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Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in .

Title: Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in .
Name(s): Tillery, Marisa M L, author
Blake-Hedges, Caitlyn, author
Zheng, Yiming, author
Buchwalter, Rebecca A, author
Megraw, Timothy L, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2018-08-28
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The centrosome is the best-understood microtubule-organizing center (MTOC) and is essential in particular cell types and at specific stages during development. The centrosome is not required zygotically for mitosis or to achieve full animal development. Nevertheless, centrosomes are essential maternally during cleavage cycles in the early embryo, for male meiotic divisions, for efficient division of epithelial cells in the imaginal wing disc, and for cilium/flagellum assembly in sensory neurons and spermatozoa. Importantly, asymmetric and polarized division of stem cells is regulated by centrosomes and by the asymmetric regulation of their microtubule (MT) assembly activity. More recently, the components and functions of a variety of non-centrosomal microtubule-organizing centers (ncMTOCs) have begun to be elucidated. Throughout development, a wide variety of unique ncMTOCs form in epithelial and non-epithelial cell types at an assortment of subcellular locations. Some of these cell types also utilize the centrosomal MTOC, while others rely exclusively on ncMTOCs. The impressive variety of ncMTOCs being discovered provides novel insight into the diverse functions of MTOCs in cells and tissues. This review highlights our current knowledge of the composition, assembly, and functional roles of centrosomal and non-centrosomal MTOCs in .
Identifier: FSU_pmch_30154378 (IID), 10.3390/cells7090121 (DOI), PMC6162459 (PMCID), 30154378 (RID), 30154378 (EID), cells7090121 (PII)
Keywords: Drosophila, Centriole, Centrosome, Microtubule, Microtubule-organizing center (MTOC), Ninein, Non-centrosomal MTOC, Patronin, γ-tubulin
Grant Number: R15 GM119078, GM119078, 7ZK06
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: Cells.
Issue: iss. 9, vol. 7

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Tillery, M. M. L., Blake-Hedges, C., Zheng, Y., Buchwalter, R. A., & Megraw, T. L. (2018). Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in . Cells. Retrieved from