanding of this relationship requires analysis of its mediating pathways, focusing on sexual behaviors. We developed a series of hypotheses based on the differential effect of educational attainment on three sexual behaviors. We tested our predictions in a systematic literature review including 65 articles reporting associations between three specific sexual behaviors–sexual initiation, number of partners, and condom use–and educational attainment or school enrollment in sub-Saharan Africa. The patterns of associations varied by behavior. The findings for condom use were particularly convergent; none of the 44 studies using educational attainment as a predictor reviewed found that more educated people were significantly less likely to use condoms. Findings for sexual initiation and number of partners were more complex. The contrast between findings for condom use on the one hand and sexual initiation and number of partners on the other supports predictions based on our theoretical framework.
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Date Issued
2011
Identifier
FSU_migr_edlp_faculty_publications-0006, 10.1080/09540121.2011.630351
Format
Citation
School Persistence in the Wake of War
Title
School Persistence in the Wake of War: Wartime Experiences, Reintegration Supports, and Dropout in Sierra Leone.
Creator
Zuilkowski, Stephanie Simmons, Betancourt, Theresa S. (Theresa Stichick)
Abstract/Description
This article examines the relationship of wartime experience and reintegration supports to students' risk of school dropout. It draws on longitudinal, mixed-methods data collected among children and youth in Sierra Leone from 2002 through 2008. The study finds that family financial support and perceived social support are positively associated with lower risk of dropout over time.
Date Issued
2014
Identifier
FSU_migr_edlp_faculty_publications-0015, 10.1086/675905
Format
Citation
Early Childhood Education, Child Development and School Readiness
Title
Early Childhood Education, Child Development and School Readiness: Evidence from Zambia.
Creator
Zuilkowski, Stephanie, Fink, Günther, Moucheraud, Corrina, Matafwali, Beatrice
Abstract/Description
While early childhood education has received increasing attention in the developing world in recent years, relatively little evidence is available from sub-Saharan Africa on its effects on child development and subsequent school enrollment. We use a prospective case-control design to evaluate the developmental impact of a community-based early childhood center in an urban area in Zambia. Comparing 40 children attending the center to 40 children not attending the center from the same community...
Show moreWhile early childhood education has received increasing attention in the developing world in recent years, relatively little evidence is available from sub-Saharan Africa on its effects on child development and subsequent school enrollment. We use a prospective case-control design to evaluate the developmental impact of a community-based early childhood center in an urban area in Zambia. Comparing 40 children attending the center to 40 children not attending the center from the same community, we find that center attendance was associated with significantly better performance in an assessment of task orientation, and was also weakly associated with increased letter familiarity. We also observed higher performance among center students on tests of receptive language and pencil-related fine motor skills. These associations were, however, smaller and not statistically significant. We conducted a follow-up one year after the initial assessment, when children were seven years old and should have been in first grade. At follow-up, 27% of non-attendees were not yet enrolled in primary school, compared to just 11% of center students, suggesting that participation in early education encourages a timely transition into first grade.
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Date Issued
2012
Identifier
FSU_migr_edlp_faculty_publications-0005X
Format
Citation
The oblique cyclops.
Title
The oblique cyclops.
Creator
Zuehlke, Karl
Date Issued
2005-12-19
Identifier
160519, FSDT160519, fsu:18949
Format
Document (PDF)
organizational view of a Leon County juvenile court
Title
An organizational view of a Leon County juvenile court.
Creator
Zuckerman, Mark
Identifier
157473, FSDT157473, fsu:17442
Format
Document (PDF)
Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.
Title
The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.
Creator
Zouaz, Amel, Auradkar, Ankush, Delfini, Marie Claire, Macchi, Meiggie, Barthez, Marine, Ela Akoa, Serge, Bastianelli, Leila, Xie, Gengqiang, Deng, Wu-Min, Levine, Stuart S,...
Show moreZouaz, Amel, Auradkar, Ankush, Delfini, Marie Claire, Macchi, Meiggie, Barthez, Marine, Ela Akoa, Serge, Bastianelli, Leila, Xie, Gengqiang, Deng, Wu-Min, Levine, Stuart S, Graba, Yacine, Saurin, Andrew J
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Abstract/Description
In metazoans, the pausing of RNA polymerase II at the promoter (paused Pol II) has emerged as a widespread and conserved mechanism in the regulation of gene transcription. While critical in recruiting Pol II to the promoter, the role transcription factors play in transitioning paused Pol II into productive Pol II is, however, little known. By studying how Hox transcription factors control transcription, we uncovered a molecular mechanism that increases productive transcription. We found that...
Show moreIn metazoans, the pausing of RNA polymerase II at the promoter (paused Pol II) has emerged as a widespread and conserved mechanism in the regulation of gene transcription. While critical in recruiting Pol II to the promoter, the role transcription factors play in transitioning paused Pol II into productive Pol II is, however, little known. By studying how Hox transcription factors control transcription, we uncovered a molecular mechanism that increases productive transcription. We found that the Hox proteins AbdA and Ubx target gene promoters previously bound by the transcription pausing factor M1BP, containing paused Pol II and enriched with promoter-proximal Polycomb Group (PcG) proteins, yet lacking the classical H3K27me3 PcG signature. We found that AbdA binding to M1BP-regulated genes results in reduction in PcG binding, the release of paused Pol II, increases in promoter H3K4me3 histone marks and increased gene transcription. Linking transcription factors, PcG proteins and paused Pol II states, these data identify a two-step mechanism of Hox-driven transcription, with M1BP binding leading to Pol II recruitment followed by AbdA targeting, which results in a change in the chromatin landscape and enhanced transcription.
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Date Issued
2017-10-02
Identifier
FSU_pmch_28871058, 10.15252/embj.201695751, PMC5623858, 28871058, 28871058, embj.201695751
Format
Citation
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells
Title
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment..
Creator
Zou, Peng, Liu, Longhua, Zheng, Louise D, Payne, Kyle K, Manjili, Masoud H, Idowu, Michael O, Zhang, Jinfeng, Schmelz, Eva M, Cheng, Zhiyong
Abstract/Description
Overactive mitochondrial fission was shown to promote cell transformation and tumor growth. It remains elusive how mitochondrial quality is regulated in such conditions. Here, we show that upregulation of mitochondrial fission protein, dynamin related protein-1 (Drp1), was accompanied with increased mitochondrial biogenesis markers (PGC1, NRF1, and Tfam) in breast cancer cells. However, mitochondrial number was reduced, which was associated with lower mitochondrial oxidative capacity in...
