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Zika virus directly infects peripheral neurons and induces cell death.

Title: Zika virus directly infects peripheral neurons and induces cell death.
Name(s): Oh, Yohan, author
Zhang, Feiran, author
Wang, Yaqing, author
Lee, Emily M, author
Choi, In Young, author
Lim, Hotae, author
Mirakhori, Fahimeh, author
Li, Ronghua, author
Huang, Luoxiu, author
Xu, Tianlei, author
Wu, Hao, author
Li, Cui, author
Qin, Cheng-Feng, author
Wen, Zhexing, author
Wu, Qing-Feng, author
Tang, Hengli, author
Xu, Zhiheng, author
Jin, Peng, author
Song, Hongjun, author
Ming, Guo-Li, author
Lee, Gabsang, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2017-09-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.
Identifier: FSU_pmch_28758997 (IID), 10.1038/nn.4612 (DOI), PMC5575960 (PMCID), 28758997 (RID), 28758997 (EID), nn.4612 (PII)
Grant Number: P01 NS097206, U54 HD079123, R35 NS097370, R21 MH087874, R33 MH087874, P30 DK089502, R37 NS047344, U19 MH106434, R01 NS093213, R21 NS095348, R21 AI119530, R01 AR070751, R01 NS051630, U19 AI131130, R01 MH105128
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Cell Death/physiology
Cells, Cultured
Cercopithecus aethiops
Mice, 129 Strain
Mice, Inbred ICR
Neural Stem Cells/pathology
Neural Stem Cells/virology
Peripheral Nervous System Diseases/pathology
Peripheral Nervous System Diseases/virology
Vero Cells
Zika Virus/physiology
Zika Virus Infection/pathology
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Nature neuroscience.
Issue: iss. 9, vol. 20

Choose the citation style.
Oh, Y., Zhang, F., Wang, Y., Lee, E. M., Choi, I. Y., Lim, H., … Lee, G. (2017). Zika virus directly infects peripheral neurons and induces cell death. Nature Neuroscience. Retrieved from