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Effect of Mild Traumatic Brain Injury in a Model of Attention Deficit Hyperactivity Disorder

Title: Effect of Mild Traumatic Brain Injury in a Model of Attention Deficit Hyperactivity Disorder.
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Name(s): Cea Salazar, Valentina Isidora, author
Type of Resource: text
Genre: Text
Bachelor Thesis
Date Issued: 2019-11-04
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Attention Deficit Hyperactivity Disorder (ADHD) can interfere with daily life due to inattention, impulsivity, and hyperactivity. Mild traumatic brain injury (mTBI), or concussion, can cause a number of post-concussive symptoms such as depression, anxiety, and headaches. Repetitive concussion appears to have more severe consequences. We hypothesized that repetitive concussion exacerbates the behaviors associated with ADHD or vice versa. To test this hypothesis four groups of mice were used: 1) mice that received anesthesia only (control), 2) mice exposed to nicotine in their drinking water during gestation and throughout the pre-weaning period (ADHD), 3) mice that received one concussion per day for five days under anesthesia at approximately 60 days of age (mTBI), and 4) ADHD mice that received a 5 concussions (ADHD+ mTBI). The n for each group was 8-12. Behavioral testing for attention, depression, anxiety, spatial working memory, and recognition memory was conducted before and after TBI was performed. mTBI caused short term attention deficits, but did not exacerbate attention deficits associated with ADHD. mTBI also did not exacerbate deficient in spatial working memory associated with ADHD. However, the combination of ADHD and mTBI resulted in depression that was not seen independently in either model, suggesting a synergistic effect of ADHD and mTBI on depression that should be the focus of future work.
Identifier: FSU_libsubv1_scholarship_submission_1556327928_c2e19c25 (IID)
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1556327928_c2e19c25
Host Institution: FSU

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Cea Salazar, V. I. (2019). Effect of Mild Traumatic Brain Injury in a Model of Attention Deficit Hyperactivity Disorder. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1556327928_c2e19c25