Show moreOveractive mitochondrial fission was shown to promote cell transformation and tumor growth. It remains elusive how mitochondrial quality is regulated in such conditions. Here, we show that upregulation of mitochondrial fission protein, dynamin related protein-1 (Drp1), was accompanied with increased mitochondrial biogenesis markers (PGC1, NRF1, and Tfam) in breast cancer cells. However, mitochondrial number was reduced, which was associated with lower mitochondrial oxidative capacity in breast cancer cells. This contrast might be owing to enhanced mitochondrial turnover through autophagy, because an increased population of autophagic vacuoles engulfing mitochondria was observed in the cancer cells. Consistently, BNIP3 (a mitochondrial autophagy marker) and autophagic flux were significantly upregulated, indicative of augmented mitochondrial autophagy (mitophagy). The upregulation of Drp1 and BNIP3 was also observed in vivo (human breast carcinomas). Importantly, inhibition of Drp1 significantly suppressed mitochondrial autophagy, metabolic reprogramming, and cancer cell viability. Together, this study reveals coordinated increase of mitochondrial biogenesis and mitophagy in which Drp1 plays a central role regulating breast cancer cell metabolism and survival. Given the emerging evidence of PGC1 contributing to tumor growth, it will be of critical importance to target both mitochondrial biogenesis and mitophagy for effective cancer therapeutics.
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Date Issued
2016-01-01
Identifier
FSU_pmch_27746856, 10.1155/2016/4085727, PMC5056295, 27746856, 27746856
Format
Citation
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells
Title
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells.
Creator
Zou, Peng, Liu, Longhua, Zheng, Louise D., Payne, Kyle K., Manjili, Masoud H., Idowu, Michael O., Zhang, Jinfeng, Schmelz, Evam, Cheng, Zhiyong
Abstract/Description
Overactive mitochondrial fission was shown to promote cell transformation and tumor growth. It remains elusive how mitochondrial quality is regulated in such conditions. Here, we show that upregulation of mitochondrial fission protein, dynamin related protein-1 (Drp1), was accompanied with increased mitochondrial biogenesis markers (PGC1 alpha, NRF1, and Tfam) in breast cancer cells. However, mitochondrial number was reduced, which was associated with lower mitochondrial oxidative capacity in...
Show moreOveractive mitochondrial fission was shown to promote cell transformation and tumor growth. It remains elusive how mitochondrial quality is regulated in such conditions. Here, we show that upregulation of mitochondrial fission protein, dynamin related protein-1 (Drp1), was accompanied with increased mitochondrial biogenesis markers (PGC1 alpha, NRF1, and Tfam) in breast cancer cells. However, mitochondrial number was reduced, which was associated with lower mitochondrial oxidative capacity in breast cancer cells. This contrast might be owing to enhanced mitochondrial turnover through autophagy, because an increased population of autophagic vacuoles engulfing mitochondria was observed in the cancer cells. Consistently, BNIP3 (a mitochondrial autophagy marker) and autophagic flux were significantly upregulated, indicative of augmented mitochondrial autophagy (mitophagy). The upregulation of Drp1 and BNIP3 was also observed in vivo (human breast carcinomas). Importantly, inhibition of Drp1 significantly suppressed mitochondrial autophagy, metabolic reprogramming, and cancer cell viability. Together, this study reveals coordinated increase of mitochondrial biogenesis and mitophagy in which Drp1 plays a central role regulating breast cancer cell metabolism and survival. Given the emerging evidence of PGC1 alpha contributing to tumor growth, it will be of critical importance to target both mitochondrial biogenesis and mitophagy for effective cancer therapeutics.
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Date Issued
2016
Identifier
FSU_libsubv1_wos_000385103100001, 10.1155/2016/4085727
Format
Citation
Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C.
Title
Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C.
Creator
Zot, Henry G, Hasbun, Javier E, Michell, Clara A, Landim-Vieira, Maicon, Pinto, Jose R
Abstract/Description
Higher affinity for TnI explains how troponin C (TnC) carrying a causative hypertrophic cardiomyopathy mutation, TnC(A8V), sensitizes muscle cells to Ca(2+). Muscle fibers reconstituted with TnC(A8V) require ∼2.3-fold less [Ca(2+)] to achieve 50% maximum-tension compared to fibers reconstituted with wild-type TnC (TnC(WT)). Binding measurements rule out a significant change in N-terminus Ca(2+)-affinity of isolated TnC(A8V), and TnC(A8V) binds the switch-peptide of troponin-I (TnI(sp)) ∼1.6...
Show moreHigher affinity for TnI explains how troponin C (TnC) carrying a causative hypertrophic cardiomyopathy mutation, TnC(A8V), sensitizes muscle cells to Ca(2+). Muscle fibers reconstituted with TnC(A8V) require ∼2.3-fold less [Ca(2+)] to achieve 50% maximum-tension compared to fibers reconstituted with wild-type TnC (TnC(WT)). Binding measurements rule out a significant change in N-terminus Ca(2+)-affinity of isolated TnC(A8V), and TnC(A8V) binds the switch-peptide of troponin-I (TnI(sp)) ∼1.6-fold more strongly than TnC(WT); thus we model the TnC-TnI(sp) interaction as competing with the TnI-actin interaction. Tension data are well-fit by a model constrained to conditions in which the affinity of TnC(A8V) for TnI(sp) is 1.5-1.7-fold higher than that of TnC(WT) at all [Ca(2+)]. Mean ATPase rates of reconstituted cardiac myofibrils is greater for TnC(A8V) than TnC(WT) at all [Ca(2+)], with statistically significant differences in the means at higher [Ca(2+)]. To probe TnC-TnI interaction in low Ca(2+), displacement of bis-ANS from TnI was monitored as a function of TnC. Whereas Ca(2+)-TnC(WT) displaces significantly more bis-ANS than Mg(2+)-TnC(WT), Ca(2+)-TnC(A8V) displaces probe equivalently to Mg(2+)-TnC(A8V) and Ca(2+)-TnC(WT), consistent with stronger Ca(2+)-independent TnC(A8V)-TnI(sp). A Matlab program for computing theoretical activation is reported. Our work suggests that contractility is constantly above normal in hearts made hypertrophic by TnC(A8V).
