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Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster.

Title: Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster.
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Name(s): De Nobrega, Aliza K, author
Mellers, Alana P, author
Lyons, Lisa C, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-10-15
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Alcohol abuse is a rising problem in middle-aged and older individuals resulting in serious health, family and economic consequences. Effective treatment necessitates the identification of factors influencing alcohol toxicity with aging. We investigated the interaction between aging, alcohol toxicity and circadian function using Drosophila as a model system. We found as wild type flies age, sensitivity to alcohol increases and circadian regulation of alcohol-induced behaviors weakens. Decreased circadian modulation is correlated with significantly greater alcohol sensitivity during the subjective day. The circadian clock modulates alcohol-induced mortality in younger flies with increased mortality following alcohol exposure at night. Older flies exhibit significantly longer recovery times following alcohol-induced sedation and increased mortality following binge-like or chronic alcohol exposure. Flies rendered arrhythmic either genetically or environmentally exhibit significantly increased alcohol sensitivity, longer recovery times and increased mortality. We hypothesize that the circadian clock phase specifically buffers behavioral and cellular alcohol sensitivity with this protection diminishing as the circadian clock weakens with age.
Identifier: FSU_pmch_28750752 (IID), 10.1016/j.exger.2017.07.014 (DOI), PMC6158789 (PMCID), 28750752 (RID), 28750752 (EID), S0531-5565(17)30055-4 (PII)
Keywords: Aging, Alcohol, Circadian rhythms, Drosophila
Grant Number: R21 AA021233
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158789.
Subject(s): Age Factors
Animals
Animals, Genetically Modified
Circadian Rhythm
Drosophila Proteins/metabolism
Drosophila melanogaster/drug effects
Drosophila melanogaster/physiology
Ethanol/adverse effects
Female
Longevity
Male
Motor Activity
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28750752
Owner Institution: FSU
Is Part Of: Experimental gerontology.
1873-6815
Issue: vol. 97

Choose the citation style.
De Nobrega, A. K., Mellers, A. P., & Lyons, L. C. (2017). Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster. Experimental Gerontology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28750752