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Neural preservation underlies speech improvement from auditory deprivation in young cochlear implant recipients.

Title: Neural preservation underlies speech improvement from auditory deprivation in young cochlear implant recipients.
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Name(s): Feng, Gangyi, author
Ingvalson, Erin M, author
Grieco-Calub, Tina M, author
Roberts, Megan Y, author
Ryan, Maura E, author
Birmingham, Patrick, author
Burrowes, Delilah, author
Young, Nancy M, author
Wong, Patrick C M, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2018-01-30
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Although cochlear implantation enables some children to attain age-appropriate speech and language development, communicative delays persist in others, and outcomes are quite variable and difficult to predict, even for children implanted early in life. To understand the neurobiological basis of this variability, we used presurgical neural morphological data obtained from MRI of individual pediatric cochlear implant (CI) candidates implanted younger than 3.5 years to predict variability of their speech-perception improvement after surgery. We first compared neuroanatomical density and spatial pattern similarity of CI candidates to that of age-matched children with normal hearing, which allowed us to detail neuroanatomical networks that were either affected or unaffected by auditory deprivation. This information enables us to build machine-learning models to predict the individual children's speech development following CI. We found that regions of the brain that were unaffected by auditory deprivation, in particular the auditory association and cognitive brain regions, produced the highest accuracy, specificity, and sensitivity in patient classification and the most precise prediction results. These findings suggest that brain areas unaffected by auditory deprivation are critical to developing closer to typical speech outcomes. Moreover, the findings suggest that determination of the type of neural reorganization caused by auditory deprivation before implantation is valuable for predicting post-CI language outcomes for young children.
Identifier: FSU_pmch_29339512 (IID), 10.1073/pnas.1717603115 (DOI), PMC5798370 (PMCID), 29339512 (RID), 29339512 (EID), 1717603115 (PII)
Keywords: Auditory deprivation, Cochlear implant, Machine learning, Neural preservation, Prediction
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798370.
Subject(s): Brain Mapping
Child
Child, Preschool
Cochlear Implantation
Cochlear Implants
Deafness/rehabilitation
Female
Hearing
Humans
Language Development
Machine Learning
Magnetic Resonance Imaging
Male
Models, Neurological
Multivariate Analysis
Nerve Net
Neuroanatomy
Neurons/physiology
Speech/physiology
Speech Perception
Speech Therapy/methods
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_29339512
Host Institution: FSU
Is Part Of: Proceedings of the National Academy of Sciences of the United States of America.
1091-6490
Issue: iss. 5, vol. 115

Choose the citation style.
Feng, G., Ingvalson, E. M., Grieco-Calub, T. M., Roberts, M. Y., Ryan, M. E., Birmingham, P., … Wong, P. C. M. (2018). Neural preservation underlies speech improvement from auditory deprivation in young cochlear implant recipients. Proceedings Of The National Academy Of Sciences Of The United States Of America. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_29339512