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Date Issued
2016-07-01
Identifier
FSU_pmch_26976709, 10.1016/j.abb.2016.03.011, PMC4899184, 26976709, 26976709, S0003-9861(16)30063-7
Format
Citation
Electron spin resonance insight into broadband absorption of the Cu3Bi(SeO3)(2)O2Br metamagnet
Title
Electron spin resonance insight into broadband absorption of the Cu3Bi(SeO3)(2)O2Br metamagnet.
Creator
Zorko, A., Gomilsek, M., Pregelj, M., Ozerov, M., Zvyagin, S. A., Ozarowski, A., Tsurkan, V., Loidl, A., Zaharko, O.
Abstract/Description
Metamagnets, which exhibit a transition from a low-magnetization to a highmagnetization state induced by the applied magnetic field, have recently been highlighted as promising materials for controllable broadband absorption. Here we show results of a multifrequency electron spin resonance (ESR) investigation of the Cu3Bi(SeO3)(2)O2Br planar metamagnet on the kagome lattice. Its mixed anti-ferromagnetic/ferromagnetic phase is stabilized in a finite range of applied fields around 0.8 T at low...
Show moreMetamagnets, which exhibit a transition from a low-magnetization to a highmagnetization state induced by the applied magnetic field, have recently been highlighted as promising materials for controllable broadband absorption. Here we show results of a multifrequency electron spin resonance (ESR) investigation of the Cu3Bi(SeO3)(2)O2Br planar metamagnet on the kagome lattice. Its mixed anti-ferromagnetic/ferromagnetic phase is stabilized in a finite range of applied fields around 0.8 T at low temperatures and is characterized by enhanced microwave absorption. The absorption signal is non-resonant and its boundaries correspond to two critical fields that determine the mixed phase. With decreasing temperature these increase like the sublattice magnetization of the antiferromagnetic phase and show no frequency dependence between 100 and 480 GHz. On the contrary, we find that the critical fields depend on the magnetic-field sweeping direction. In particular, the higher critical field, which corresponds to the transition from the mixed to the ferromagnetic phase, shows a pronounced hysteresis effect, while such a hysteresis is absent for the lower critical field. The observed hysteresis is enhanced at lower temperatures, which suggests that thermal fluctuations play an important role in destabilizing the highly absorbing mixed phase. (C) 2016 Author(s).
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Date Issued
2016-05
Identifier
FSU_libsubv1_wos_000377962500235, 10.1063/1.4943534
Format
Citation
Cellular Distribution of the Fragile X Mental Retardation Protein in the Mouse Brain
Title
Cellular Distribution of the Fragile X Mental Retardation Protein in the Mouse Brain.
Creator
Zorio, Diego A.R., Jackson, Christine M., Liu, Yong, Rubel, Edwin W, Wang, Yuan
Abstract/Description
The fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal morphologies in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS). Despite FMRP importance for proper brain function, its overall expression pattern in the mammalian brain at the resolution of individual neuronal cell groups is not known. In this study we used FMR1...
Show moreThe fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal morphologies in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS). Despite FMRP importance for proper brain function, its overall expression pattern in the mammalian brain at the resolution of individual neuronal cell groups is not known. In this study we used FMR1 knockout and isogenic wildtype mice to systematically map the distribution of FMRP expression in the entire mouse brain. Using immunocytochemistry and cellular quantification analyses, we identified a large number of prominent cell groups expressing high levels of FMRP at the subcortical levels, in particular sensory and motor neurons in the brainstem and thalamus. In contrast, many cell groups in the midbrain and hypothalamus exhibit low FMRP levels. More important, we describe differential patterns of FMRP distribution in both cortical and subcortical brain regions. Almost all major brain areas contain high and low levels of FMRP cell groups adjacent to each other or between layers of the same cortical areas. These differential patterns indicate that FMRP expression appears to be specific to individual neuronal cell groups instead of being associated with all neurons in distinct brain regions, as previously considered. Taken together, these findings support the notion of FMRP differential neuronal regulation and strongly implicate the contribution of fundamental sensory and motor processing at subcortical levels to FXS pathology.
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Date Issued
2017-03-01
Identifier
FSU_libsubv1_scholarship_submission_1511838919_1f7fa4f4, 10.1002/cne.24100
Format
Citation
Cellular distribution of the fragile X mental retardation protein in the mouse brain.
Title
Cellular distribution of the fragile X mental retardation protein in the mouse brain.
Creator
Zorio, Diego A R, Jackson, Christine M, Liu, Yong, Rubel, Edwin W, Wang, Yuan
Abstract/Description
The fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal morphologies in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS). Despite FMRP importance for proper brain function, its overall expression pattern in the mammalian brain at the resolution of individual neuronal cell groups is not known. In this study we used FMR1...
Show moreThe fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal morphologies in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS). Despite FMRP importance for proper brain function, its overall expression pattern in the mammalian brain at the resolution of individual neuronal cell groups is not known. In this study we used FMR1 knockout and isogenic wildtype mice to systematically map the distribution of FMRP expression in the entire mouse brain. Using immunocytochemistry and cellular quantification analyses, we identified a large number of prominent cell groups expressing high levels of FMRP at the subcortical levels, in particular sensory and motor neurons in the brainstem and thalamus. In contrast, many cell groups in the midbrain and hypothalamus exhibit low FMRP levels. More important, we describe differential patterns of FMRP distribution in both cortical and subcortical brain regions. Almost all major brain areas contain high and low levels of FMRP cell groups adjacent to each other or between layers of the same cortical areas. These differential patterns indicate that FMRP expression appears to be specific to individual neuronal cell groups instead of being associated with all neurons in distinct brain regions, as previously considered. Taken together, these findings support the notion of FMRP differential neuronal regulation and strongly implicate the contribution of fundamental sensory and motor processing at subcortical levels to FXS pathology. J. Comp. Neurol. 525:818-849, 2017. © 2016 Wiley Periodicals, Inc.
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Date Issued
2017-03-01
Identifier
FSU_pmch_27539535, 10.1002/cne.24100, PMC5558202, 27539535, 27539535
Format
Citation
Homer's Battle of the frogs and mice: with the remarks of Zoilus
Title
Homer's Battle of the frogs and mice: with the remarks of Zoilus.
Creator
Zoilus, Parnell, Thomas, Pope, Alexander
Date Issued
1717
Identifier
06371711, FSU_PA4025A5P671717, fsu:643649
Format
E-book
FREENESS OF HOPF ALGEBRAS OVER GROUPLIKE SUBALGEBRAS
Title
FREENESS OF HOPF ALGEBRAS OVER GROUPLIKE SUBALGEBRAS.
