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Controversies on lung cancers manifesting as part-solid nodules.

Title: Controversies on lung cancers manifesting as part-solid nodules.
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Name(s): Yip, Rowena, author
Li, Kunwei, author
Liu, Li, author
Xu, Dongming, author
Tam, Kathleen, author
Yankelevitz, David F, author
Taioli, Emanuela, author
Becker, Betsy, author
Henschke, Claudia I, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2018-02-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs). PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs <80% or category PSNs ≥80%. Twenty studies reported on PSNs <80%: 7 reported DFS and 2 OS of 100%, 6 DFS 96.3-98.7%, and 11 OS 94.7-98.9% (median DFS 100% and OS 97.5%). Twenty-seven studies reported on PSNs ≥80%: 1 DFS and 2 OS of 100%, 19 DFS 48.0%-98.0% (median 82.6%), and 16 reported OS 43.0%-98.0% (median DFS 82.6%, OS 85.5%). Both DFS and OS were always higher for PSNs <80%. A clear definition of the upper limit of solid component of a PSN is needed to avoid misclassification because cell-types and outcomes are different for PSN and solid nodules. The workup should be based on the size of the solid component. • Lung cancers manifesting as PSNs are slow growing with high cure rates. • Upper limits of the solid component are important for correct interpretation. • Consensus definition is important for the management of PSNs. • Median disease-free-survival (DFS) increased with decreasing size of the nodule.
Identifier: FSU_pmch_28835992 (IID), 10.1007/s00330-017-4975-9 (DOI), PMC5996385 (PMCID), 28835992 (RID), 28835992 (EID), 10.1007/s00330-017-4975-9 (PII)
Keywords: Ground-glass, Lymph node metastases, Staging, Subsolid nodules, Survival
Grant Number: P30 CA196521
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996385.
Subject(s): Adenocarcinoma/diagnostic imaging
Adenocarcinoma/mortality
Adenocarcinoma/pathology
Adenocarcinoma/surgery
Disease-Free Survival
Humans
Multiple Pulmonary Nodules/diagnostic imaging
Multiple Pulmonary Nodules/mortality
Multiple Pulmonary Nodules/pathology
Multiple Pulmonary Nodules/surgery
Retrospective Studies
Tomography, X-Ray Computed
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28835992
Owner Institution: FSU
Is Part Of: European radiology.
1432-1084
Issue: iss. 2, vol. 28

Choose the citation style.
Yip, R., Li, K., Liu, L., Xu, D., Tam, K., Yankelevitz, D. F., … Henschke, C. I. (2018). Controversies on lung cancers manifesting as part-solid nodules. European Radiology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28835992