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Characterization of Dengue Virus Infections Among Febrile Children Clinically Diagnosed With a Non-Dengue Illness, Managua, Nicaragua.

Title: Characterization of Dengue Virus Infections Among Febrile Children Clinically Diagnosed With a Non-Dengue Illness, Managua, Nicaragua.
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Name(s): Waggoner, Jesse J, author
Gresh, Lionel, author
Mohamed-Hadley, Alisha, author
Balmaseda, Angel, author
Soda, K James, author
Abeynayake, Janaki, author
Sahoo, Malaya K, author
Liu, Yuanyuan, author
Kuan, Guillermina, author
Harris, Eva, author
Pinsky, Benjamin A, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-06-15
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: We sought to characterize dengue virus (DENV) infections among febrile children enrolled in a pediatric cohort study who were clinically diagnosed with a non-dengue illness ("C cases"). DENV infections were detected and viral load quantitated by real-time reverse transcription-polymerase chain reaction in C cases presenting between January 2007 and January 2013. One hundred forty-one of 2892 C cases (4.88%) tested positive for DENV. Of all febrile cases in the study, DENV-positive C cases accounted for an estimated 52.0% of patients with DENV viremia at presentation. Compared with previously detected, symptomatic dengue cases, DENV-positive C cases were significantly less likely to develop long-lasting humoral immune responses to DENV, as measured in healthy annual serum samples (79.7% vs 47.8%; P < .001). Humoral immunity was associated with viral load at presentation: 40 of 43 patients (93.0%) with a viral load ≥7.0 log10 copies/mL serum developed the expected rise in anti-DENV antibodies in annual samples versus 13 of 68 (19.1%) patients with a viral load below this level (P < .001). Antibody responses to DENV-positive C cases differ from responses to classic symptomatic dengue. These findings have important implications for DENV transmission modeling, immunology, and epidemiologic surveillance.
Identifier: FSU_pmch_28863466 (IID), 10.1093/infdis/jix195 (DOI), PMC5853235 (PMCID), 28863466 (RID), 28863466 (EID), 3747427 (PII)
Keywords: Dengue virus, Humoral immunity, RRT-PCR, Viral load
Grant Number: K08 AI110528, P01 AI106695, R01 AI099631
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853235.
Subject(s): Antibodies, Viral/blood
Antibody Formation/immunology
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Dengue/diagnosis
Dengue/epidemiology
Dengue/virology
Dengue Virus/immunology
Enzyme-Linked Immunosorbent Assay
Female
Fever/etiology
Humans
Incidence
Male
Nicaragua/epidemiology
RNA, Viral/blood
Reverse Transcriptase Polymerase Chain Reaction
Viremia/genetics
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28863466
Owner Institution: FSU
Is Part Of: The Journal of infectious diseases.
1537-6613
Issue: iss. 12, vol. 215

Choose the citation style.
Waggoner, J. J., Gresh, L., Mohamed-Hadley, A., Balmaseda, A., Soda, K. J., Abeynayake, J., … Pinsky, B. A. (2017). Characterization of Dengue Virus Infections Among Febrile Children Clinically Diagnosed With a Non-Dengue Illness, Managua, Nicaragua. The Journal Of Infectious Diseases. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28863466