Creator
ZOELLER, MARTHA BETTINA., Florida State University
Abstract/Description
Throughout, H is a Hopf algebra over a field k of characteristic p, G(H) is the group of grouplikes of H and L is any subgroup of G(H). We denote the antipode of H by S. We investigate the freeness of Hopf algebras as modules over their group algebras of grouplikes., In chapter II we consider semisimple group algebras kL. We prove that for finite dimensional H all nonzero objects in the category (' )(, ) of left (H,kL)-Hopf modules are free kL-modules. We also prove this in the case when S('2...
Show moreThroughout, H is a Hopf algebra over a field k of characteristic p, G(H) is the group of grouplikes of H and L is any subgroup of G(H). We denote the antipode of H by S. We investigate the freeness of Hopf algebras as modules over their group algebras of grouplikes., In chapter II we consider semisimple group algebras kL. We prove that for finite dimensional H all nonzero objects in the category (' )(, ) of left (H,kL)-Hopf modules are free kL-modules. We also prove this in the case when S('2) = id. Hence, for a finite dimensional H, the number of one-dimensional ideals divides the dimension of H and the order of S divides 4(.)dimension of H., In chapter III we prove that a finite dimensional H is a free k-module for any g (ELEM) G(H), even if p divides the order of g. Further we establish that a finite dimensional H is a free kL-module if and only if H is a free kA-module for any elementary abelian p-subgroup A of L., In chapter IV we prove that a finite dimensional H over an algebraically closed field k of characteristic p is a free kL-module, if H does not contain any simple subcoalgebra of dimension (lp)('2) for any natural number 1 (GREATERTHEQ) 2. Further we construct an example of an infinite dimensional H showing that not all objects in (' )(, ) are free kL-modules. Finally we show that any infinite dimensional H is a free kL-module, if L is an infinite group which contains no nontrivial finite subgroup. Also, if the dimension of H equals the dimension of the coradical of H, then H is a free module over any of its semisimple group algebras k where g (ELEM) G(H).
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Date Issued
1985, 1985
Identifier
AAI8605802, 3086283, FSDT3086283, fsu:75766
Format
Document (PDF)
BIOMIMETIC SYNTHESES OF SEVERAL MORPHINE ALKALOID ANALOGUES
Title
BIOMIMETIC SYNTHESES OF SEVERAL MORPHINE ALKALOID ANALOGUES.
Creator
ZODA, MICHAEL FRANCIS., Florida State University
Abstract/Description
N-Ethoxycarbonyl-5'-hydroxynorreticuline (1) was oxidized with vanadium oxytrichloride (VOCl(,3)) to give the para-ortho coupled N-ethoxycarbonyl-2-hydroxynorsalutaridine (2) in 55% yield., Dienone 2 was converted into N-ethoxycarbonyl-2-hydroxynorthebaine (3) in 47% yield. Hydrolysis of 3 gave an 85% yield of N-ethoxycarbonyl-2-hydroxynorcodeinone (4) which upon reduction produced ((+OR-))-2-hydroxycodeine (5)., Reaction of the protected thebaine analogue 6 with singlet oxygen generated the...
Show moreN-Ethoxycarbonyl-5'-hydroxynorreticuline (1) was oxidized with vanadium oxytrichloride (VOCl(,3)) to give the para-ortho coupled N-ethoxycarbonyl-2-hydroxynorsalutaridine (2) in 55% yield., Dienone 2 was converted into N-ethoxycarbonyl-2-hydroxynorthebaine (3) in 47% yield. Hydrolysis of 3 gave an 85% yield of N-ethoxycarbonyl-2-hydroxynorcodeinone (4) which upon reduction produced ((+OR-))-2-hydroxycodeine (5)., Reaction of the protected thebaine analogue 6 with singlet oxygen generated the protected 2,14-dihydroxynorcodeinone derivative 7. Selective dehydroxylation with concurrent double bond reduction gave the known N-ethoxycarbonylnoroxycodone (8); subsequent hydrolysis of 8 then concluded the total synthesis of ((+OR-))-noroxycodone (9).
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Date Issued
1981, 1981
Identifier
AAI8113273, 3084904, FSDT3084904, fsu:74402
Format
Document (PDF)
A comparative analysis of measures of family system concepts
Title
A comparative analysis of measures of family system concepts.
Creator
Zoda, Michael F., Florida State University
Abstract/Description
The purpose of this study was to investigate the construct validity of key concepts from three prominent instruments in the family therapy field (FACES III, SFI, and FES). Through analysis of the shared variance between the items and scales which make up these instruments the convergent and divergent validity of these measures was established. Specific objectives included the assessment of (1) psychometric properties of these instruments, (2) the relative importance of the different...
Show moreThe purpose of this study was to investigate the construct validity of key concepts from three prominent instruments in the family therapy field (FACES III, SFI, and FES). Through analysis of the shared variance between the items and scales which make up these instruments the convergent and divergent validity of these measures was established. Specific objectives included the assessment of (1) psychometric properties of these instruments, (2) the relative importance of the different theoretical constructs (operationalized in the scales), (3) a higher order variable working throughout each construct., Three hundred thirty-two college students participated in this study. Each subject filled out a packet containing a demographic questionnaire and each of the three instruments. The findings were analyzed through a variety of methods. Reliabilities and factor analyses were calculated for each scale within each instrument. The instruments were then combined and additional factor analyses were run on both the item and scale level. Pearson Product Correlations were calculated between each scale as well. Finally a LISREL analysis was attempted for each instrument., The findings of this study revealed a sense of belonging as the primary dimension from which these subjects viewed their family. The dimensions of Organization, Intellectual-Cultural Orientation, and Moral-Religious Emphasis fell out as well. While several scales of the SFI and FES loaded on this central dimension, many of the dimensions researchers believed to be important to family functioning were not discerned by these family members. Thus a single higher order construct operating throughout all the scales was not found. Questions regarding the utility of these instruments were raised and implications for future research were made.
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Date Issued
1988, 1988
Identifier
AAI8905757, 3161717, FSDT3161717, fsu:77916
Format
Document (PDF)
THE SPECTROSCOPIC CHANNEL BASIS: EFFECTIVE SYSTEM EXCITED STATES
Title
THE SPECTROSCOPIC CHANNEL BASIS: EFFECTIVE SYSTEM EXCITED STATES.
