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GLP-1R Role in Cognition and Mood

Title: GLP-1R Role in Cognition and Mood.
Name(s): Henderson, Natalie Lynn, author
Type of Resource: text
Genre: Text
Bachelor Thesis
Date Issued: 2019-04-26
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Major Depressive Disorder (MDD) is a common mental illness that produces cognitive deficits in patients, hindering affected individuals from performing daily life activities. In 2017, 17.3 million adults had at least one episode of major depression and more than half of these patients also experienced cognitive impairments (National Survey on Drug Use and Health). Current pharmacotherapies for MDD are somewhat effective at treating symptoms related to affect but are not effective in treating the cognitive impairments associated with MDD. A promising answer to an effective antidepressant pharmacotherapy for both core mood and cognitive symptoms is being sought in glucagon-like peptide-1 receptor (GLP-1R) agonists. Activation of this receptors plays a role in some types of learning and memory and increases hippocampal neurogenesis, a critical component of antidepressant efficacy. We utilized Progressive Ratio (PR), Spatial and Novel Object Recognition (SNOR) and Location Discrimination (LD) tasks to investigate motivation, spatial learning and memory, respectively. We hypothesize that GLP-1R activation enhances execution of these tasks. Our results demonstrate that GLP-1R activation enhances cognitive performance in the LD task in a sex-dependent manner and spatial learning in the SNOR task. These data indicate that GLP-1R has potential to treat cognitive impairment associated with MDD, but its role in improving motivational and mood aspects of MDD requires further investigation.
Identifier: FSU_libsubv1_scholarship_submission_1556303918_622ab141 (IID)
Keywords: Major Depressive Disorder, cognitive deficits, cognitive enhancements, GLP-1 receptors, Location Discrimination, Progressive Ratio, Spatial and Novel Object Recognition
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Host Institution: FSU

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Henderson, N. L. (2019). GLP-1R Role in Cognition and Mood. Retrieved from