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Challenges And Guidelines Toward 4d Nucleome Data And Model Standards

Title: Challenges And Guidelines Toward 4d Nucleome Data And Model Standards.
Name(s): Marti-Renom, Marc A., author
Almouzni, Genevieve, author
Bickmore, Wendy A., author
Bystricky, Kerstin, author
Cavalli, Giacomo, author
Fraser, Peter, author
Gasser, Susan M., author
Giorgetti, Luca, author
Heard, Edith, author
Nicodemi, Mario, author
Nollmann, Marcelo, author
Orozco, Modesto, author
Pombo, Ana, author
Torres-Padilla, Maria-Elena, author
Type of Resource: text
Genre: Journal Article
Journal Article
Date Issued: 2018-10-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Due to recent advances in experimental and theoretical approaches, the dynamic three-dimensional organization (3D) of the nucleus has become a very active area of research in life sciences. We now understand that the linear genome is folded in ways that may modulate how genes are expressed during the basic functioning of cells. Importantly, it is now possible to build 3D models of how the genome folds within the nucleus and changes over time (4D). Because genome folding influences its function, this opens exciting new possibilities to broaden our understanding of the mechanisms that determine cell fate. However, the rapid evolution of methods and the increasing complexity of data can result in ambiguity and reproducibility challenges, which may hamper the progress of this field. Here, we describe such challenges ahead and provide guidelines to think about strategies for shared standardized validation of experimental 4D nucleome data sets and models.
Identifier: FSU_libsubv1_wos_000446047000006 (IID), 10.1038/s41588-018-0236-3 (DOI)
Keywords: in-vivo, gene-expression, embryonic stem-cells, hi-c, transcription factors, 3-dimensional architecture, chromosome conformation capture, multifocus microscopy, protein data-bank, range genomic interactions
Publication Note: The publisher’s version of record is available at
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: Nature Genetics.
Issue: iss. 10, vol. 50

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Marti-Renom, M. A., Almouzni, G., Bickmore, W. A., Bystricky, K., Cavalli, G., Fraser, P., … Torres-Padilla, M. -E. (2018). Challenges And Guidelines Toward 4d Nucleome Data And Model Standards. Nature Genetics. Retrieved from