Creator
ZIV, ALAN RANDALL., The Florida State University
Date Issued
1975, 1975
Identifier
AAI7602731, 2988164, FSDT2988164, fsu:72671
Format
Document (PDF)
The role of phonological awareness and orthographic knowledge in first-grade reading achievement
Title
The role of phonological awareness and orthographic knowledge in first-grade reading achievement.
Creator
Zirps, Fotena Anatolia., Florida State University
Abstract/Description
Three hundred children were tested in the fall and spring of their first grade year. They were given measures of phonological awareness, orthographic knowledge, reading, spelling, IQ and memory. Their teachers were surveyed as to the amount of time they spent in phonics, sight vocabulary, and reading practice instruction., The results of confirmatory factor analysis, path analysis, regression analysis, and partial time lag correlation analysis suggested that a model of synthesis versus...
Show moreThree hundred children were tested in the fall and spring of their first grade year. They were given measures of phonological awareness, orthographic knowledge, reading, spelling, IQ and memory. Their teachers were surveyed as to the amount of time they spent in phonics, sight vocabulary, and reading practice instruction., The results of confirmatory factor analysis, path analysis, regression analysis, and partial time lag correlation analysis suggested that a model of synthesis versus analysis better explained the pattern of results than a model of sensitivity versus awareness or a general model. The results also suggested that orthographic knowledge contributes unique and independent variance to reading and spelling achievement beyond that contributed by phonological awareness, even for beginning readers. Furthermore, the data suggested that orthographic knowledge enables and is enabled by beginning reading and spelling., In this study, the instructional variables did not contribute unique variance to reading and spelling achievement beyond that of phonological awareness and orthographic knowledge. The measures used in this study were reliable and should be considered for use in the first grade classroom. The teacher survey did not, however, capture the role of instruction. Instructional variables need further exploration in future research.
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Date Issued
1990, 1990
Identifier
AAI9112124, 3162166, FSDT3162166, fsu:78364
Format
Document (PDF)
RELATIONSHIP OF HEME PIGMENTS TO LIPID OXIDATION IN ANIMAL TISSUES
Title
RELATIONSHIP OF HEME PIGMENTS TO LIPID OXIDATION IN ANIMAL TISSUES.
Creator
ZIPSER, MARELYNN WEISS., The Florida State University
Date Issued
1963, 1963
Identifier
AAI6407590, 2985212, FSDT2985212, fsu:69723
Format
Document (PDF)
THE DISTRIBUTION AND DEPTH OF CONVECTIVE CLOUDS OVER THE TROPICAL ATLANTIC OCEAN, AS DETERMINED FROM METEOROLOGICAL SATELLITE AND OTHER DATA
Title
THE DISTRIBUTION AND DEPTH OF CONVECTIVE CLOUDS OVER THE TROPICAL ATLANTIC OCEAN, AS DETERMINED FROM METEOROLOGICAL SATELLITE AND OTHER DATA.
Creator
ZIPSER, EDWARD J., The Florida State University
Date Issued
1965, 1965
Identifier
AAI6605463, 2985446, FSDT2985446, fsu:69955
Format
Document (PDF)
PARENT KNOWLEDGE AND ATTITUDES TOWARD ESEA, TITLE I PROGRAMS AND THEIR ABILITY TO ASSESS CHILD ACHIEVEMENT
Title
PARENT KNOWLEDGE AND ATTITUDES TOWARD ESEA, TITLE I PROGRAMS AND THEIR ABILITY TO ASSESS CHILD ACHIEVEMENT.
Creator
ZIPPERER, DOROTHY JEAN., The Florida State University
Date Issued
1978, 1978
Identifier
AAI7822217, 2988970, FSDT2988970, fsu:73477
Format
Document (PDF)
Determinants of economic growth.
Title
Determinants of economic growth.
Creator
Zipfel, Jacob
Date Issued
2004-10-29
Identifier
160518, FSDT160518, fsu:18948
Format
Document (PDF)
THE DESEGREGATION OF A PUBLIC JUNIOR COLLEGE: A CASE STUDY OF ITS NEGRO FACULTY
Title
THE DESEGREGATION OF A PUBLIC JUNIOR COLLEGE: A CASE STUDY OF ITS NEGRO FACULTY.
Creator
ZION, CAROL LEE., The Florida State University
Date Issued
1965, 1965
Identifier
AAI6605462, 2985445, FSDT2985445, fsu:69954
Format
Document (PDF)
A STUDY OF CURRICULUM DEVELOPMENT PROCEDURES IN THE SECONDARY SCHOOLS OF SARASOTA COUNTY, FLORIDA, 1946-1955
Title
A STUDY OF CURRICULUM DEVELOPMENT PROCEDURES IN THE SECONDARY SCHOOLS OF SARASOTA COUNTY, FLORIDA, 1946-1955.
Creator
ZINTGRAFF, PAUL EDWARD., The Florida State University
Date Issued
1957, 1957
Identifier
AAI0023990, 2984793, FSDT2984793, fsu:69222
Format
Document (PDF)
CONTINUOUS TIME MARKOV INDEPENDENT PARTICLE SYSTEMS WITH CONTINUOUS TIME INPUT
Title
CONTINUOUS TIME MARKOV INDEPENDENT PARTICLE SYSTEMS WITH CONTINUOUS TIME INPUT.
Creator
ZINSMEISTER, ALAN ROBERT., The Florida State University
Date Issued
1979, 1979
Identifier
AAI8007531, 2989439, FSDT2989439, fsu:73946
Format
Document (PDF)
DEVELOPMENT OF A VALID AND RELIABLE INSTRUMENT TO IDENTIFY A PERSONAL PHILOSOPHY OF ADULT EDUCATION
Title
DEVELOPMENT OF A VALID AND RELIABLE INSTRUMENT TO IDENTIFY A PERSONAL PHILOSOPHY OF ADULT EDUCATION.
Creator
ZINN, LORRAINE MARIE., Florida State University
Abstract/Description
This study resulted in a valid and reliable instrument that identifies an individual's personal philosophy of adult education. The Philosophy of Adult Education Inventory yields scores which categorize an individual's personal philosophy of adult education with respect to five prevailing adult education philosophies: Liberal, Behaviorist, Progressive, Humanistic, and Radical. Support for the need for adult educators to identify their personal education philosophy was offered from literature...
