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Bell-shaped Dose-response of Topical FGF-1 in Accelerating Dermal Wound Healing in Aged Female BALB/cByJ Mice

Title: A Bell-shaped Dose-response of Topical FGF-1 in Accelerating Dermal Wound Healing in Aged Female BALB/cByJ Mice.
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Name(s): Hagerott, Brooke, author
Blumstein, Alli, author
McGarry, Lauren, author
Cohen, Hannah, author
Tenorio, Connie, author
Powell, Brett, author
Nagy, Tamas, author
Blaber, Michael, author
Type of Resource: text
Genre: Text
Journal Article
Date Issued: 2020-06-20
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The objective of this study was to characterize the therapeutic dose-response characteristics for topical FGF-1 in the full-thickness dermal healing of aged female BALB/cByJ mice. The approach utilized a splinted excisional model of dermal healing, and a novel fine-sampled photographic methodology, to quantify key wound healing parameters for different doses of topical FGF-1. The histology of healed wounds, representative of each dose cohort, was also evaluated by section and staining. The results show that topical FGF-1 pharmacotherapy for accelerating dermal healing in aged BALB/cByJ female mice yields a narrow dose-response curve, with diminished therapeutic effect at high concentration (i.e. “bell-shaped” dose-response). The physiological response of FGF-1 in wound healing involves a combination of cell types (including vascular endothelial cells, epidermal keratinocytes and dermal fibroblasts). These individual cells types in culture can have different FGF-1 dose-response curves; however, only the response of fibroblasts is bell-shaped. The bell-shaped dose-response in dermal healing therefore principally reflects the effect upon fibroblasts. A narrow bell-shaped dose-response requires precise dosing of FGF-1 for therapeutic benefit. The results identify the practical dose range to elicit such a benefit.
Identifier: FSU_libsubv1_scholarship_submission_1591883645_68fa5c0c (IID), 10.1007/s42485-020-00040-z (DOI)
Keywords: wound healing, FGF-1, pharmacotherapy, aging
Publication Note: This is the accepted manuscript, and the publisher's version of the record can be found at https://doi.org/10.1007/s42485-020-00040-z.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1591883645_68fa5c0c
Host Institution: FSU
Is Part Of: Journal of Proteins and Proteomics.

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Hagerott, B., Blumstein, A., McGarry, L., Cohen, H., Tenorio, C., Powell, B., … Blaber, M. (2020). A Bell-shaped Dose-response of Topical FGF-1 in Accelerating Dermal Wound Healing in Aged Female BALB/cByJ Mice. Journal Of Proteins And Proteomics. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1591883645_68fa5c0c