You are here

Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain.

Title: Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain.
0 views
0 downloads
Name(s): Nätt, Daniel, author
Barchiesi, Riccardo, author
Murad, Josef, author
Feng, Jian, author
Nestler, Eric J, author
Champagne, Frances A, author
Thorsell, Annika, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-09-11
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Childhood malnutrition is a risk factor for mental disorders, such as major depression and anxiety. Evidence shows that similar early life adversities induce sex-dependent epigenetic reprogramming. However, little is known about how genes are specifically affected by early malnutrition and the implications for males and females respectively. One relevant target is neuropeptide Y (NPY), which regulates both stress and food-intake. We studied maternal low protein diet (LPD) during pregnancy/lactation in mice. Male, but not female, offspring of LPD mothers consistently displayed anxiety- and depression-like behaviors under acute stress. Transcriptome-wide analysis of the effects of acute stress in the amygdala, revealed a list of transcription factors affected by either sex or perinatal LPD. Among these immediate early genes (IEG), members of the Early growth response family (Egr1/2/4) were consistently upregulated by perinatal LPD in both sexes. EGR1 also bound the NPY receptor Y1 gene (Npy1r), which co-occurred with sex-specific effects of perinatal LPD on both Npy1r DNA-methylation and gene transcription. Our proposed pathway connecting early malnutrition, sex-independent regulatory changes in Egr1, and sex-specific epigenetic reprogramming of its effector gene, Npy1r, represents the first molecular evidence of how early life risk factors may generate sex-specific epigenetic effects relevant for mental disorders.
Identifier: FSU_pmch_28894112 (IID), 10.1038/s41598-017-10803-2 (DOI), PMC5593991 (PMCID), 28894112 (RID), 28894112 (EID), 10.1038/s41598-017-10803-2 (PII)
Grant Number: P50 MH096890
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593991.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28894112
Host Institution: FSU
Is Part Of: Scientific reports.
2045-2322
Issue: iss. 1, vol. 7

Choose the citation style.
Nätt, D., Barchiesi, R., Murad, J., Feng, J., Nestler, E. J., Champagne, F. A., & Thorsell, A. (2017). Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain. Scientific Reports. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28894112