Show moreThis study resulted in a valid and reliable instrument that identifies an individual's personal philosophy of adult education. The Philosophy of Adult Education Inventory yields scores which categorize an individual's personal philosophy of adult education with respect to five prevailing adult education philosophies: Liberal, Behaviorist, Progressive, Humanistic, and Radical. Support for the need for adult educators to identify their personal education philosophy was offered from literature which included adult education, educational philosophy, values clarification, organizational development, and human resource development and training., The Inventory was field-tested by 78 individuals over a period of ten months. After revision, it was tested for content and construct validity, internal consistency, and stability. Content validity was establiched by a jury of six individuals; construct validity was established through factor analysis. Data for factor analysis and reliability testing were obtained from 86 individuals from six states and the District of Columbia. Internal consistency and test retest stability were determined based on Pearson product moment correlations for individual response options, items, and overall scales. The instrument was judged to have a fairly high degree of validity, based on jury mean scores of > .50 (on a 7-point scale) on 93% of the response options and communality coefficients of > .50 on 87% of the response options. Reliability coefficients of > .40 on 87% of the response options and alpha coefficients ranging from .75 to .86 on the five scales were considered measures of moderate to high reliability. Test-retest data were judged unreliable due to the small size of the sample (n = 8); however, retest data did show a tendency toward moderate to high reliability (r of .48 to .83) for the five scales., The Philosophy of Adult Education Inventory was designed to assist the adult educator to begin a process of philosophical inquiry which will potentially result in greater effectiveness in selecting instructional content; establishing teaching and learning objectives; selecting and/or developing instructional materials; interacting with learners; and evaluating educational outcomes.
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Date Issued
1983, 1983
Identifier
AAI8323851, 3085619, FSDT3085619, fsu:75111
Format
Document (PDF)
Exploration of bifurcations of periodic orbits
Title
Exploration of bifurcations of periodic orbits.
Creator
Zink, Christopher Jason
Date Issued
1996
Identifier
157111, FSDT157111, fsu:17268
Format
Document (PDF)
Complete and incomplete momentum transfer processes in the reaction oxygen + silicon(nat)
Title
Complete and incomplete momentum transfer processes in the reaction oxygen + silicon(nat).
Creator
Zingarelli, Robert Alan., Florida State University
Abstract/Description
Complete and incomplete fusion components from the nuclear reaction $\sp{16}$O + $\sp{nat}$Si were studied at 39.2, 59.0, 80.6, 96.4, 112.4, and 127.8 MeV bombarding energy. Inclusive measurements of evaporation residues (ERs) were made at all energies; ER/$\alpha$-particle coincidence measurements were made at 127.8 MeV., Theoretical predictions of observable features of fusion and incomplete fusion reactions are discussed, for inclusive and coincidence measurements., The design,...
Show moreComplete and incomplete fusion components from the nuclear reaction $\sp{16}$O + $\sp{nat}$Si were studied at 39.2, 59.0, 80.6, 96.4, 112.4, and 127.8 MeV bombarding energy. Inclusive measurements of evaporation residues (ERs) were made at all energies; ER/$\alpha$-particle coincidence measurements were made at 127.8 MeV., Theoretical predictions of observable features of fusion and incomplete fusion reactions are discussed, for inclusive and coincidence measurements., The design, construction, and calibration of a new time of flight (TOF) heavy ion spectrometer for the detection of ERs from this reaction is discussed. Incorporation of a silicon surface-barrier E-$\Delta$E $\alpha$-particle detector into the spectrometer for coincidence measurements is also discussed., A model-independent method for extracting complete and incomplete momentum transfer components (CMT and ICMT) of the inclusive data, which are expected to correspond to complete and incomplete fusion (CF and ICF), is presented. A means of analysing coincidence data is discussed., Results of the collection and analysis of both the inclusive and coincidence data are presented. From the inclusive data, the mass, velocity, and angular distributions of the ERs resulting from CMT processes were found in agreement with predictions for CF reactions. From the ERs resulting from ICMT processes, the velocity distributions were found to agree with a two-body projectile fragmentation model; net absorption of clusters of one, two, or three $\alpha$-particles seems to be the predominant process. In the coincidence data no clearly separable signature distinguishing CF and ICF reactions could be found, however fits to coincident $\alpha$-particle energy spectra indicate that the signature is there but masked by a large fusion-evaporation component.
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Date Issued
1990, 1990
Identifier
AAI9112123, 3162194, FSDT3162194, fsu:78392
Format
Document (PDF)
LITURGICAL MUSIC ARRANGED TO MEET THE NEEDS OF GRADES SEVEN, EIGHT, AND NINE SINGING GROUPS IN CATHOLIC PAROCHIAL SCHOOLS OF FLORIDA. (PARTS I AND II)
Title
LITURGICAL MUSIC ARRANGED TO MEET THE NEEDS OF GRADES SEVEN, EIGHT, AND NINE SINGING GROUPS IN CATHOLIC PAROCHIAL SCHOOLS OF FLORIDA. (PARTS I AND II).
Creator
ZINGALE, JOSEPH LAWRENCE., The Florida State University
Date Issued
1958, 1958
Identifier
AAI5805999, 2984837, FSDT2984837, fsu:69277
Format
Document (PDF)
A THEORETICAL AND EMPIRICAL ANALYSIS OF THE CITY SIZE INCOME RELATIONSHIP
Title
A THEORETICAL AND EMPIRICAL ANALYSIS OF THE CITY SIZE INCOME RELATIONSHIP.
Creator
ZINGALE, JAMES ANTHONY., The Florida State University
Date Issued
1975, 1975
Identifier
AAI7602730, 2988126, FSDT2988126, fsu:72633
Format
Document (PDF)
MECHANISMS OF PRECIPITATION OF POLY-L-GLUTAMIC ACID
Title
MECHANISMS OF PRECIPITATION OF POLY-L-GLUTAMIC ACID.
Creator
ZIMMERMAN, STEPHEN SCOTT., The Florida State University
Date Issued
1973, 1973
Identifier
AAI7408421, 2987499, FSDT2987499, fsu:72008
Format
Document (PDF)
AN INVESTIGATION OF THE EFFECT OF STUDENTS' SELF-CONCEPT OF WRITING ABILITY ON THEIR WRITING PROCESSES AND WRITING ACHIEVEMENT: CASE STUDIES OF ELEVEN BLACK COLLEGE FRESHMEN
Title
AN INVESTIGATION OF THE EFFECT OF STUDENTS' SELF-CONCEPT OF WRITING ABILITY ON THEIR WRITING PROCESSES AND WRITING ACHIEVEMENT: CASE STUDIES OF ELEVEN BLACK COLLEGE FRESHMEN.
