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Causal evidence for lateral prefrontal cortex dynamics supporting cognitive control.

Title: Causal evidence for lateral prefrontal cortex dynamics supporting cognitive control.
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Name(s): Nee, Derek Evan, author
D'Esposito, Mark, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-09-13
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The lateral prefrontal cortex (LPFC) is essential for higher-level cognition, but the nature of its interactions in supporting cognitive control remains elusive. Previously (Nee and D'Esposito, 2016), dynamic causal modeling (DCM) indicated that mid LPFC integrates abstract, rostral and concrete, caudal influences to inform context-appropriate action. Here, we use continuous theta-burst transcranial magnetic stimulation (cTBS) to test this model causally. cTBS was applied to three LPFC sites and a control site in counterbalanced sessions. Behavioral modulations resulting from cTBS were largely predicted by information flow within the previously estimated DCM. However, cTBS to caudal LPFC unexpectedly impaired processes that are presumed to involve rostral LPFC. Adding a pathway from caudal to mid-rostral LPFC significantly improved the model fit and accounted for the observed behavioral findings. These data provide causal evidence for LPFC dynamics supporting cognitive control and demonstrate the utility of combining DCM with causal manipulations to test and refine models of cognition.
Identifier: FSU_pmch_28901287 (IID), 10.7554/eLife.28040 (DOI), PMC5640427 (PMCID), 28901287 (RID), 28901287 (EID), 28040 (PII)
Keywords: Cognitive control, Dynamic causal modeling, FMRI, Hierarchy, Human, Neuroscience, Prefrontal cortex, Transcranial magnetic stimulation
Grant Number: F32 NS082069, P01 NS040813, R01 MH063901
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640427.
Subject(s): Adolescent
Adult
Cognition
Female
Humans
Magnetic Resonance Imaging
Male
Models, Neurological
Neural Pathways/physiology
Prefrontal Cortex/physiology
Transcranial Magnetic Stimulation
Young Adult
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28901287
Host Institution: FSU
Is Part Of: eLife.
2050-084X
Issue: vol. 6

Choose the citation style.
Nee, D. E., & D'Esposito, M. (2017). Causal evidence for lateral prefrontal cortex dynamics supporting cognitive control. Elife. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28901287