Creator
ZIMMERMAN, JUNE WOODARD., The Florida State University
Date Issued
1977, 1977
Identifier
AAI7808979, 2988848, FSDT2988848, fsu:73355
Format
Document (PDF)
Distribution and abundance of frogs in a central Amazonian forest
Title
Distribution and abundance of frogs in a central Amazonian forest.
Creator
Zimmerman, Barbara L., Florida State University
Abstract/Description
This study is the first comprehensive survey of a frog assemblage in the central Amazon. Forty-three species of frog were found in a 2,000 hectare tract of primary forest near Manaus, Brazil. Breeding habitat affiliation, breeding phenology, spatial distribution, and relative abundance were determined for most species principally by counting calling males along variable-width strip transects. Frogs were also censused with visual detection methods and in litter plots. However, these techniques...
Show moreThis study is the first comprehensive survey of a frog assemblage in the central Amazon. Forty-three species of frog were found in a 2,000 hectare tract of primary forest near Manaus, Brazil. Breeding habitat affiliation, breeding phenology, spatial distribution, and relative abundance were determined for most species principally by counting calling males along variable-width strip transects. Frogs were also censused with visual detection methods and in litter plots. However, these techniques were not as powerful as audio transects for assessing species composition, habitat occupancy, and abundances throughout a large area. Anuran species and generic richnesses are similar throughout the Amazon except for Eleutherodactylus which is depauperate in the central and lower Amazon. As many species were abundant in the study area as were rare. The distribution of breeding habitat abundance parallels the distribution of species-abundance and so breeding habitat availability seems the best candidate to explain the relative abundances of species in the study area., There is pervasive correlation between life history variables, particularly reproductive mode and habitat affiliation, and phylogeny in tropical forest anurans. This association supports a hypothesis that, at a regional scale, the history of an area's colonization and speciation rates of the colonists influenced the distribution of habitat use by frogs in forest assemblages more than selection., Litter plot sampling was biased in favour of conspicuously behaving litter species. Since the proportion of the litter fauna that is conspicuously behaving is much lower in southeast Asia than the Neotropics, there is no evidence that litter frogs per se are more abundant in the Neotropics. However, abundances of conspicuously behaving species are higher in the Neotropics. Practically all abundant species at Manaus undergo terrestrial development. It appears that terrestrial reproduction releases frog populations from dependence on limited aquatic habitat. Since two prominent Neotropical families of litter frog reproduce terrestrially whereas terrestrial development is not associated with any southeast Asian taxon, the historical colonization of these regions by different lineages explains inter-regional abundance differences most parsimoniously.
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Date Issued
1991, 1991
Identifier
AAI9126987, 3087579, FSDT3087579, fsu:76396
Format
Document (PDF)
RESONANCE RAMAN STUDIES OF THE INTERMEDIATES OF THE CATALYTIC CYCLES OF HORSERADISH PEROXIDASE: COMPARISON OF COMPOUND III TO OXYMYOGLOBIN (HEME PROTEINS, OXIDASE, STOPPED-FLOW)
Title
RESONANCE RAMAN STUDIES OF THE INTERMEDIATES OF THE CATALYTIC CYCLES OF HORSERADISH PEROXIDASE: COMPARISON OF COMPOUND III TO OXYMYOGLOBIN (HEME PROTEINS, OXIDASE, STOPPED-FLOW).
Creator
ZIMMER, JOHN RAYMOND., Florida State University
Abstract/Description
Resonance Raman spectroscopy and cryoenzymology have been combined to study the structures of intermediates in the peroxidase and oxidase pathways of HRP. The intermediates compound I, II, and III, have been stabilized at subzero temperatures in buffered methanol solutions. Vibrational spectra of the heme group of compounds II and III have been obtained by excitation in the vicinity of the B and Q transitions of the heme. The resultant spectra contain bands whose frequencies reveal the...
Show moreResonance Raman spectroscopy and cryoenzymology have been combined to study the structures of intermediates in the peroxidase and oxidase pathways of HRP. The intermediates compound I, II, and III, have been stabilized at subzero temperatures in buffered methanol solutions. Vibrational spectra of the heme group of compounds II and III have been obtained by excitation in the vicinity of the B and Q transitions of the heme. The resultant spectra contain bands whose frequencies reveal the structure and coordination properties of the heme group in each catalytic intermediate. A comparison of these results with those for Mb, particularly between oxy-Mb and Compound III, reveal substantial differences in the low frequency regions (200 to 800 cm('-1)) and small differences in the high frequency skeletal modes., Comparing these differences to model compounds, especially the isotopically sensitive Fe-O(,2) mode at 570 cm('-1) in Mb and 559 cm('-1) in compound III, demonstrates that the functional differences between these two proteins lies in the disposition of the proximal imidazole relative to the heme plane.
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Date Issued
1984, 1984
Identifier
AAI8503171, 3085979, FSDT3085979, fsu:75465
Format
Document (PDF)
Field notebook of Jessica Zimmer, Castro Site, August to September 2000
Title
Field notebook of Jessica Zimmer, Castro Site, August to September 2000.
Creator
Zimmer, Jessica
Identifier
FSU_ANT_Castro_fieldnote_Fall_Zimmer_parent
Format
Set of related objects
OCD candidate gene /EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
Title
OCD candidate gene /EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
Creator
Zike, Isaac D, Chohan, Muhammad O, Kopelman, Jared M, Krasnow, Emily N, Flicker, Daniel, Nautiyal, Katherine M, Bubser, Michael, Kellendonk, Christoph, Jones, Carrie K, Stanwood...
Show moreZike, Isaac D, Chohan, Muhammad O, Kopelman, Jared M, Krasnow, Emily N, Flicker, Daniel, Nautiyal, Katherine M, Bubser, Michael, Kellendonk, Christoph, Jones, Carrie K, Stanwood, Gregg, Tanaka, Kenji Fransis, Moore, Holly, Ahmari, Susanne E, Veenstra-VanderWeele, Jeremy
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Abstract/Description
Obsessive-compulsive disorder (OCD) is a chronic, disabling condition with inadequate treatment options that leave most patients with substantial residual symptoms. Structural, neurochemical, and behavioral findings point to a significant role for basal ganglia circuits and for the glutamate system in OCD. Genetic linkage and association studies in OCD point to , which encodes the neuronal glutamate/aspartate/cysteine transporter excitatory amino acid transporter 3 (EAAT3)/excitatory amino...
Show moreObsessive-compulsive disorder (OCD) is a chronic, disabling condition with inadequate treatment options that leave most patients with substantial residual symptoms. Structural, neurochemical, and behavioral findings point to a significant role for basal ganglia circuits and for the glutamate system in OCD. Genetic linkage and association studies in OCD point to , which encodes the neuronal glutamate/aspartate/cysteine transporter excitatory amino acid transporter 3 (EAAT3)/excitatory amino acid transporter 1 (EAAC1). However, no previous studies have investigated EAAT3 in basal ganglia circuits or in relation to OCD-related behavior. Here, we report a model of loss based on an excisable STOP cassette that yields successful ablation of EAAT3 expression and function. Using amphetamine as a probe, we found that EAAT3 loss prevents expected increases in () locomotor activity, () stereotypy, and () immediate early gene induction in the dorsal striatum following amphetamine administration. Further, -STOP mice showed diminished grooming in an SKF-38393 challenge experiment, a pharmacologic model of OCD-like grooming behavior. This reduced grooming is accompanied by reduced dopamine D receptor binding in the dorsal striatum of -STOP mice. -STOP mice also exhibit reduced extracellular dopamine concentrations in the dorsal striatum both at baseline and following amphetamine challenge. Viral-mediated restoration of /EAAT3 expression in the midbrain but not in the striatum results in partial rescue of amphetamine-induced locomotion and stereotypy in -STOP mice, consistent with an impact of EAAT3 loss on presynaptic dopaminergic function. Collectively, these findings indicate that the most consistently associated OCD candidate gene impacts basal ganglia-dependent repetitive behaviors.
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Date Issued
2017-05-30
Identifier
FSU_pmch_28507136, 10.1073/pnas.1701736114, PMC5465902, 28507136, 28507136, 1701736114
Format
Citation
A case study of selected community colleges' exemplary institutional effectiveness models
Title
A case study of selected community colleges' exemplary institutional effectiveness models.
Creator
Ziel, Joan Williams., Florida State University
Abstract/Description
Institutional effectiveness models are examined in two community colleges, judged to have exemplary institutional effectiveness systems in place. One community college is organized within the context of a state level governance system and one is organized under the authority of a local Board of Trustees., The institutional effectiveness models are examined through an integrated framework of open systems theory and the concepts of effective planning and evaluation processes required by the...
Show moreInstitutional effectiveness models are examined in two community colleges, judged to have exemplary institutional effectiveness systems in place. One community college is organized within the context of a state level governance system and one is organized under the authority of a local Board of Trustees., The institutional effectiveness models are examined through an integrated framework of open systems theory and the concepts of effective planning and evaluation processes required by the criteria contained in Section III of the Southern Association of Colleges and Schools' accreditation criteria., The research questions addressed in this study focus on: (a) the events and circumstances that impeded or encouraged the development of the institutional effectiveness model, (b) the elements and strategies of exemplary planning and evaluation practices in the selected institutions, (c) how planning and evaluation practices are integrated into the operational activities of the case institutions, (d) how the existing governance structure influences the institutional effectiveness process, and (e) the role the governing board plays in the utilization of evaluation data to improve institutional effectiveness in the case institutions., Qualitative research data were collected through interviews, institutional documents, and observations. Triangulation of the data ensured the trustworthiness of the study. A narrative report was reviewed by the designated liaisons at the case institutions to verify interpretations of the data., The results of the study suggested that presidential leadership was a major factor in the development of the institutional effectiveness systems. Other significant factors included regional accreditation criteria and state policies encouraging institutional effectiveness efforts., Contextual factors such as the unique institutional culture, governance structure, administrative organizations, and institutional resource development played an integral role in the development of the institutional effectiveness systems. The findings revealed that planning and evaluation information was utilized to focus institutional energies and resources upon the achievement of quality educational experiences to support student success.
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Date Issued
1992, 1992
Identifier
AAI9222438, 3087812, FSDT3087812, fsu:76622
Format
Document (PDF)
A neural network which rapidly learns to perform a multistep task
Title
A neural network which rapidly learns to perform a multistep task.
Creator
Ziegler, Uta Maria., Florida State University
Abstract/Description
This research develops a neural network which can learn to perform a multi-step task. The particular task chosen is the autonomous navigation of a vehicle. The task is taught in three phases: to approach a given goal location in the absence of obstacles; to avoid collisions with obstacles during the goal approach; and to move through groups of obstacles while approaching the goal., The network architecture and learning rules for the first phase support a rapid acquisition of domain concepts...
Show moreThis research develops a neural network which can learn to perform a multi-step task. The particular task chosen is the autonomous navigation of a vehicle. The task is taught in three phases: to approach a given goal location in the absence of obstacles; to avoid collisions with obstacles during the goal approach; and to move through groups of obstacles while approaching the goal., The network architecture and learning rules for the first phase support a rapid acquisition of domain concepts from demonstrated examples and from learning-by-doing. Large weight changes early during the learning process permit a fast approximation of the target behavior. Each weight change is limited by the weight's plasticity value which represents the network's belief that the weight is incorrect., One of the subnetworks into which the network is broken is a very simplified short-term memory. It provides the contextual information for the next step which is crucial for the network to be able to perform the multi-step task correctly., The next two phases employ additional components which learn how to influence the overall behavior by changing the previously learned spread of activation among components rather than within components. Previous behavior is overlaid by the new knowledge, but remains intact., The new components of phases two and three enhance the network's perceptual capabilities. Additional features can be detected which contribute to the overall improvement of the network's behavior., The network is implemented on a Cray YM-P in FORTRAN.
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Date Issued
1991, 1991
Identifier
AAI9124641, 3087562, FSDT3087562, fsu:76380
Format
Document (PDF)
A THREE BODY MODEL OF THE DEUTERON OPTICAL POTENTIAL
Title
A THREE BODY MODEL OF THE DEUTERON OPTICAL POTENTIAL.
Creator
ZIEGLER, JERRY LOUIS., The Florida State University
Date Issued
1968, 1968
Identifier
AAI6807806, 2985771, FSDT2985771, fsu:70280
Format
Document (PDF)

Pages